|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
228-638 |
0e+00 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 724.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 228 VHHALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPI 307
Cdd:cd17387 1 VYHAVVVIFLEFFAWGLLTTPMITVLHETFPQHTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 308 PLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 387
Cdd:cd17387 81 PLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLVVLVATI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 388 IALLDVFFILVAVPESLSEKMRPASWGAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG 467
Cdd:cd17387 161 VALLDICFILLAVPESLPEKMRPASWGAPISWEQADPFASLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFVYLKQVMG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 468 FNYVEVSVFIAIVGILSITVQVTLGSFMQV-FGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAISA 546
Cdd:cd17387 241 FEYEEVAAFIAVVGILSITAQTLLLSILMRsIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 547 FVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVDLNDDHDSHakSSGSRATNVEKISQHVPGPPFVFGALC 626
Cdd:cd17387 321 LVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYLFHVDLNEIKPVQ--SSKQRMQNPSLEGAIIPGPPFLFGAIS 398
|
410
....*....|..
gi 386770446 627 VFCAIIVSAFIP 638
Cdd:cd17387 399 VLLAILVASFIP 410
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
231-636 |
4.27e-64 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 215.91 E-value: 4.27e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLtMPIISTLNQTF--PDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIP 308
Cdd:cd17330 1 LFLVVFLDALGFGIV-FPVLPFYVREFnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 309 LM--SINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALST 386
Cdd:cd17330 80 LLglSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 387 AIALLDVFFILVAVPeslsekmrpaswgapisweqadpflalrkvgtdkTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKM 466
Cdd:cd17330 160 ALALLNLVLVLFFLP----------------------------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRF 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 467 GFNYVEVSVFIAIVGILSITVQVTL-GSFMQVFGAKRTIIMGLALEIVQLLWYGFGS-QKWMMWSAGVVAALGSITYPAI 544
Cdd:cd17330 206 GFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLLLLPFASsVPLLVLAAAILAFGTGIVFPAL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 545 SAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNvdlnddhdshakssgsratnvekisqhvPGPPFVFGA 624
Cdd:cd17330 286 SALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG----------------------------PGVPFLLAA 337
|
410
....*....|..
gi 386770446 625 LCVFCAIIVSAF 636
Cdd:cd17330 338 GLLLIALFLLSL 349
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
231-636 |
4.40e-46 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 168.20 E-value: 4.40e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLtMPIISTLNQTFPDHT---FLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPI 307
Cdd:cd17388 4 ILVTVLLDAMGIGLI-MPVLPTLLREFVGDSadaATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 308 PLM--SINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEmYGDT---LVV 382
Cdd:cd17388 83 LLMafAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRapfLVA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 383 ALSTAIALLDVFFILvavPESLSEKMRPASwgapiSWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYL 462
Cdd:cd17388 162 AGLNGLNFLLGLFVL---PESLPPERRRAF-----RWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 463 KLKMGFNYVEVSVFIAIVGILSITVQVTL-GSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITY 541
Cdd:cd17388 234 EDRFDWSPTMVGLSLAVFGLLHALFQAFVtGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 542 PAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFnvdlnddhdshakssgsratnvekiSQHVPGPPFV 621
Cdd:cd17388 314 PALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAS-------------------------PATWPGLAWI 368
|
410
....*....|....*
gi 386770446 622 FGALCVFCAIIVSAF 636
Cdd:cd17388 369 IGAALYLICLVLAYR 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
232-586 |
6.22e-38 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 145.03 E-value: 6.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 232 LVVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLV-TVFFTCLPIPLM 310
Cdd:cd17325 2 SLALFLDMLGYGII-IPILPLYAESLGASVAQI-GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLgLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 SINTWWFFAMIS-ISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAI 388
Cdd:cd17325 80 FATSYWQLLLARfLQGlASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 389 ALLDVFFILVAVPESlsekmRPASWGAPISweQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGF 468
Cdd:cd17325 160 ALLALVLALLLLPEP-----RPPPNKRAVS--AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 469 NYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAF 547
Cdd:cd17325 233 SPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGlGLVFPATLAL 312
|
330 340 350
....*....|....*....|....*....|....*....
gi 386770446 548 VSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLF 586
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
232-574 |
1.38e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 137.80 E-value: 1.38e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 232 LVVIFLEFFAWGLLtMPIISTLNQTFpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMS 311
Cdd:COG2814 16 ALGAFLSGLGIGIV-LPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 312 I--NTWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAI 388
Cdd:COG2814 94 LapSLWLLLAARFLQGlGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 389 ALLDVFFILVAVPESLSEKMRPASWgapisweqadpflALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGF 468
Cdd:COG2814 174 ALLALLLLLRLLPESRPAARARLRG-------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 469 NYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAF 547
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQAL 320
|
330 340
....*....|....*....|....*..
gi 386770446 548 VSLYAAPESQGAVQGMITGMRGLCNGL 574
Cdd:COG2814 321 VAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
266-587 |
4.44e-34 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 133.89 E-value: 4.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFAMISISG-AFAVTFSVVFAYVADVT 342
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFahSPWLFAIALVLTGfGGGLFEPASEAMIADVT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 343 TPEERSKAYGLASATFAASLVISPALGnALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPaswgapiswEQA 422
Cdd:cd17329 118 TPENRTRAFSLLYWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA---------EKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 423 DPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKR 502
Cdd:cd17329 188 EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRK 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 503 TIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITY-PAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGV 581
Cdd:cd17329 268 ILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVfPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGL 347
|
....*.
gi 386770446 582 VFYLFN 587
Cdd:cd17329 348 LLDLLG 353
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
232-576 |
8.81e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 126.76 E-value: 8.81e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 232 LVVIFLEFFAWGLLTMPIISTLNQTFpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLP--IPL 309
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL-GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGllLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 310 MSINTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAI 388
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 389 ALLdvFFILVAVPESLSEKMRPASWGApiswEQADPFLALRKVGTDKTVLMLCLTVLLSYLpeageYSCMFVYL---KLK 465
Cdd:pfam07690 161 SLL--AAVLLLLPRPPPESKRPKPAEE----ARLSLIVAWKALLRDPVLWLLLALLLFGFA-----FFGLLTYLplyQEV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 466 MGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIV---QLLWYGFGSQKWMMWSAGVVAALG-SITY 541
Cdd:pfam07690 230 LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILaalGLLLLSLTLSSLWLLLALLLLGFGfGLVF 309
|
330 340 350
....*....|....*....|....*....|....*
gi 386770446 542 PAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGP 576
Cdd:pfam07690 310 PALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
231-587 |
1.59e-28 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 117.91 E-value: 1.59e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLTMPIISTLNQTfpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 310
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF--GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 SINT---WWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDT-----LVV 382
Cdd:cd06174 79 AFAPsfwLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwravfLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 383 ALSTAIALLDVFFILVAVPESLSEKMRPASWgapisweqADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYL 462
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESARAKNEEASS--------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 463 KLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQ-VFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SIT 540
Cdd:cd06174 231 LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGlGGL 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 386770446 541 YPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFN 587
Cdd:cd06174 311 LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
234-583 |
8.26e-22 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 97.73 E-value: 8.26e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 234 VIFLEFFAWGLltmpiISTLNQTFPD--HTFLMNGLVMGIKGILSflsAPLIGALSDIWGRKFFLLVTVF-----FTCLP 306
Cdd:cd17386 7 IVFLYMFASVL-----SGPVTQNFVYaaNFYLYMNLMGSIPPLFS---SLFLGSWSDRYGRKPPLLMSLVglllsSLILV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 307 -IPLMSINT--WWFF---AMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTL 380
Cdd:cd17386 79 lIVYFTTVPsvWWFYlsaIPLALFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 381 VVALSTAIALLDVFFILVAVpeslsekmrpaswgapisweqadpflalrkvgtdKTVLMLCLTVLLSYLPEAGEYSCMFV 460
Cdd:cd17386 159 SFSISAALLLIALLYILFFL----------------------------------TLLILLLLAAFLTIFVLSGESDVLYL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 461 YLKLKMGFNYVEVSVFIAivgiLSITVQVTLGSFMQVF------GAKRTIIM-GLALEIVQLLWYGFGSQKWMMWSAGVV 533
Cdd:cd17386 205 FVLEKFAWNVKDFSYFST----LGSLIYLTGMLGGVLLlrcllkMSDSTLAMlGLASHILSSLLFAFATNTWMMYLAAVV 280
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 386770446 534 AALGSITYPAISAFVSLYAAPESQGAVQGMItgmrGLCNGLGPAVFGVVF 583
Cdd:cd17386 281 GMFNGIVGPMIRSILSKLVPKSEQGKIFSLL----SVLESLSPLVASPIY 326
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
263-586 |
2.02e-21 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 96.96 E-value: 2.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 263 LMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTclpipLMSINTWWF---FAMISIS----GAFAVTFSVVF 335
Cdd:cd17389 64 LFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGL-----AISYALWAVsrsFTIFLLSrivgGISKGNVSLST 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 336 AYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA------IALLDVFFILVAVPESLSEKMR 409
Cdd:cd17389 139 AIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMPalfalvLALADLLFIFFFLPETLPSNLR 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 410 PASWGApisweqadpFLALrkvgtdktvlmlcltVLLSYLpeagEYSCMFVyLKLKMGFNYVEVSVFIAIVGILSITVQv 489
Cdd:cd17389 219 RLGLVY---------FLYL---------------FLFSGL----EFTLTFL-THQRFQYTSMQQGKMFFFIGIIMALVQ- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 490 tlGSFMQ---VFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGS-ITYPAISAFVSLYAAPESQGAVQGMIT 565
Cdd:cd17389 269 --GGYVRrikPGKEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAaTVVPCLTTLVSGYGSDDQKGTVMGIFR 346
|
330 340
....*....|....*....|.
