lethal (2) giant discs 1, isoform B [Drosophila melanogaster]
Protein Classification
C2 domain-containing protein; PLC family C2 domain-containing protein( domain architecture ID 10653458)
C2 domain-containing protein may be a Ca2+-dependent membrane-targeting protein that binds a wide variety of substances including phospholipids, inositol polyphosphates, and intracellular proteins through its C2 domain| PLC (phosphoinositide-specific phospholipases C) family C2 domain-containing protein similar to PLCs that are involved in the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PIP2) to d-myo-inositol-1,4,5-trisphosphate (1,4,5-IP3) and sn-1,2-diacylglycerol (DAG)
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| C2_Freud-1 | cd08690 | C2 domain found in 5' repressor element under dual repression binding protein-1 (Freud-1); ... |
661-832 | 2.55e-80 | ||||
C2 domain found in 5' repressor element under dual repression binding protein-1 (Freud-1); Freud-1 is a novel calcium-regulated repressor that negatively regulates basal 5-HT1A receptor expression in neurons. It may also play a role in the altered regulation of 5-HT1A receptors associated with anxiety or major depression. Freud-1 contains two DM-14 basic repeats, a helix-loop-helix DNA binding domain, and a C2 domain. The Freud-1 C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-II topology. : Pssm-ID: 176072 [Multi-domain] Cd Length: 155 Bit Score: 254.92 E-value: 2.55e-80
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
362-420 | 1.34e-22 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; : Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 91.59 E-value: 1.34e-22
|
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
260-318 | 4.69e-22 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; : Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 90.05 E-value: 4.69e-22
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
499-557 | 1.76e-21 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; : Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 88.51 E-value: 1.76e-21
|
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
142-200 | 3.34e-20 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; : Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 84.66 E-value: 3.34e-20
|
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| Name | Accession | Description | Interval | E-value | ||||
| C2_Freud-1 | cd08690 | C2 domain found in 5' repressor element under dual repression binding protein-1 (Freud-1); ... |
661-832 | 2.55e-80 | ||||
C2 domain found in 5' repressor element under dual repression binding protein-1 (Freud-1); Freud-1 is a novel calcium-regulated repressor that negatively regulates basal 5-HT1A receptor expression in neurons. It may also play a role in the altered regulation of 5-HT1A receptors associated with anxiety or major depression. Freud-1 contains two DM-14 basic repeats, a helix-loop-helix DNA binding domain, and a C2 domain. The Freud-1 C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-II topology. Pssm-ID: 176072 [Multi-domain] Cd Length: 155 Bit Score: 254.92 E-value: 2.55e-80
|
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
362-420 | 1.34e-22 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 91.59 E-value: 1.34e-22
|
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
260-318 | 4.69e-22 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 90.05 E-value: 4.69e-22
|
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
499-557 | 1.76e-21 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 88.51 E-value: 1.76e-21
|
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
142-200 | 3.34e-20 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 84.66 E-value: 3.34e-20
|
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| C2 | pfam00168 | C2 domain; |
666-796 | 6.65e-08 | ||||
C2 domain; Pssm-ID: 425499 [Multi-domain] Cd Length: 104 Bit Score: 51.17 E-value: 6.65e-08
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| C2 | smart00239 | Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, ... |
666-786 | 8.69e-06 | ||||
Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles. Pssm-ID: 214577 [Multi-domain] Cd Length: 101 Bit Score: 45.17 E-value: 8.69e-06
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| Name | Accession | Description | Interval | E-value | ||||
| C2_Freud-1 | cd08690 | C2 domain found in 5' repressor element under dual repression binding protein-1 (Freud-1); ... |
661-832 | 2.55e-80 | ||||
C2 domain found in 5' repressor element under dual repression binding protein-1 (Freud-1); Freud-1 is a novel calcium-regulated repressor that negatively regulates basal 5-HT1A receptor expression in neurons. It may also play a role in the altered regulation of 5-HT1A receptors associated with anxiety or major depression. Freud-1 contains two DM-14 basic repeats, a helix-loop-helix DNA binding domain, and a C2 domain. The Freud-1 C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-II topology. Pssm-ID: 176072 [Multi-domain] Cd Length: 155 Bit Score: 254.92 E-value: 2.55e-80
|
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
362-420 | 1.34e-22 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 91.59 E-value: 1.34e-22
|
||||||||
| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
260-318 | 4.69e-22 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 90.05 E-value: 4.69e-22
|
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
499-557 | 1.76e-21 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 88.51 E-value: 1.76e-21
|
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| DM14 | smart00685 | Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; |
142-200 | 3.34e-20 | ||||
Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Pssm-ID: 128928 [Multi-domain] Cd Length: 59 Bit Score: 84.66 E-value: 3.34e-20
|
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| C2 | pfam00168 | C2 domain; |
666-796 | 6.65e-08 | ||||
C2 domain; Pssm-ID: 425499 [Multi-domain] Cd Length: 104 Bit Score: 51.17 E-value: 6.65e-08
|
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| C2 | smart00239 | Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, ... |
666-786 | 8.69e-06 | ||||
Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles. Pssm-ID: 214577 [Multi-domain] Cd Length: 101 Bit Score: 45.17 E-value: 8.69e-06
|
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| C2 | cd00030 | C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ... |
666-796 | 1.02e-05 | ||||
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Pssm-ID: 175973 [Multi-domain] Cd Length: 102 Bit Score: 45.14 E-value: 1.02e-05
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| C2C_KIAA1228 | cd04030 | C2 domain third repeat present in uncharacterized human KIAA1228-like proteins; KIAA proteins ... |
668-723 | 2.19e-03 | ||||
C2 domain third repeat present in uncharacterized human KIAA1228-like proteins; KIAA proteins are uncharacterized human proteins. They were compiled by the Kazusa mammalian cDNA project which identified more than 2000 human genes. They are identified by 4 digit codes that precede the KIAA designation. Many KIAA genes are still functionally uncharacterized including KIAA1228. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology. Pssm-ID: 175996 [Multi-domain] Cd Length: 127 Bit Score: 38.79 E-value: 2.19e-03
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| Blast search parameters | ||||
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