|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
53-845 |
0e+00 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 585.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 53 DPEYLFSPIAGEGKTERAIVEQYFKVNYtHRFNVGRITRPGRFgrVIVITKDGDENMIRREVFQELRQLDN-IIQNATTT 131
Cdd:pfam02460 5 DIVYTRTPDDARSFTERGVRSEYEPLVE-NKFFPGDSYPEARF--LIITAKGRNSNILDISYLNDIYQLNDyISTNVEIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 132 YDGDTYTYKDNCARWEN-ECFENDILNLDALMDDIEAGqLNLTFPFMF---NPVTWDAHlfpvfFGGTKLTEDNYVISVP 207
Cdd:pfam02460 82 VDGIIISFKDLCSRYCDlNCPVNKHYNGMLLSRRHNTR-IDITYPIMPvlgTPIYLGPH-----FGGVDFEPPGNISYAK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 208 AIQLVYFVTADTKRQDAKGAEWEETFLRVVgnaENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSII 287
Cdd:pfam02460 156 AIVLWYFLKFDEEEVEEDSKEWEDELSQLL---HNKYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSII 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 288 TCM-----MGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPV 362
Cdd:pfam02460 233 VSVtlssyTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 363 AERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGC 442
Cdd:pfam02460 313 KKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVW 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 443 rvqpMSVAIKEKRNflykaimaGGIDANDPDNPIDNKDHmlmaFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQI 522
Cdd:pfam02460 393 ----ATSSPQRIDS--------EGSEPDKSHNIEQLKSR----FFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNI 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 523 KEGLERRKLSREDSYSVEFF-DREDDYYREFpYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSF 601
Cdd:pfam02460 457 KEGLEPDKLVLEDSPLVEYLsLREKHFWPEG-LQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLREY 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 602 LSFLERNNELlnVTVDDEQTFIDAVKEHWL-FPGNPF-SLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQIC 679
Cdd:pfam02460 536 ENFLSTLNME--EEEDEEKEWSYGNLPSFLkAPGNSHwAGDLVWDDNTTMVTKFRFTLAGKGLSTWNDRTRALQEWRSIA 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 680 -KDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDS 758
Cdd:pfam02460 614 dQYPEFNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDP 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 759 ISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVI 838
Cdd:pfam02460 694 ISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVV 773
|
....*..
gi 386767136 839 FFGAMHG 845
Cdd:pfam02460 774 AIGLLHG 780
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
12-845 |
7.82e-51 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 196.28 E-value: 7.82e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 12 LNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSpiageGKTERAIVE-QYFKVNYTHRFnvgrit 90
Cdd:TIGR00917 309 LARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWV-----APGSRAALEkQYFDTHFGPFY------ 377
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 91 rpgRFGRVIVITKDGDEN-----MIRREVFQELRQLDNIIQNATTTYDGDTYTYKDNCAR---------------WENEC 150
Cdd:TIGR00917 378 ---RIEQLIIATVQTSSHekapeILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKpnhpyncfiystckkLQNMY 454
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 151 FENDILNLD--ALMDDIEAGQLNLTFPfmfNPV--TWDAHLFP-VFFGGTkltEDNYVISVPAIQLVYFVTADTKRQDA- 224
Cdd:TIGR00917 455 SKLKPENYDdyGGVDYVKYCFEHFTSP---ESClsAFGGPVDPtTVLGGF---SGNNFSEASAFVVTFPVNNFVNKTNKt 528
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 225 -KGAEWEETFLRVVGNAENSGQFKHISVSyfASRTLDHELEKNTKTVVPYFSSTFLLMglFSIITCMMGDA-------VR 296
Cdd:TIGR00917 529 eKAVAWEKAFIQLAKDELLPMVQATISFS--AERSIEDELKRESTADVITIAISYLVM--FAYISLTLGDSprlkslyVT 604