gi 386770446 566 GMRGLCNGLGPAVFGVVFYLF 586
Cdd:cd17389 347 SLGALARALGPIVACTVYWLA 367
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
266-638 |
2.13e-21 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 97.67 E-value: 2.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSD----IWG-RKFFLLVTVFFTCLPIPLM--------SINTWWFFAMISISGAFAVTFS 332
Cdd:COG2211 49 GLILLVARLWDAITDPLIGALSDrtrtRWGrRRPWILIGAIPLALSFVLLftapdlspTGKLIYALVTYLLLGLAYTLVN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 333 VVF-AYVADVTT-PEERSKAYGLASATFAASLVISPALGNALMEMYGD------TLVVALSTAIALLDVFFILVAVPESL 404
Cdd:COG2211 129 IPYsALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGdaalgyRLTALIFAVLGLLAFLLTFFGTKERP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 405 SEKMRPASWGApisweqadpflALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILS 484
Cdd:COG2211 209 VPEEEKVSLKE-----------SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 485 ITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGF--GSQKWMMWSAGVVAALGSITY----PAISAFVSLYAAPESQG 558
Cdd:COG2211 278 LLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIGLGAIlvlpWAMLADVVDYDEWKTGR 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 559 AVQGMITGMRGLCN----GLGPAVFGVVFYLFNVDLNDDHDSHAKSSGSRATnvekisqhvpgppFVFGALCVFCAIIVS 634
Cdd:COG2211 358 RREGLYFGIFTFAIklgqALAGALAGLLLALFGYVAGAAQSPSALTGIRLLF-------------FLLPAVLLLLAALLL 424
|
....
gi 386770446 635 AFIP 638
Cdd:COG2211 425 LFYP 428
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
231-583 |
4.51e-21 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 95.69 E-value: 4.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLTmPIISTLNQTFPdhtflMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 310
Cdd:cd17324 8 AFAIGTTEYVIQGLLP-DIARDFGVSVA-----QAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 SINTWWFFAMIS---ISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 387
Cdd:cd17324 82 ALAPSFALLLLAralAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 388 IALLDVFFILVAVPESLSEKMRPASwgapisweqadPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG 467
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLG-----------LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 468 FNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISA 546
Cdd:cd17324 231 FSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGfFAAHSALQT 310
|
330 340 350
....*....|....*....|....*....|....*..
gi 386770446 547 FVSlYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 583
Cdd:cd17324 311 RVL-RLAPEARGLASSLYLAAYNLGGALGAALGGLVL 346
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
231-583 |
2.32e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.79 E-value: 2.32e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLTMPIISTLNQTfPDHTFLMNGLVMgikgILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 310
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPPLAEEFGLS-AAQLGLLFAIPV----LVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 S--INTWWFFAMISISGAFA-VTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGdtlvvaLSTA 387
Cdd:COG2223 88 AlaVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG------WRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 388 IALLDVFFILVAVPESLseKMRPASWGAPISweQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG 467
Cdd:COG2223 162 FLILGILLLVVAVLAWL--FLRDPPAGAAAA--AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 468 FNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQ--LLWYGFGSQKWMMWSAGVVAALGSITYPAIS 545
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGllLLALALGSLWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350
....*....|....*....|....*....|....*...
gi 386770446 546 AFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 583
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
266-588 |
5.20e-20 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 92.68 E-value: 5.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVT-------VFFTCLPIPLMSINTWWFFAMISISGAFAVTFSVVF-AY 337
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllrallAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARqAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 338 VADVTTPEERSKAYGLASATFAASLVISPALGNALMemygdtLVVALSTAIALLDVFFILVAVPESLSEKMRPASWGAPI 417
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLV------ALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 418 SWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQV 497
Cdd:cd06173 191 SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 498 FGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITY-PAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGP 576
Cdd:cd06173 271 RRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFnVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGA 350
|
330
....*....|..
gi 386770446 577 AVFGVVFYLFNV 588
Cdd:cd06173 351 LLAGLLADALGL 362
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
232-583 |
1.91e-19 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 90.73 E-value: 1.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 232 LVVIFLEFFAWGLL--TMPI-ISTLNQTfpdhTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIP 308
Cdd:cd17489 2 LLANFFFFLSFYLLlpVLPLyAHDLGGS----EAVA-GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 309 LMSI--NTWWFFAMISISGA-FAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALS 385
Cdd:cd17489 77 LYLLatSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 386 TAIALLDVFFILVaVPESLSEKmrpaswgAPISWEQADPFLALRkvgtDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLK 465
Cdd:cd17489 157 AVLALLALLLVFL-VKDPPPVA-------AEEAEAGTRAFRRLV----EKKVLPPALILFLASIAYGAISTFLPLYAAER 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 466 mgfNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAI 544
Cdd:cd17489 225 ---GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPAL 301
|
330 340 350
....*....|....*....|....*....|....*....
gi 386770446 545 SAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 583
Cdd:cd17489 302 QALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
233-526 |
9.56e-19 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 88.05 E-value: 9.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 233 VVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI 312
Cdd:cd17390 3 LVGFLDLFGVSMI-LPLLSTHIRSLGASPTVI-GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 313 NTWWFFAMIS--ISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVA-LSTAIA 389
Cdd:cd17390 81 STSLALLFLSriPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVAlLCSAIF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 390 LLDVFFILVAVPESLSekmrpaswgapisweqadpFLALRkvgtdktvLMLCLTVLLSylpeageYSCMFVYLKLKMGFN 469
Cdd:cd17390 161 ILNAGLVWFLLSKLWD-------------------LLLVR--------FLMGFSVLLF-------RSNFSLYLEERFDLS 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 470 YVEVSVFIAIVGILSITVQVTLGSFMqVFGAKRTIIMGLALEIVQ---LLWYGFGSQKWM 526
Cdd:cd17390 207 PKTIGYLISYSGVLGALSGFLVGRIL-KLYKNNEYLLLLHSFILLalsLLGLALAPSIWL 265
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
226-582 |
1.93e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 87.99 E-value: 1.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 226 PSVHHALVVIFLEFFAWGLLTM---PIISTLNQTFpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFF 302
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATAlwgPLIPALKDAF-GLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 303 TCLPIPLMSI-NTWWFF--AMISISGAFAVTFSVVFAYVADVtTPEERSKAYGLASATFAASLVISPALGNALMEMYGDT 379
Cdd:COG0738 83 MALGLLLFALaPSYPLLllALFLLGLGLGLLDVAANPYVAAL-GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 380 LVVALSTAIALLDVFFILVAVPESLSEKMRPASwgapiswEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMF 459
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRSKLPEIEEEEE-------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 460 VYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-S 538
Cdd:COG0738 235 LYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGlS 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 386770446 539 ITYPAISAFVsLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVV 582
Cdd:COG0738 315 LMFPTIFSLA-LDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
231-583 |
3.53e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 86.85 E-value: 3.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLTMPIISTLNqtFPDHTFlmnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 310
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLG--LSAAQL---GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 SI--NTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGdtlvvaLSTA 387
Cdd:COG2271 93 GFatSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG------WRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 388 IALLDVFFILVAVPeslsekmrpaswgapisweqadpflalrkvgtdkTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG 467
Cdd:COG2271 167 FLILGLPGLLLALL----------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 468 FNYVEVSVFIAIVGILSITVQVTLGSFMQVFGA--KRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSI-TYPAI 544
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGgAFGLL 292
|
330 340 350
....*....|....*....|....*....|....*....
gi 386770446 545 SAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 583
Cdd:COG2271 293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
231-400 |
1.13e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.32 E-value: 1.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 310
Cdd:cd17325 204 LFLAIFVLAFAFGAL-EPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 SINT--WWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 387
Cdd:cd17325 283 PLATsfWLLLLLLALLGlGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
|
170
....*....|...
gi 386770446 388 IALLDVFFILVAV 400
Cdd:cd17325 363 LLLLAAVLFLLLR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
243-567 |
1.46e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 81.85 E-value: 1.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 243 GLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCL--PIPLMSINTWWFFAM 320
Cdd:cd17473 15 GAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIggVAGLFLDSLYALLAS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 321 ISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDT--LVVALSTAIALLDVFFIL 397
Cdd:cd17473 95 RALLGiGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRApfLVYLLALPVLILVLLFLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 398 VAVPESLSEKMRPASWGAPISWEQADPFLALrkvgtdKTVLMLCLTVLLSYLPeageyscmfVYLKLKMGFNYVEVSVFI 477
Cdd:cd17473 175 EPARKSKSAASPGAATAAALPWKRVLPIYFL------AFLAMLLFYVIPIQLP---------FLLQERGGGSAALIGLAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 478 AIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPES 556
Cdd:cd17473 240 AIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGfGLLLPTLNSWAMSLVPPEL 319
|
330
....*....|.
gi 386770446 557 QGAVQGMITGM 567
Cdd:cd17473 320 RGRAMGIVTSA 330
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
236-587 |
2.97e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 81.08 E-value: 2.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 236 FLEFFAWGLLTmPIISTLNQTFpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLP--IPLMSIN 313
Cdd:cd17474 9 LLAVLGVSIVD-PILPAIAEAL-GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGglLCGLSDS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 314 TWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEM--YGDTLVVALSTAIAL 390
Cdd:cd17474 87 FALLLAGRALQGiGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIswRYPFFLLAALIPVAF 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 391 LDVFFILvavpESLSEKMRPASWGAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPeageyscmfVYLKLKMGFNY 470
Cdd:cd17474 167 LAILFLL----PEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP---------FLLELLYGISP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 471 VEVSVFIAIVGILSITVQVTLGSFMQV-FGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGS-ITYPAISAFV 548
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLV 313
|
330 340 350
....*....|....*....|....*....|....*....
