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Conserved domains on  [gi|372466582|ref|NP_001243224|]
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protein C-ets-2 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAM_PNT-ETS-2 cd08543
Sterile alpha motif (SAM)/Pointed domain of ETS-2; SAM Pointed domain of ETS-2 subfamily of ...
 225-313 5.37e-58

Sterile alpha motif (SAM)/Pointed domain of ETS-2; SAM Pointed domain of ETS-2 subfamily of ETS transcriptional regulators is a protein-protein interaction domain. It contains a docking site for Cdk10 (cyclin-dependent kinase 10), a member of the Cdc2 kinase family. The interaction between ETS-2 and Cdk10 kinase inhibits ETS-2 transactivation activity in mammals. ETS-2 is also regulated by ERK2 MAP kinase. ETS-2, which is phosphorylated by ERK2, can interact with coactivators and enhance transactivation. ETS-2 transcriptional activators are involved in embryonic development and cell cycle control. The Ets-2 gene is a proto-oncogene. It is overexpressed in breast and prostate cancer cells and its overexpression is necessary for transformation of such cells. Members of ETS-2 subfamily are potential molecular targets for selective cancer therapy.


:

Pssm-ID: 188884  Cd Length: 89  Bit Score: 189.30  E-value: 5.37e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582 225 ATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLE 304
Cdd:cd08543    1 DTFSGFSKEQRRLGIPKNPWLWTEQQVCQWLLWATNEFSLVNVNFQQFLMNGQELCNLGKERFLELAPDFVGDILWEHLE 80


                 ....*....
gi 372466582 305 QMIKENQEK 313
Cdd:cd08543   81 QMIKENQEK 89
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 502-586 7.71e-50

erythroblast transformation specific domain; variation of the helix-turn-helix motif


:

Pssm-ID: 197710  Cd Length: 87  Bit Score: 167.44  E-value: 7.71e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   502 PIQLWQFLLELLSDKSCQSFISWTG-DGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVY 580
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDrDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVY 80


                   ....*.
gi 372466582   581 RFVCDL 586
Cdd:smart00413  81 KFVKNP 86
Ets1_N_flank super family cl44939
Ets1 N-terminal flanking region of Ets domain; Ets1 is a member of the Ets family of ...
 416-502 7.54e-19

Ets1 N-terminal flanking region of Ets domain; Ets1 is a member of the Ets family of transcription factors in which the DNA-binding activity is in an autoinhibited state. The autoinhibition of Ets1 is mediated by structural coupling of the regions flanking the Ets domain. The inhibitory regions are folded as helices HI1 and HI2 N-terminal to the ETS domain and as H4 C-terminal to the ETS domain, which are packed together to form an inhibitory module. This domain represents the N-terminal flanking region of Ets domain which contains the residues forming HI1 and HI2 helices and additional residues(244-301) N-terminal to HI1. HI1 and HI2 exert the autoinhibitory function by directing the inhibitory residues N-terminal to HI1 to mask the Ets domain DNA-binding surface. These residues are flexible and function by masking the DNA-binding surface of the Ets domain. Phosphorylation of serine residues present in this region enhances autoinhibition dramatically. These inhibitory sequences are required for cooperative DNA binding.


The actual alignment was detected with superfamily member pfam19525:

Pssm-ID: 466113  Cd Length: 188  Bit Score: 84.66  E-value: 7.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  416 HDSPENgADSFESSDSLLQSWNSQSSLLDVQRVPSFESFE-DDCSQSLCLNKPTMSFKDYIQERSDpVEQGKPVIPAAVL 494
Cdd:pfam19525 103 QDSFES-IESYDSCDRLTQSWSSQSSFQSLQRVPSYDSFDsEDYPAALPSHKPKGTFKDYVRDRAD-LNKDKPVIPAAAL 180


                  ....*...
gi 372466582  495 AGFTGSGP 502
Cdd:pfam19525 181 AGYTGRMM 188
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 14-136 8.54e-07

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 52.30  E-value: 8.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  14 RLPFGATSTTAPSLRNSkGRFGVRALAPerTPSAPRKVSARLPGRTLARTWGRGPAPGASGPAGEGPSRVTAGGGGKLRA 93
Cdd:PRK07764 384 RLGVAGGAGAPAAAAPS-AAAAAPAAAP--APAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAA 460

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 372466582  94 PGAARP--ASGLPDRLWPAPSPSPGAHRAAAGAEQPPSRPSAGPA 136
Cdd:PRK07764 461 APSAQPapAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAG 505
 
Name Accession Description Interval E-value
SAM_PNT-ETS-2 cd08543
Sterile alpha motif (SAM)/Pointed domain of ETS-2; SAM Pointed domain of ETS-2 subfamily of ...
 225-313 5.37e-58

Sterile alpha motif (SAM)/Pointed domain of ETS-2; SAM Pointed domain of ETS-2 subfamily of ETS transcriptional regulators is a protein-protein interaction domain. It contains a docking site for Cdk10 (cyclin-dependent kinase 10), a member of the Cdc2 kinase family. The interaction between ETS-2 and Cdk10 kinase inhibits ETS-2 transactivation activity in mammals. ETS-2 is also regulated by ERK2 MAP kinase. ETS-2, which is phosphorylated by ERK2, can interact with coactivators and enhance transactivation. ETS-2 transcriptional activators are involved in embryonic development and cell cycle control. The Ets-2 gene is a proto-oncogene. It is overexpressed in breast and prostate cancer cells and its overexpression is necessary for transformation of such cells. Members of ETS-2 subfamily are potential molecular targets for selective cancer therapy.


