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Conserved domains on  [gi|386768140|ref|NP_001246375|]
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uncharacterized protein Dmel_CG5348, isoform C [Drosophila melanogaster]

Protein Classification

sodium/calcium exchanger protein( domain architecture ID 10483990)

sodium/calcium exchanger protein may regulate intracellular Ca2+ concentrations

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 86-186 9.08e-08

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


:

Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 49.91  E-value: 9.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768140   86 FVAFCFQILVLLIYTINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVERHVP--VFANNLSSALFVIT 163
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPdlALGNVIGSNIFNIL 80

                          90       100
                  ....*....|....*....|...
gi 386768140  164 ISGGLIFYISPFKMNSYETVRDI 186
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDL 103
 
Name Accession Description Interval E-value
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 86-186 9.08e-08

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 49.91  E-value: 9.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768140   86 FVAFCFQILVLLIYTINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVERHVP--VFANNLSSALFVIT 163
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPdlALGNVIGSNIFNIL 80

                          90       100
                  ....*....|....*....|...
gi 386768140  164 ISGGLIFYISPFKMNSYETVRDI 186
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDL 103
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 41-143 7.64e-05

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 43.21  E-value: 7.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768140  41 FEERCEFVQKAEDCnSSTNVIPYMRLLACDLKcinQFQEMIFIALFVAfcfqiLVLLIY----TINVYYSPALKAVSRFL 116
Cdd:PLN03151 103 YADQCEFLKAHPIC-SSGGFFDYLKFFYCSCE---DFRILGYAVLGVW-----LVALFYllgnTAADYFCCSLEKLSKLL 173

                         90       100
                 ....*....|....*....|....*..
gi 386768140 117 HMNEHLAGVTLMAFGNTSADFFANLAS 143
Cdd:PLN03151 174 RLPPTVAGVTLLPLGNGAPDVFASIAA 200
 
Name Accession Description Interval E-value
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 86-186 9.08e-08

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 49.91  E-value: 9.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768140   86 FVAFCFQILVLLIYTINVYYSPALKAVSRFLHMNEHLAGVTLMAFGNTSADFFANLASVERHVP--VFANNLSSALFVIT 163
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPdlALGNVIGSNIFNIL 80

                          90       100
                  ....*....|....*....|...
gi 386768140  164 ISGGLIFYISPFKMNSYETVRDI 186
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDL 103
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 41-143 7.64e-05

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 43.21  E-value: 7.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768140  41 FEERCEFVQKAEDCnSSTNVIPYMRLLACDLKcinQFQEMIFIALFVAfcfqiLVLLIY----TINVYYSPALKAVSRFL 116
Cdd:PLN03151 103 YADQCEFLKAHPIC-SSGGFFDYLKFFYCSCE---DFRILGYAVLGVW-----LVALFYllgnTAADYFCCSLEKLSKLL 173

                         90       100
                 ....*....|....*....|....*..
gi 386768140 117 HMNEHLAGVTLMAFGNTSADFFANLAS 143
Cdd:PLN03151 174 RLPPTVAGVTLLPLGNGAPDVFASIAA 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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