gi 386770446 549 SLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFN 587
Cdd:cd17474 314 TELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
281-638 |
4.05e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 80.68 E-value: 4.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 281 PLIGALSDIWGRK-FFLLVTVFFT--CLpIPLMSINTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASA 356
Cdd:cd17321 49 LLAGRLGDRFGRKrVFLIGLALFGlaSL-LCALAPSLAFLIAARALQGIGaAAIMPASLALIAATFPGERRGRALGLWGA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 357 TFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFIlvavpeslsekmrPASWGAPISweqadPFLalrkvgtdkt 436
Cdd:cd17321 128 VVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA-------------RTFSGAVLA-----AFL---------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 437 vLMLCLTVLLSYLPeageyscmfVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLL 516
Cdd:cd17321 180 -LGAALGGLLFLLP---------LYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 517 WYGF---GSQKWMMWSAGVVAALGS-ITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVDLND 592
Cdd:cd17321 250 LLALlgaDSSVWLLLPGLVLLGLGLgLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLG 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 386770446 593 DHDSHAKSSGSRATNVEKISQhvpgpPFVFGALCVFCAIIVSAFIP 638
Cdd:cd17321 330 DSGVAALLSAAAAAFAAGFHL-----AFLVAAALALLAALLALLLP 370
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
266-587 |
5.31e-15 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 77.50 E-value: 5.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRK-----FFLLVTVFFTCLpIPLMSINTWWFFAMISISGAFAVTFSVVF--AYV 338
Cdd:COG2270 55 GYALAIAGLLVALLAPVLGAIADRSGRKkpflaFFTLLGVLATAA-LFFVAPGGLWLGLLLFVLANIGFEGSLVFynAFL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 339 ADVTTPEERSKAYGLASA--------TFAASLVI---SPALGnaLMEMYGDTLVVALSTAIALLdVFFI--LVAVPESLS 405
Cdd:COG2270 134 PDIATPEEIGRVSGLGWAlgylggvlLLLINLALflkPEAFG--LPDAGEAVRISFLLTALWWL-LFALplFLFLPERPR 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 406 EKMRPASWGAPISWEQAdpFLALRKVGTDKTVLMLcltvLLSYL----PEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVG 481
Cdd:COG2270 211 PGPAPPRGAVRAGFREL--RRTLRELRRYRDLLRF----LLAYFfyrdGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQ 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 482 ILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAIS-AFVSLYAAPESQG-- 558
Cdd:COG2270 285 IVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSrSLLARLIPPGREAef 364
|
330 340 350
....*....|....*....|....*....|...
gi 386770446 559 ----AVQGMITGMrglcngLGPAVFGVVFYLFN 587
Cdd:COG2270 365 fglyALSGKAASF------LGPLLFGLVTQLTG 391
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
282-583 |
2.38e-14 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 75.30 E-value: 2.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 282 LIGALSDIWGRKFFLLVTVFFTCLP--IPLMSINTWWFFAMISISGAFAVTFSVV-FAYVADVTTPEERSKAYGLASATF 358
Cdd:cd17320 53 LYGPLSDRFGRRPVLLAGLLLFILAslLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYSGAELAKIFSLLMMIL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 359 AASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPASWGAPISweqadpflALRKVGTDKTVL 438
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLR--------AYKRVLKNRRFL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 439 MLCLTVLLSYLPEAGEYSCM-FVYLKLkMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLW 517
Cdd:cd17320 205 GYALALGLSFAGLFAYLAAApFIYIEQ-LGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALV 283
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386770446 518 ------YGFGSQKWMMWSAGVVAALGSITYP-AISAFVSLYaaPESQGAVQGMITGMRGLCNGLGPAVFGVVF 583
Cdd:cd17320 284 lllaalLGGLSLWPLVAPLFLIFFGFGLIFPnATSLALEPF--PHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
273-583 |
1.03e-13 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 73.41 E-value: 1.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 273 GILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFamIS-ISGAFAVTFSVVFAYVADVTTPEERSK 349
Cdd:cd17331 45 SVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFasSVPMLF--LSrLPSVFMHAMQAAQMVVTDLTDPGERAA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 350 AYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPASwGAPISWEQADPFLALR 429
Cdd:cd17331 123 ALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEA-KESASPPSVFNLKEIL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 430 KVGTDKTVLMLCLTVLLSYLPeAGEYSCMF-VYLKLKMGFNYVEVSVFIAIVGILSITVQ-VTLGSFMQVFGAKRTIIMG 507
Cdd:cd17331 202 RLLRLPGVAFLLLVKLLSGLP-IGMFQSMFsLVAMDFFGLTPEENGYLMSYAGVLGMVVQgLLVGPLTKRFGERSLLKLS 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386770446 508 LALEIVQLLWYGF-GSQKWMMWSAGVVAALGSITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 583
Cdd:cd17331 281 VALLAIGYLLLAFvTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALL 357
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
236-635 |
2.21e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 68.78 E-value: 2.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 236 FLEFFAWGLLTMPIISTLNqtfPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--N 313
Cdd:cd17316 12 AYDFFLIGFVAPVLAAEFS---LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLlpT 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 314 TWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLvvalstaiaLLD 392
Cdd:cd17316 89 PILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDW---------GWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 393 VFFILVAVPESLSEKMRPASWGAPISWeqadpflalrkvgtdkTVLMLCLTVLLSYLPeageyscmfVYLKLKMGFNYVE 472
Cdd:cd17316 160 ILFLIGALPALLALLLRRRTLLLILLW----------------FFISFGYYGLTTFLP---------TYLQTVLGLSPAT 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 473 VSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKwmmwSAGVVAALGSITYPAISAFVSLYA 552
Cdd:cd17316 215 SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSG----SPTLLLLLLFILSFFVGGVWGALY 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 553 A--PESqgavqgMITGMR----GLCNGLGPAVFGVVFYLFNVDLnddhdshakssgsratnvekISQHVPGPPFVFGALC 626
Cdd:cd17316 291 AylAEL------FPTEVRatgvGLSYNLGRLGGGGAPPLIALLL--------------------ASTGGTGVPALILALL 344
|
....*....
gi 386770446 627 VFCAIIVSA 635
Cdd:cd17316 345 AIVALIVAL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
231-500 |
3.04e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 67.91 E-value: 3.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLTmPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 310
Cdd:COG0477 19 LALGTFLEGLDFTIVN-VALPSIAADLGASSAQL-GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 SI--NTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 387
Cdd:COG0477 97 GLapSPELLIAARALQGIGaGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 388 IALLdVFFILVAVPESLSEKMRPASWGAPISWEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG 467
Cdd:COG0477 177 LGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLA 255
|
250 260 270
....*....|....*....|....*....|...
gi 386770446 468 FNYVEVSVFIAIVGILSITVQVTLGSFMQVFGA 500
Cdd:COG0477 256 LLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
266-583 |
3.55e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 68.45 E-value: 3.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSINT--WWFFAMISISGAF--AVTFSVVFAYVADV 341
Cdd:cd17355 41 SLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATslWQLYLLWGLLGGGgaGTLAAVAFATVAAW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 342 TTPEERSKAYGLASATFAASLVISPALGNALMEMYG-DTLVVALSTAIALLDVFFILVAVPESLSEKMRPASWGAPiswe 420
Cdd:cd17355 121 WFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGwRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASP---- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 421 qADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKmGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGA 500
Cdd:cd17355 197 -ASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSP 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 501 KRTIIMGLALEIVQLLWYGFG-SQKWMMWSAGVVAALGSITY-PAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAV 578
Cdd:cd17355 275 RRLLAASYALRALGLALLLLLpFPPLALLLFAALFGLGWGATvPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWL 354
|
....*
gi 386770446 579 FGVVF 583
Cdd:cd17355 355 GGLLY 359
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
259-589 |
3.60e-12 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 68.81 E-value: 3.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 259 DHTFLmnGLVMGIKGILSFLSAPLIGALSDI----WG-RKFFLLVTVFFTCLPIPLMSINTWWFFAMISISGAFAVTFSV 333
Cdd:cd17313 32 SHALI--GFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAADIGLALGDGPRTWALVLFV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 334 VF----------------AYVADVTTPEERSKAYGLASATFAASLVISPALG------NALMEMYGDTLVVA--LSTAIA 389
Cdd:cd17313 110 LGivlldfamnvcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGailwdhNWFGFALGGNLKVPfyIGAIIL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 390 LLDVFFILVAVPEslsEKMRPASWGAPISWEQADPFLALRKVGT--DKTVLMLCLTVLLSYLpeagEYSCMFVYLKLKMG 467
Cdd:cd17313 190 LVCVLVTLFFVKE---PPLSPEAGEHSENPSLGEVLKSLLKLLKimPRSLLRLLLVIFFWWI----AFFPFELFFTDYMG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 468 FNY------------VEVSVFIAIVGILSITVQVT---LGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMmwsAGV 532
Cdd:cd17313 263 EEVyhgtsaasshygAGVRMGAWGLLIFSLAFLIFslpIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTV---ALV 339
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386770446 533 VAALGSITYPAIS----AFVSLYAAP--ESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVD 589
Cdd:cd17313 340 LFALGGIGWATINinpyPLVSDYHSEsgRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYG 402
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
233-562 |
4.41e-12 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 68.01 E-value: 4.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 233 VVIFLEFFawGL-LTMPIISTLNQTFPDHTFLMNGLVMGIKGIL-SFLSAPLiGALSDIWGRKFFLLV--TVFFTCLPIP 308
Cdd:cd17472 3 LIFSLRML--GMfLVLPVLSVYAKSLPGATPTLIGLALGIYGLTqAIFQIPF-GLLSDRIGRKPVILFglLLFIAGSLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 309 LMSINTWWFFAMISISGAFAVTfSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAI 388
Cdd:cd17472 80 AYATSIYGLILGRALQGSGAIS-SVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 389 ALLDVFFILVAVPESLSEKM-RPASWGAPISWEQADPFLALRKVG-TDKTVLMLCLTVLLSYLPEAGeyscmfvYLKLKM 466
Cdd:cd17472 159 SLVSLLILLFFVPDPPKIVQiSEKEKKKLKKLLKNKRLLRLDFSIfILHFVLMAFFYILPLLLTQLG-------GGKGQL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 467 GFNYveVSVFIAIVGILSITVqvtlgsfmqVFGAKRT-----IIMGLALEIVQLLWYGFGSQKWMMWSAGVVAA-LGSIT 540
Cdd:cd17472 232 WKVY--LPAILIGFILMVPFV---------IYAEKKGkmkqvFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFfIGFNL 300
|
330 340
....*....|....*....|...
