BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091   12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEE-----FLLDGTTPEVFQIFLDFIYAPNDDQFGNLEP 86
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESEssvseITLDDVSPEDFEALLEFMYTGKLISEENVDD 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 386771091   87 dvlmcLLKCANMWLAVEIEERCIDILLDLS 116
Cdd:pfam00651  83 -----LLAAADKLQIPSLVDKCEEFLIKSL 107

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091   12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEE-----FLLDGTTPEVFQIFLDFIYAPNDDQFGNLEP 86
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESEssvseITLDDVSPEDFEALLEFMYTGKLISEENVDD 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 386771091   87 dvlmcLLKCANMWLAVEIEERCIDILLDLS 116
Cdd:pfam00651  83 -----LLAAADKLQIPSLVDKCEEFLIKSL 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  13 LMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLF----QEDSE-EFLLDGTTPEVFQIFLDFIYAPNDDqFGNLEPD 87
Cdd:cd18287   16 LFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmRESQQsEIELKDTNAEAFKALLKYIYTGRLT-LTDLKED 94

                         90
                 ....*....|....*....
gi 386771091  88 VLMCLLKCANMWLAVEIEE 106
Cdd:cd18287   95 VLLDVLGLAHQYGFEELEA 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLF----QEDSEEFL-LDGTTPEVFQIFLDFIYApnddqfGNLE- 85
Cdd:cd18256   13 KLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFaggmSESSKDVVqIHGVEPDIFHILLDFIYT------GVVEv 86

                         90       100
                 ....*....|....*....|....*...
gi 386771091  86 -PDVLMCLLKCANMWLAVEIEERCIDIL 112
Cdd:cd18256   87 tVSNVQELLVAADMLQLTEVVEICCEFL 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEE-----FLLDGTTPEVFQIFLDFIYApnddqfGNLE- 85
Cdd:cd18306   11 ALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGesiltVKLDGLDPDAVEVLVNYAYT------SRLEv 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 386771091  86 -PDVLMCLLKCANMWLAVEIEERCIDILLD-LSPD 118
Cdd:cd18306   85 pADLVKSVYSAAKKLKMDRVKKACGDFLLEkLTPQ 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEE----FLLDGTTPEVFQIFLDFIYAPN 77
Cdd:cd18212   16 EQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVgqsiYMLEGMVAETFGALLEFIYTGC 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386771091  13 LMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLF-----QEDSEEFLLDGTTPEVFQIFLDFIY 74
Cdd:cd18242   15 LRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFtsemsEKGKSEVELQGLTASTMEILLDFVY 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 386771091  18 HFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEEFL--LDGTTPEVFQIFLDFIY 74
Cdd:cd18221   17 QFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLveIEGVSNMAFRHLIEFTY 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386771091  12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLF-----QEDSEEFLLDGTTPEVFQIFLDFIYA---PND 78
Cdd:cd18280    7 ALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLfgpmrEENEGEIVIEDVEPPVFKALLHFIYKdelPDD 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  20 SDVCIRIDCISFRCHKIILACASEFFERLFQ----EDSEEFL-LDGTTPEVFQIFLDFIYapnDDQFGnLEPDVLMCLLK 94
Cdd:cd18298   13 SDLKFRVDGKYIYVHKAILKIRCEYFRSMFQshwnEDDKNVIeIDQYSYPVYYAFLRYLY---TDQVD-LPPEDAIGLLD 88

                         90
                 ....*....|....*...
gi 386771091  95 CANMWLAVEIEERCIDIL 112
Cdd:cd18298   89 LANSYCEERLKKLCEDII 106

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  19 FSDVCIRIDCISFRCHKIILACASEFFERLFQE----DSEEFLLDGTTPEVFQIFLDFIY 74
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtppdEHPVIILPDVPYSELKALLDFIY 60

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386771091  17 GHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEEFL-LDGTTPEVFQIFLDFIYAPN---DDQFGN 83
Cdd:cd18334   19 GFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLdTDMVNPTVFRQILDFIYTGKlltSDQPGE 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386771091  30 SFRCHKIILACASEFFERLFQEDSE-----EFLLDGTTPEVFQIFLDFIYApnddQFGNLEPDVLMCLLKCANM 98
Cdd:cd01165    9 KFHVNKELLAQSSEYFRALFRGGFResgqaEINLRDISPEDFRALLEFLYG----GKRDLDASNLLELLEAANF 78

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  12 KLMKSGHFSDVCIRIDCISFRCHK-IILACASEFF-----ERLFQEDSEEFLLDGTTPEVFQIFLDFIYAPNDDQfGNLE 85
Cdd:cd18285    8 RLLREELHTDVTFYVGSTLFKAHKaILLARVPEFFshiigKLSSLEDQEPINIENLEASEFKTFLRQVYTSDKNI-KMLE 86

                 ....
gi 386771091  86 PDVL 89
Cdd:cd18285   87 EEIL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386771091  17 GHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSE------EFLLDGTTPEVFQIFLDFIY 74
Cdd:cd18207   25 GRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGdggtprELEMHTISSKVFGDILDFAY 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 386771091  12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFF 45
Cdd:cd18228   12 SLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFF 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386771091  12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQE----DSEEFLL----DGTTPEVFQIFLDFIYA 75
Cdd:cd18292   10 QLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNdwwsESKQSEIelveDPECAAVFEKFLRYLYT 81

