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Conserved domains on  [gi|384475530|ref|NP_001244960|]
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serine incorporator 4 isoform 1 [Homo sapiens]

Protein Classification

serine incorporator domain-containing protein( domain architecture ID 10505724)

serine incorporator domain-containing protein similar to Homo sapiens serine incorporators that may incorporate serine into membranes and facilitate the synthesis of serine-derived lipids such as phosphatidylserine, and to Saccharomyces cerevisiae membrane protein TMS1

Gene Ontology:  GO:0016020
PubMed:  16120614|31907454

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Serinc pfam03348
Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which ...
 36-477 6.77e-148

Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.


:

Pssm-ID: 460891  Cd Length: 434  Bit Score: 430.83  E-value: 6.77e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530   36 CCCGPAPCASCChSRWPSLTASTCSRLFYILLHVGASAICCLLLSRTVVERVwgKTHRIQMPSglCAHLFGLSDCpvlSG 115
Cdd:pfam03348   2 CCCGSAACSLCC-SCCPSCKSSTSTRLAYALLLLLNSLVSWIMLSPWVQKKL--KKLSLKWPG--CPGGKGGGEC---YG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  116 SGAVYRVCAGTATFHLLQAVLLVHLHSPTSPRAQLHNSFWLLKLLFLLGLCAIAFCIPDEhLFPAWHYIGICGGFAFILL 195
Cdd:pfam03348  74 YSAVYRVCFALALFFLLLALLLIGVKSSKDPRAAIQNGFWFFKFLALLGLVVGAFFIPNG-FFTFWGYIGLIGGFLFILI 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  196 QLVLITAFAHSWNKNWQTGAAQ--DCSWFLAVLLATLGFYSMAGVGAVLLFHYYTHPaGCLLNKMLLSLHLCFCGLISFL 273
Cdd:pfam03348 153 QLILLVDFAHSWNESWVEKYEEtnSKLWYAALLGSTLLMYALAIALTVLMYIFFTGS-GCGLNKFFISINLILCVIVSVV 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  274 SIAPCIRLKQPRSGLLQASVISCYIMYLTFSALSSRPPERVilqgqnhtlCLPGLSKMepQTPDISLAMLSASIMYACVL 353
Cdd:pfam03348 232 SILPKVQEANPRSGLLQSSVVSLYCTYLTWSALSSEPDDKN---------CNPLLRSS--EGTRTASVVLGAIFTFLCVA 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  354 FACNEASYLAEVFGPLWivKVYSYEFQKPSLCFCCPETVEADKGQRGGAarpADQETPPAPPVQVQHLSYNYSAFHFVFF 433
Cdd:pfam03348 301 YSTTRAASNSAVLGLQG--SGTTQEGSRDSLRFEALRAAVEEGSLPASA---LDDDGGKVLDDEKEGVAYSYSFFHFIFF 375

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 384475530  434 LASLYVMVTLTNWFSYEGAElEKTFIKGSWATFWVKVASCWACV 477
Cdd:pfam03348 376 LASLYVAMLLTNWYSPDDAG-DFTPVGRSWAAVWVKIVSSWVCY 418
 
Name Accession Description Interval E-value
Serinc pfam03348
Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which ...
 36-477 6.77e-148

Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.