Pssm-ID: 188884  Cd Length: 89  Bit Score: 189.30  E-value: 5.37e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582 225 ATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLE 304
Cdd:cd08543    1 DTFSGFSKEQRRLGIPKNPWLWTEQQVCQWLLWATNEFSLVNVNFQQFLMNGQELCNLGKERFLELAPDFVGDILWEHLE 80


                 ....*....
gi 372466582 305 QMIKENQEK 313
Cdd:cd08543   81 QMIKENQEK 89
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 502-586 7.71e-50

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 167.44  E-value: 7.71e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   502 PIQLWQFLLELLSDKSCQSFISWTG-DGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVY 580
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDrDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVY 80


                   ....*.
gi 372466582   581 RFVCDL 586
Cdd:smart00413  81 KFVKNP 86
Ets pfam00178
Ets-domain;
504-582 9.28e-46

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 156.12  E-value: 9.28e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  504 QLWQFLLELLSDKSCQSFISWT-GDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRF 582
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTdKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYRF 80
SAM_PNT pfam02198
Sterile alpha motif (SAM)/Pointed domain;
227-310 9.73e-37

Sterile alpha motif (SAM)/Pointed domain;


Pssm-ID: 460486  Cd Length: 83  Bit Score: 131.64  E-value: 9.73e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  227 FSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPdFVGDILWEHLEQM 306
Cdd:pfam02198   1 LPSFEKEQLRLWIPADPRLWTKDHVLEWLEWAVDEFDLSKIDFSQFDMNGKALCSLGKEEFLQRAP-GPGDILWSHLQIL 79


                  ....
gi 372466582  307 IKEN 310
Cdd:pfam02198  80 RKAS 83
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
 227-309 1.08e-36

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 131.62  E-value: 1.08e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   227 FSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPdFVGDILWEHLEQM 306
Cdd:smart00251   1 PPNFEKEQKRLGIPADPQLWTEDHVLEWLEWAVKEFSLSPIDFSKFDMSGKELCSMSKEEFLERAP-FGGDILWSHLQIL 79


                   ...
gi 372466582   307 IKE 309
Cdd:smart00251  80 RKA 82
Ets1_N_flank pfam19525
Ets1 N-terminal flanking region of Ets domain; Ets1 is a member of the Ets family of ...
 416-502 7.54e-19

Ets1 N-terminal flanking region of Ets domain; Ets1 is a member of the Ets family of transcription factors in which the DNA-binding activity is in an autoinhibited state. The autoinhibition of Ets1 is mediated by structural coupling of the regions flanking the Ets domain. The inhibitory regions are folded as helices HI1 and HI2 N-terminal to the ETS domain and as H4 C-terminal to the ETS domain, which are packed together to form an inhibitory module. This domain represents the N-terminal flanking region of Ets domain which contains the residues forming HI1 and HI2 helices and additional residues(244-301) N-terminal to HI1. HI1 and HI2 exert the autoinhibitory function by directing the inhibitory residues N-terminal to HI1 to mask the Ets domain DNA-binding surface. These residues are flexible and function by masking the DNA-binding surface of the Ets domain. Phosphorylation of serine residues present in this region enhances autoinhibition dramatically. These inhibitory sequences are required for cooperative DNA binding.


Pssm-ID: 466113  Cd Length: 188  Bit Score: 84.66  E-value: 7.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  416 HDSPENgADSFESSDSLLQSWNSQSSLLDVQRVPSFESFE-DDCSQSLCLNKPTMSFKDYIQERSDpVEQGKPVIPAAVL 494
Cdd:pfam19525 103 QDSFES-IESYDSCDRLTQSWSSQSSFQSLQRVPSYDSFDsEDYPAALPSHKPKGTFKDYVRDRAD-LNKDKPVIPAAAL 180


                  ....*...
gi 372466582  495 AGFTGSGP 502
Cdd:pfam19525 181 AGYTGRMM 188
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 14-136 8.54e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 52.30  E-value: 8.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  14 RLPFGATSTTAPSLRNSkGRFGVRALAPerTPSAPRKVSARLPGRTLARTWGRGPAPGASGPAGEGPSRVTAGGGGKLRA 93
Cdd:PRK07764 384 RLGVAGGAGAPAAAAPS-AAAAAPAAAP--APAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAA 460

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 372466582  94 PGAARP--ASGLPDRLWPAPSPSPGAHRAAAGAEQPPSRPSAGPA 136
Cdd:PRK07764 461 APSAQPapAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAG 505
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 60-140 2.62e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.84  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  60 LARTWGRGPAPGAS---GPAGEGPSRVTAGGGGKLRAPGAARPASGL---------PDRLWPAPSPSPGAHRAAAGAEQP 127
Cdd:NF041121  11 LAAQMGRAAAPPSPegpAPTAASQPATPPPPAAPPSPPGDPPEPPAPepaplpapyPGSLAPPPPPPPGPAGAAPGAALP 90

                         90
                 ....*....|...
gi 372466582 128 PSRPSAGPARSGR 140
Cdd:NF041121  91 VRVPAPPALPNPL 103
 
Name Accession Description Interval E-value
SAM_PNT-ETS-2 cd08543
Sterile alpha motif (SAM)/Pointed domain of ETS-2; SAM Pointed domain of ETS-2 subfamily of ...
 225-313 5.37e-58

Sterile alpha motif (SAM)/Pointed domain of ETS-2; SAM Pointed domain of ETS-2 subfamily of ETS transcriptional regulators is a protein-protein interaction domain. It contains a docking site for Cdk10 (cyclin-dependent kinase 10), a member of the Cdc2 kinase family. The interaction between ETS-2 and Cdk10 kinase inhibits ETS-2 transactivation activity in mammals. ETS-2 is also regulated by ERK2 MAP kinase. ETS-2, which is phosphorylated by ERK2, can interact with coactivators and enhance transactivation. ETS-2 transcriptional activators are involved in embryonic development and cell cycle control. The Ets-2 gene is a proto-oncogene. It is overexpressed in breast and prostate cancer cells and its overexpression is necessary for transformation of such cells. Members of ETS-2 subfamily are potential molecular targets for selective cancer therapy.


Pssm-ID: 188884  Cd Length: 89  Bit Score: 189.30  E-value: 5.37e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582 225 ATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLE 304
Cdd:cd08543    1 DTFSGFSKEQRRLGIPKNPWLWTEQQVCQWLLWATNEFSLVNVNFQQFLMNGQELCNLGKERFLELAPDFVGDILWEHLE 80


                 ....*....
gi 372466582 305 QMIKENQEK 313
Cdd:cd08543   81 QMIKENQEK 89
ETS smart00413
erythroblast transformation specific domain; variation of the helix-turn-helix motif
 502-586 7.71e-50

erythroblast transformation specific domain; variation of the helix-turn-helix motif


Pssm-ID: 197710  Cd Length: 87  Bit Score: 167.44  E-value: 7.71e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   502 PIQLWQFLLELLSDKSCQSFISWTG-DGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVY 580
Cdd:smart00413   1 GIQLWQFLLDLLLDPENSDIIKWTDrDEGEFKLVDPEEVARLWGQRKNKPNMNYEKLSRALRYYYKKNILEKVPGKRLVY 80


                   ....*.
gi 372466582   581 RFVCDL 586
Cdd:smart00413  81 KFVKNP 86
Ets pfam00178
Ets-domain;
504-582 9.28e-46