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 297 SKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAA-PFLMIGIGIDDTFVMLAGWR-----------RTKAKMPVAE 364
Cdd:TIGR00917 605 SKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEViPFLVLAVGVDNIFILVFFYFyleyfyrqvgvDNEQELTLER 684
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 365 RMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCrv 444
Cdd:TIGR00917 685 RLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPC-- 762
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 445 qpmsVAIKEkrnflykaimaGGIDANDPDNPidNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKE 524
Cdd:TIGR00917 763 ----IKTSK-----------SSISAEKGSGQ--RKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEI 825
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 525 GLERRKLSREDSYSVEFFDREDDYYREFPyRMQVIIAGPLNYSDPLVQEQV--------ENLTSTLEHTSYVTsrRYTES 596
Cdd:TIGR00917 826 GLDQQIVLPQDSYLQIYFASLTPLLEVGP-PFYIVIKGDYNYTDFESQNKLctmggcdkDSIVNVFNNLSYIA--KPASS 902
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 597 WLRSFLSFLE---------RNNELLNVTVDDE-----------------QTFIDAVKehWLFPGNP-----------FSL 639
Cdd:TIGR00917 903 WLDDYLVWLSpqascccrkFTNGTFCNGPDPQcfrcadlssdaqgrpstTQFKEKLP--WFLNALPsadcakgghaaYSS 980
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 640 DVRFNEDETQIIASRF------LIQAVNITDTNHEKEMVRDlrQICKDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIG 713
Cdd:TIGR00917 981 AVDLQGYATIIQASSFrtyhtpLNTQVDFINAMRAAQEFAA--KVSRSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIA 1058
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 714 AIIMMIISFVFIPnilCSLWVAFSVIsIELGVA-----GYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKR 788
Cdd:TIGR00917 1059 LGAIFIVCLFLLQ---LNALSVVNLI-MSVGMAvvfcvGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHF 1134
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 386767136 789 SPKARVREALHSLGLPIIQGSSST-ILGIVALLLAQSYIFLVF-FKMVFLVIFFGAMHG 845
Cdd:TIGR00917 1135 SRNHRAKEALGGMGSSVFSGITLTkLVGVVVLGFSRSEIFVVYyFRMYLALVLLGFLHG 1193
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
13-843 |
4.36e-30 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 128.44 E-value: 4.36e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 13 NKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYFKVNYThrfnvgritrp 92
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGDDTV----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 93 grfgrVIVITkdGDENMIRREVFQELRQLDNIIQ-----NATTTYDGDTYTYKDNCARWENECFENDILNLDALMDDI-- 165
Cdd:COG1033 70 -----VVAVE--GKDDIFTPETLEALRELTEELEeipgvDSVTSLTNVRATEGTEDGLTVEPLIPDELPASPEELAELre 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 166 EAGQLNLTFPFMFNPvTWDAHLFPVFFGGTKLTEDnyvisVPAIQLVYFVTADTKRQDAKGAEweetfLRVVGNAENSGQ 245
Cdd:COG1033 143 KVLSSPLYVGRLVSP-DGKATLIVVTLDPDPLSSD-----LDRKEVVAEIRAIIAKYEDPGVE-----VYLTGFPVLRGD 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 246 FKHISvsyfasrtldheleknTKTVVPYFSSTFLLMGLFSIITCmmgdavRSkPFLGLMGNVSAIMATLAAFGLAMYCGI 325
Cdd:COG1033 212 IAEAI----------------QSDLAIFFPLALLLILLLLFLFF------RS-LRGVLLPLLVVLLAVIWTLGLMGLLGI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 326 EFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAK-MPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCT 404
Cdd:COG1033 269 PLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKgLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGI 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 405 YSVFAVCFTFLWHITFFAACMAIsgyrerknlhsifgcrvqpmsvaikekrnflykaimaggIDANDPDNPIDNKDHMLM 484
Cdd:COG1033 349 VAAIGVLLAFLTSLTLLPALLSL---------------------------------------LPRPKPKTRRLKKPPELG 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 485 AFFkDKMAAVINNKWcKAIIILAFASyLVGACYGITQIKEGLERRKLSREDS---YSVEFFDREddyyreFP--YRMQVI 559
Cdd:COG1033 390 RLL-AKLARFVLRRP-KVILVVALVL-AVVSLYGISRLKVEYDFEDYLPEDSpirQDLDFIEEN------FGgsDPLEVV 460
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 560 I--AGPLNYSDPLVQEQVENLTSTLEHTSYVTSrryteswLRSFLSFLERNNELLN------VTVDDEQTFIDAVkehWL 631
Cdd:COG1033 461 VdtGEPDGLKDPEVLKEIDRLQDYLESLPEVGK-------VLSLADLVKELNQALNegdpkyYALPESRELLAQL---LL 530
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 632 FPGNPFSLDVR--FNEDETQIiasRFLIQaVNITDTNHEKEMVRDLRQICKD----SPLNASIFHPYFVFFDQFELVR-- 703
Cdd:COG1033 531 LLSSPPGDDLSrfVDEDYSAA---RVTVR-LKDLDSEEIKALVEEVRAFLAEnfppDGVEVTLTGSAVLFAAINESVIes 606
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 704 -PVSLqAMVIGAI-IMMIISF--------VFIPNILCSLWVAfsvisielgvaGYMALWDVNLDSISMINLIMCIGFSVD 773
Cdd:COG1033 607 qIRSL-LLALLLIfLLLLLAFrslrlgliSLIPNLLPILLTF-----------GLMGLLGIPLNIATAVVASIALGIGVD 674
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386767136 774 FTAHICYTYMS--SKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAqSYIFLVFFKMVFLVIFFGAM 843
Cdd:COG1033 675 YTIHFLSRYREerRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFS-SFPPLADFGLLLALGLLVAL 745
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
53-845 |
0e+00 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 585.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 53 DPEYLFSPIAGEGKTERAIVEQYFKVNYtHRFNVGRITRPGRFgrVIVITKDGDENMIRREVFQELRQLDN-IIQNATTT 131
Cdd:pfam02460 5 DIVYTRTPDDARSFTERGVRSEYEPLVE-NKFFPGDSYPEARF--LIITAKGRNSNILDISYLNDIYQLNDyISTNVEIQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 132 YDGDTYTYKDNCARWEN-ECFENDILNLDALMDDIEAGqLNLTFPFMF---NPVTWDAHlfpvfFGGTKLTEDNYVISVP 207
Cdd:pfam02460 82 VDGIIISFKDLCSRYCDlNCPVNKHYNGMLLSRRHNTR-IDITYPIMPvlgTPIYLGPH-----FGGVDFEPPGNISYAK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 208 AIQLVYFVTADTKRQDAKGAEWEETFLRVVgnaENSGQFKHISVSYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSII 287
Cdd:pfam02460 156 AIVLWYFLKFDEEEVEEDSKEWEDELSQLL---HNKYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSII 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 288 TCM-----MGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPV 362
Cdd:pfam02460 233 VSVtlssyTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 363 AERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGC 442
Cdd:pfam02460 313 KKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRHCLFVW 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 443 rvqpMSVAIKEKRNflykaimaGGIDANDPDNPIDNKDHmlmaFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQI 522
Cdd:pfam02460 393 ----ATSSPQRIDS--------EGSEPDKSHNIEQLKSR----FFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNI 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 523 KEGLERRKLSREDSYSVEFF-DREDDYYREFpYRMQVIIAGPLNYSDPLVQEQVENLTSTLEHTSYVTSRRYTESWLRSF 601
Cdd:pfam02460 457 KEGLEPDKLVLEDSPLVEYLsLREKHFWPEG-LQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLREY 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 602 LSFLERNNELlnVTVDDEQTFIDAVKEHWL-FPGNPF-SLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQIC 679
Cdd:pfam02460 536 ENFLSTLNME--EEEDEEKEWSYGNLPSFLkAPGNSHwAGDLVWDDNTTMVTKFRFTLAGKGLSTWNDRTRALQEWRSIA 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 680 -KDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELGVAGYMALWDVNLDS 758
Cdd:pfam02460 614 dQYPEFNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDP 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 759 ISMINLIMCIGFSVDFTAHICYTYMSSKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAQSYIFLVFFKMVFLVI 838
Cdd:pfam02460 694 ISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVV 773
|
....*..