gi 386770446 541 Y-PAISAFVSLYAAPESQGAVQG 562
Cdd:cd17472 301 LeALLPSLVSKIAPKEYRGTAMG 323
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
266-582 |
5.93e-12 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 67.99 E-value: 5.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWG-RKFFLLVTVFFTC---LPIPLMSINTWWFFAMISISGAF---AVTF--SVVFA 336
Cdd:cd17335 35 GILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVlffLSLFFVAQIFWLLLLLVILGAFFsapVVPLvdSITLQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 337 YVadvttpEERSKAYGL----ASATFAASlviSPALGnALMEMYgdTLVVALSTAIALLDVFFILVAVpesLSEKMRPAS 412
Cdd:cd17335 115 YL------GEERERYGKqrlwGSIGFGIA---ALLVG-ILIDRS--STYKNYTIAFYVFAVLMLLALL---LALKFPFRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 413 WGApiswEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKlKMGFNYVEVSVFIAIVGILSITVQVTLG 492
Cdd:cd17335 180 KHP----EPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQ-DLGGSKTLIGLLWTVGVVSEIPFFFFSS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 493 SFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMwsaGVVAALGSITY----PAISAFVSLYAAPESQGAVQGMITgmr 568
Cdd:cd17335 255 RLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLV---LPIELLHGLTFalvwAAAVSYASAAAPPGLRATAQGLLQ--- 328
|
330
....*....|....
gi 386770446 569 GLCNGLGPAVFGVV 582
Cdd:cd17335 329 GLYFGLGGGLGSLI 342
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
278-638 |
8.39e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 67.22 E-value: 8.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 278 LSAPLIGALSDIWGRKFFLLVTVFFTCLPIPL--MSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLAS 355
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLaaFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 356 ATFAASLVISPALGNALMEMYGDTLVVALSTAIALLdvFFILVavpeslsekmrpaswgapisweqadPFLALRKVgTDK 435
Cdd:cd17504 126 ATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL--LAALV-------------------------PLIDLRLL-RRR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 436 TVLMLCLTVLLSYLPEAGEYSCMFVYLKLK----MGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALE 511
Cdd:cd17504 178 NVLLANITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVIS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 512 IVQLLWYGF-GSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFNVD 589
Cdd:cd17504 258 AVGLLLLALlHSSLWALVVALLLIGIGlGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVS 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 386770446 590 LNDdhdshAKSSGSRATNVEkisqhvpgppFVFGALCVFCAIIVSAFIP 638
Cdd:cd17504 338 ITS-----GGVPTEGAYVLA----------FLIGAALALAALLLSLLIP 371
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
266-587 |
1.08e-11 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 66.88 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRK------FFLLVTVFFTCLPIPLMSINTWWFFAMISISGAFAVTfSVVFAYVA 339
Cdd:pfam12832 37 GLITAILPLTRILAPPIWGWLADRTGKRkavvrlASILAAVLFLSVLFIPISLTFWWLALLVVLFSFFWNA-ILPQFEVA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 340 DVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTL--VVALSTAIALLDVFFILVAVPeslsekmrPASWGAPI 417
Cdd:pfam12832 116 TLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLlpSVLFYLFAALMLLSLLLPLAP--------PEMEYESK 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 418 SWEQADPFLALRkvgtDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKlKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQV 497
Cdd:pfam12832 188 GGSKAVFWNLLK----QPEVIIFFLAAFLLGFSHGPFYTFLFLYLE-NLGASNTLLGALWALGVVAEIPLFFYAHRLLRR 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 498 FGAKRTIIMGLALEIVQLLWYGFGSQKWmmWSAGVVAALGSITY----PAISAFVSLYAAPESQGAVQGMITGMR-GLCN 572
Cdd:pfam12832 263 FGHRNLLIIALLLTALRWLLYAFFVENP--WLVLPIQFLHAISFglthAAAIEYVRRIFPGSLQGTGQALYSGLYfGLGG 340
|
330
....*....|....*
gi 386770446 573 GLGPAVFGVVFYLFN 587
Cdd:pfam12832 341 ALGSLIGGQLWDLFG 355
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
266-633 |
1.71e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 66.41 E-value: 1.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWG-RKFFLLVTVFFTCLPIPLMSI-NTWWFFAMISISGAF--AVTFSVVFAYVADV 341
Cdd:cd17370 37 GLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALaGSWQLVLLLRILERLgkGIRTPPRDALLADA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 342 TTPEERSKAYGLASA--TFAAslVISPALGNALMEMYGDT--LVVALSTAIALLDVFFILVAVPESlSEKMRPASWGAPI 417
Cdd:cd17370 117 TPPSGRGKAFGLHRAldTLGA--VLGPLLAALLLYLLGGNyrTIFLLAAIPALLALLILLFVVKEY-PRPPKLRKKSKKT 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 418 SWEQADPFLalrkvgtdKTVLMLCLTVLLSYLPEAgeyscMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQV 497
Cdd:cd17370 194 SLKKLPKAF--------WLYLLAVALFALGNFSFA-----FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 498 FGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGP 576
Cdd:cd17370 261 IGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLAS 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 386770446 577 AVFGVVFYLFNvdlnddhdshakssgsratnvekisqhvPGPPFVFGALCVFCAIIV 633
Cdd:cd17370 341 LIAGYLWDLIS----------------------------PSAAFLFSAVLALIALLL 369
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
261-582 |
2.65e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 65.66 E-value: 2.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 261 TFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFAMISISG----AFAVTFSVV 334
Cdd:cd17478 29 SYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFapNYWLLLLLVALAGigsaAFHPEGARL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 335 FAYVAdvttPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESlseKMRPASWG 414
Cdd:cd17478 109 ASQAA----GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK---KPEAKKAA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 415 APISWeqadpflALRKVGTDKTVLMLCLTVLLSYLPeageYSCMFVYLKL---KMGFNYVEVSVFIAIVGILSITVQVTL 491
Cdd:cd17478 182 AKSSA-------RSTLKGVWRALLLLLIIVFLRSWV----LSSLTTFLPFylvQRGYSLVFAGLLLSLFLFAGAIGTLIG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 492 GSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAISAFVSLYaAPESQGAVQGMITGMRGLC 571
Cdd:cd17478 251 GPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQEL-LPGNVGLASGLMMGLSFGL 329
|
330
....*....|.
gi 386770446 572 NGLGPAVFGVV 582
Cdd:cd17478 330 GGIGAPVLGAL 340
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
231-402 |
1.21e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 63.74 E-value: 1.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLT-MPIIstLNQTFpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPL 309
Cdd:COG2271 186 ALAYFLVYFALYGFLTwLPTY--LVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALAL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 310 MSI----NTWWFFAMISISGAFA-VTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVAL 384
Cdd:COG2271 263 LLLallpSPALAIALLFLAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL 342
|
170
....*....|....*...
gi 386770446 385 STAIALLDVFFILVAVPE 402
Cdd:COG2271 343 LAALALLAALLALLLLRE 360
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
231-582 |
2.12e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 62.96 E-value: 2.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLtMPIISTL--NQTFPDhtfLMNGLVMGIKGILSFLSAPLIGALSDIWG--RKFFLLVTVFFTCLP 306
Cdd:cd17477 1 LLLSVALLGLGSGLL-LPLLSLRleREGVST---ALIGLVASAYYLGILLGSPLVPRLIRRVGhiRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 307 IPLMSINTWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGnALMEMYGDT--LVVA 383
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGiGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLL-ALVGTAGALpfLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 384 LSTAIALLDVFFILVAVPESLSEkmrpaswgapiswEQADPFLALRKVGtdktvlMLCLTVLLSYLPEAGEYSCMFVYLk 463
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEA-------------ESISLRRLLRIAP------LALLGAFVAGFLEGAFYSLLPLYG- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 464 LKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTII-MGLALEIVQLLWYGFGSQKWMMWSAGVV--AALGSIt 540
Cdd:cd17477 216 LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLgCALLGALAALLLPLVPGLPLALLVLLFLwgGAAGPL- 294
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 386770446 541 YPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVV 582
Cdd:cd17477 295 YTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGAL 336
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
231-366 |
2.91e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 62.44 E-value: 2.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLTMpIISTLNQTFpDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVF------FTC 304
Cdd:pfam07690 205 LLLALLLFGFAFFGLLT-YLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLllilaaLGL 282
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386770446 305 LPIPLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISP 366
Cdd:pfam07690 283 LLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
266-589 |
1.33e-09 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 60.59 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWG-RK-------FFLLVTVFFTCLPIPLMsiNTWWFFAMISISGA----FAVTFSV 333
Cdd:cd17337 35 ALLFTVYGLTVAIASWLSGVLAELFGpRRvmligliIWLVFEVLFLAFGLPSH--NYPLMLLTYGLRGFgyplFAYSFLV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 334 VFAYVADvttPEERSKAYGLASATFAASL-VISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPAS 412
Cdd:cd17337 113 WITYRTP---AERLGSAVGWFWFAFTGGLpVLGSYLASFTIPVIGEIGTLWLSLVFVALGGLIALFLVRDRTGEQPLANP 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 413 WGAPISweqaDPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLG 492
Cdd:cd17337 190 SEEPLK----ELLSGITILFRNPKIAIGGIVRIINTLSQFGFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 493 SFMQVFGAKRTII----MGLALEIVqLLWYG---FGSQKWMMWSAGVVAALGsitypaISAFVSLYA-----APESQGAV 560
Cdd:cd17337 266 ILGDKIGWRRTVRwfggVGCAISTL-LFYYVpqlFGHNYWAALIAAILFGIG------LAGFVPLSAlmpslAPEHKGAA 338
|
330 340
....*....|....*....|....*....
