NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|386763425|ref|NP_001245416|]
View 

Rho GTPase activating protein at 102A, isoform D [Drosophila melanogaster]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 1569)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 874-1069 1.28e-72

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04376:

Pssm-ID: 470621  Cd Length: 206  Bit Score: 240.42  E-value: 1.28e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTF 953
Cdd:cd04376     9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYTAF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  954 LKTQRIrNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDIWSTEGCCLTlGNKMDSYNLATVFAPNILRSTH 1033
Cdd:cd04376    89 IGTALL-EPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVS-GNKMTSLNLATIFGPNLLHKQK 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 386763425 1034 LTFSRDKEQ----ENMIDAINVVRTMINHYEEIFNISAEL 1069
Cdd:cd04376   167 SGEREFVQAslriEESTAIINVVQTMIDNYEELFMVSPEL 206
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 874-1069 1.28e-72

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 240.42  E-value: 1.28e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTF 953
Cdd:cd04376     9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYTAF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  954 LKTQRIrNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDIWSTEGCCLTlGNKMDSYNLATVFAPNILRSTH 1033
Cdd:cd04376    89 IGTALL-EPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVS-GNKMTSLNLATIFGPNLLHKQK 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 386763425 1034 LTFSRDKEQ----ENMIDAINVVRTMINHYEEIFNISAEL 1069
Cdd:cd04376   167 SGEREFVQAslriEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 875-1033 1.24e-53

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 183.90  E-value: 1.24e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425   875 PIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVD-TCPHDVATLLKEFLRDLPEPLLCNTLYLTF 953
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEeEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425   954 LKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILRSTH 1033
Cdd:pfam00620   81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV------------NKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 873-1059 2.19e-49

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 172.84  E-value: 2.19e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425    873 MVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISV-DTCPHDVATLLKEFLRDLPEPLLCNTLYL 951
Cdd:smart00324    2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLsEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425    952 TFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDdiwstegccltlGNKMDSYNLATVFAPNILRs 1031
Cdd:smart00324   82 EFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE------------ENKMTARNLAIVFGPTLLR- 148

                           170       180       190
                    ....*....|....*....|....*....|.
gi 386763425   1032 thltfSRDKEQENMIDA---INVVRTMINHY 1059
Cdd:smart00324  149 -----PPDGEVASLKDIrhqNTVIEFLIENA 174
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 874-1069 1.28e-72

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 240.42  E-value: 1.28e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTF 953
Cdd:cd04376     9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYTAF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  954 LKTQRIrNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDIWSTEGCCLTlGNKMDSYNLATVFAPNILRSTH 1033
Cdd:cd04376    89 IGTALL-EPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVS-GNKMTSLNLATIFGPNLLHKQK 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 386763425 1034 LTFSRDKEQ----ENMIDAINVVRTMINHYEEIFNISAEL 1069
Cdd:cd04376   167 SGEREFVQAslriEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 875-1033 1.24e-53

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 183.90  E-value: 1.24e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425   875 PIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVD-TCPHDVATLLKEFLRDLPEPLLCNTLYLTF 953
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEeEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425   954 LKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILRSTH 1033
Cdd:pfam00620   81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV------------NKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 873-1059 2.19e-49

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 172.84  E-value: 2.19e-49
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425    873 MVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISV-DTCPHDVATLLKEFLRDLPEPLLCNTLYL 951
Cdd:smart00324    2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLsEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425    952 TFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDdiwstegccltlGNKMDSYNLATVFAPNILRs 1031
Cdd:smart00324   82 EFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE------------ENKMTARNLAIVFGPTLLR- 148

                           170       180       190
                    ....*....|....*....|....*....|.
gi 386763425   1032 thltfSRDKEQENMIDA---INVVRTMINHY 1059
Cdd:smart00324  149 -----PPDGEVASLKDIrhqNTVIEFLIENA 174
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 875-1058 6.12e-48