gi 386767136 839 FFGAMHG 845
Cdd:pfam02460 774 AIGLLHG 780
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
12-845 |
7.82e-51 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 196.28 E-value: 7.82e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 12 LNKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSpiageGKTERAIVE-QYFKVNYTHRFnvgrit 90
Cdd:TIGR00917 309 LARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWV-----APGSRAALEkQYFDTHFGPFY------ 377
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 91 rpgRFGRVIVITKDGDEN-----MIRREVFQELRQLDNIIQNATTTYDGDTYTYKDNCAR---------------WENEC 150
Cdd:TIGR00917 378 ---RIEQLIIATVQTSSHekapeILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKpnhpyncfiystckkLQNMY 454
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 151 FENDILNLD--ALMDDIEAGQLNLTFPfmfNPV--TWDAHLFP-VFFGGTkltEDNYVISVPAIQLVYFVTADTKRQDA- 224
Cdd:TIGR00917 455 SKLKPENYDdyGGVDYVKYCFEHFTSP---ESClsAFGGPVDPtTVLGGF---SGNNFSEASAFVVTFPVNNFVNKTNKt 528
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 225 -KGAEWEETFLRVVGNAENSGQFKHISVSyfASRTLDHELEKNTKTVVPYFSSTFLLMglFSIITCMMGDA-------VR 296
Cdd:TIGR00917 529 eKAVAWEKAFIQLAKDELLPMVQATISFS--AERSIEDELKRESTADVITIAISYLVM--FAYISLTLGDSprlkslyVT 604
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 297 SKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAA-PFLMIGIGIDDTFVMLAGWR-----------RTKAKMPVAE 364
Cdd:TIGR00917 605 SKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEViPFLVLAVGVDNIFILVFFYFyleyfyrqvgvDNEQELTLER 684
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 365 RMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCrv 444
Cdd:TIGR00917 685 RLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPC-- 762
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 445 qpmsVAIKEkrnflykaimaGGIDANDPDNPidNKDHMLMAFFKDKMAAVINNKWCKAIIILAFASYLVGACYGITQIKE 524
Cdd:TIGR00917 763 ----IKTSK-----------SSISAEKGSGQ--RKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEI 825
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 525 GLERRKLSREDSYSVEFFDREDDYYREFPyRMQVIIAGPLNYSDPLVQEQV--------ENLTSTLEHTSYVTsrRYTES 596
Cdd:TIGR00917 826 GLDQQIVLPQDSYLQIYFASLTPLLEVGP-PFYIVIKGDYNYTDFESQNKLctmggcdkDSIVNVFNNLSYIA--KPASS 902
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 597 WLRSFLSFLE---------RNNELLNVTVDDE-----------------QTFIDAVKehWLFPGNP-----------FSL 639
Cdd:TIGR00917 903 WLDDYLVWLSpqascccrkFTNGTFCNGPDPQcfrcadlssdaqgrpstTQFKEKLP--WFLNALPsadcakgghaaYSS 980
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 640 DVRFNEDETQIIASRF------LIQAVNITDTNHEKEMVRDlrQICKDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIG 713
Cdd:TIGR00917 981 AVDLQGYATIIQASSFrtyhtpLNTQVDFINAMRAAQEFAA--KVSRSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIA 1058
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 714 AIIMMIISFVFIPnilCSLWVAFSVIsIELGVA-----GYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKR 788
Cdd:TIGR00917 1059 LGAIFIVCLFLLQ---LNALSVVNLI-MSVGMAvvfcvGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHF 1134
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 386767136 789 SPKARVREALHSLGLPIIQGSSST-ILGIVALLLAQSYIFLVF-FKMVFLVIFFGAMHG 845
Cdd:TIGR00917 1135 SRNHRAKEALGGMGSSVFSGITLTkLVGVVVLGFSRSEIFVVYyFRMYLALVLLGFLHG 1193
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
294-442 |
2.87e-39 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 143.11 E-value: 2.87e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 294 AVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEF-IGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSE 372
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLtLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 373 AAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYRERKNLHSIFGC 442
Cdd:pfam12349 81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACC 150
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
193-858 |
1.87e-34 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 143.48 E-value: 1.87e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 193 GGTKLTEDNYVISVPAIQLV---------------YFVTADTKRQDAKGAE----WEETFLRVVGNA--ENSGQfkhiSV 251
Cdd:TIGR00918 304 GGTKRNRSGKLLSAQALQSMfqlmtpkqmyehfkgYYKVHHIGWNEEKAAAvleaWQRNFSEEVQQSlpKNSSQ----KI 379
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 252 SYFASRTLDHELEKNTKTVVPYFSSTFLLMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFigiN 331
Cdd:TIGR00918 380 LVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISF---N 456
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 332 LAA----PFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSV 407
Cdd:TIGR00918 457 AATtqvlPFLALGVGVDDVFLLAHAFSETGQNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAA 536
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 408 FAVCFTFLWHITFFAACMAISGYRERKNLHSIFGCRVQPMSV-AIKEKRNFL--------YKAIMAGGIDAN-------- 470
Cdd:TIGR00918 537 IVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFFSPCSArVIQIEPQAYadgsappvYSSHMQSTVQLRteydpgtq 616
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 471 ------DPDNPI--DNKD-------------HMLMAFFKDKMAAVIN---------------------NKWCKAIIILAF 508
Cdd:TIGR00918 617 hyyttnEPRSHLsvQPSDplscqspdiagstRDLLSQFEDSKAACLSlpcarwtlatfaekhyapfllQSWAKVVVIFLF 696
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 509 ASYLVGACYGITQIKEGLERRKLSREDSYSVEFFDREDDYYrEFpYRMQVIIAGPLNYsdPLVQEQVENLTSTLEHTSYV 588
Cdd:TIGR00918 697 LALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYF-SF-YNMYAVTQGNFDY--PTQQQLLYDLHQSFSSVKYV 772
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 589 T---SRRYTESWLRSFLSFLE--------------------RNN--------ELLNVT------VDDEQ-TFIDAVKEHW 630
Cdd:TIGR00918 773 LkedNGQLPRMWLHYFRDWLQglqkafdedwrdgritkenyRNGsddavlayKLLVQTghrdkpVDKEQlTTQRLVNADG 852
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 631 LFPGNPF--SLDVRFNEDETQIIASR----------------FLIQAVNI------------------TDTNHEKEMVRD 674
Cdd:TIGR00918 853 IINPNAFyiYLSAWVSNDPVAYAASQaniyphppewlhdkndYDPENLRIpaaepleyaqfpfylnglRETSQFVEAIEH 932
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 675 LRQICKdsplNASIF--HPY-----FVFFDQFELVRpvSLQAMVIGaiIMMIISFVFIPNILCSLWVA-FSVISIELGVA 746
Cdd:TIGR00918 933 VRAICN----NYEGFglPSYpsgypFLFWEQYMGLR--HWLLLSIS--VVLACTFLVCALLLLNPWTAgLIVLVLALMTV 1004
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 747 ---GYMALWDVNLDSISMINLIMCIGFSVDFTAHICYTYMSSKKrSPKARVREAL-HSLGlPIIQGSSSTILGIvaLLLA 822
Cdd:TIGR00918 1005 elfGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIG-DRNRRAVLALeHMFA-PVLDGALSTLLGV--LMLA 1080
|
810 820 830
....*....|....*....|....*....|....*....
gi 386767136 823 QS---YIFLVFFKMVFLVIFFGAMHGLFLLPVLLSLFGP 858
Cdd:TIGR00918 1081 GSefdFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGP 1119
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
13-843 |
4.36e-30 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 128.44 E-value: 4.36e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 13 NKSFYHLGICIAKHPGYFIIIPVLLTLLCMTGYQQLKYQIDPEYLFSPIAGEGKTERAIVEQYFKVNYThrfnvgritrp 92
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGDDTV----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 93 grfgrVIVITkdGDENMIRREVFQELRQLDNIIQ-----NATTTYDGDTYTYKDNCARWENECFENDILNLDALMDDI-- 165
Cdd:COG1033 70 -----VVAVE--GKDDIFTPETLEALRELTEELEeipgvDSVTSLTNVRATEGTEDGLTVEPLIPDELPASPEELAELre 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 166 EAGQLNLTFPFMFNPvTWDAHLFPVFFGGTKLTEDnyvisVPAIQLVYFVTADTKRQDAKGAEweetfLRVVGNAENSGQ 245
Cdd:COG1033 143 KVLSSPLYVGRLVSP-DGKATLIVVTLDPDPLSSD-----LDRKEVVAEIRAIIAKYEDPGVE-----VYLTGFPVLRGD 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 246 FKHISvsyfasrtldheleknTKTVVPYFSSTFLLMGLFSIITCmmgdavRSkPFLGLMGNVSAIMATLAAFGLAMYCGI 325