Ets-domain;


Pssm-ID: 459700  Cd Length: 80  Bit Score: 156.12  E-value: 9.28e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  504 QLWQFLLELLSDKSCQSFISWT-GDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTSGKRYVYRF 582
Cdd:pfam00178   1 QLWQFLLDLLTDPEYSDIIKWTdKEEGEFRLVDPEAVARLWGKRKGNPKMTYEKLSRALRYYYKKGILEKVPGKRLTYRF 80
SAM_PNT-ETS-1 cd08542
Sterile alpha motif (SAM)/Pointed domain of ETS-1; SAM Pointed domain of ETS-1 subfamily of ...
 225-312 7.33e-41

Sterile alpha motif (SAM)/Pointed domain of ETS-1; SAM Pointed domain of ETS-1 subfamily of ETS transcriptional activators is a protein-protein interaction domain. The ETS-1 activator is regulated by phosphorylation. It contains a docking site for the ERK2 MAP (Mitogen Activated Protein) kinase, while the ERK2 phosphorylation site is located in the N-terminal disordered region upstream of the SAM Pointed domain. Mutations of the kinase docking site residues inhibit phosphorylation. ETS-1 activators play a role in a number of different physiological processes, and they are expressed during embryonic development, including blood vessel formation, hematopoietic, lymphoid, neuronal and osteogenic differentiation. The Ets-1 gene is a proto-oncogene involved in progression of different tumors (including breast cancer, meningioma, and prostate cancer). Members of this subfamily are potential molecular targets for selective cancer therapy.


Pssm-ID: 176092  Cd Length: 88  Bit Score: 143.20  E-value: 7.33e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582 225 ATFSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLE 304
Cdd:cd08542    1 ATFSGFTKEQQRLGIPKDPREWTETHVREWVMWAVNEFSLKGVDFQKFCMSGAALCALGKECFLELAPDFVGDILWEHLE 80


                 ....*...
gi 372466582 305 QMIKENQE 312
Cdd:cd08542   81 ILQKEDPK 88
SAM_PNT-ETS-1,2 cd08533
Sterile alpha motif (SAM)/Pointed domain of ETS-1,2 family; SAM Pointed domain of ETS-1,2 ...
 240-310 1.62e-40

Sterile alpha motif (SAM)/Pointed domain of ETS-1,2 family; SAM Pointed domain of ETS-1,2 family of transcriptional activators is a protein-protein interaction domain. It carries a kinase docking site and mediates interaction between ETS transcriptional activators and protein kinases. This group of transcriptional factors is involved in the Ras/MAP kinase signaling pathway. MAP kinases phosphorylate the transcription factors. Phosphorylated factors then recruit coactivators and enhance transactivation. Members of this group play a role in regulation of different embryonic developmental processes. ETS-1,2 transcriptional activators are proto-oncogenes involved in malignant transformation and tumor progression. They are potential molecular targets for selective cancer therapy.


Pssm-ID: 188879  Cd Length: 71  Bit Score: 141.74  E-value: 1.62e-40
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 372466582 240 PKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKEN 310
Cdd:cd08533    1 PKDPRQWSETQVAYWLDWAANEFSLEGVNLSNFCMSGRDMCALGKEAFLSLAPPFVGDILWEHLDILQKEC 71
SAM_PNT pfam02198
Sterile alpha motif (SAM)/Pointed domain;
227-310 9.73e-37

Sterile alpha motif (SAM)/Pointed domain;


Pssm-ID: 460486  Cd Length: 83  Bit Score: 131.64  E-value: 9.73e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  227 FSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPdFVGDILWEHLEQM 306
Cdd:pfam02198   1 LPSFEKEQLRLWIPADPRLWTKDHVLEWLEWAVDEFDLSKIDFSQFDMNGKALCSLGKEEFLQRAP-GPGDILWSHLQIL 79


                  ....
gi 372466582  307 IKEN 310
Cdd:pfam02198  80 RKAS 83
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
 227-309 1.08e-36

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 131.62  E-value: 1.08e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   227 FSGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPdFVGDILWEHLEQM 306
Cdd:smart00251   1 PPNFEKEQKRLGIPADPQLWTEDHVLEWLEWAVKEFSLSPIDFSKFDMSGKELCSMSKEEFLERAP-FGGDILWSHLQIL 79


                   ...
gi 372466582   307 IKE 309
Cdd:smart00251  80 RKA 82
SAM_PNT-GABP-alpha cd08534
Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain; SAM Pointed ...
 228-304 1.68e-26

Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain; SAM Pointed domain of GA-binding protein (GABP) alpha subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. This type of transcriptional regulators forms heterotetramers containing two alpha and two beta subunits. It interacts with GA repeats (purine rich repeats). GABP transcriptional factors control gene expression in cell cycle control, apoptosis, and cellular respiration. GABP participates in regulation of transmembrane receptors and key hormones especially in myeloid cells and at the neuromuscular junction.


Pssm-ID: 176084  Cd Length: 89  Bit Score: 103.20  E-value: 1.68e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 372466582 228 SGFKKEQRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLE 304
Cdd:cd08534    4 SNYRKEQERLKIPYDPMEWTEDHVLHWLQWAVKEFGLTGINLSDWNITGRELCSLTQEEFLQRVPKDPGDIFWTHLE 80
SAM_PNT cd08203
Sterile alpha motif (SAM)/Pointed domain; Sterile alpha motif (SAM)/Pointed domain is found in ...
 242-304 2.07e-20

Sterile alpha motif (SAM)/Pointed domain; Sterile alpha motif (SAM)/Pointed domain is found in about 40% of transcriptional regulators of ETS family (initially named for Erythroblastosis virus, E26-E Twenty Six). SAM Pointed domain containing proteins of this family additionally have a C-terminal ETS DNA-binding domain. In a few cases, SAM Pointed domain appears as a single domain protein. Members of this group are mostly involved in regulation of embryonic development and growth control in eukaryotes. SAM Pointed domains mediate protein-protein interactions. Depending on the subgroup, they can interact with other SAM Pointed domains forming homo or hetero dimers/oligomers and/or they can recruit a protein kinase to its target which can be a SAM Pointed domain containing protein itself or another protein that has no kinase docking site. Thus, SAM Pointed domains participate in transcriptional regulation and signal transduction. Some genes coding ETS family transcriptional regulators are proto-oncogenes. They are prone to chromosomal translocations resulting in gene fusions. Chimeric proteins with SAM Pointed domains were found in a number of different human tumors including myeloid leukemia, lymphoblastic leukemia, Ewing's sarcoma and primitive neuroectodermal tumor. Members of this family are potential targets for cancer therapy.