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 168.63  E-value: 6.12e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  875 PIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTFL 954
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  955 KTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILRSTHL 1034
Cdd:cd00159    81 ELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEV------------NKMTASNLAIVFAPTLLRPPDS 148

                         170       180
                  ....*....|....*....|....
gi 386763425 1035 TfsrDKEQENMIDAINVVRTMINH 1058
Cdd:cd00159   149 D---DELLEDIKKLNEIVEFLIEN 169
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 872-1071 8.33e-39

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 144.03  E-value: 8.33e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  872 LMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISV--DTCPHDVATLLKEFLRDLPEPLLCNTL 949
Cdd:cd04391    20 SKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEGTFLwdQVKQHDAASLLKLFIRELPQPLLTVEY 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  950 YLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNIL 1029
Cdd:cd04391   100 LPAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEK------------NKMNLWNVAMIMAPNLF 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 386763425 1030 --RSTHLTfSRDKEQENMIDAI---NVVRTMINHYEEIFNISAELLN 1071
Cdd:cd04391   168 ppRGKHSK-DNESLQEEVNMAAgcaNIMRLLIRYQDLLWTVPSFLIN 213
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 867-1059 4.12e-32

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 123.96  E-value: 4.12e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  867 QEHSQLMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKD---IYFGISVDTcPHDVATLLKEFLRDLPEP 943
Cdd:cd04385     8 QQLTDNDIPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKDarsVQLREGEYT-VHDVADVLKRFLRDLPDP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  944 LLCNTLYLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATV 1023
Cdd:cd04385    87 LLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDE------------NQMSVHNLALV 154

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 386763425 1024 FAPNILRSTHLTFSRDKEQenmidaINVVRTMINHY 1059
Cdd:cd04385   155 FGPTLFQTDEHSVGQTSHE------VKVIEDLIDNY 184
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 870-1069 1.58e-30

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 120.16  E-value: 1.58e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  870 SQLMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDK--DIYFGISVDTcPHDVATLLKEFLRDLPEPLLCN 947
Cdd:cd04397    23 GKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKnpTEVPDLSKEN-PVQLAALLKKFLRELPDPLLTF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  948 TLYLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVA--AHSDDiwstegcclTLGNKMDSYNLATVFA 1025
Cdd:cd04397   102 KLYRLWISSQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSsfSHIDE---------ETGSKMDIHNLATVIT 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 386763425 1026 PNILRSTHltfSRDKEQENMIDAINVVRTMINHYEEIFNISAEL 1069
Cdd:cd04397   173 PNILYSKT---DNPNTGDEYFLAIEAVNYLIENNEEFCEVPDEL 213
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 874-1063 8.21e-30

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 117.50  E-value: 8.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYfgisvDTCPHD--------VATLLKEFLRDLPEPLL 945
Cdd:cd04395    18 VPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGF-----DIDLQDprwrdvnvVSSLLKSFFRKLPEPLF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  946 CNTLYLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFA 1025
Cdd:cd04395    93 TNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEV------------NKMEPRNLAIVFG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 386763425 1026 PNILRSthltfsrdkEQENMIDAIN-------VVRTMINHYEEIF 1063
Cdd:cd04395   161 PTLVRT---------SDDNMETMVThmpdqckIVETLIQHYDWFF 196
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 873-1063 3.04e-28

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 113.20  E-value: 3.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  873 MVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDK--DIYFGISVDtcPHDVATLLKEFLRDLPEPLLCNTLY 950
Cdd:cd04404    22 PIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMgePVDFDQYED--VHLPAVILKTFLRELPEPLLTFDLY 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  951 LTFLKTQRIRNrRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILR 1030
Cdd:cd04404   100 DDIVGFLNVDK-EERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ------------NKMTNSNLAVVFGPNLLW 166

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 386763425 1031 SthltfsrdKEQENMIDAIN----VVRTMINHYEEIF 1063
Cdd:cd04404   167 A--------KDASMSLSAINpintFTKFLLDHQDEIF 195
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 884-1069 4.68e-28

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 113.28  E-value: 4.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  884 YLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTFLKTQRIRNRR 963
Cdd:cd04375    30 WLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADMLKQYFRDLPEPLLTNKLSETFIAIFQYVPKE 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  964 LQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILRSTHLTFSR----- 1038
Cdd:cd04375   110 QRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQE------------NQMTATNLAVCLAPSLFHLNTSRRENsspar 177

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 386763425 1039 ------------DKEQENMIDAINVVRTMINHYEEIFNISAEL 1069
Cdd:cd04375   178 rmqrkkslgkpdQKELSENKAAHQCLAYMIEECNTLFMVPKEM 220
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 872-1068 1.04e-27

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 111.62  E-value: 1.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  872 LMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEF----------DKDIyfgisvdtcpHDVATLLKEFLRDLP 941
Cdd:cd04382    15 PMIPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFlrgktvpnlsKVDI----------HVICGCLKDFLRSLK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  942 EPLLCNTLYLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDdiwstegccltlgNKMDSYNLA 1021
Cdd:cd04382    85 EPLITFALWKEFMEAAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQSPE-------------CKMDINNLA 151

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 386763425 1022 TVFAPNIlrsthLTFSRDKEQENMIDAINVVRTMInhYEEIFNISAE 1068
Cdd:cd04382   152 RVFGPTI-----VGYSVPNPDPMTILQDTVRQPRV--VERLLEIPSD 191
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 875-1063 1.16e-27

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 111.45  E-value: 1.16e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  875 PIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKD---------IYFGISVdtcphdVATLLKEFLRDLPEPLL 945
Cdd:cd04372    17 PMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDgekadisatVYPDINV------ITGALKLYFRDLPIPVI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  946 CNTLYLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFA 1025
Cdd:cd04372    91 TYDTYPKFIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKD------------NKMNAENLGIVFG 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 386763425 1026 PNILR------STHLTfsrdkeqeNMIDAINVVRTMINHYEEIF 1063
Cdd:cd04372   159 PTLMRppedsaLTTLN--------DMRYQILIVQLLITNEDVLF 194
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 868-1043 1.21e-26

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 108.32  E-value: 1.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  868 EHSQLM---VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFD--KDIYFGISVDTCPhdVATLLKEFLRDLPE 942
Cdd:cd04393    11 QQAGQPengVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDsgEEVDLSKEADVCS--AASLLRLFLQELPE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  943 PLLCNTLYLTFLKT-QRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLA 1021
Cdd:cd04393    89 GLIPASLQIRLMQLyQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHE------------NRMTAENLA 156

                         170       180
                  ....*....|....*....|....
gi 386763425 1022 TVFAPNILrstHLT--FSRDKEQE 1043
Cdd:cd04393   157 AVFGPDVF---HVYtdVEDMKEQE 177
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 868-1063 2.98e-26

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 107.10  E-value: 2.98e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  868 EHSQLMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIyfgISVDTCP--------HDVATLLKEFLRD 939
Cdd:cd04398    10 LREGDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDP---LNVLLISpedyesdiHSVASLLKLFFRE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  940 LPEPLLCNTLYLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYN 1019
Cdd:cd04398    87 LPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESV------------NRMSVNN 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 386763425 1020 LATVFAPNILRSTHltfsrdkeqENMIDA---INVVRTMINHYEEIF 1063
Cdd:cd04398   155 LAIIWGPTLMNAAP---------DNAADMsfqSRVIETLLDNAYQIF 192
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 874-1062 1.05e-25

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 106.02  E-value: 1.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNgLQQVGLFRVSTSKKRVKQLREEFDKdiyfGISVDTC--PHDVATLLKEFLRDLPEPLLCNTLYL 951
Cdd:cd04394    20 VPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEG----GEACLSSalPCDVAGLLKQFFRELPEPLLPYDLHE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  952 TFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILRS 1031
Cdd:cd04394    95 ALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSE------------NKMDSSNLAVIFAPNLFQS 162

                         170       180       190
                  ....*....|....*....|....*....|...
gi 386763425 1032 T--HLTFSRDKEQENMIDAiNVVRTMINHYEEI 1062
Cdd:cd04394   163 EegGEKMSSSTEKRLRLQA-AVVQTLIDNASNI 194
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 874-1030 1.89e-25

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 104.83  E-value: 1.89e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYfGISVDTCP-HDVATLLKEFLRDLPEPLLCNTLYLT 952
Cdd:cd04377    15 VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPD-SVNLEDYPiHVITSVLKQWLRELPEPLMTFELYEN 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386763425  953 FLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILR 1030
Cdd:cd04377    94 FLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEV------------NRMSANALAIVFAPCILR 159
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 881-1064 5.21e-25

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 104.08  E-value: 5.21e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  881 CIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDiYFGISVD---TCPHDVATLLKEFLRDLPEPLLCNTLYLTFLKTQ 957
Cdd:cd04386    27 CVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAG-TFSLPLDefySDPHAVASALKSYLRELPDPLLTYNLYEDWVQAA 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  958 RIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILRSTHLTFS 1037
Cdd:cd04386   106 NKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDE------------NKMSPSNIAIVLAPNLLWAKNEGSL 173

                         170       180
                  ....*....|....*....|....*..
gi 386763425 1038 RDKEQENMIDAINVVRTMINHYEEIFN 1064
Cdd:cd04386   174 AEMAAGTSVHVVAIVELIISHADWFFP 200
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 874-1029 9.32e-25

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 104.03  E-value: 9.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCP---HDVATLLKEFLRDLPEPLLCNTLY 950
Cdd:cd04396    32 IPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDYGKSFDWDGytvHDAASVLRRYLNNLPEPLVPLDLY 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  951 LTFLKTQRIRNRRLQL--------------EAIS---HLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgN 1013
Cdd:cd04396   112 EEFRNPLRKRPRILQYmkgrineplntdidQAIKeyrDLITRLPNLNRQLLLYLLDLLAVFARNSDK------------N 179

                         170
                  ....*....|....*.
gi 386763425 1014 KMDSYNLATVFAPNIL 1029
Cdd:cd04396   180 LMTASNLAAIFQPGIL 195
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 882-1069 1.97e-24

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 102.54  E-value: 1.97e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  882 IDYLEDNgLQQVGLFRVSTSKKRVKQLREEF--DKDIYFGiSVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTFLK---- 955
Cdd:cd04392    17 IEYLEKN-LRVEGLFRKPGNSARQQELRDLLnsGTDLDLE-SGGFHAHDCATVLKGFLGELPEPLLTHAHYPAHLQiadl 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  956 --------TQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPN 1027
Cdd:cd04392    95 cqfdekgnKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDK------------NKMSADNLALLFTPH 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 386763425 1028 ILRSTHLTfsRDKEQENMIDAINVVRTMINHYEEIFNISAEL 1069
Cdd:cd04392   163 LICPRNLT--PEDLHENAQKLNSIVTFMIKHSQKLFKAPAYL 202
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 867-1063 2.58e-24

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 101.75  E-value: 2.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  867 QEHSQLMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLC 946
Cdd:cd04390    15 RKFGPRLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  947 NTLYLTFLK-TQRI-RNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVF 1024
Cdd:cd04390    95 WAQYEDFLScAQLLsKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSV------------NKMSVQNLATVF 162

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 386763425 1025 APNILRSTHLTFSRDKEQENMIDAINVVrtMINHYEEIF 1063
Cdd:cd04390   163 GPNILRPKVEDPATIMEGTPQIQQLMTV--MISKHEPLF 199
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 867-1030 1.22e-22

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 96.69  E-value: 1.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  867 QEHSqlMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYfgISVDTCP----HDVATLLKEFLRDLPE 942
Cdd:cd04403    11 RENS--TVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEK--LDLDDSKwediHVITGALKLFFRELPE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  943 PLLCNTLYLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLAT 1022
Cdd:cd04403    87 PLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEK------------NRMTTQNLAI 154


