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Conserved domains on  [gi|385198068|ref|NP_001245241|]
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dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 3 [Homo sapiens]

Protein Classification

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1( domain architecture ID 10763433)

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1 (PDE1) is a cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
222-443 5.76e-108

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 459723  Cd Length: 238  Bit Score: 322.58  E-value: 5.76e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068  222 YHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAY 301
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068  302 RLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKT--------MSLILHAADISH 373
Cdd:pfam00233  81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDFLENeedrrlllLSMLIKAADISN 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385198068  374 PAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQSQIGFIDFIVEPTFSLLTDSTEKI 443
Cdd:pfam00233 161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPEL 231
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 77-137 2.03e-29

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


:

Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 110.12  E-value: 2.03e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385198068   77 RLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVER 137
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
222-443 5.76e-108

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 322.58  E-value: 5.76e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068  222 YHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAY 301
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068  302 RLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKT--------MSLILHAADISH 373
Cdd:pfam00233  81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDFLENeedrrlllLSMLIKAADISN 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385198068  374 PAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQSQIGFIDFIVEPTFSLLTDSTEKI 443
Cdd:pfam00233 161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPEL 231
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 77-137 2.03e-29

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 110.12  E-value: 2.03e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385198068   77 RLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVER 137
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 222-393 2.77e-12

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 64.28  E-value: 2.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068 222 YHNLIHAADVTQTVHYIMLHTGimhwLTELEILAMVFAAAIHDYEHTGTTNNFhiqtrsdvailYNDRSVLENHHVSAAY 301
Cdd:cd00077    1 EHRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068 302 RLmqeeemnilinLSKDDWRDLRNLVIEMVLSTDMSgHFQQIKniRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLH 381
Cdd:cd00077   66 EI-----------LRELLLEEVIKLIDELILAVDAS-HHERLD--GLGYPDGLKGEEITLEARIVKLADRLDALRRDSRE 131

                        170
                 ....*....|....
gi 385198068 382 YR--WTMALMEEFF 393
Cdd:cd00077  132 KRrrIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 220-384 6.01e-11

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 60.00  E-value: 6.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068   220 NPYHNLIHAADVTQTVHYIMLHTGimhwltELEILAMVFAAAIHDYEHTGTTNNFHIQTrsdvailyndrSVLENHHVSA 299
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAALAEELG------LLDIELLLLAALLHDIGKPGTPDSFLVKT-----------SVLEDHHFIG 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068   300 AYRLMQEEEMNILINLskddwrdlrnlviemvLSTDMSGHFQQIKnirnslqqPEGIDRAKTMSLILHAADISHPAKSWK 379
Cdd:smart00471  64 AEILLEEEEPRILEEI----------------LRTAILSHHERPD--------GLRGEPITLEARIVKVADRLDALRADR 119


                   ....*
gi 385198068   380 LHYRW 384
Cdd:smart00471 120 RYRRV 124
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
222-443 5.76e-108

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 322.58  E-value: 5.76e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068  222 YHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAY 301
Cdd:pfam00233   1 YHNWRHAFDVTQTMYYLLKTGKLKEVLTDLEILALLIAALCHDVDHPGTNNAFLIKTKSPLAILYNDSSVLENHHCATAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068  302 RLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKT--------MSLILHAADISH 373
Cdd:pfam00233  81 QILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESKKTLDFLENeedrrlllLSMLIKAADISN 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385198068  374 PAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDR-KSTMVAQSQIGFIDFIVEPTFSLLTDSTEKI 443
Cdd:pfam00233 161 PTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDReKKTSLPKSQIGFIDFIVLPLFEALAKLFPEL 231
PDEase_I_N pfam08499
3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of ...
 77-137 2.03e-29

3'5'-cyclic nucleotide phosphodiesterase N-terminal; This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (pfam00233).


Pssm-ID: 462497 [Multi-domain]  Cd Length: 61  Bit Score: 110.12  E-value: 2.03e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 385198068   77 RLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVER 137
Cdd:pfam08499   1 RLLDEEDELSEIQSDAVPSEVRDWLASTFTRQMAAHKRRSEEKPKFRSVAHAVQAGIFVER 61
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
 222-393 2.77e-12

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 64.28  E-value: 2.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068 222 YHNLIHAADVTQTVHYIMLHTGimhwLTELEILAMVFAAAIHDYEHTGTTNNFhiqtrsdvailYNDRSVLENHHVSAAY 301
Cdd:cd00077    1 EHRFEHSLRVAQLARRLAEELG----LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGA 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068 302 RLmqeeemnilinLSKDDWRDLRNLVIEMVLSTDMSgHFQQIKniRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLH 381
Cdd:cd00077   66 EI-----------LRELLLEEVIKLIDELILAVDAS-HHERLD--GLGYPDGLKGEEITLEARIVKLADRLDALRRDSRE 131

                        170
                 ....*....|....
gi 385198068 382 YR--WTMALMEEFF 393
Cdd:cd00077  132 KRrrIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
 220-384 6.01e-11

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 60.00  E-value: 6.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068   220 NPYHNLIHAADVTQTVHYIMLHTGimhwltELEILAMVFAAAIHDYEHTGTTNNFHIQTrsdvailyndrSVLENHHVSA 299
Cdd:smart00471   1 SDYHVFEHSLRVAQLAAALAEELG------LLDIELLLLAALLHDIGKPGTPDSFLVKT-----------SVLEDHHFIG 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 385198068   300 AYRLMQEEEMNILINLskddwrdlrnlviemvLSTDMSGHFQQIKnirnslqqPEGIDRAKTMSLILHAADISHPAKSWK 379
Cdd:smart00471  64 AEILLEEEEPRILEEI----------------LRTAILSHHERPD--------GLRGEPITLEARIVKVADRLDALRADR 119


                   ....*
gi 385198068   380 LHYRW 384
Cdd:smart00471 120 RYRRV 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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