Pssm-ID: 188876  Cd Length: 67  Bit Score: 85.07  E-value: 2.07e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 372466582 242 NPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLE 304
Cdd:cd08203    1 DPLEWTPEHVQQWLSWVSKKFSLDPIDPDRFPMNGKELCALSKEDFRERAPSRGGDVLASHLA 63
Ets1_N_flank pfam19525
Ets1 N-terminal flanking region of Ets domain; Ets1 is a member of the Ets family of ...
 416-502 7.54e-19

Ets1 N-terminal flanking region of Ets domain; Ets1 is a member of the Ets family of transcription factors in which the DNA-binding activity is in an autoinhibited state. The autoinhibition of Ets1 is mediated by structural coupling of the regions flanking the Ets domain. The inhibitory regions are folded as helices HI1 and HI2 N-terminal to the ETS domain and as H4 C-terminal to the ETS domain, which are packed together to form an inhibitory module. This domain represents the N-terminal flanking region of Ets domain which contains the residues forming HI1 and HI2 helices and additional residues(244-301) N-terminal to HI1. HI1 and HI2 exert the autoinhibitory function by directing the inhibitory residues N-terminal to HI1 to mask the Ets domain DNA-binding surface. These residues are flexible and function by masking the DNA-binding surface of the Ets domain. Phosphorylation of serine residues present in this region enhances autoinhibition dramatically. These inhibitory sequences are required for cooperative DNA binding.


Pssm-ID: 466113  Cd Length: 188  Bit Score: 84.66  E-value: 7.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  416 HDSPENgADSFESSDSLLQSWNSQSSLLDVQRVPSFESFE-DDCSQSLCLNKPTMSFKDYIQERSDpVEQGKPVIPAAVL 494
Cdd:pfam19525 103 QDSFES-IESYDSCDRLTQSWSSQSSFQSLQRVPSYDSFDsEDYPAALPSHKPKGTFKDYVRDRAD-LNKDKPVIPAAAL 180


                  ....*...
gi 372466582  495 AGFTGSGP 502
Cdd:pfam19525 181 AGYTGRMM 188
SAM_PNT-Tel_Yan cd08535
Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; SAM Pointed domain of Tel ...
 243-309 2.41e-18

Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; SAM Pointed domain of Tel (Translocation, Ets, Leukemia)/Yan subfamily of ETS transcriptional repressors is a protein-protein interaction domain. SAM Pointed domains of this type of regulators can interact with each other, forming head-to-tail homodimers or homooligomers, and/or interact with SAM Pointed domains of another subfamily of ETS factors forming heterodimers. The oligomeric form is able to block transcription of target genes and is involved in MAPK signaling. They participate in regulation of different processes during embryoniv development including hematopoietic differentiation and eye development. Tel/Yan transcriptional factors are frequent targets of chromosomal translocations resulting in fusions of SAM domain with new neighboring genes. Such chimeric proteins were found in different tumors. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 176085  Cd Length: 68  Bit Score: 79.35  E-value: 2.41e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 372466582 243 PWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPdFVGDILWEHLEQMIKE 309
Cdd:cd08535    3 PRQWSREDVLQWLRWAENEFSLPPIDSNTFEMNGKALCLLTKEDFRYRCP-HAGDVLYNLLQHLLKQ 68
SAM_PNT-ERG_FLI-1 cd08531
Sterile alpha motif (SAM)/Pointed domain of ERG (Ets related gene) and FLI-1 (Friend leukemia ...
 239-303 2.35e-16

Sterile alpha motif (SAM)/Pointed domain of ERG (Ets related gene) and FLI-1 (Friend leukemia integration 1) transcription factors; SAM Pointed domain of ERG/FLI-1 subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. The ERG and FLI regulators are involved in endothelial cell differentiation, bone morphogenesis and neural crest development. They are proto-oncogenes implicated in cancer development such as myeloid leukemia, Ewing's sarcoma and erythroleukemia. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188877  Cd Length: 75  Bit Score: 73.98  E-value: 2.35e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 372466582 239 IPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRF-GMNGQMLCNLGKERFLELAPDFVGDILWEHL 303
Cdd:cd08531    1 VPADPLLWTREHVRQWVEWAIKEYSLKDVDVSRFdNIDGKELCRMTRDDFLRLTSAYNGDVLISHL 66
SAM_PNT-FLI-1 cd08541
Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription ...
 234-303 1.96e-13

Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator; SAM Pointed domain of FLI-1 (Friend Leukemia Integration) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. The FLI-1 protein participates in regulation of cellular differentiation, proliferation, and survival. The Fli-1 gene was initially described in Friend virus-induced erythroleukemias as a site for virus integration. It is highly expressed in hematopoietic tissues and at lower level in lungs, heart, and ovaries. Fli-1 is a proto-oncogene implicated in Ewing's sarcoma and erythroleukemia. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188883  Cd Length: 91  Bit Score: 66.23  E-value: 1.96e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 372466582 234 QRRLGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRF-GMNGQMLCNLGKERFLELAPDFVGDILWEHL 303
Cdd:cd08541    8 ERRVIVPADPTLWSQDHVRQWLEWAIKEYGLMEIDTSLFqNMDGKELCKMSKEDFLRLTSLYNTEVLLSHL 78
SAM_PNT-ERG cd08540
Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor; SAM Pointed domain of ...
 239-303 2.65e-13

Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor; SAM Pointed domain of ERG subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It may participate in formation of homodimers or heterodimers with ETS-2, Fli-1, ER81, and Pu-1. However, dimeric forms are inactive and SAM Pointed domain is not essential for dimerization, since ER81 and Pu-1 do not have it. In mouse, a regulator of this type binds the ESET histone H3-specific methyltransferase (human homolog is SETDB1), which leads to modification of the local chromatin structure through histone methylation. ERG regulators are involved in endothelial cell differentiation, bone morphogenesis and neural crest development. The Erg gene is a proto-oncogene. It is a target of chromosomal translocations resulting in fusions with other neighboring genes. Chimeric proteins were found in solid tumors such as myeloid leukemia or Ewing's sarcoma. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 176090  Cd Length: 75  Bit Score: 65.37  E-value: 2.65e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 372466582 239 IPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRF-GMNGQMLCNLGKERFLELAPDFVGDILWEHL 303
Cdd:cd08540    1 VPADPTLWSTDHVRQWLEWAVKEYGLPDVDVLLFqNIDGKELCKMTKEDFQRLTPSYNADILLSHL 66
SAM_PNT-PDEF-like cd08532
Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; SAM Pointed domain of ...
 237-304 2.69e-11

Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; SAM Pointed domain of PDEF-like (Prostate-Derived ETS Factor) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. In human males this activator is highly expressed in the prostate gland and enhances androgen-mediated activation of the PSA promoter though interaction with the DNA binding domain of androgen receptor. PDEF may play a role in prostate cancer development as well as in goblet cell formation and mucus production in the epithelial lining of respiratory and intestinal tracts.