Pssm-ID: 460891  Cd Length: 434  Bit Score: 430.83  E-value: 6.77e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530   36 CCCGPAPCASCChSRWPSLTASTCSRLFYILLHVGASAICCLLLSRTVVERVwgKTHRIQMPSglCAHLFGLSDCpvlSG 115
Cdd:pfam03348   2 CCCGSAACSLCC-SCCPSCKSSTSTRLAYALLLLLNSLVSWIMLSPWVQKKL--KKLSLKWPG--CPGGKGGGEC---YG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  116 SGAVYRVCAGTATFHLLQAVLLVHLHSPTSPRAQLHNSFWLLKLLFLLGLCAIAFCIPDEhLFPAWHYIGICGGFAFILL 195
Cdd:pfam03348  74 YSAVYRVCFALALFFLLLALLLIGVKSSKDPRAAIQNGFWFFKFLALLGLVVGAFFIPNG-FFTFWGYIGLIGGFLFILI 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  196 QLVLITAFAHSWNKNWQTGAAQ--DCSWFLAVLLATLGFYSMAGVGAVLLFHYYTHPaGCLLNKMLLSLHLCFCGLISFL 273
Cdd:pfam03348 153 QLILLVDFAHSWNESWVEKYEEtnSKLWYAALLGSTLLMYALAIALTVLMYIFFTGS-GCGLNKFFISINLILCVIVSVV 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  274 SIAPCIRLKQPRSGLLQASVISCYIMYLTFSALSSRPPERVilqgqnhtlCLPGLSKMepQTPDISLAMLSASIMYACVL 353
Cdd:pfam03348 232 SILPKVQEANPRSGLLQSSVVSLYCTYLTWSALSSEPDDKN---------CNPLLRSS--EGTRTASVVLGAIFTFLCVA 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  354 FACNEASYLAEVFGPLWivKVYSYEFQKPSLCFCCPETVEADKGQRGGAarpADQETPPAPPVQVQHLSYNYSAFHFVFF 433
Cdd:pfam03348 301 YSTTRAASNSAVLGLQG--SGTTQEGSRDSLRFEALRAAVEEGSLPASA---LDDDGGKVLDDEKEGVAYSYSFFHFIFF 375

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 384475530  434 LASLYVMVTLTNWFSYEGAElEKTFIKGSWATFWVKVASCWACV 477
Cdd:pfam03348 376 LASLYVAMLLTNWYSPDDAG-DFTPVGRSWAAVWVKIVSSWVCY 418
 
Name Accession Description Interval E-value
Serinc pfam03348
Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which ...
 36-477 6.77e-148

Serine incorporator (Serinc); This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.


Pssm-ID: 460891  Cd Length: 434  Bit Score: 430.83  E-value: 6.77e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530   36 CCCGPAPCASCChSRWPSLTASTCSRLFYILLHVGASAICCLLLSRTVVERVwgKTHRIQMPSglCAHLFGLSDCpvlSG 115
Cdd:pfam03348   2 CCCGSAACSLCC-SCCPSCKSSTSTRLAYALLLLLNSLVSWIMLSPWVQKKL--KKLSLKWPG--CPGGKGGGEC---YG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  116 SGAVYRVCAGTATFHLLQAVLLVHLHSPTSPRAQLHNSFWLLKLLFLLGLCAIAFCIPDEhLFPAWHYIGICGGFAFILL 195
Cdd:pfam03348  74 YSAVYRVCFALALFFLLLALLLIGVKSSKDPRAAIQNGFWFFKFLALLGLVVGAFFIPNG-FFTFWGYIGLIGGFLFILI 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  196 QLVLITAFAHSWNKNWQTGAAQ--DCSWFLAVLLATLGFYSMAGVGAVLLFHYYTHPaGCLLNKMLLSLHLCFCGLISFL 273
Cdd:pfam03348 153 QLILLVDFAHSWNESWVEKYEEtnSKLWYAALLGSTLLMYALAIALTVLMYIFFTGS-GCGLNKFFISINLILCVIVSVV 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  274 SIAPCIRLKQPRSGLLQASVISCYIMYLTFSALSSRPPERVilqgqnhtlCLPGLSKMepQTPDISLAMLSASIMYACVL 353
Cdd:pfam03348 232 SILPKVQEANPRSGLLQSSVVSLYCTYLTWSALSSEPDDKN---------CNPLLRSS--EGTRTASVVLGAIFTFLCVA 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 384475530  354 FACNEASYLAEVFGPLWivKVYSYEFQKPSLCFCCPETVEADKGQRGGAarpADQETPPAPPVQVQHLSYNYSAFHFVFF 433
Cdd:pfam03348 301 YSTTRAASNSAVLGLQG--SGTTQEGSRDSLRFEALRAAVEEGSLPASA---LDDDGGKVLDDEKEGVAYSYSFFHFIFF 375

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 384475530  434 LASLYVMVTLTNWFSYEGAElEKTFIKGSWATFWVKVASCWACV 477
Cdd:pfam03348 376 LASLYVAMLLTNWYSPDDAG-DFTPVGRSWAAVWVKIVSSWVCY 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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