                  ....*...
gi 386763425 1023 VFAPNILR 1030
Cdd:cd04403   155 VFGPTLLR 162
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 870-1030 1.32e-22

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 96.37  E-value: 1.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  870 SQLMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGI-SVDTCPHDVATLLKEFLRDLPEPLLCNT 948
Cdd:cd04373    11 SEKPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLvSKDFTVNAVAGALKSFFSELPDPLIPYS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  949 LYLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNI 1028
Cdd:cd04373    91 MHLELVEAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKV------------NLMTSENLSICFWPTL 158


                  ..
gi 386763425 1029 LR 1030
Cdd:cd04373   159 MR 160
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 874-1028 7.57e-22

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 94.35  E-value: 7.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNG-LQQVGLFRVSTSKKRVKQLREEFDKdiyfGISVDTC-------PHDVATLLKEFLRDLPEPLL 945
Cdd:cd04400    22 LPSVVYRCIEYLDKNRaIYEEGIFRLSGSASVIKQLKERFNT----EYDVDLFssslypdVHTVAGLLKLYLRELPTLIL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  946 CNTLYLTFLKTQRIRNRRLQLEAI-SHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVF 1024
Cdd:cd04400    98 GGELHNDFKRLVEENHDRSQRALElKDLVSQLPQANYDLLYVLFSFLRKIIEHSDV------------NKMNLRNVCIVF 165


                  ....*.
gi 386763425 1025 AP--NI 1028
Cdd:cd04400   166 SPtlNI 171
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 874-1030 1.28e-20

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 90.82  E-value: 1.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYfGISVDTCP-HDVATLLKEFLRDLPEPLLCNTLYLT 952
Cdd:cd04407    15 VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPE-NVKLENYPiHAITGLLKQWLRELPEPLMTFAQYND 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386763425  953 FLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDdiwstegccltlGNKMDSYNLATVFAPNILR 1030
Cdd:cd04407    94 FLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEED------------VNRMSPNALAIVFAPCLLR 159
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 873-1063 2.40e-20

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 90.05  E-value: 2.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  873 MVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKdiyfGISVD---TCPHDVATLLKEFLRDLPEPLLCNTL 949
Cdd:cd04402    14 NLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNS----GVEVDlkaEPVLLLASVLKDFLRNIPGSLLSSDL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  950 YLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNIL 1029
Cdd:cd04402    90 YEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSET------------NKMDAFNLAVCIAPSLL 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 386763425 1030 rstHLTFSRDKEQENMIDAINVVRTMINHYEEIF 1063
Cdd:cd04402   158 ---WPPASSELQNEDLKKVTSLVQFLIENCQEIF 188
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 862-1035 3.70e-20

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 90.17  E-value: 3.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  862 FVKAYQEHsqlmVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFD--KDIyFGISvDTCPHDVATLLKEFLRD 939
Cdd:cd04378     8 VPRDFPDE----VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFEngKDL-VELS-ELSPHDISSVLKLFLRQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  940 LPEPLLCNTLYLTFL----KTQRI--RNRRLQLEAISH--------LIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwste 1005
Cdd:cd04378    82 LPEPLILFRLYNDFIalakEIQRDteEDKAPNTPIEVNriirklkdLLRQLPASNYNTLQHLIAHLYRVAEQFEE----- 156

                         170       180       190
                  ....*....|....*....|....*....|
gi 386763425 1006 gccltlgNKMDSYNLATVFAPNILRSTHLT 1035
Cdd:cd04378   157 -------NKMSPNNLGIVFGPTLIRPRPGD 179
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 869-1034 2.56e-19

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 87.11  E-value: 2.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  869 HSQLMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISvDTCPHDVATLLKEFLRDLPEPLLCNT 948
Cdd:cd04381    15 HDGIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLE-EYEPPTVASLLKQYLRELPEPLLTKE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  949 LYLTFLKTQRIRNRRLQLEAISHLIRLLPiPHRDTLyvllvfLAKVAAHSDDIWSTEGCcltlgNKMDSYNLATVFAPNI 1028
Cdd:cd04381    94 LMPRFEEACGRPTEAEREQELQRLLKELP-ECNRLL------LAWLIVHMDHVIAQELE-----TKMNIQNISIVLSPTV 161