Pssm-ID: 188878  Cd Length: 81  Bit Score: 59.68  E-value: 2.69e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 372466582 237 LGIPKNPWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDfVGDILWEHLE 304
Cdd:cd08532    8 LGISPDPYQWSTANVQAWLQWTEHQYRLPPNPPRCFQMNGKTLCALSEEDFVRRAPQ-GGDTLHAQLE 74
SAM_PNT-Mae cd08536
Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog; Mae (Modulator of the ...
 243-301 1.15e-08

Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog; Mae (Modulator of the Activity of ETS) subfamily represents a group of SAM Pointed monodomain proteins. SAM Pointed domain is a protein-protein interaction domain. It can interact with other SAM pointed domains forming head-to-tail heterodimers and also provides a kinase docking site. For example, in Drosophila Mae is required for facilitating phosphorylation of the Yan factor and for blocking phosphorylation of the ETS-2 regulator. Mae interacts with the SAM Pointed domains of Yan and ETS-2. Binding enhances access of the kinase to the Yan phosphorylation site by providing a kinase docking site, or inhibits phosphorylation of ETS-2 by blocking its docking site. This type of factors participates in regulation of kinase signaling particularly during embryogenesis.


Pssm-ID: 176086  Cd Length: 66  Bit Score: 51.95  E-value: 1.15e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 372466582 243 PWLWSEQQVCQWLLWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDfVGDILWE 301
Cdd:cd08536    2 PRSWSREHVRTWLRWVSARYQLEVVDLDKFLMNGKGLCLMSLEGFLYRVPV-GGKLLYE 59
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 14-136 8.54e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 52.30  E-value: 8.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  14 RLPFGATSTTAPSLRNSkGRFGVRALAPerTPSAPRKVSARLPGRTLARTWGRGPAPGASGPAGEGPSRVTAGGGGKLRA 93
Cdd:PRK07764 384 RLGVAGGAGAPAAAAPS-AAAAAPAAAP--APAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAA 460

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 372466582  94 PGAARP--ASGLPDRLWPAPSPSPGAHRAAAGAEQPPSRPSAGPA 136
Cdd:PRK07764 461 APSAQPapAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAG 505
SAM_PNT_ESE cd08757
Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM ...
 243-305 1.74e-06

Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM Pointed domain of ESE-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. ETS factors are important for cell differentiation. They can be involved in regulation of gene expression in different types of epithelial cells. They are expressed in salivary gland, intestine, stomach, pancreas, lungs, kidneys, colon, mammary gland, and prostate. Members of this group are proto-oncogenes. Expression profiles of these factors are altered in epithelial cancers, which makes them potential targets for cancer therapy.


Pssm-ID: 188885  Cd Length: 69  Bit Score: 45.79  E-value: 1.74e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 372466582 243 PWLWSEQQVCQWLL-WA-TNEFSLVNVNLQRF-GMNGQMLCNLGKERFLELAPDFvGDILWEHLEQ 305
Cdd:cd08757    2 PQHWTKNDVLDWLLfVAeQNKIDAEEINFQKFdNIDGQTLCSMSLEEFIERDGVY-GNLLYAELRR 66
PHA03378 PHA03378
EBNA-3B; Provisional
 16-136 2.11e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 50.84  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  16 PFGATSTTAPSLRNSKGRFGVRALAPERTPSAPrKVSARLPGRTLARTWGRGPAPGASGP--AGEGPSRVTAGGGGKLR- 92
Cdd:PHA03378 678 PTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAP-PGRAQRPAAATGRARPPAAAPGRARPpaAAPGRARPPAAAPGRARp 756

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 372466582  93 ---APGAARPASGLPDRLWPAPSPS--PGAHRAAAGAEQPPSRPSAGPA 136
Cdd:PHA03378 757 paaAPGRARPPAAAPGAPTPQPPPQapPAPQQRPRGAPTPQPPPQAGPT 805
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 37-136 6.09e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.21  E-value: 6.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  37 RALAPeRTPSAPRKVSARLPgrTLARtwgRGPAPGASGPAGEGPSRVTAGGGGKLRAPGAARPASGLPdrlwPAPSPSPG 116
Cdd:PRK07764 361 RMLLP-SASDDERGLLARLE--RLER---RLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAA----PAPAAAPQ 430

                         90       100
                 ....*....|....*....|
gi 372466582 117 AHRAAAGAEQPPSRPSAGPA 136
Cdd:PRK07764 431 PAPAPAPAPAPPSPAGNAPA 450
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
19-138 1.69e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.95  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  19 ATSTTAPSLRNSKGRFGVRALAPERTPsAPRKVSARLPGRTLARTWGRGPAPGASGPAGEGPSRVTAGGGGklraPGAAR 98
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAAAPAPAA-PPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP----GGAPA 449

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 372466582  99 PASGlpdrlwPAPSPSPGAHRAAAGAEQPPSRPSAGPARS 138
Cdd:PRK12323 450 PAPA------PAAAPAAAARPAAAGPRPVAAAAAAAPARA 483
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 40-141 2.78e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.29  E-value: 2.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  40 APERTPSAPRKVSARLPGRTLARTWGRGPAPGAS--GPAGEGPSRVTAGGGGKLRAPGAARPASGLPDRLWPAPSPSPGA 117
Cdd:PRK07764 620 APAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHpkHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPA 699

                         90       100
                 ....*....|....*....|....
gi 372466582 118 HRAAAGAEQPPSRPSAGPARSGRM 141
Cdd:PRK07764 700 QPAPAPAATPPAGQADDPAAQPPQ 723
SAM_PNT-ESE-1-like cd08537
Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM ...
 242-306 5.00e-05

Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators; SAM Pointed domain of ESE-1-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. SAM Pointed domain of ESE-1 provides a potential docking site for signaling kinase Pak1 in humans. ESE-1 factors are involved in regulation of gene expression in different types of epithelial cells. ESE-1 is expressed in many different organs including intestine, stomach, pancreas, lungs, kidneys, and prostate. The DNA binding consensus motif for ESE-1 consists of a purine-rich GGA[AT] core sequence. The expression profile of these factors is altered in epithelial cancers if compared to normal tissues. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188880  Cd Length: 81  Bit Score: 42.14  E-value: 5.00e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 372466582 242 NPWLWSEQQVCQWLLW--ATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQM 306
Cdd:cd08537   11 NPQFWSKQNVLEWISYhvEKNKYDASSLDLSYCTMDGLTLCACAKEQLMLVFGPELGDLLHHSLEEL 77
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
59-158 6.38e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.00  E-value: 6.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  59 TLARTWGRGPAPGA-SGPAGEGPSRV---------TAGGGGKLRAPGAARPASGLPDRlwpAPSPSPGAHRAAAGAEQPP 128
Cdd:PRK07003 351 TLLRMLAFEPAVTGgGAPGGGVPARVagavpapgaRAAAAVGASAVPAVTAVTGAAGA---ALAPKAAAAAAATRAEAPP 427

                         90       100       110
                 ....*....|....*....|....*....|
gi 372466582 129 SRPSagPARSGrmnDFGIKNMDQVAPVANS 158
Cdd:PRK07003 428 AAPA--PPATA---DRGDDAADGDAPVPAK 452
PHA03378 PHA03378
EBNA-3B; Provisional
 45-137 6.73e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 6.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  45 PSAPRKVSARlPGRtlARTWGRGPAPGASGPAGEGPSRVTAGGGGKLR----APGAARPASGLPDRLWPaPSPSPGAHRA 120
Cdd:PHA03378 681 ANTMLPIQWA-PGT--MQPPPRAPTPMRPPAAPPGRAQRPAAATGRARppaaAPGRARPPAAAPGRARP-PAAAPGRARP 756

                         90
                 ....*....|....*..
gi 372466582 121 AAGAEQPPSRPSAGPAR 137
Cdd:PHA03378 757 PAAAPGRARPPAAAPGA 773
SAM_PNT-ESE-3-like cd08539
Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM ...
 242-306 1.62e-04

Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM Pointed domain of ESE-3-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. The ESE-3 transcriptional activator is involved in regulation of glandular epithelium differentiation through the MAP kinase signaling cascade. It is found to be expressed in glandular epithelium of prostate, pancreas, salivary gland, and trachea. Additionally, ESE-3 is differentially expressed during monocyte-derived dendritic cells development. DNA binding consensus motif for ESE-3 consists of purine-rich GGAA/T core sequence. The expression profiles of these factors are altered in epithelial cancers. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188882  Cd Length: 78  Bit Score: 40.40  E-value: 1.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 372466582 242 NPWLWSEQQVCQWL--LWATNEFSLVNVNLQRFGMNGQMLCNLGKERFLELAPDfVGDILWEHLEQM 306
Cdd:cd08539    8 HPQYWTKFQVWEWLqhLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGT-AGQLLYSNLQHL 73
SAM_PNT-ESE-2-like cd08538
Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators; SAM ...
 242-291 1.87e-04

Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators; SAM Pointed domain of ESE-2-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. ESE-2 factors are involved in regulation of gene expression in a variety of epithelial (glandular and secretory) cells. ESE-2 mRNA was found in skin keratinocytes, salivary gland, mammary gland, stomach, prostate, and kidneys. The DNA binding consensus motif for ESE-2 consists of a GGA core and AT-rich flanks. The expression profiles of these factors are altered in epithelial cancers. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188881  Cd Length: 84  Bit Score: 40.39  E-value: 1.87e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 372466582 242 NPWLWSEQQVCQWLLWATNEFSL-VN-VNLQRFGMNGQMLCNLGKERFLELA 291
Cdd:cd08538   12 HPEYWTKRHVWEWLQFCCDQYKLdANcISFCHFNISGLQLCSMTQEEFLDAA 63
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 34-140 2.28e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 2.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  34 FGVRALAPERTPSAPRKV--SARLPGRTLARTWGRGPAPGASGPAGEGPSRVTAGGGGklRAPGAARPASGLPDRLWPAP 111
Cdd:PRK07764 387 VAGGAGAPAAAAPSAAAAapAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSP--AGNAPAGGAPSPPPAAAPSA 464

                         90       100
                 ....*....|....*....|....*....
gi 372466582 112 SPSPGAHRAAAGAEQPPSRPSAGPARSGR 140
Cdd:PRK07764 465 QPAPAPAAAPEPTAAPAPAPPAAPAPAAA 493
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 60-140 2.62e-04

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 43.84  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  60 LARTWGRGPAPGAS---GPAGEGPSRVTAGGGGKLRAPGAARPASGL---------PDRLWPAPSPSPGAHRAAAGAEQP 127
Cdd:NF041121  11 LAAQMGRAAAPPSPegpAPTAASQPATPPPPAAPPSPPGDPPEPPAPepaplpapyPGSLAPPPPPPPGPAGAAPGAALP 90

                         90
                 ....*....|...
gi 372466582 128 PSRPSAGPARSGR 140
Cdd:NF041121  91 VRVPAPPALPNPL 103
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
18-168 4.46e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 4.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  18 GATSTTAPSLRNSKGRFGVRALAPErtPSAPRKVSARLPGRTLARTwgRGPAPGASGPAGEGPSRVTAGGGGKLRAPGAA 97
Cdd:PRK07003 384 GARAAAAVGASAVPAVTAVTGAAGA--ALAPKAAAAAAATRAEAPP--AAPAPPATADRGDDAADGDAPVPAKANARASA 459

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 372466582  98 RPASGLPDrlwPAPSPSPGAHRAAAGaEQPPSRPSAGPARSGRMNDFGIKNMDQVAPVANSYRGTLKRQPA 168
Cdd:PRK07003 460 DSRCDERD---AQPPADSGSASAPAS-DAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAA 526
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2-140 6.13e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 6.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582    2 GSAQFQGLITQARLPFGATSTTAPSLRNSKGRfGVRALAPERTPSAPRKvSARLPGRTLARTWGRGPAPGASGPAGEGPS 81
Cdd:PHA03307  258 PRPAPITLPTRIWEASGWNGPSSRPGPASSSS-SPRERSPSPSPSSPGS-GPAPSSPRASSSSSSSRESSSSSTSSSSES 335