Cdd:COG1033 212 IAEAI----------------QSDLAIFFPLALLLILLLLFLFF------RS-LRGVLLPLLVVLLAVIWTLGLMGLLGI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 326 EFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAK-MPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCT 404
Cdd:COG1033 269 PLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKgLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGI 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 405 YSVFAVCFTFLWHITFFAACMAIsgyrerknlhsifgcrvqpmsvaikekrnflykaimaggIDANDPDNPIDNKDHMLM 484
Cdd:COG1033 349 VAAIGVLLAFLTSLTLLPALLSL---------------------------------------LPRPKPKTRRLKKPPELG 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 485 AFFkDKMAAVINNKWcKAIIILAFASyLVGACYGITQIKEGLERRKLSREDS---YSVEFFDREddyyreFP--YRMQVI 559
Cdd:COG1033 390 RLL-AKLARFVLRRP-KVILVVALVL-AVVSLYGISRLKVEYDFEDYLPEDSpirQDLDFIEEN------FGgsDPLEVV 460
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 560 I--AGPLNYSDPLVQEQVENLTSTLEHTSYVTSrryteswLRSFLSFLERNNELLN------VTVDDEQTFIDAVkehWL 631
Cdd:COG1033 461 VdtGEPDGLKDPEVLKEIDRLQDYLESLPEVGK-------VLSLADLVKELNQALNegdpkyYALPESRELLAQL---LL 530
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 632 FPGNPFSLDVR--FNEDETQIiasRFLIQaVNITDTNHEKEMVRDLRQICKD----SPLNASIFHPYFVFFDQFELVR-- 703
Cdd:COG1033 531 LLSSPPGDDLSrfVDEDYSAA---RVTVR-LKDLDSEEIKALVEEVRAFLAEnfppDGVEVTLTGSAVLFAAINESVIes 606
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 704 -PVSLqAMVIGAI-IMMIISF--------VFIPNILCSLWVAfsvisielgvaGYMALWDVNLDSISMINLIMCIGFSVD 773
Cdd:COG1033 607 qIRSL-LLALLLIfLLLLLAFrslrlgliSLIPNLLPILLTF-----------GLMGLLGIPLNIATAVVASIALGIGVD 674
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386767136 774 FTAHICYTYMS--SKKRSPKARVREALHSLGLPIIQGSSSTILGIVALLLAqSYIFLVFFKMVFLVIFFGAM 843
Cdd:COG1033 675 YTIHFLSRYREerRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFS-SFPPLADFGLLLALGLLVAL 745
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
280-823 |
6.94e-11 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 66.78 E-value: 6.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 280 LMGLFSIITCMMGDAVRSKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDdtFVMlagwrRTKAK 359
Cdd:TIGR00921 198 TMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGID--YGI-----QTLNR 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 360 MPVAERMGLMMSEAAVS--------ITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAISGYR 431
Cdd:TIGR00921 271 YEEERDIGRAKGEAIVTavrrtgraVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIG 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 432 ERKNLHSIFGCRVQPmsvaikEKRNFLYKAImaGGIDANDPdnpidnkdhmlmaffkdkmaavinnkwcKAIIILAFASY 511
Cdd:TIGR00921 351 REKVKKEIIAIGGKS------SEIEEELSKV--LSITVRHP----------------------------VPALVAALIIT 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 512 LVGAcYGITQIKEGLERRKLSREDSYSVEFFDReddyyrefpyrMQVIIAGPLNYSDPLVQEQVENLTSTLEhtsyvtsr 591
Cdd:TIGR00921 395 GLGL-YGAAGIKPEVNIEKFIPQDLPSLQARKV-----------IESHMGGSHDFATILVKADDVRDPELVR-------- 454
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 592 rytesWLRSFLSFLERNNELLNVTvdDEQTFIDAVKEHWLFPGNPFSLDVRFNEDETQI------IASRFLIQAVNITDT 665
Cdd:TIGR00921 455 -----FMDELSRDIKATGVAARVF--GAPSIIDLVKEVEGLPAPERSALEPIPEDEEGGyisggqIKVAVIQVQLKQGEP 527
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 666 NHEKE-MVRDLRQICKDSPLNASIFHPYFVFFDQFELVRPVSLQAMVIGAIIMMIISFVFIPNILCSLWVAFSVISIELG 744
Cdd:TIGR00921 528 KVQGRkILRDVQHEHPPPGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILW 607
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 745 VAGYMALWDV--NLDSISMINLIMCIGfsVDFTAHICYTYMSSKK-RSPKARVREALHSLGLPIIQGSSSTILGIVALLL 821
Cdd:TIGR00921 608 AIGLMGLRGIpsFLAMATTISIILGLG--MDYSIHLAERYFEERKeHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLL 685
|
..
gi 386767136 822 AQ 823
Cdd:TIGR00921 686 SH 687
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
280-415 |
1.15e-08 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 59.49 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 280 LMGLFSIITCMMGDAVRS--KPFLGLMGNVSAIMATLAAFGLAmycGIEF-IGINLAAPfLMIGIGIDDTFVMLAGWRRT 356
Cdd:COG1033 611 LLLALLLIFLLLLLAFRSlrLGLISLIPNLLPILLTFGLMGLL---GIPLnIATAVVAS-IALGIGVDYTIHFLSRYREE 686
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 357 KAK-MPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFL 415
Cdd:COG1033 687 RRKgGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALL 746
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
638-843 |
3.09e-06 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 51.53 E-value: 3.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 638 SLDVRFNEDETQIIASRFLIQAVNITDTNHEKEMVRDLRQickdsplnasiFHP----YFVFFDQFELVRpVSLQAMV-- 711
Cdd:pfam00873 269 RGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKP-----------TFPqgveIVVVYDTTPFIR-ASIEEVVkt 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 712 --IGAIIMMIISFVFIPNILCSLWVAFSV-ISIeLGVAGYMALWDVNLDSISMINLIMCIGFSVDfTAHI----CYTYMS 784
Cdd:pfam00873 337 llEAIVLVILVMFLFLQNWRATLIPAIAIpLSL-LGTFAVMKAFGFSINTLTLGGLVLAIGLVVD-DAIVvvenIERVLE 414
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 386767136 785 SKKRSPKARVREALHSLGLPIIqgssstilGIVALLLAqsyiflVFFKMVFLVIFFGAM 843
Cdd:pfam00873 415 ENGLKPLEAAYKSMGEIGGALV--------AIALVLSA------VFLPILFLGGLTGRI 459
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
692-836 |
3.64e-04 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 44.71 E-value: 3.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 692 YFVFFDQFELVRpVSLQAMV----IGAIIMMIISFVFIPNILCSLWVAFSV-ISIeLGVAGYMALWDVNLDSISMINLIM 766
Cdd:COG0841 316 LTIVYDQSEFIR-ASIEEVVktllEAILLVVLVVFLFLRSWRATLIPAVAIpVSL-IGTFAVMYLLGFSLNILTLFALVL 393
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386767136 767 CIGFSVDFtA-----HIcYTYMSSKKrSPKARVREALHSLGLPIIqgssSTILGIVAlllaqsyiflVFFKMVFL 836
Cdd:COG0841 394 AIGIVVDD-AivvveNI-ERHMEEGL-SPLEAAIKGAREVAGAVI----ASTLTLVA----------VFLPLAFM 451
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
264-423 |
3.12e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 41.75 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 264 EKNTKTVVPYFsstFLLMGLFSIItcmmgdavRS--KPFLGLMGNVSAIMATLAAFGLAmycGIEFIGINLAAPFLMIGI 341
Cdd:TIGR00921 568 GMRRMTIAGAI---LVLMILLAVF--------RNpiKAVFPLIAIGSGILWAIGLMGLR---GIPSFLAMATTISIILGL 633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 342 GIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVSITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFF 421
Cdd:TIGR00921 634 GMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVF 713
|
..
gi 386767136 422 AA 423
Cdd:TIGR00921 714 PA 715
|
|
| 2A060605 |
TIGR00920 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ... |
297-427 |
6.18e-03 |
|
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273339 [Multi-domain] Cd Length: 886 Bit Score: 40.99 E-value: 6.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386767136 297 SKPFLGLMGNVSAIMATLAAFGLAMYCGIEFIGINLAAPFLMIGIGIDDTFVMLAGWRRTKAKMPVAERMGLMMSEAAVS 376
Cdd:TIGR00920 88 SKYILGIAGLFTIFSSFVFSTAVIHFLGSELTGLNEALPFFLLLIDLSKASALAKFALSSNSQDEVRDNIARGMAILGPT 167
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 386767136 377 ITITSVTDFISFLIGIISPFRSVRIFCTYSVFAVCFTFLWHITFFAACMAI 427
Cdd:TIGR00920 168 ITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMTFFPACLSL 218
|
|
| |
