BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  30 LVDVTLAAEGRQLQAHKIVLSACSSYFQALFT-TNPCQHPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEM 108
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 386770453 109 LKIKG 113
Cdd:cd18315   81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  30 LVDVTLAAEGRQLQAHKIVLSACSSYFQALFT-TNPCQHPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEM 108
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 386770453 109 LKIKG 113
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453    32 DVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPC--QHPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEML 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 386770453   110 KIKGLAEM 117
Cdd:smart00225  81 QIPGLVEL 88

hypothetical protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  13 HQPNFISVCSSLLHNGTLVDVTLA-AEGRQLQAHKIVLSACSSYFQALFTTNPCQHPIVILKDVQY---DDLKTMVDFMY 88
Cdd:PHA02713   8 HNRRVVSNISNLLDDDILCDVIITiGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQMfdkDAVKNIVQYLY 87

                         90       100
                 ....*....|....*....|....*.
gi 386770453  89 ygEVNVSQEQLPHILKTAEMLKIKGL 114
Cdd:PHA02713  88 --NRHISSMNVIDVLKCADYLLIDDL 111

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  30 LVDVTLAAEGRQLQAHKIVLSACSSYFQALFT-TNPCQHPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEM 108
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKeTPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 386770453 109 LKIKG 113
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453    32 DVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPC--QHPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEML 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 386770453   110 KIKGLAEM 117
Cdd:smart00225  81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  11 NNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTN--PCQHPIVILKDVQYDDLKTMVDFMY 88
Cdd:cd18242    2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEmsEKGKSEVELQGLTASTMEILLDFVY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 386770453  89 YGEVNVSQEQLPHILKTAEMLKIKGLA-------EMPTDPAN 123
Cdd:cd18242   82 TETVHVTVENVQELLPAACLLQLKGVKqacceflESQLDPSN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  16 NFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTN--PCQHPIVILKDVQYDDLKTMVDFMYYGEVN 93
Cdd:cd18238    1 DSFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEmaESKQDSITIKDIDEEAVELLVDFAYTGKLT 80

                         90       100
                 ....*....|....*....|...
gi 386770453  94 VSQEQLPHILKTAEMLKIKGLAE 116
Cdd:cd18238   81 LTVDNVQSLLYAASLLQVEEVAK 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  13 HQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQHPI--VILKDVQYDDLKTMVDFMYYG 90
Cdd:cd18339    4 HMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAkkIEIKDVDGQTLSKLIDYIYTA 83

                         90       100
                 ....*....|....*....|.
gi 386770453  91 EVNVSQEQLPHILKTAEMLKI 111
Cdd:cd18339   84 EIEVTEENVQVLLPAASLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  30 LVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPC---QHPIViLKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTA 106
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVReatEEEIK-LKDVDPDALWTLVQYCYTGRLELKEDNVESLLATA 79

                 ....*
gi 386770453 107 EMLKI 111
Cdd:cd18234   80 CLLQL 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  13 HQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTN--PCQHPIVILKDVQYDDLKTMVDFMYYG 90
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDhrESREMLVEINGILAEAMDCFLQYVYTG 80

                         90       100
                 ....*....|....*....|....*.
gi 386770453  91 EVNVSQEQLPHILKTAEMLKIKGLAE 116
Cdd:cd18253   81 KVKITTENVQYLFETSSLFQISPLRD 106

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  24 LLHNGTLVDVTLAAEGRQ-LQAHKIVLSACSSYFQALFTTnpcqHPIVIL-KDVQYDDLKTMVDFMYYGEVNVSQEQLPH 101
Cdd:cd18299    6 LLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLFLM----MTVVTLdSDITPEAFRRVLEFLYTGVLDENEDDLKE 81

                         90       100
                 ....*....|....*....|..
gi 386770453 102 ILKTAEMLKIKGLAEMPTDPAN 123
Cdd:cd18299   82 LKDAAELLELFDLVMMCTNVLN 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  22 SSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTT--NPCQHPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQL 99
Cdd:cd18255   10 NALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCI 89

                         90
                 ....*....|..
gi 386770453 100 PHILKTAEMLKI 111
Cdd:cd18255   90 QDVLGAAVHLQM 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  12 NHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPC--QHPIVILKDVQYDDLKTMVDFMYY 89
Cdd:cd18326    7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVvdQQNVYEIDFVSAEALTALLDFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|.
gi 386770453  90 GEVNVSQEQLPHILKTAEMLKIKGLAEMPTD 120
Cdd:cd18326   87 ATLTVSTSNVGDILSAARLLEIPAVSHVCAD 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453   6 FCLrwNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQH--PIVILKDVQYDDLKTM 83
Cdd:cd18259   10 FCL--PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESisARVEIKDVDPAVMESL 87

                         90       100
                 ....*....|....*....|....*.
gi 386770453  84 VDFMYYGEVNVSQEQLPHILKTAEML 109
Cdd:cd18259   88 IDFAYTGKLTINQGNVEALIRTSNRL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  12 NHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPC--QHPIVILKDVQYDDLKTMVDFMYY 89
Cdd:cd18328    7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLadQPYVYEIDFVTPEALSAILEFAYT 86

                         90       100
                 ....*....|....*....|...
gi 386770453  90 GEVNVSQEQLPHILKTAEMLKIK 112
Cdd:cd18328   87 STLTITTSNVKHILNAAQMLEIQ 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  32 DVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQ--HPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEML 109
Cdd:cd18256   22 DVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSEssKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADML 101

