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Conserved domains on  [gi|386767850|ref|NP_001246288|]
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N-methyl-D-aspartate receptor-associated protein, isoform G [Drosophila melanogaster]

Protein Classification

protein lifeguard( domain architecture ID 10179627)

protein lifeguard similar to human protein lifeguard 2, an antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis, and regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
92-309 4.62e-106

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


:

Pssm-ID: 198410  Cd Length: 217  Bit Score: 308.32  E-value: 4.62e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  92 SFDDQSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIF 171
Cdd:cd10428    1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 172 LGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITL 251
Cdd:cd10428   81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 386767850 252 VYASIGALLFSVYLIYDTQLMMGGeHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 309
Cdd:cd10428  161 VYASLGALLFSLYLAVDTQLLMGG-RKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
92-309 4.62e-106

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 308.32  E-value: 4.62e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  92 SFDDQSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIF 171
Cdd:cd10428    1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 172 LGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITL 251
Cdd:cd10428   81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 386767850 252 VYASIGALLFSVYLIYDTQLMMGGeHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 309
Cdd:cd10428  161 VYASLGALLFSLYLAVDTQLLMGG-RKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
100-308 2.27e-42

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 145.01  E-value: 2.27e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  100 RGFIRKVYLILMGQLIVTfGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTML-SMACCESVRRQTPTNFIFLGLFTAA 178
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFgALLLARKRKYSSNVALLLLLAFTLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  179 QSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASIGA 258
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGV 159
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 386767850  259 LLFSVYLIYDTQLMMggEHKYSISPEEYIFAALNLYLDIINIFMYILTII 308
Cdd:pfam01027 160 LLFSGFILYDTQRII--KRYGEYGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
96-312 1.13e-31

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 117.97  E-value: 1.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  96 QSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVtMLSMACCESVRRQTPTNFIFLGLF 175
Cdd:COG0670   16 DAGLRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLG-LVFLLSKLANRANSAAALALLFAY 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 176 TAAQ----SFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITL 251
Cdd:COG0670   95 TALMgltlSPILLVYTGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSL 174
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386767850 252 VYASIGALLFSVYLIYDTQ-LMMGGEhkysiSPEEYIFAALNLYLDIINIFMYILTIIGASR 312
Cdd:COG0670  175 AISVAGVLLFSGLTLYDTQrIKHGYE-----TNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
PRK10447 PRK10447
FtsH protease modulator YccA;
195-312 1.40e-06

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 48.30  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 195 VLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDT-QLMM 273
Cdd:PRK10447 106 IALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFILISSGAILFETsNIIH 185
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 386767850 274 GGEhkysispEEYIFAALNLYLDIINIFMYILTIIGASR 312
Cdd:PRK10447 186 GGE-------TNYIRATVSLYVSLYNIFVSLLSILGFAS 217
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
92-309 4.62e-106

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 308.32  E-value: 4.62e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  92 SFDDQSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIF 171
Cdd:cd10428    1 PFDDKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 172 LGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITL 251
Cdd:cd10428   81 LGIFTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHI 160
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 386767850 252 VYASIGALLFSVYLIYDTQLMMGGeHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 309
Cdd:cd10428  161 VYASLGALLFSLYLAVDTQLLMGG-RKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
97-312 3.32e-61

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 194.36  E-value: 3.32e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  97 SIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACcesVRRQTPTNFIFLGLFT 176
Cdd:cd10429   25 EIRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLISLIGSLILLIALYW---KRHSHPVNLILLSLFT 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 177 AAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFV-KGKIITLVYAS 255
Cdd:cd10429  102 LCEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILLALIFQFFpYSPTFELVYAG 181
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 386767850 256 IGALLFSVYLIYDTQLMMggeHKYsiSPEEYIFAALNLYLDIINIFMYILTIIGASR 312
Cdd:cd10429  182 LGALLFSGYIVYDTQLIM---KRL--SPDEYILAAISLYLDIINLFLSILRILAAMN 233
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
100-308 2.27e-42

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 145.01  E-value: 2.27e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  100 RGFIRKVYLILMGQLIVTfGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTML-SMACCESVRRQTPTNFIFLGLFTAA 178
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFgALLLARKRKYSSNVALLLLLAFTLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  179 QSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASIGA 258
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGV 159
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 386767850  259 LLFSVYLIYDTQLMMggEHKYSISPEEYIFAALNLYLDIINIFMYILTII 308
Cdd:pfam01027 160 LLFSGFILYDTQRII--KRYGEYGDYDAILAALSLYLDFINLFLSLLRIL 207
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
98-309 4.77e-35

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 125.99  E-value: 4.77e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  98 IRRGFIRKVYLILMGQLIVTFGAVALFVYHEgtktfarnNMWLFWVALGVMLVTMLS-MACCESVRRQTPTNFIFLGLFT 176
Cdd:cd06181    1 STKDFLRKVYMILALQLLLTAATATAFTVCD--------PGWYWSPALMGLLTSMLAlMATAAMIRAKMPVNLILLFGFT 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 177 AAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASI 256
Cdd:cd06181   73 GLMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAV 152
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 386767850 257 GALLFSVYLIYDTQLMMggeHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 309
Cdd:cd06181  153 GLVLFCGFLLYDTQLII---HKAEVGPEDYINACISLYLDIINIFIRLLTILA 202
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
96-312 1.13e-31