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 372466582   82 RVTAGGGgklRAPGAARPASGLPDRLWPAPSPSPgahRAAAGAEQPPSRPSAGPARSGR 140
Cdd:PHA03307  336 SRGAAVS---PGPSPSRSPSPSRPPPPADPSSPR---KRPRPSRAPSSPAASAGRPTRR 388
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 45-154 7.72e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 7.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  45 PSAPRKVSARLPGRTLARtwgrgpaPGASGPAGEGPSRVTAGGGGKLRAPGAARPASGLPDRLWPAPSPSPGAHRAAAGA 124
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPAR-------PEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAP 438

                         90       100       110
                 ....*....|....*....|....*....|
gi 372466582 125 EQPPSRPSAGPARSGRMNDFGIKNMDQVAP 154
Cdd:PRK14951 439 AAAPAAVALAPAPPAQAAPETVAIPVRVAP 468
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 40-135 9.96e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 9.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  40 APERTPSAPRKVSARLPGRTLARTWGRGPAPGASGPAGEGPSRVTAGGGGKLRAPGAARPASGLPDRLWPAPSP-SPGAH 118
Cdd:PRK07764 682 PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPaQPPPP 761

                         90
                 ....*....|....*..
gi 372466582 119 RAAAGAEQPPSRPSAGP 135
Cdd:PRK07764 762 PAPAPAAAPAAAPPPSP 778
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 9-141 1.15e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582    9 LITQARLPFGATSTTAPSLRNSKGRFGVRALAPERtPSAPRKVSARLPGRTLARTWGRGPAPGASGPAGEGPSRVTAGGG 88
Cdd:PHA03307  775 LEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAA-DAASRTASKRKSRSHTPDGGSESSGPARPPGAAARPPPARSSES 853

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 372466582   89 GKLR-APGAARPASGLPDRLWPAPSPSPGAHRAAAGAEQPPSRPSAGPARSGRM 141
Cdd:PHA03307  854 SKSKpAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRP 907
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 55-137 1.17e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.97  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  55 LPGRTLARTWGRGPAPGASGPAGEGpsrvtAGGGGKLRAPGAAR-----------PASGLPDRLWPAPSPSPgahrAAAG 123
Cdd:PRK14959 366 MPVESLRPSGGGASAPSGSAAEGPA-----SGGAATIPTPGTQGpqgtapaagmtPSSAAPATPAPSAAPSP----RVPW 436

                         90
                 ....*....|....*
gi 372466582 124 AEQPPSRP-SAGPAR 137
Cdd:PRK14959 437 DDAPPAPPrSGIPPR 451
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
40-137 1.62e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  40 APERTPSAPR--KVSARLPGRTLARTWGRGPAPGASGPAGEGPSRVTAGGGGK----LRAPGAARPASGLPDRLWPAPSP 113
Cdd:PRK12323 373 GPATAAAAPVaqPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARrspaPEALAAARQASARGPGGAPAPAP 452

                         90       100
                 ....*....|....*....|....
gi 372466582 114 SPGAhrAAAGAEQPPSRPSAGPAR 137
Cdd:PRK12323 453 APAA--APAAAARPAAAGPRPVAA 474
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 37-115 1.64e-03

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 41.03  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  37 RALAPERTPSAPRKVSARLPGRTLARTwgrgpAPGASGPAGEGPSRVTAGGGGKLRAPGA------------ARPASGLP 104
Cdd:PHA03201   7 RSPSPPRRPSPPRPTPPRSPDASPEET-----PPSPPGPGAEPPPGRAAGPAAPRRRPRGcpagvtfsssapPRPPLGLD 81

                         90
                 ....*....|.
gi 372466582 105 DRlwPAPSPSP 115
Cdd:PHA03201  82 DA--PAATPPP 90
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
36-140 2.03e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  36 VRALAPERTPSAPRKVSARLPGRTLARTWGRGPAPGASGPAGEGPSRV-------TAGGGGKLRAPGAARPASGLPDRLW 108
Cdd:PRK12323 459 AAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFaspapaqPDAAPAGWVAESIPDPATADPDDAF 538

                         90       100       110
                 ....*....|....*....|....*....|..
gi 372466582 109 PAPSPSPGAHRAAAGAEQPPSRPSAGPARSGR 140
Cdd:PRK12323 539 ETLAPAPAAAPAPRAAAATEPVVAPRPPRASA 570
PHA03247 PHA03247
large tegument protein UL36; Provisional
 28-138 2.18e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   28 RNSKGRFGVRALAPERTPSAPRKVSARLPGRTLArTWGRGPAPgasGPAGEGPSRVTAGGGGKLRAPGAARPASGLPDrL 107
Cdd:PHA03247 2663 RPRRARRLGRAAQASSPPQRPRRRAARPTVGSLT-SLADPPPP---PPTPEPAPHALVSATPLPPGPAAARQASPALP-A 2737

                          90       100       110
                  ....*....|....*....|....*....|..
gi 372466582  108 WPAPSPSPGAHRAAAGAEQPPSRPS-AGPARS 138
Cdd:PHA03247 2738 APAPPAVPAGPATPGGPARPARPPTtAGPPAP 2769
PHA03247 PHA03247
large tegument protein UL36; Provisional
 21-136 2.65e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   21 STTAPSLRNSKGRFGVRALAPERT-PSAPRKVSARLPGRTlartwgrgPAPGASGPAGEGPSRVTAGGGGKLRA-PGAAR 98
Cdd:PHA03247  382 TRKRRSARHAATPFARGPGGDDQTrPAAPVPASVPTPAPT--------PVPASAPPPPATPLPSAEPGSDDGPApPPERQ 453

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 372466582   99 PASGLPDRLWPAPSPSPGAHRAAAGAEQPPSRPSAGPA 136
Cdd:PHA03247  454 PPAPATEPAPDDPDDATRKALDALRERRPPEPPGADLA 491
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
19-136 2.83e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  19 ATSTTAPSLRNSKGRFGVRALAPERTPSAPRKVSARLPGRTLARTWGRGPAPGASGPAgegPSRVTAGGGGKLRAPGAAR 98
Cdd:PRK07003 436 ADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPA---PRAAAPSAATPAAVPDARA 512

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 372466582  99 PASG-LPDRLWPAPSPSPGAHRAAAGAEQPPSRPSAGPA 136
Cdd:PRK07003 513 PAAAsREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAA 551
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 18-136 2.85e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 2.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  18 GATSTTAPSLRNSkGRFGVRALAPERT--PSAPRKVSARLPGRTLARTWGRGPAPGASGPAGEGPSRVTAGGGGKLRAPG 95
Cdd:PRK07764 596 GGEGPPAPASSGP-PEEAARPAAPAAPaaPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAG 674

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 372466582  96 AARPASglpdrlwPAPSPSPGAHRAAAGaeQPPSRPSAGPA 136
Cdd:PRK07764 675 GAAPAA-------PPPAPAPAAPAAPAG--AAPAQPAPAPA 706
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 16-135 3.36e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 3.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  16 PFGATSTTAPSLRNSKGRFGVRALAPERTPSAPRKVSARLPGRTlARTWGRGPAPGASGPAGEGPSRVTAGGGGKLRAPG 95
Cdd:PRK07764 627 PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP-AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 372466582  96 AARPASGlpdrlwPAPSPSPGAHRAAAGAEQPPSRPSAGP 135
Cdd:PRK07764 706 AATPPAG------QADDPAAQPPQAAQGASAPSPAADDPV 739
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 12-140 3.61e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 3.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   12 QARLPFGATSTTAPSLRNSKGRFGVRALAPERTPSAPRK-----VSARLPGRTLARTWGRGPAPGASGPAGEGPSRVTAG 86
Cdd:PHA03307  171 QAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRsspisASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWG 250

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 372466582   87 GGGKLRAPGAARPAsgLPDRLW-------PAPSPSPGAHRAAAGAEQP---PSRPSAGPARSGR 140
Cdd:PHA03307  251 PENECPLPRPAPIT--LPTRIWeasgwngPSSRPGPASSSSSPRERSPspsPSSPGSGPAPSSP 312
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 28-136 4.06e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 4.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  28 RNSKGRFGVRALAPERTPSAPRKVSARLPGRTLARtwgrGPAPGASGPAGEGPSRVTAGGGGKLRAPGAARPASGLPDRL 107
Cdd:PRK14951 367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAP----APAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAP 442

                         90       100
                 ....*....|....*....|....*....
gi 372466582 108 WPAPSPSPGAHRAAAGAEQPPSRPSAGPA 136
Cdd:PRK14951 443 AAVALAPAPPAQAAPETVAIPVRVAPEPA 471
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
36-138 4.41e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.22  E-value: 4.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  36 VRALAPERTPSAPRKVSARLPgrtlARTWGRGPAPGASGPAGEGPSRVTAGGGGKLRAPGAARPASGLPDRLWPAPSPSP 115
Cdd:PRK07003 353 LRMLAFEPAVTGGGAPGGGVP----ARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPA 428

                         90       100
                 ....*....|....*....|...
gi 372466582 116 GAHRAAAGAEQPPSRPSAGPARS 138
Cdd:PRK07003 429 APAPPATADRGDDAADGDAPVPA 451
PHA03247 PHA03247
large tegument protein UL36; Provisional
 76-155 4.68e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 4.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   76 AGEGPSRVTAGGGGklRAPGAARPASGLPDRLWPAP-----SPSPGAHRAA-AGA----EQPPSRPSAGPARSGRMNDFG 145
Cdd:PHA03247  253 AAPAPPPVVGEGAD--RAPETARGATGPPPPPEAAApngaaAPPDGVWGAAlAGAplalPAPPDPPPPAPAGDAEEEDDE 330

                          90
                  ....*....|
gi 372466582  146 IKNMDQVAPV 155
Cdd:PHA03247  331 DGAMEVVSPL 340
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
68-140 4.82e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.86  E-value: 4.82e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 372466582  68 PAPGASGPAGEGPSRVTAGGGGKLRAPGAARPASGLPDRLWPAPSPSPGAH----RAAAGAEQPPSRPSAGPARSGR 140
Cdd:PRK12323 387 PAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARqasaRGPGGAPAPAPAPAAAPAAAAR 463
PHA03247 PHA03247
large tegument protein UL36; Provisional
 16-134 5.40e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   16 PFGATSTTAPSLRNSKGRFGVRAL----APERTPSAP-RKVSARLPGRTLARTWGRGPAPGAsGPAGEGPSRVTAGGGGK 90
Cdd:PHA03247 2712 PHALVSATPLPPGPAAARQASPALpaapAPPAVPAGPaTPGGPARPARPPTTAGPPAPAPPA-APAAGPPRRLTRPAVAS 2790

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 372466582   91 LRAPGAARPASglpdrlwPAPSPSPGAHRAAAGAEQPPSRPSAG 134
Cdd:PHA03247 2791 LSESRESLPSP-------WDPADPPAAVLAPAAALPPAASPAGP 2827
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
38-131 7.03e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 7.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  38 ALAPERTPSAPRKVSARLPGRTLARTWGRGPAPGASGPAgegPSRVTAggggklRAPGAARPASGLPDRLWPAPSPSPGA 117
Cdd:PRK12323 413 AAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA---PAPAAA------PAAAARPAAAGPRPVAAAAAAAPARA 483

                         90
                 ....*....|....
gi 372466582 118 HRAAAGAEQPPSRP 131
Cdd:PRK12323 484 APAAAPAPADDDPP 497
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 2-139 9.50e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 38.78  E-value: 9.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582   2 GSAQFQGLITQARLPFGATSTTAPSLRNSKGRFGVRALAPERTPSAPRKVSARlPGRTLArtwgrGPAPGASGPA-GEGP 80
Cdd:PTZ00436 197 AAAKQKAAAKKAAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAA-PAKAAA-----PPAKAAAPPAkAAAP 270

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 372466582  81 SRVTAGGGGKLRAPGAARPASGLPDRLWPAPSPSPGAHRAAAGAEQ--PPSRPSAGPARSG 139
Cdd:PTZ00436 271 PAKAAAPPAKAAAPPAKAAAPPAKAAAAPAKAAAAPAKAAAAPAKAaaPPAKAAAPPAKAA 331
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 57-136 9.95e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 9.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 372466582  57 GRTLARTWGRGPAPGASGPAGegpsrvTAGGGGKLRAPGAARPASGLPdrlWPAPSPSPGAHRAAAGAEQPPSRPSAGPA 136
Cdd:PRK07764 579 GGDWQVEAVVGPAPGAAGGEG------PPAPASSGPPEEAARPAAPAA---PAAPAAPAPAGAAAAPAEASAAPAPGVAA 649
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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