                         90       100
                 ....*....|....*....|.
gi 386770453 110 KIKGLAEM-------PTDPAN 123
Cdd:cd18256  102 QLTEVVEIcceflkgQLHPSN 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  13 HQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALF--TTNPCQHPIVILKDVQYDDLKTMVDFMYYG 90
Cdd:cd18250    4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFagELRESRADRVVLHGVSAEILGLLLDFSYTG 83

                         90       100
                 ....*....|....*....|....*.
gi 386770453  91 EVNVSQEQLPHILKTAEMLKIKGLAE 116
Cdd:cd18250   84 RVTVTQDNVEALLRAADLFQFPSVKE 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453   9 RWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFT--TNPCQHPIVILKDVQYDDLKTMVDF 86
Cdd:cd18266    4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigMREAHQKEVELVGASYIGLKAVIDF 83

                         90       100
                 ....*....|....*....|....*
gi 386770453  87 MYYGEVNVSQEQLPHILKTAEMLKI 111
Cdd:cd18266   84 LYSSELPLDGGNIDYVLETAHLLQI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  23 SLLHNGTLV--------------DVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQHpIVILKDVQYDDLKTMVDFMY 88
Cdd:cd18226    1 SLQYNKNLLkylnddrqkqssfcDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTD-AVTLDHVSYSVFQHLLEFLY 79

                         90       100
                 ....*....|....*....|...
gi 386770453  89 YGEVNVSQEQLPHILKTAEMLKI 111
Cdd:cd18226   80 TSEFFVYENEIPLVLEAAKFLDI 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  28 GTLVDVTLAAEGRQLQ----AHKIVLSACSSYFQALFTTNP---CQHPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLP 100
Cdd:cd18211   23 GHLCDVTVQVEHQGSKeefsAHKAVLAASSKYFKEVFLNEKisdGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQ 102

                         90
                 ....*....|....*.
gi 386770453 101 HILKTAEMLKIKGLAE 116
Cdd:cd18211  103 RMLEIAEKLKCLDLSE 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  27 NGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQHPI--VILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILK 104
Cdd:cd18306   15 NRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESIltVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYS 94

                 ....*...
gi 386770453 105 TAEMLKIK 112
Cdd:cd18306   95 AAKKLKMD 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  13 HQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQHPIVI--LKDVQYDDLKTMVDFMYYG 90
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVInlDPEIEPEGFRILLDFMYTS 81

                         90       100
                 ....*....|....*....|.
gi 386770453  91 EVNVSQEQLPHILKTAEMLKI 111
Cdd:cd18215   82 RLNLREGNIMAVMATAMYLQM 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  30 LVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTN--PCQHPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAE 107
Cdd:cd18249   23 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGElaESRQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAAC 102

                         90       100
                 ....*....|....*....|...
gi 386770453 108 MLKIKGLAEM-------PTDPAN 123
Cdd:cd18249  103 LLQLAEIQEVcceflkrQLDPSN 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  12 NHQPNFISVcSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTT--NPCQHPIVILKDVQYDDLKTMVDFMYY 89
Cdd:cd18246   22 HYHDAFVSM-NRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNemSESRQTHVTLHDIDPQALEQLVQYAYT 100

                         90       100
                 ....*....|....*....|....*
gi 386770453  90 GEVNVSQEQLPHILKTAEMLKIKGL 114
Cdd:cd18246  101 AEIVVGEGNVQTLLPAASLLQLNGV 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453   7 CLRWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTN-PCQHPIVILK-DVQYDDLKTMV 84
Cdd:cd18331    1 CIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQlKCNLSVINLDpEINPEGFNILL 80

                         90       100
                 ....*....|....*....|....*..
gi 386770453  85 DFMYYGEVNVSQEQLPHILKTAEMLKI 111
Cdd:cd18331   81 DFMYTSRLNLREGNIMAVMATAMYLQM 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453   9 RWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFT--TNPCQHPIVILKDVQYDDLKTMVDF 86
Cdd:cd18251    2 RSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAggLREMQQTEVLIHGVSYNAMCKILDF 81

                         90       100
                 ....*....|....*....|....*
gi 386770453  87 MYYGEVNVSQEQLPHILKTAEMLKI 111
Cdd:cd18251   82 IYTSELELSLDNVQETLTAACQLQI 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  13 HQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLsACSS-YFQALFT--TNPCQHPIVILKDVQYDDLKTMVDFMYY 89
Cdd:cd18264   11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLL-ACSSdYFRALFKdyTQESKARVIHLPVVSAAGLQRVLDFIYT 89

                         90       100
                 ....*....|....*....|..
gi 386770453  90 GEVNVSQEQLPHILKTAEMLKI 111
Cdd:cd18264   90 SWLSLSLDTLEDTLEAASYLQV 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  32 DVTLAAEGRQLQAHKIVLSACSSYFQALFTTNpcqhpIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKI 111
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRD-----ILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQM 80

                 ....*....
gi 386770453 112 KGLAEMPTD 120
Cdd:cd18275   81 PCAAQCAVD 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  16 NFISVC-SSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPC---QHPIViLKDVQYDDLKTMVDFMYYGE 91
Cdd:cd18287    7 HFLSEDiGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMResqQSEIE-LKDTNAEAFKALLKYIYTGR 85

                         90       100
                 ....*....|....*....|....
gi 386770453  92 VNVSQeqlphiLKTAEMLKIKGLA 115
Cdd:cd18287   86 LTLTD------LKEDVLLDVLGLA 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770453  13 HQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLsACSSYFQALFTTNPCQHPIVILKDVQYDDLKTMVDFMYYGEV 92
Cdd:cd18218    1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVL-AGASQQLGRQLTNPNPGQWCLGEGISPSTFKQLLDFVYGESV 79