gi 386770446 561 QGMITGMRGLCNGLGPAVFGVVFYLFNVD 589
Cdd:cd17337 339 MSILNLGAGLSNFVGPAIVTLFLGSFGAG 367
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
266-400 |
2.80e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.51 E-value: 2.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRK---FFLLVTVFFTCLPIPLMSINTWWFF-AMISISGAFAVTFSVVFAYVADV 341
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRrvlLIVFALMALGLLLLALALGSLWLFLvLFLLLGLALGGGNGAVFALVPDI 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 386770446 342 TTPEERSKAYGLASATFAASLVISPALGNALMEMYGdtlvvALSTAIALLDVFFILVAV 400
Cdd:COG2223 324 FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG-----SYTAAFLVFAVLALVALV 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
231-358 |
5.38e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.45 E-value: 5.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 310
Cdd:COG2814 212 LLLLAFLLGFGFFAL-FTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL 290
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 386770446 311 SI--NTWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATF 358
Cdd:COG2814 291 ALagSLWLLLLALFLLGfGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
440-587 |
1.74e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 56.66 E-value: 1.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 440 LCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYG 519
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386770446 520 FGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFN 587
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
245-585 |
3.33e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 56.12 E-value: 3.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 245 LTMPI----ISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFF 318
Cdd:cd17391 14 LIAPFlplyIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFvtNVWQLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 319 AMISISGAFAVTFSVVFAYVAdVTTPEERS-KAYG-LASATFAASLvISPALGNALMEMYGDTLVVALSTAIALLDVFFI 396
Cdd:cd17391 94 ILRLLQGVFSGYVPNATALIA-SQTPKEKSgWALGtLSTGVVAGTL-IGPLLGGFLADLFGIRNVFFITGGLLFLAFLLT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 397 LVAVPESLSekmrpaswgaPISWEQADPFLALRKVGTDKTVLMlcLTVLLSYLPEAGEYS---CMFVYLKLKMGF--NYV 471
Cdd:cd17391 172 LFFVKEDFK----------PVEKKKMVSTKEVWNSVPNPSLLI--SLFVTTFIIQLANQSiepILTLYIRQLMGDasNLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 472 EVS-VFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKW-MMWSAGVV-AALGSITyPAISAFV 548
Cdd:cd17391 240 FISgLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWqLGILRFLLgLATGGLL-PAINSLL 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 386770446 549 SLYAAPESQGAVQGMITGMRGLCNGLGP-------AVFG--VVFYL 585
Cdd:cd17391 319 AKITPKEVAGRIFGYNQSFQYLGNVAGPllgsaiaAHFGyrAVFVV 364
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
266-396 |
4.36e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 55.64 E-value: 4.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVF---FTCLPIPLMSINTWWFFAMISISGAFAVT-FSVVFAYVADV 341
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALlgaLAALLLPLVPGLPLALLVLLFLWGGAAGPlYTLALALAGDR 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 386770446 342 TTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFI 396
Cdd:cd17477 306 LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
231-398 |
9.20e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.53 E-value: 9.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 310
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQTVLGLSPATS-SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 SI----NTWWFFAMISISGAFAVTFSVVF-AYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALS 385
Cdd:cd17316 261 FYllsgSPTLLLLLLFILSFFVGGVWGALyAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALI 340
|
170
....*....|...
gi 386770446 386 TAIALLDVFFILV 398
Cdd:cd17316 341 LALLAIVALIVAL 353
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
440-664 |
1.10e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 54.35 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 440 LCLTVLLSYLPEAGEYScMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYG 519
Cdd:cd06174 1 LLLGFFLTGLARGLISP-LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 520 FGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFnvdlnddhdsha 598
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGsGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL------------ 147
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386770446 599 kssgsratnvekiSQHVPGPPFVFGALCVFCAIIVSAFIPEGQTSTLEKKRKGPQTPLLISSPSHL 664
Cdd:cd06174 148 -------------GFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVL 200
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
232-397 |
2.21e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 53.70 E-value: 2.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 232 LVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMnGLVMGIKGILSFLSAPLIGALSDIWGRKFfLLVTVFFTCLPIPLM- 310
Cdd:cd17370 204 LYLLAVALFALGNFSFAFLILRAQELGLSAALI-PLLYALFNLVYALAAYPAGRLSDRIGRKK-LLILGYLSLALAYLGf 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 --SINTWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTA 387
Cdd:cd17370 282 alGSSLWLLLLGFILWGlYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAV 361
|
170
....*....|
gi 386770446 388 IALLDVFFIL 397
Cdd:cd17370 362 LALIALLLLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
437-587 |
2.37e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.44 E-value: 2.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 437 VLMLCLTVLLSYLPeageyscmfvYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLL 516
Cdd:COG2814 21 LSGLGIGIVLPALP----------LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386770446 517 WYGFGSQKWMMWSAGVVAALGS-ITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFN 587
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAgALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
234-397 |
3.79e-07 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 53.00 E-value: 3.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 234 VIFLEFF---AWGLLTMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRK---FFLLVTVFFTCLPI 307
Cdd:cd17353 217 LLWLMFFlnaTAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKntlSIAFLIQGVAMFLL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 308 PLMSINTWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALST 386
Cdd:cd17353 297 PFIGSVAVLFVLGVALIGfCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAA 376
|
170
....*....|.
gi 386770446 387 AIALLDVFFIL 397
Cdd:cd17353 377 ALSLVALALAL 387
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
281-638 |
4.87e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.58 E-value: 4.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 281 PLIGALSDIWG-RKFFLLVTVFFTclpipLMSI------NTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYG 352
Cdd:cd17503 49 PLSGWLADRFGtRRLFLTALALFT-----LGSLlcglapNLASLIIFRILQGFGgGVLIPLAQTILLRIYPPEKRGAAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 353 LASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFIlvavpeslsekmrpaswgapisweqadPFLALRkVG 432
Cdd:cd17503 124 LVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA---------------------------PLLDLR-LF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 433 TDKTVLMLCLTVLLSYLpeaGEYSCMFV---YLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLA 509
Cdd:cd17503 176 KDRNFTLGLLLSFLLGL---GLFGAMFLlplYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 510 LEIVQLLWYGFGS-QKWMMWSAGVVAALG---SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYL 585
Cdd:cd17503 253 LLALGTLLLAFLTpDTSLWLIILPLFIRGlgmGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTN 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 386770446 586 FNvdlnddHDSHAKSSGSRATNVEKISQHVP-GPPFVFGALCVFCAIIVSAFIP 638
Cdd:cd17503 333 RT------QFHHSRLSELLAQQVQKQALIIAfNDAFLVSAILLLVGLLLALFLR 380
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
266-582 |
5.13e-07 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 52.22 E-value: 5.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRK-----FFLLVTVFFTCLPIpLMSINTWWFFAMISISGAFAVTFSVVF--AYV 338
Cdd:cd17482 42 GYANSIASLVIALLAPILGAIADYSGRKkrflaFFCLIGVVSTALLF-FVTPGQWLLALLLFILANIGFSGANVFydAFL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 339 ADVTTPEER----SKAYGLASATFAASLVIspalgNALMEMYGDTLVVALSTAIALLdvfFILVAVpeslsekmrpasWG 414
Cdd:cd17482 121 PDVASPERMdrvsSLGYALGYIGGGLLFAV-----NLVLILGPDAFGLDTAEAVRLS---FLSVAL------------WW 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 415 APISweqadpfLALRKVgtdktvlmlcLTVLLSYLPEA-GEYSCMF---VYLKLKMGFNYVEVSVFIAIVGILSITVQVT 490
Cdd:cd17482 181 ALFS-------IPLKQL----------LLFLIAYFFYIdGVQTIIRmatIYGAEEGKLGSSALILALLLTQFVAFPGALL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 491 LGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAAL--GSITypAISAfvSLYA--APESQGA------- 559
Cdd:cd17482 244 FGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLvqGGIQ--ALSR--SLFGrlIPKGKSAeffgfyn 319
|
330 340
....*....|....*....|...
