NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|386767933|ref|NP_001246317|]
View 

I[[h]] channel, isoform M [Drosophila melanogaster]

Protein Classification

Ion_trans_N and PLN03192 domain-containing protein( domain architecture ID 10552540)

Ion_trans_N and PLN03192 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ion_trans_N pfam08412
Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 ...
 37-79 4.11e-23

Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.


:

Pssm-ID: 400630  Cd Length: 43  Bit Score: 88.13  E-value: 4.11e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 386767933   37 LQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSS 79
Cdd:pfam08412   1 LKSLLQPSDNKLSMKLFGSKKAVEKEKERQKEAGVWIIHPCSN 43
PLN03192 super family cl33658
Voltage-dependent potassium channel; Provisional
 69-173 7.19e-11

Voltage-dependent potassium channel; Provisional


The actual alignment was detected with superfamily member PLN03192:

Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 61.81  E-value: 7.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767933  69 SGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMqqDNAEQVIL 148
Cdd:PLN03192  49 SDGWIISPMDSRYRWWETLMVVLVAYSAWVYPFEVAFLNASPKRGLEIADNVVDLFFAVDIVLTFFVAYI--DPRTQLLV 126

                         90       100
                 ....*....|....*....|....*.
gi 386767933 149 -DPKLIAKHYLRTWFFLDLISSIPLD 173
Cdd:PLN03192 127 rDRKKIAVRYLSTWFLMDVASTIPFQ 152
 
Name Accession Description Interval E-value
Ion_trans_N pfam08412
Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 ...
 37-79 4.11e-23

Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.


Pssm-ID: 400630  Cd Length: 43  Bit Score: 88.13  E-value: 4.11e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 386767933   37 LQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSS 79
Cdd:pfam08412   1 LKSLLQPSDNKLSMKLFGSKKAVEKEKERQKEAGVWIIHPCSN 43
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 69-173 7.19e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 61.81  E-value: 7.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767933  69 SGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMqqDNAEQVIL 148
Cdd:PLN03192  49 SDGWIISPMDSRYRWWETLMVVLVAYSAWVYPFEVAFLNASPKRGLEIADNVVDLFFAVDIVLTFFVAYI--DPRTQLLV 126

                         90       100
                 ....*....|....*....|....*.
gi 386767933 149 -DPKLIAKHYLRTWFFLDLISSIPLD 173
Cdd:PLN03192 127 rDRKKIAVRYLSTWFLMDVASTIPFQ 152
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 81-208 5.99e-06

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 46.11  E-value: 5.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767933   81 RFYWDLCMLLLLVANLIILPVAISF-FNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGImqqdnaeqvildpklIAKHYLR 159
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFqPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAG---------------FKKRYFR 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 386767933  160 T-WFFLDLISSIPLDYIFLIfnqimklqDFSDSFQILHAGRALRILRLAK 208
Cdd:pfam00520  66 SpWNILDFVVVLPSLISLVL--------SSVGSLSGLRVLRLLRLLRLLR 107
 
Name Accession Description Interval E-value
Ion_trans_N pfam08412
Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 ...
 37-79 4.11e-23

Ion transport protein N-terminal; This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.


Pssm-ID: 400630  Cd Length: 43  Bit Score: 88.13  E-value: 4.11e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 386767933   37 LQSWFQPTDNRLAMKLFGSRKALVKERIRQKTSGHWVIHPCSS 79
Cdd:pfam08412   1 LKSLLQPSDNKLSMKLFGSKKAVEKEKERQKEAGVWIIHPCSN 43
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 69-173 7.19e-11

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 61.81  E-value: 7.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767933  69 SGHWVIHPCSSFRFYWDLCMLLLLVANLIILPVAISFFNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGIMqqDNAEQVIL 148
Cdd:PLN03192  49 SDGWIISPMDSRYRWWETLMVVLVAYSAWVYPFEVAFLNASPKRGLEIADNVVDLFFAVDIVLTFFVAYI--DPRTQLLV 126

                         90       100
                 ....*....|....*....|....*.
gi 386767933 149 -DPKLIAKHYLRTWFFLDLISSIPLD 173
Cdd:PLN03192 127 rDRKKIAVRYLSTWFLMDVASTIPFQ 152
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 81-208 5.99e-06

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 46.11  E-value: 5.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767933   81 RFYWDLCMLLLLVANLIILPVAISF-FNDDLSTRWIAFNCLSDTIFLIDIVVNFRTGImqqdnaeqvildpklIAKHYLR 159
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFqPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAG---------------FKKRYFR 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 386767933  160 T-WFFLDLISSIPLDYIFLIfnqimklqDFSDSFQILHAGRALRILRLAK 208
Cdd:pfam00520  66 SpWNILDFVVVLPSLISLVL--------SSVGSLSGLRVLRLLRLLRLLR 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH