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Conserved domains on  [gi|375298767|ref|NP_001243566|]
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desmoglein-2.1 precursor [Danio rerio]

Protein Classification

cadherin( domain architecture ID 10638918)

cadherin is a glycoprotein involved in Ca2+-mediated cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-254 1.45e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767  156 VDELSAVGTEVMRLNCFDADEPgnPNSQIKYEIVDQQPAGqsMFTVENNRRVVVANPNLDRETVDQYVLLVKASDLNGAP 235
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*....
gi 375298767  236 ggNAATGTVTIKINDVNDN 254
Cdd:cd11304    82 --LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 436-523 8.10e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.72  E-value: 8.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767  436 IIARYPAIDTDTGKEAtNVKY-IKSSDPDNWLTIDEKTGAIRMNKAPDRESKylvnGTYYAKVLSITQDLPSKTATGTIA 514
Cdd:cd11304    15 VVLTVSATDPDSGENG-EVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGPPLSSTATVT 89


                  ....*....
gi 375298767  515 IQVEDFNDH 523
Cdd:cd11304    90 ITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 74-146 1.06e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 1.06e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 375298767     74 LRYSLrgvgADQEPFNLFVVNPETGYVRITGILDRESISQYNLSGIALFTDGSIAENDIGLRIKVKDQNDNAP 146
Cdd:smart00112   13 VTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 806-853 3.43e-10

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 56.78  E-value: 3.43e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 375298767   806 DDPMVYDYEGKGSPVGSVgcCSLL-----EDQnDLEFLNDLGPKFTTLADICG 853
Cdd:pfam01049   11 DSLQTYAYEGDGSSAGSL--SSLEsstsdSDQ-DYDYLSDWGPRFKKLAELYG 60
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-254 1.45e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767  156 VDELSAVGTEVMRLNCFDADEPgnPNSQIKYEIVDQQPAGqsMFTVENNRRVVVANPNLDRETVDQYVLLVKASDLNGAP 235
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*....
gi 375298767  236 ggNAATGTVTIKINDVNDN 254
Cdd:cd11304    82 --LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 173-256 4.16e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 4.16e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767    173 DADEPgnPNSQIKYEIVDQQPAGqsMFTVENNRRVVVANPNLDRETVDQYVLLVKASDLNGAPggNAATGTVTIKINDVN 252
Cdd:smart00112    4 DADSG--ENGKVTYSILSGNDDG--LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVN 77


                    ....
gi 375298767    253 DNVP 256
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
153-249 6.15e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 6.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767   153 PGAVDELSAVGTEVMRLNCFDADEPgnPNSQIKYEIVDQQPAGqsMFTVE-NNRRVVVANPnLDRETVDQYVLLVKASDL 231
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDpDTGDISTTKP-LDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*...
gi 375298767   232 ngapGGNAATGTVTIKIN 249
Cdd:pfam00028   77 ----GGPPLSSTATVTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 436-523 8.10e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.72  E-value: 8.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767  436 IIARYPAIDTDTGKEAtNVKY-IKSSDPDNWLTIDEKTGAIRMNKAPDRESKylvnGTYYAKVLSITQDLPSKTATGTIA 514
Cdd:cd11304    15 VVLTVSATDPDSGENG-EVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGPPLSSTATVT 89


                  ....*....
gi 375298767  515 IQVEDFNDH 523
Cdd:cd11304    90 ITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 442-525 1.98e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 1.98e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767    442 AIDTDTGKEAtNVKY-IKSSDPDNWLTIDEKTGAIRMNKAPDRESKylvnGTYYAKVLSITQDLPSKTATGTIAIQVEDF 520
Cdd:smart00112    2 ATDADSGENG-KVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 375298767    521 NDHCP 525
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 74-146 1.06e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 1.06e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 375298767     74 LRYSLrgvgADQEPFNLFVVNPETGYVRITGILDRESISQYNLSGIALFTDGSIAENDIGLRIKVKDQNDNAP 146
Cdd:smart00112   13 VTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 806-853 3.43e-10

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 56.78  E-value: 3.43e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 375298767   806 DDPMVYDYEGKGSPVGSVgcCSLL-----EDQnDLEFLNDLGPKFTTLADICG 853
Cdd:pfam01049   11 DSLQTYAYEGDGSSAGSL--SSLEsstsdSDQ-DYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 58-144 1.18e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767   58 FIAKIR-SDKEVAHMKYLRYSLRGvgadQEPFNLFVVNPETGYVRITGILDRESISQYNLSGIAlfTDG------SIAEn 130
Cdd:cd11304    15 VVLTVSaTDPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA--TDGggpplsSTAT- 87

                          90
                  ....*....|....
gi 375298767  131 digLRIKVKDQNDN 144
Cdd:cd11304    88 ---VTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
423-518 1.07e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 1.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767   423 IPISEGKAFDSTeiIARYPAIDTDTGkEATNVKY-IKSSDPDNWLTIDEKTGAIRMNKAPDRESkylvNGTYYAKVLSIT 501
Cdd:pfam00028    3 ASVPENAPVGTE--VLTVTATDPDLG-PNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 375298767   502 QDLPSKTATGTIAIQVE 518
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
73-127 3.97e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 3.97e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 375298767    73 YLRYSLRGvgadQEPFNLFVVNPETGYVRITGILDRESISQYNLSGIAlfTDGSI 127
Cdd:pfam00028   30 RIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA--TDSGG 78
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 156-254 1.45e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.37  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767  156 VDELSAVGTEVMRLNCFDADEPgnPNSQIKYEIVDQQPAGqsMFTVENNRRVVVANPNLDRETVDQYVLLVKASDLNGAP 235
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*....
gi 375298767  236 ggNAATGTVTIKINDVNDN 254
Cdd:cd11304    82 --LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 173-256 4.16e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 4.16e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767    173 DADEPgnPNSQIKYEIVDQQPAGqsMFTVENNRRVVVANPNLDRETVDQYVLLVKASDLNGAPggNAATGTVTIKINDVN 252
Cdd:smart00112    4 DADSG--ENGKVTYSILSGNDDG--LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVN 77


                    ....
gi 375298767    253 DNVP 256
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
153-249 6.15e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 6.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767   153 PGAVDELSAVGTEVMRLNCFDADEPgnPNSQIKYEIVDQQPAGqsMFTVE-NNRRVVVANPnLDRETVDQYVLLVKASDL 231
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDpDTGDISTTKP-LDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*...
gi 375298767   232 ngapGGNAATGTVTIKIN 249
Cdd:pfam00028   77 ----GGPPLSSTATVTIT 90
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 436-523 8.10e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.72  E-value: 8.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767  436 IIARYPAIDTDTGKEAtNVKY-IKSSDPDNWLTIDEKTGAIRMNKAPDRESKylvnGTYYAKVLSITQDLPSKTATGTIA 514
Cdd:cd11304    15 VVLTVSATDPDSGENG-EVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGPPLSSTATVT 89


                  ....*....
gi 375298767  515 IQVEDFNDH 523
Cdd:cd11304    90 ITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 442-525 1.98e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 1.98e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767    442 AIDTDTGKEAtNVKY-IKSSDPDNWLTIDEKTGAIRMNKAPDRESKylvnGTYYAKVLSITQDLPSKTATGTIAIQVEDF 520
Cdd:smart00112    2 ATDADSGENG-KVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 375298767    521 NDHCP 525
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 74-146 1.06e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.90  E-value: 1.06e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 375298767     74 LRYSLrgvgADQEPFNLFVVNPETGYVRITGILDRESISQYNLSGIALFTDGSIAENDIGLRIKVKDQNDNAP 146
Cdd:smart00112   13 VTYSI----LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 806-853 3.43e-10

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 56.78  E-value: 3.43e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 375298767   806 DDPMVYDYEGKGSPVGSVgcCSLL-----EDQnDLEFLNDLGPKFTTLADICG 853
Cdd:pfam01049   11 DSLQTYAYEGDGSSAGSL--SSLEsstsdSDQ-DYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 58-144 1.18e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767   58 FIAKIR-SDKEVAHMKYLRYSLRGvgadQEPFNLFVVNPETGYVRITGILDRESISQYNLSGIAlfTDG------SIAEn 130
Cdd:cd11304    15 VVLTVSaTDPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTA--TDGggpplsSTAT- 87

                          90
                  ....*....|....
gi 375298767  131 digLRIKVKDQNDN 144
Cdd:cd11304    88 ---VTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
423-518 1.07e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 1.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767   423 IPISEGKAFDSTeiIARYPAIDTDTGkEATNVKY-IKSSDPDNWLTIDEKTGAIRMNKAPDRESkylvNGTYYAKVLSIT 501
Cdd:pfam00028    3 ASVPENAPVGTE--VLTVTATDPDLG-PNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 375298767   502 QDLPSKTATGTIAIQVE 518
Cdd:pfam00028   76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
73-127 3.97e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.14  E-value: 3.97e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 375298767    73 YLRYSLRGvgadQEPFNLFVVNPETGYVRITGILDRESISQYNLSGIAlfTDGSI 127
Cdd:pfam00028   30 RIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA--TDSGG 78
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 76-144 2.27e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.26  E-value: 2.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 375298767   76 YSLRGVGADQEPfNLFVVNPETGYVRITGILDRESISQYNLSGIALFTDGSIAENDIGLRIKVKDQNDN 144
Cdd:cd00031    31 IKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 443-523 1.84e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.86  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375298767  443 IDTDTGKEATNVKYIKSS---DPDNWLTIDEKTGAIRMNKAPDRESKylvnGTYYAKVLSITQDLPSKTATGTIAIQVED 519
Cdd:cd00031    19 IPTDLIASSGEIIKISAAgkeALPSWLHWEPHSGILEGLEKLDREDK----GVHYISVSAASLGANVPQTSSVFSIEVYD 94


                  ....
gi 375298767  520 FNDH 523
Cdd:cd00031    95 ENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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