gi 386770446 560 VQGMITGMrglcngLGPAVFGVV 582
Cdd:cd17482 320 ISGKFAAI------IGPLLFGLI 336
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
233-400 |
6.19e-07 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 52.03 E-value: 6.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 233 VVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMNGLvMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFF------TCLP 306
Cdd:cd17314 213 IAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKL-MSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTilglglCAFL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 307 IPLMSINtWWFFAMISISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALS 385
Cdd:cd17314 292 FLLKMTP-VGLVLTGSLLGfSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYI 370
|
170
....*....|....*
gi 386770446 386 TAIALLDVFFILVAV 400
Cdd:cd17314 371 YAVIVFLASAILLAV 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
231-391 |
7.67e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.04 E-value: 7.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLTMPIISTLNQTFPDHTFLMN---GLVMGIKGILSFLSAPLIGALSD-IWGRKFFLLVTVFFT--C 304
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVavaGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMalG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 305 LPIPLMSINTWWFFAMISISGAFAVTFSVV-FAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDT---- 379
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLsFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLtgaf 363
|
170
....*....|....*
gi 386770446 380 ---LVVALSTAIALL 391
Cdd:cd06174 364 lvlAVLLLLAAILLL 378
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
264-510 |
9.71e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.45 E-value: 9.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 264 MNGLVMGIKGILSFLSAPLIGALSDIWG-RKFFLLVTVFFTCL--PIPLMSINTWWFFAMISISGAFA---VTFSVVFAY 337
Cdd:cd17490 32 MIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLasLIMILFPSPWGLLIARFLSGIAAatwVSFTVLYAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 338 VADvttPEERSKAYGLASATFAASLVISPALGNALMEMYGDT---LVVALSTAIALLDVFFIlvavPESLSEKMRpaswg 414
Cdd:cd17490 112 YFP---PDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRapfLLAALAGVLGFILSLFI----KEERREKKP----- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 415 APISWEqadpflALRKVGTDKTVLMLC-LTVLLSYLPEAGEYSCMFVYLKLkMGFNYVE---VSVFIAIVGILSITVQVT 490
Cdd:cd17490 180 VLTELK------ELLSVLKDKKLLFFSlLAILQQMITFSTTFGFTPLIAKQ-LGASSFQlglLSIIYLLPNALASLLSGT 252
|
250 260
....*....|....*....|
gi 386770446 491 LgsFMQVFGAKRTIIMGLAL 510
Cdd:cd17490 253 L--FYKKLGERNTIIIGFLL 270
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
247-369 |
1.01e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.42 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 247 MPIISTLNQTFPDHTFLMNgLVMGIKgILSFLSAPLIGA-LSDIWGRKFFLLVTVF-FTCLPIPL-MSINTWWFFAMISI 323
Cdd:cd17323 19 SPALPQIAEDFHVSEEVAN-LGVSLF-VLGFGLGPLIWApLSELYGRRPVYLVSLFiFVIFQIGCaLAPNIAMLIILRFL 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 386770446 324 SGAFAVTF-SVVFAYVADVTTPEERSKAYGLasatFAASLVISPALG 369
Cdd:cd17323 97 QGFFGSSPlAIGAGTIADLFTPEERGKAMGV----YSLGPLLGPALG 139
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
266-372 |
1.09e-06 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 51.44 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVT-----VFFTCLPIPLMSINTWWFFAMIS---ISGAFAVTFSVVFAY 337
Cdd:cd17326 39 GWVVAAYSLGQLVFSPVFGYWSNKTSSVKEPLIVsiliaIVGNILYALAEYFPSNRKYVMLVarfLIGVGAGNVAVLRAY 118
|
90 100 110
....*....|....*....|....*....|....*
gi 386770446 338 VADVTTPEERSKAYGLASATFAASLVISPALGNAL 372
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAF 153
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
266-583 |
1.25e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.41 E-value: 1.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFA-MISISGAFAVTFSVVFAYVADVT 342
Cdd:COG2807 56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLapSVALLLAgTALIGAGIAVGNVLLPGLIKRWF 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 343 tPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESlsekmRPASWGAPISWeqa 422
Cdd:COG2807 136 -PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR-----PAAAAAAPAAA--- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 423 dpflALRKVGTDKTVLMLCLTVLLSylpeAGEYSCMFVYLK---LKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFG 499
Cdd:COG2807 207 ----SLRSLWRSPLAWLLTLFFGLQ----SLLYYAVVAWLPpilRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 500 AKRTIIMG-LALEIVQLLWYGFGSQKWMMWSAGVVAALGSITYPAISAFVSLYAAPESQ-GAVQGMITGMRGLCNGLGPA 577
Cdd:COG2807 279 DRRPLLLLlGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPL 358
|
....*.
gi 386770446 578 VFGVVF 583
Cdd:COG2807 359 LVGALH 364
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
226-397 |
1.74e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 50.63 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 226 PSVHHALVVIFLEFFAWGLLtMPIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFT-- 303
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFAL-YTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAaa 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 304 CLPIPLMSINTWWFFAMISISG-AFAVTFSVVFAYVADVTtPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVV 382
Cdd:cd17324 277 LLLLTLLGPSPLLLLVGLVLWGlGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVG 355
|
170
....*....|....*
gi 386770446 383 ALSTAIALLDVFFIL 397
Cdd:cd17324 356 WVGAALLLLALLLAL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
266-583 |
1.85e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 50.65 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWG-RKFFLLVTVFFTCLPIPLMSINTWWFFAMISI-SGAF-AVTFSVVFAYVADVT 342
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGaRKVLAVSMLLWSLFTALTGFATSLTSLYVLRFlLGVAeAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 343 TPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPeslsekmrpASWGapisweqa 422
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR---------QVWG-------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 423 dpfLALRKVGTDktvlmLCLTVLLSYLPeageyscmfVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLG---SFMQVFG 499
Cdd:cd17319 184 ---LALGYFGIN-----YALYGLLTWLP---------TYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGrlsDRLLRGA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 500 AKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAV 578
Cdd:cd17319 247 RRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGiGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
....*
gi 386770446 579 FGVVF 583
Cdd:cd17319 327 IGYLV 331
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
266-583 |
1.32e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 47.98 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSD----IWG--RKFFLLVTVFFTCL-------PIPLMSINTWWFFAMISISGAFAVTFS 332
Cdd:cd17332 38 GTIFLVARIIDAINDPLMGYLIDrtrsRWGrfRPWLLWGAIPLALLfvllfttPDGSGTGKLIYALITYILLDLLYTLVN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 333 VVF-AYVADVTT-PEERSKAYGLASATFAASLVISPALGNALMEMYGDT----------LVVALSTAIALLDVFFIL--- 397
Cdd:cd17332 118 IPYtALIPELTDdPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGnasrgyfltaLIIGIIGIILLLICFFGTrer 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 398 VAVPESLSEKMRPA-SWGAPISWeqaDPFLALrkvgtdkTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVF 476
Cdd:cd17332 198 VVPPEEEKSKLPLLkSLKALLKN---RPFLIL-------LLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 477 IAIVGILSITVqvtlgsFMQVFGAKRTIIMGLALEIVQLLWYGFGS--QKWMMWSAGVVAALG-SITYP---AISAFVSL 550
Cdd:cd17332 268 GALLALLPWPP------LKKRFGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIGyGGANLlpwAMLADVID 341
|
330 340 350
....*....|....*....|....*....|...
gi 386770446 551 YAAPESQGAVQGMITGMRGLCNGLGPAVFGVVF 583
Cdd:cd17332 342 YGELKTGKRREGIFYSVMTFFRKLGLALAGALV 374
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
282-578 |
1.47e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 47.76 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 282 LIGALSDIWGRKFFLL--VTVFFTCLPIPLMSINTWWFFAMISISGAFAVTFSVV-FAYVADVTTPEERSKAYGLASATF 358
Cdd:TIGR00710 59 LWGPLSDRYGRRPVLLlgLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVIsQALVRDIYPGEELSRIYSILMPVL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 359 AASLVISPALGNALMEMYG---DTLVVALSTAIALLDVFFILvavPESLSEKMRPASwgaPISWEQadpFLALRKvgtDK 435
Cdd:TIGR00710 139 ALAPAVAPLLGGYILVWLSwhaIFAFLSLAGILLSALIFFIL---PETLPYEARIQI---STYFET---FLLLLK---SK 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 436 TVLMLCLTVllsylpeAGEYSCMFVYLK----LKMGFNYVEVSVF---IAIVGILSITVQVTLGSFMQVFGAKRTIIMGL 508
Cdd:TIGR00710 207 MFWGYALIY-------GASFGGFFAFFSgapfVYIDIMGVSPSVFgllFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGL 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 509 ALEIVQLLWYGF----GSQKWMMwsAGVVAALGSITYPAISAFVSLYAAPE------SQGAVQGMITGmrGLCNGLGPAV 578
Cdd:TIGR00710 280 ILFAVSAVLLEItailGLGSWAM--IIGPMMFVGIGNSMISSIAMAYALEDfphvagTASALFGTLRL--VLGAIVGYLV 355
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
236-588 |
1.49e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 47.68 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 236 FLEFFAWGL-----LTMP-IISTLNQTFPDHTF------LMNGLVMGIKGILSflsapliGALSDIWGRKFFLLVTV--- 300
Cdd:cd17371 2 WAAFLGWALdgfdlLLLGlVLPALIAEFGLDEAeagllgTVTLAGGAIGGILG-------GILADRFGRVRVLVITIllf 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 301 -FFTCLpipLMSINTWWFFAMI-SISG-AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYG 377
Cdd:cd17371 75 aVFTLL---CGFAQNYWQLLILrALAGlGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 378 DTL---VVALSTAIALLDVFFILVAVPEslsekmrPASWGAPISWEQADPFLA-LRKVGTDKTVLMLCLTVLLSYLPEAG 453
Cdd:cd17371 152 PEIawrVLFLLGALPALLVLFIRRFVKE-------PPQWQAARAARRHFADRPsLRELFSPPLLRTTLLASLLATGALGG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 454 EYSCMF---VYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWY-----GFGSQKW 525
Cdd:cd17371 225 YYGITTwlpSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYfflplSPTLILI 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386770446 526 MMWSAG--VVAALGSITYPAISAFVSL---------YAAPESQGAVQGMITGMRGLCNGLGPA--VFGVVFYLFNV 588
Cdd:cd17371 305 LGFPLGffASGPFSGMGAYLTELFPTAvrataqgfcYNVGRIIGALFPFLVGFLATSGSLGTAiaVFAAVYYIAGL 380
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
236-391 |
2.62e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 236 FLEFFAWGLLTMPIISTLNQTFPDH-------TFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLV-TVFFT--CL 305
Cdd:cd17329 202 FLLFLLASFLISLIYFQLESTLPVYvveilglGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIgILLFAigFA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 306 PIPLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTL----- 380
Cdd:cd17329 282 VLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLpwlil 361
|
170
....*....|..
