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Conserved domains on  [gi|386770037|ref|NP_001246135|]
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uncharacterized protein Dmel_CG17715, isoform G [Drosophila melanogaster]

Protein Classification

TMEM65 family protein( domain architecture ID 10564727)

TMEM65 family protein similar to human transmembrane protein 65 (TMEM65) that may play an important role in cardiac development and function

Gene Ontology:  GO:0016020
TCDB:  8.A.205

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM65 pfam10507
Transmembrane protein 65; MEM65 is an intercalated disc protein that interacts with with ...
 151-258 3.96e-57

Transmembrane protein 65; MEM65 is an intercalated disc protein that interacts with with connexin 43 (Cx43) and is required for correct localization of Cx43 to the intercalated disc. It is essential for cardiac function in zebrafish.


:

Pssm-ID: 463123  Cd Length: 108  Bit Score: 178.07  E-value: 3.96e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770037  151 VNAVPFIAFGFLDNFIMIMAGEYIEYYLGHFITLSTMAAAGLGNTISDILGITMATYVENGCQILGLKQPNLTPAQFELK 230
Cdd:pfam10507   1 SAAIPFVGFGFLDNAIMIAAGEYIDHTLGVYLGLSTMAAAALGNVISDVAGVGLGGYVERAAQRLGLPPPVLTPAQLMSP 80

                          90       100
                  ....*....|....*....|....*...
gi 386770037  231 SSKRSSSYGRIVGITVGCLLGMCPLWFM 258
Cdd:pfam10507  81 STRRASNAGAALGVTIGCLLGMLPLLFF 108
 
Name Accession Description Interval E-value
TMEM65 pfam10507
Transmembrane protein 65; MEM65 is an intercalated disc protein that interacts with with ...
 151-258 3.96e-57

Transmembrane protein 65; MEM65 is an intercalated disc protein that interacts with with connexin 43 (Cx43) and is required for correct localization of Cx43 to the intercalated disc. It is essential for cardiac function in zebrafish.


Pssm-ID: 463123  Cd Length: 108  Bit Score: 178.07  E-value: 3.96e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770037  151 VNAVPFIAFGFLDNFIMIMAGEYIEYYLGHFITLSTMAAAGLGNTISDILGITMATYVENGCQILGLKQPNLTPAQFELK 230
Cdd:pfam10507   1 SAAIPFVGFGFLDNAIMIAAGEYIDHTLGVYLGLSTMAAAALGNVISDVAGVGLGGYVERAAQRLGLPPPVLTPAQLMSP 80

                          90       100
                  ....*....|....*....|....*...
gi 386770037  231 SSKRSSSYGRIVGITVGCLLGMCPLWFM 258
Cdd:pfam10507  81 STRRASNAGAALGVTIGCLLGMLPLLFF 108
 
Name Accession Description Interval E-value
TMEM65 pfam10507
Transmembrane protein 65; MEM65 is an intercalated disc protein that interacts with with ...
 151-258 3.96e-57

Transmembrane protein 65; MEM65 is an intercalated disc protein that interacts with with connexin 43 (Cx43) and is required for correct localization of Cx43 to the intercalated disc. It is essential for cardiac function in zebrafish.


Pssm-ID: 463123  Cd Length: 108  Bit Score: 178.07  E-value: 3.96e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386770037  151 VNAVPFIAFGFLDNFIMIMAGEYIEYYLGHFITLSTMAAAGLGNTISDILGITMATYVENGCQILGLKQPNLTPAQFELK 230
Cdd:pfam10507   1 SAAIPFVGFGFLDNAIMIAAGEYIDHTLGVYLGLSTMAAAALGNVISDVAGVGLGGYVERAAQRLGLPPPVLTPAQLMSP 80

                          90       100
                  ....*....|....*....|....*...
gi 386770037  231 SSKRSSSYGRIVGITVGCLLGMCPLWFM 258
Cdd:pfam10507  81 STRRASNAGAALGVTIGCLLGMLPLLFF 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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