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 117.97  E-value: 1.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  96 QSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVtMLSMACCESVRRQTPTNFIFLGLF 175
Cdd:COG0670   16 DAGLRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLG-LVFLLSKLANRANSAAALALLFAY 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 176 TAAQ----SFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITL 251
Cdd:COG0670   95 TALMgltlSPILLVYTGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGLIIASLVNIFLQSPALSL 174
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386767850 252 VYASIGALLFSVYLIYDTQ-LMMGGEhkysiSPEEYIFAALNLYLDIINIFMYILTIIGASR 312
Cdd:COG0670  175 AISVAGVLLFSGLTLYDTQrIKHGYE-----TNKQYIMAALSLYLDFINLFLSLLRLLGGRR 231
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
99-309 9.01e-31

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 114.97  E-value: 9.01e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850  99 RRGFIRKVYLILMGQLIVTfGAVALFVYHEGTkTFARNNMWLFWVALGVMLVTMLSMacceSVRRQTP---TNFIFLGLF 175
Cdd:cd10432    2 LRSFMKKVYGLMAAGLLLT-AVGAYVGASTPA-LLLIAGSPLMWVLLIAELALVFGL----SFRINKMsvaTALPLFFAF 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 176 TAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYAS 255
Cdd:cd10432   76 AALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISA 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 386767850 256 IGALLFSVYLIYDTQ--LMMGGEHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 309
Cdd:cd10432  156 IGVLIFSGLIAYDTQriKRMYEAGGGESGYKDAIMGALSLYLDFINLFLFLLRLFG 211
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
142-313 1.26e-15

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 74.16  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 142 WVALGVMLVTMLSMACCESVRRQTPTNFIFLGLFTaaqsFLMGVS---------ATKYAPKEVLMAVGITAAVCLALTIF 212
Cdd:cd10433   35 IMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFT----GFMGYTlgpilnmylALPNGGQIIMTALGGTAAIFFGLSAY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 213 ALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDTQLMM-GGEhkysispEEYIFAAL 291
Cdd:cd10433  111 ALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAFVLFSSGFILYDTSRIIhGGE-------TNYIMATV 183
                        170       180
                 ....*....|....*....|..
gi 386767850 292 NLYLDIINIFMYILTIIGASRD 313
Cdd:cd10433  184 SLYVSIYNLFVSLLNLLGAFSG 205
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
105-307 1.72e-11

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 62.62  E-value: 1.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 105 KVYLILMGQLIVTFGAVALFVYhegtkTFARNNMWLFWValgvmLVTMLSMACCESVRRQTPTNFIFLGLFtaaqSFLMG 184
Cdd:cd10430   14 KVYLTLAVALLAAAVGAYVHMV-----INIGGLLTGLLS-----LGLSLWLAFTPSTGKNEPKRLGLLLGF----AFLTG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 185 VS-------ATKYAPKEVLMAVGITAAVCLALTIFALQTKY-DFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASI 256
Cdd:cd10430   80 ASlgplldlVIAINPSIIVTAFLGTAVIFACFSLAALLAKRrEYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELYL 159
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 386767850 257 GALLFSVYLIYDTQLMMggeHKYSISPEEYIFAALNLYLDIINIFMYILTI 307
Cdd:cd10430  160 GLLVFCGFVLFDTQMII---EKAENGDRDYIWHALDLFVDFVALFRRLLII 207
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
100-312 4.00e-07

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 50.46  E-value: 4.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 100 RGFIRKVYLILMGQLIVT-FGAVALFVYHEGTKTFARNNmwlfWVALGVMLVTML-SMACCESVRRQTPTNFIFLgLFTA 177
Cdd:cd10431   41 RDRIHSTYMYFGGSLGLTaLAAVALSRSPALMRLMAAGP----WLAIGATLAAMIgSGMLVRSYTYPENPGAKHL-AWLG 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 178 AQSFLMGVSATKY--APKEVLMAVGITAAVCLALTIFALQTKYD-FTMMGGILIACMVVFLIFGIVAIFVKGKIITL-VY 253
Cdd:cd10431  116 HSGVQGAVLAPLCflGGPLLIRAALYTAGIVGGLSTVAACAPSEkFLYMGGPLAIGLGVVFASSLGSMFLPPTTALGaGL 195
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386767850 254 ASI----GALLFSVYLIYDTQLMMGGEH---KYSISPEEYIFAALNLYLDIINIFMYILTIIGASR 312
Cdd:cd10431  196 YSVslygGLVLFGGFLLYDTQKIIKRAEthpLYGVRKYDPINASMSIYMDTINIFIRLVTILAGGG 261
PRK10447 PRK10447
FtsH protease modulator YccA;
195-312 1.40e-06

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 48.30  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767850 195 VLMAVGITAAVCLALTIFALQTKYDFTMMGGILIACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDT-QLMM 273
Cdd:PRK10447 106 IALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFILISSGAILFETsNIIH 185
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 386767850 274 GGEhkysispEEYIFAALNLYLDIINIFMYILTIIGASR 312
Cdd:PRK10447 186 GGE-------TNYIRATVSLYVSLYNIFVSLLSILGFAS 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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