                  ....*.
gi 386763425 1029 LRSTHL 1034
Cdd:cd04381   162 QISNRL 167
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 867-1030 8.87e-19

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 85.75  E-value: 8.87e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  867 QEHSQlmVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFD---KDIYFGIS-VDTcpHDVATLLKEFLRDLPE 942
Cdd:cd04387    11 RERSK--VPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDtnnKDVSVMLSeMDV--NAIAGTLKLYFRELPE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  943 PLLCNTLYLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLAT 1022
Cdd:cd04387    87 PLFTDELYPNFAEGIALSDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEV------------NKMSLHNLAT 154


                  ....*...
gi 386763425 1023 VFAPNILR 1030
Cdd:cd04387   155 VFGPTLLR 162
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 877-1031 9.82e-19

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 85.91  E-value: 9.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  877 FVNNCIDYLEDNGLQQVGLFRVSTSKKRV-KQLREEFDKDIYFGISVDTCPHD-----VATLLKEFLRDLPEPLLCNTLY 950
Cdd:cd04374    31 FVRKCIEAVETRGINEQGLYRVVGVNSKVqKLLSLGLDPKTSTPGDVDLDNSEweiktITSALKTYLRNLPEPLMTYELH 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  951 LTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILR 1030
Cdd:cd04374   111 NDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKK------------NLMTVSNLGVVFGPTLLR 178


                  .
gi 386763425 1031 S 1031
Cdd:cd04374   179 P 179
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 874-1035 3.73e-18

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 83.90  E-value: 3.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTF 953
Cdd:cd04406    15 VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEF 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  954 LKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILRSTH 1033
Cdd:cd04406    95 LRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEET------------NRMSANALAIVFAPCILRCPD 162


                  ..
gi 386763425 1034 LT 1035
Cdd:cd04406   163 TT 164
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 866-1058 4.68e-18

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 83.62  E-value: 4.68e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  866 YQEHSQLMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDK--DIYFGISVDTCPHDVATLLKEFLRDLPEP 943
Cdd:cd04383    10 YIQDSGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERgeDPLADDQNDHDINSVAGVLKLYFRGLENP 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  944 LLCNTLYLTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATV 1023
Cdd:cd04383    90 LFPKERFEDLMSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDE------------NMMDPYNLAIC 157

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 386763425 1024 FAPNILRsthltFSRDKEQENMIDAIN-VVRTMINH 1058
Cdd:cd04383   158 FGPTLMP-----VPEGQDQVSCQAHVNeLIKTIIIH 188
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 874-1031 1.03e-17

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 82.55  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQvGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHD---VATLLKEFLRDLPEPLLCNTLY 950
Cdd:cd04384    18 VPQVLKSCTEFIEKHGIVD-GIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDihsVSSLCKLYFRELPNPLLTYQLY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  951 LTFLKTQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHsddiwstegCCLTlgnKMDSYNLATVFAPNILR 1030
Cdd:cd04384    97 EKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKY---------CSIT---NMHAKNLAIVWAPNLLR 164


                  .
gi 386763425 1031 S 1031
Cdd:cd04384   165 S 165
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 867-1029 4.30e-17

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 81.36  E-value: 4.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  867 QEHSQLMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDK---------DIYFGISVDTCphdvatLLKEFL 937
Cdd:cd04379    11 REGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERnsaavelseELYPDINVITG------VLKDYL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  938 RDLPEPLLCNTLYLTFLKTQRIR-------NRRLQLEAISHLIRLLpiphRDTLYVLLVFLAKVAAHSDDiwstegcclt 1010
Cdd:cd04379    85 RELPEPLITPQLYEMVLEALAVAlpndvqtNTHLTLSIIDCLPLSA----KATLLLLLDHLSLVLSNSER---------- 150