gi 386770446 381 -VVALSTAIALL 391
Cdd:cd17329 362 aALGLIAAALLL 373
|
|
| Nuc_H_symport |
pfam03825 |
Nucleoside H+ symporter; |
233-589 |
2.69e-05 |
|
Nucleoside H+ symporter;
Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 47.07 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 233 VVIFLEFFAWGLLTMPIISTLNQTFPDHTFLmnGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM-- 310
Cdd:pfam03825 9 VMMFLQFFIWGAWLVTLGSYMFVTGFDGASI--GAVYSSLGIAAIFMPALLGIIADRWFSAERVLAVCHLIGAITLFMaa 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 -SINTWWFFAMISI-SGAF----AVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVAl 384
Cdd:pfam03825 87 qVTTFEAFFLVILVnSLAYmptlALTNSIAFANLQDPVTDFPPIRVWGTIGWIMASWPFVMWVVSLAGFELSHMQLLIA- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 385 STAIALLDVFfilvavpeSLSEKMRPASWGAPISWEQA---DPFLALRkvgtDKTVLMLCLTVLLSYLPEAGEYSCMFVY 461
Cdd:pfam03825 166 AGLSALLVLF--------ALTLPHTPAKQKANQSWTTLlglDAFALLK----NKRMAVFFIFSFLLGAELQIYNVFANTF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 462 LKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGS---------QKWMMWSAGV 532
Cdd:pfam03825 234 LTSFDKFIVKHASIIMSLGQISEILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGAdptpfgtalLLLSMIVHGV 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 386770446 533 VAALGSITypaISAFVSLYAAPESQGAVQGMITGM-RGLCNGLGPAVFGVVFYLFNVD 589
Cdd:pfam03825 314 AYDFFNIT---GYIFVDKEVPPAIRASAQGLFLLMtNGFGCILGSILSGMVVEMFTQD 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
279-372 |
2.73e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.79 E-value: 2.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 279 SAPLIGALSDIWGRKFFLLVTVFFTCLPIPL--MSINTWWFFAMISISGAFA-VTFSVVFAYVADVTTPEERSKAYGLAS 355
Cdd:cd17502 46 FQPIYGKLSDLFGRKWVLLIAIVIFELGSLLcgLAPNMTMLIVGRAIQGIGGgGLMSLAFIIIADLVPPRERGKYQGYIG 125
|
90
....*....|....*..
gi 386770446 356 ATFAASLVISPALGNAL 372
Cdd:cd17502 126 AVFGIASVAGPLIGGAF 142
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
233-589 |
3.30e-05 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 46.85 E-value: 3.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 233 VVIFLEFFAWGLLTMPIISTLNQTfPDHTFLMNGLVMGIKGILSFLSAPLIGALSDiwgRKF----FLLVTVFFTCLPIP 308
Cdd:cd06177 4 VMMFLQFFIWGAWLVTLGGYMGST-LGFTGAQIGAVYSTTGIAAIIMPFFLGIIAD---RFFaaekVLAVLHLIGAAALF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 309 LMSINT--WWFFAMISISGAF-----AVTFSVVFAYVADVTTPEERSKAYGLAsATFAASLVIspalGNALMEMYGDTLV 381
Cdd:cd06177 80 YAATVTdfSVFFWVMLLYSLCymptlALTNSIAFSNLEDPVKDFPPIRVWGTI-GWIAAGWPV----GFLGWEASNLQFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 382 VAlSTAIALLDVF-FILVAVPeslsekmrPASWGAPISWEQA---DPFLALRkvgtDKTVLMLCLTVLLSYLPEAGEYSC 457
Cdd:cd06177 155 IA-AGASLLLGLYsLTLPHTP--------PKKAGKGVSKRSLlglDAFVLLK----NPFFAVFFIFSFLLGAPLQFYYTF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 458 MFVYLKlKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG 537
Cdd:cd06177 222 ANPFLN-DFGMIVKNPAGIMSLGQISEILFMLAIPFFLKRLGIKKVMLIGMLAWVLRFGLFAYGDPSPGVWMLVLSIILH 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386770446 538 SITYPAISAFVSLY---AAPES-QGAVQGMITGMrglCNGLGpAVFG------VVFYLFNVD 589
Cdd:cd06177 301 GVCYDFFFVTGYIYvdkKAPKDiRASAQGLFMLM---TNGVG-ALVGsilsgkVVDKFTTVE 358
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
265-398 |
3.63e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.44 E-value: 3.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 265 NGLVMGIKGILSFLS-APLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFFAMISISGAFAVTFSVVF-AYVAD 340
Cdd:cd17331 245 NGYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFvtTVWQLLVLLLPLVIGGSVLYTVItSLLTK 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 386770446 341 VTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILV 398
Cdd:cd17331 325 AVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
435-586 |
4.15e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 4.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 435 KTVLMLCLTVLLSYLPEAGeYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQ 514
Cdd:COG2271 10 RILALLFLAYFLNYLDRSN-LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386770446 515 LLWYGFGSQKWMMWSAGVVAALG-SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLF 586
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
437-639 |
7.09e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.64 E-value: 7.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 437 VLMLCLTVLLSYLPeageyscmfVYLKlKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLL 516
Cdd:cd17325 7 LDMLGYGIIIPILP---------LYAE-SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 517 WYGFGSQKWMMWSAGVVAALGS-ITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYLFnvdlnddhd 595
Cdd:cd17325 77 LFAFATSYWQLLLARFLQGLASaAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL--------- 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 386770446 596 shakssGSRAtnvekisqhvpgpPFVF-GALCVFCAIIVSAFIPE 639
Cdd:cd17325 148 ------GYRA-------------PFLVcAALALLALVLALLLLPE 173
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
267-395 |
1.11e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 45.21 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 267 LVMGIKGILSFLSAPLIGALSDIWGRK-FFLLVTVFFTCLPIPLMSI-----NTWWFFAMISISGAF-AVTFSVVFAYVA 339
Cdd:cd17369 268 LAVLIASVVAAITIPLFGWLSDRVGRRpVYLAGALLAALFAFPFFWLldtgsTWLIVLAAVVVLGVLhGMMYGPQAAFLA 347
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386770446 340 DVTTPEER----SKAYGLASATFAAslvISPALGNALMEMYGDT----LVVALSTAIALLDVFF 395
Cdd:cd17369 348 ELFPTRVRytgaSLGYQLGAILGGG---FAPLIATALVAATGSWwpvaLYLAALAVISLVAALF 408
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
263-527 |
1.31e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 44.91 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 263 LMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMSI--NTWWFF---AMISISGAFAVTFSVVFAy 337
Cdd:PRK09874 54 MWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLaqNIWQFLilrALLGLLGGFVPNANALIA- 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 338 vadVTTPEERSK-AYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSekmrpaswgaP 416
Cdd:PRK09874 133 ---TQVPRNKSGwALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQ----------P 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 417 ISWEQadpFLALRKVGTD----KTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMG--FNYVEVSVFIAIV-GILSITVQV 489
Cdd:PRK09874 200 VSKKE---MLHMREVVTSlknpKLVLSLFVTTLIIQVATGSIAPILTLYVRELAGnvSNIAFISGMIASVpGVAALLSAP 276
|
250 260 270
....*....|....*....|....*....|....*...
gi 386770446 490 TLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMM 527
Cdd:PRK09874 277 RLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQL 314
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
266-427 |
1.60e-04 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 44.61 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSAPLIGALSDIWGRKFFLLV--TVFFTCLPIPLMSINTWWFFAMISISG---AFAVTFSvvFAYVAD 340
Cdd:cd17383 33 GVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIglTVMFLSTAVFAFGESYAVLFFARSLQGvgsAFADTAG--LAMIAD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 341 VTTPE-ERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFIL-VAVPESLSEKMR-PASWGAPI 417
Cdd:cd17383 111 RFTEEaERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLlVMKPVRRETRANmPEPVGTPI 190
|
170
....*....|
gi 386770446 418 SWEQADPFLA 427
Cdd:cd17383 191 HRLLMDPYIA 200
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
277-403 |
3.89e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.47 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 277 FLSAPLIGALSDIWGRKFFLLVTVFFTCLP--IPLMSINTWWFFAMISISGAFAVTFSVV-FAYVADVTTPEERSKAYGL 353
Cdd:TIGR00898 141 LLGSFVFGYLSDRFGRKKVLLLSTLVTAVSgvLTAFSPNYTVFLVFRLLVGMGIGGIWVQaVVLNTEFLPKKQRAIVGTL 220
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 386770446 354 ASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFilvaVPES 403
Cdd:TIGR00898 221 IQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWF----VPES 266
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
458-585 |
4.85e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.98 E-value: 4.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 458 MFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSAGVVAALG 537
Cdd:cd17329 22 MAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFG 101
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 386770446 538 -SITYPAISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVVFYL 585
Cdd:cd17329 102 gGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY 150
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
263-541 |
5.20e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.92 E-value: 5.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 263 LMNGLVMGIKGILSFLSAPLIGALSD-IWGRKFFLLVTVFF---TCLPIPLMSiNTWWFFAM-ISISGAFAVTFSVVFAY 337
Cdd:cd17471 32 LQIGIFMTLSALSGIVVSQWLGRLSDrGGDRKPLILLALLAgalGYLLFAFLR-NYWVLLLVgVVLLSLGAAAFPQLFAL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 338 ---VADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKmrpaswg 414
Cdd:cd17471 111 areYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPA------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 415 apiswEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGFNYVEVSVFIAIVGILSITVQVTLGSF 494
Cdd:cd17471 184 -----QKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLL 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 386770446 495 MQVFGAKRTIIMGLALEIVQLLWYGFGSQKWMMWSA--------GVVAALGsITY 541
Cdd:cd17471 259 AKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALqllnaifiGITAGLG-ISY 312
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
231-415 |
5.67e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.55 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 231 ALVVIFLEFFAWGLLTMpIISTLNQTFPDHTFLMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLM 310
Cdd:cd17321 173 AVLAAFLLGAALGGLLF-LLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 311 SI----NTWWFF--AMISISGAFAVTFSVVFAYVADVTTPEERskayGLASATFAASLVISPALGNALMemyGDTLVVAL 384
Cdd:cd17321 252 ALlgadSSVWLLlpGLVLLGLGLGLFATPLTNAALSSVPKEKA----GAASGILNTARQLGGALGVALL---GALLTAGL 324
|
170 180 190
....*....|....*....|....*....|.
gi 386770446 385 STAIALLDVFFILVAVPESLSEKMRPASWGA 415
Cdd:cd17321 325 SANLGDSGVAALLSAAAAAFAAGFHLAFLVA 355
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
241-582 |
6.41e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.60 E-value: 6.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 241 AWGLLTMPIISTLNQTFPDhtflmNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPLMS--INTWWFF 318
Cdd:cd17353 21 AWSVFNPPLSSALGWSLAS-----VALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAfaISLPLLF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 319 -AMISISGAfavtfSVVFAYVADVTT-----PEERSKAYGLASATFAASLVISPALGNALMEMYGdtlvvaLSTAIALLD 392
Cdd:cd17353 96 lGYGVLGGI-----GAGIGYITPVSTavkwfPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVG------VPTTFLILG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 393 VFFILVAVPESLSEKMRPASWGAPIS------WEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKM 466
Cdd:cd17353 165 IIFLIIIVIGAFLIRDPPKGWVPPGVdplannAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 467 GFNYVEVSVFIAIVGILSITVQVTLGSFMQVFGAKRTIIMGLALEIV-QLLWYGFGSQKWM--MWSAGVVAALGSItYPA 543
Cdd:cd17353 245 GLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVaMFLLPFIGSVAVLfvLGVALIGFCYGGG-FAL 323
|
330 340 350
....*....|....*....|....*....|....*....
gi 386770446 544 ISAFVSLYAAPESQGAVQGMITGMRGLCNGLGPAVFGVV 582
Cdd:cd17353 324 FPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYV 362
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
266-400 |
1.41e-03 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 41.72 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 266 GLVMGIKGILSFLSaPLIGALSD------------IWGRKFFLLVTVFFTCLPIPLMSINTWWF--------FAMISIsg 325
Cdd:cd06176 39 GLLIALHYLVAPLR-VWIGHRSDthplrgyrrtpyIWLGMLLLALGLALAPFAALLLAGAAFWLglalavlaFLLYGI-- 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386770446 326 AFAVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAV 400
Cdd:cd06176 116 GVGAAGTAFLALLADLTPEERRPRAVTVVWTMLILGIIVTAIVFGRLLDPYSPERLIQVFQIVALVALLLALLAL 190
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
263-582 |
2.10e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 41.14 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 263 LMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVTVFFTCLPIPlmsintwwFFAMISISGafavtfsvvfayvadvT 342
Cdd:pfam13347 72 LLSAIILAVSFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIP--------YWSLGPELT----------------R 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 343 TPEERSKA---------YGLASATFAASLVISPaLGNALMEMYGDTLVVALSTAIALLDVFFILVAVPESLSEKMRPASW 413
Cdd:pfam13347 128 DYDERTSLtsyrsffsvGGGLLAAALAFPLVLI-LGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 414 GApiswEQADPFLALRKVGTDKTVLMLCLTVLLSYLPEAGEYSCMFVYLKLKMGfNYVEVSVFIAIVGILSITVQVTLGS 493
Cdd:pfam13347 207 QK----EAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLG-NGFAASAFPLVFTIGALLGIPLWPP 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 494 FMQVFGAKRTIIMGLALEIVqLLWYGFGSQKWMMWSAGVVAALGSITYPAI-SAFVSLYAAPESQGAVQ------GMITG 566
Cdd:pfam13347 282 LAKRIGKKNTYILGALITIA-GFALALLLGPNNTLLFLVLYIIIGFGYGSSfFLPWSMLADVVDYGELRtgkrreGTFFA 360
|
330 340
....*....|....*....|
gi 386770446 567 MRGLCN----GLGPAVFGVV 582
Cdd:pfam13347 361 MWSFISklatGVGLGVSGLL 380
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
263-639 |
2.37e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.63 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 263 LMNGLVMGIKGILSFLSAPLIGALSDIWGRKFFLLVT--VFFTCLPIPLMSINTWWFFAMiSISGAFAVTFS--VVFAYV 338
Cdd:cd17359 36 FLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISavLFFISALGSAFSPNFTIFIIA-RIIGGLAVGGAsaLVPMYI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 339 ADVTTPEERSKAYGL--------ASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLdVFFILVAVPES---LSEK 407
Cdd:cd17359 115 AEVAPAEIRGRLVSLnqlmivfgQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAIL-FLLGMLFIPESprwLVSK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 408 MRPASWgAPISWEQADPFlalrkVGTDktvlmlcltVLLSYLPEAGEyscmfvylklKMGFNyvEVSVFIAIVGILSITV 487
Cdd:cd17359 194 GKPILI-IGIGLAIFQQF-----VGIN---------VIFYYGPEIFQ----------NAGFS--ENAALLQTIGIGVVNV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 488 QVTLGSFMQV--FGAKRTIIMGLALEIVQLLWYGfgsqkWMMWSAGVVAALGSITYPAISAFVSLYAApeSQGAVQGMIT 565
Cdd:cd17359 247 IFTIIAILLVdkVGRKPLLLIGSIGMAISLLLIG-----TAFYFAPGSQASGIVALVLILLFVAFFAM--SWGPVTWVLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 566 G------MRGLcnGLGPAVFG------VVFYLFNVDLNDDHdshakssgsratnvekisqhvPGPPF-VFGALCVFCAII 632
Cdd:cd17359 320 SeifpnrIRGL--AMGIAVFFlwianfLVSLTFPILLAAFG---------------------LAFTFlIFAVICVLAFLF 376
|
....*..
gi 386770446 633 VSAFIPE 639
Cdd:cd17359 377 VWKFVPE 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
232-397 |
2.84e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 2.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 232 LVVIFLEFFAWG--LLTMPIIstLNQTFPDHTFlMNGLVMGIKGILSFLSAPLIGALSDI-WGRKFFLLVTVFFTCLPIP 308
Cdd:cd17474 204 LVSAFLYFFLYFafLTYLPFL--LELLYGISPI-IIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 309 LMSI--NTWWFFAMISISGAF-AVTFSVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALS 385
Cdd:cd17474 281 LLGFvpSLALLLIAIVLFGLGlGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVG 360
|
170
....*....|..
gi 386770446 386 TAIALLDVFFIL 397
Cdd:cd17474 361 AAIALAAAVLLA 372
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
261-403 |
3.28e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 40.33 E-value: 3.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 261 TFLMNGLVMGIKGILSFLSAPLIgalsDIWGRKFFLLV--------TVFFTCLPIPLMSINTWW-----FFAMISIsGAF 327
Cdd:pfam00083 289 SFLVTIIVGVVNFVFTFIAIFLV----DRFGRRPLLLLgaagmaicFVILGIVALLGVSKSDWAgivaiVFIALFI-AFF 363
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386770446 328 AVTF-SVVFAYVADVTTPEERSKAYGLASAT-FAASLVISpALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPES 403
Cdd:pfam00083 364 AMGWgPVPWVIVSELFPLSVRSKAMALATAAnWLANFLIG-FLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPET 440
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
270-398 |
3.87e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.90 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 270 GIKGILSFLSAPLIGALS-DIWGRKF---FLLVTVFF----TCLPIPLMSiNTWWFFAMISISG-AFAVTFSVVFAYVAD 340
Cdd:cd17490 233 GLLSIIYLLPNALASLLSgTLFYKKLgerNTIIIGFLllgaYCFLIPFAP-NLTLLYLLQALNGfGTGILFPLLMSLSIE 311
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 386770446 341 VTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILV 398
Cdd:cd17490 312 GVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
267-401 |
3.94e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 267 LVMGIKGILSFLSAPLIGALSD-----IWGRKFFLLVTVFFTCLPIPLMsiNTWWFFAMISISGAFAVTFSVVFAYV--A 339
Cdd:cd17352 222 FLLSIIGISDIVGRILLGLLADkprigRLYLYIFTLLILGLSLLAFPLA--TTYVGLIVFSVLFGFCSGSYSSLTPVilA 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386770446 340 DVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVP 401
Cdd:cd17352 300 DLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
282-398 |
5.77e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.53 E-value: 5.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 282 LIGA-LSDIWGRK----------FFLLVTVFFTCLPIPLMSINTWWFFAMISISGAFA-VTFSVVFAYVADVTTPEERSK 349
Cdd:cd17328 265 LLGGiLADRLRRKtpradplvcaVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLsLNWAPVFAILLYVVIPTRRST 344
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 386770446 350 AYG---LASATF--AASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILV 398
Cdd:cd17328 345 ASAiqiLLSHLLgdAGSPYLIGLISDLLRQNKDSPLAEAASLQYALLLCSFVLV 398
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
264-406 |
7.17e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 39.48 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 264 MNGLVMGIKGILSFLSAPLigaLSDIWGRKFFLLVT------------VFFTCLPIPLMSINTWWF--FAMISISGAFAV 329
Cdd:cd17358 278 TATIIIGVVQVVGTLVATL---LVDRLGRRPLLLVSaigmgigllalgLYFYLQEHGALLSSVSWLplVGLVIYIISFSI 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 330 TF-SVVFAYVADVTTPEERSKAYGLASATFAASLVISPALGNALMEMYGDTLVVALSTAIALLDVFFILVAVPE----SL 404
Cdd:cd17358 355 GLgPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPEtkgkSL 434
|
..
gi 386770446 405 SE 406
Cdd:cd17358 435 EE 436
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
273-378 |
8.67e-03 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 39.16 E-value: 8.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 273 GILSFLSAPLIGALSDIWGRKFFLlvtVFFTCLPI----PLMSintwWFFAMISISGAFAVT--FSVVF--------AYV 338
Cdd:PRK15075 284 GVSNFIWLPIGGALSDRIGRRPVL---IAFTVLAIltayPALS----WLVAAPSFARMLAVElwLSFLYgsyngamvVAL 356
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 386770446 339 ADVTTPEER----SKAYGLASATFAAslvISPALGNALMEMYGD 378
Cdd:PRK15075 357 TEVMPAEVRtagfSLAYSLATAIFGG---FTPAISTWLIHVTGD 397
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
278-374 |
9.09e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.15 E-value: 9.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770446 278 LSAPLIGALSDIWGRKFFLLVTVFFTCLP--IPLMSINTWWFFAMISISGAFAVTFSVVFAYVADVTTPEERSKAYGLAS 355
Cdd:cd06179 47 VLGPIVGRLSDLFGRRWFFIGGNLLGVVGsiVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVN 126
|
90
....*....|....*....
gi 386770446 356 ATFAASLVISPALGNALME 374
Cdd:cd06179 127 LVASPGSALGPLIAGALVE 145
|
|
| |