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386771091  12 KLMKSGHFSDVCIRIDC-ISFRCHKIILACASEFFERLFQEDSEEFLLDGTTPEVFQIFLDFIY 74
Cdd:cd18299    5 NLLHSPSCADVVFILQGgVRIFAHRIVLAAASSVFADLFLMMTVVTLDSDITPEAFRRVLEFLY 68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  17 GHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSE-EFLLDGT-TPEVFQIFLDFIY 74
Cdd:cd18289   27 GLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKsAFELPATvPPACFQQILSFCY 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 386771091  17 GHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEEFL-LDGTTPEVFQIFLDFIY 74
Cdd:cd18216   18 GFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNLIHLdQDMVSPTVFQQILDFIY 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386771091  17 GHFSDVCIRIDCISFRCHKIILACASEFFERLFQE-----DSEEFLLDGTTPEVFQIFLDFIY 74
Cdd:cd18198   23 GLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSgavvdQQNVYEIDFVSPEALTALLEFAY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386771091  12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEE-----FLLDGTTPEVFQIFLDFIY 74
Cdd:cd18253   11 EFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHREsremlVEINGILAEAMDCFLQYVY 78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386771091  13 LMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEEFLLDGTT-----PEVFQIFLDFIY 74
Cdd:cd18238    9 FYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITikdidEEAVELLVDFAY 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091   2 STSLRSSRGIK--LMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEE-----FLLDGTTPEVFQIFLDFIY 74
Cdd:cd18272   13 SHSSRVAQSIMdlCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEarnrvIELKDVSESVFQLLVDYIY 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386771091  17 GHFSDVCIRIDCISFRCHKIILACASEFFERLFQedSEEFLLDGTT-------PEVFQIFLDFIYA 75
Cdd:cd18223   16 GILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFS--SQEIWISSHVlelpdlkAEVFAEILNFIYS 79

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  19 FSDVCIRIDCISFRCHKIILACASEFFERLF-----QEDSEEFLLDGTTPEVFQIFLDFIYapnddqFGN--LEPDVLMC 91
Cdd:cd18314    6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLtgsmiESNLKEVTLEDVEPEIFETVLKYMY------TGQvtLSEENVLD 79

                         90
                 ....*....|....*..
gi 386771091  92 LLKCANMWLAVEIEERC 108
Cdd:cd18314   80 LLMLASKYQVPDLEKLC 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEEflldGTTP---------EVFQIFLDFIYAPNDDQFG 82
Cdd:cd18297    5 HYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTE----AQTPvieipdiryDIFQLMMQYLYTGGVESLD 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 386771091  83 NlEPDVLMCLLKCANMWLAVEIEERCiDILLDLSPDMD 120
Cdd:cd18297   81 V-AQDDALELLRAASFFQLDGLKRHC-EILLSQQIDLD 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386771091  10 GIK-LMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSE-----EFLLDGTTPEVFQIFLDFIYAPNDD 79
Cdd:cd18269   17 GLKdLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEeskkkEVVLEDVDPDVMGMILKYLYTSEID 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  13 LMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEEFLLD-----GTTPEVFQIFLDFIY---APNDDQFGNl 84
Cdd:cd18345   12 LFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNrveitDVDHEVMREMLRFIYtgkAPNLDKMAD- 90

                         90       100
                 ....*....|....*....|..
gi 386771091  85 epDVLMCLLKCANMWLAVEIEE 106
Cdd:cd18345   91 --DLLAAADKYALERLKVMCEE 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386771091  15 KSGHFSDVCIRIDCISFRCHKIILACASEFFERLF---QEDSEEFL---LDGTTPEVFQIFLDFIYA 75
Cdd:cd18230   17 QHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYcqvQKTSDQATvthLDIVTAQGFKAIIDFMYS 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386771091  13 LMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEE-----FLLDGTTPEVFQIFLDFIY 74
Cdd:cd18264   22 LRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQEskarvIHLPVVSAAGLQRVLDFIY 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  12 KLMKSGHFSDVCIRIDC----ISFRCHKIILACASEFFERLFQEDSeefLLDGTTPEV---------FQIFLDFIYAPND 78
Cdd:cd18211   18 KLRLLGHLCDVTVQVEHqgskEEFSAHKAVLAASSKYFKEVFLNEK---ISDGKNTNVmlneiytadFASFLEFVYTAKV 94

                         90       100       110
                 ....*....|....*....|....*....|...
gi 386771091  79 DqfgnLEPDVLMCLLKCANMWLAVEIEERCIDI 111
Cdd:cd18211   95 E----VEEDRVQRMLEIAEKLKCLDLSETCFQL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771091  34 HKIILACASEFFERLF----QEDSEEFLLDGTTPEVFQIFLDFIYAPNDDqfgnLEPDVLMCLLKCANMWLAVEIEERCI 109
Cdd:cd18349   27 HKYVLAVGSSVFYAMFygdlAEVKSEIHIPDVEPAAFLILLKYMYSDEID----LEADTVLATLYAAKKYIVPALAKACV 102

                 ...
gi 386771091 110 DIL 112
Cdd:cd18349  103 NFL 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386771091  12 KLMKSGHFSDVCIRIDCISFRCHKIILACASEFFERLFQEDSEE-----FLLDGTTPEVFQIFLDFIY 74
Cdd:cd18332   12 ELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEgvsvlTLPSGLEARGFQLLLDFMY 79