                         170
                  ....*....|....*....
gi 386763425 1011 lgNKMDSYNLATVFAPNIL 1029
Cdd:cd04379   151 --NKMTPQNLAVCFGPVLM 167
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 874-1030 2.82e-16

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 78.70  E-value: 2.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTF 953
Cdd:cd04408    16 VPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDDF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  954 L----KTQRIRNRRLQLEAISH--------LIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLA 1021
Cdd:cd04408    96 IalakELQRDSEKAAESPSIVEniirslkeLLGRLPVSNYNTLRHLMAHLYRVAERFED------------NKMSPNNLG 163


                  ....*....
gi 386763425 1022 TVFAPNILR 1030
Cdd:cd04408   164 IVFGPTLLR 172
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 874-1035 1.69e-15

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 76.77  E-value: 1.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  874 VPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTF 953
Cdd:cd04409    16 IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKLYLRQLPEPLILFRLYNEF 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  954 L----KTQRI----------RNRRLQLEA--------ISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltl 1011
Cdd:cd04409    96 IglakESQHVnetqeakknsDKKWPNMCTelnrillkSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEE----------- 164

                         170       180
                  ....*....|....*....|....
gi 386763425 1012 gNKMDSYNLATVFAPNILRSTHLT 1035
Cdd:cd04409   165 -NKMSASNLGIIFGPTLIRPRPTD 187
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 888-1033 6.44e-15

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 74.35  E-value: 6.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  888 NGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTcPHDVATLLKEFLRDLPEPLLCNTLYltflktQRIRNRRLQLE 967
Cdd:cd04389    36 GGFQTEGIFRVPGDIDEVNELKLRVDQWDYPLSGLED-PHVPASLLKLWLRELEEPLIPDALY------QQCISASEDPD 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386763425  968 AISHLIRLLPIPHRDTLYVLLVFL-----AKVAAHsddiwstegccltlgNKMDSYNLATVFAPNILRSTH 1033
Cdd:cd04389   109 KAVEIVQKLPIINRLVLCYLINFLqvfaqPENVAH---------------TKMDVSNLAMVFAPNILRCTS 164
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 881-1031 4.84e-10

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 60.82  E-value: 4.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  881 CIDYLEDNGLQQVGLFR----VSTSKKRVKQLREEFDKDIYFGISvdTCPHDVATLLKEFLRDLPEPLLCNTLYLTFLKt 956
Cdd:cd04380    57 LVDYLYTRGLAQEGLFEepglPSEPGELLAEIRDALDTGSPFNSP--GSAESVAEALLLFLESLPDPIIPYSLYERLLE- 133

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386763425  957 qrirNRRLQLEAISHLIRL-LPIPHRDTLYVLLVFLAKVAAHSDDiwstegccltlgNKMDSYNLATVFAPNILRS 1031
Cdd:cd04380   134 ----AVANNEEDKRQVIRIsLPPVHRNVFVYLCSFLRELLSESAD------------RGLDENTLATIFGRVLLRD 193
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 882-1030 2.53e-03

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 40.63  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386763425  882 IDYLEDNGLQQVGLFRVSTSKKRVkQLREEFDKDiyfGISVDTCPHDVATL---LKEFLRDLPEPLLCNTLYLTFLK-TQ 957
Cdd:cd04388    23 VEAIEKKGLESSTLYRTQSSSSLT-ELRQILDCD---AASVDLEQFDVAALadaLKRYLLDLPNPVIPAPVYSEMISrAQ 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386763425  958 RIRNRRLQLEAISHLIRLLPIPHRD--TLYVLLVFLAKVAAHSDdiwstegccltlGNKMDSYNLATVFAPNILR 1030
Cdd:cd04388    99 EVQSSDEYAQLLRKLIRSPNLPHQYwlTLQYLLKHFFRLCQSSS------------KNLLSARALAEIFSPLLFR 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH