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Conserved domains on  [gi|371872799|ref|NP_001243094|]
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calcium load-activated calcium channel isoform c [Homo sapiens]

Protein Classification

EMC3/TMCO1 family protein( domain architecture ID 10487831)

EMC3/TMCO1 family protein is a DUF106 domain-containing integral membrane protein; similar to Homo sapiens calcium load-activated calcium channel (TMCO1) and ER membrane protein complex subunit 3 (EMC3)

Gene Ontology:  GO:0016020
PubMed:  27212239|26256539

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMC3_TMCO1 pfam01956
Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and ...
 11-153 4.27e-39

Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and archaeal proteins. Eukaryotic members include EMC3, a subunit of the ER membrane protein complex (EMC) required for protein folding, and TMCO1, a ER calcium load-activated calcium channel. Archaeal members may function as insertases of the archaeal plasma membrane.


:

Pssm-ID: 396507  Cd Length: 169  Bit Score: 130.86  E-value: 4.27e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371872799   11 SGITWVLVYRT--DKYKRLKAEVEKQSKKLEkkketitESAGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTA 88
Cdd:pfam01956  32 ELLQKLLIDRKkmEKYKKRMKEFQKRARELR-------KNGDKLSLKKFEKRQEELMEDQKEMMMDMMKPNFAIMIPQIP 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 371872799   89 LMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLA 153
Cdd:pfam01956 105 IMFWINYFFSGFVVAKLPFPLTGRFKGMLQRGLDGLDVTWVSSISWYFLCSFGLSQVIRKLLGIA 169
 
Name Accession Description Interval E-value
EMC3_TMCO1 pfam01956
Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and ...
 11-153 4.27e-39

Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and archaeal proteins. Eukaryotic members include EMC3, a subunit of the ER membrane protein complex (EMC) required for protein folding, and TMCO1, a ER calcium load-activated calcium channel. Archaeal members may function as insertases of the archaeal plasma membrane.


Pssm-ID: 396507  Cd Length: 169  Bit Score: 130.86  E-value: 4.27e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371872799   11 SGITWVLVYRT--DKYKRLKAEVEKQSKKLEkkketitESAGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTA 88
Cdd:pfam01956  32 ELLQKLLIDRKkmEKYKKRMKEFQKRARELR-------KNGDKLSLKKFEKRQEELMEDQKEMMMDMMKPNFAIMIPQIP 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 371872799   89 LMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLA 153
Cdd:pfam01956 105 IMFWINYFFSGFVVAKLPFPLTGRFKGMLQRGLDGLDVTWVSSISWYFLCSFGLSQVIRKLLGIA 169
 
Name Accession Description Interval E-value
EMC3_TMCO1 pfam01956
Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and ...
 11-153 4.27e-39

Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and archaeal proteins. Eukaryotic members include EMC3, a subunit of the ER membrane protein complex (EMC) required for protein folding, and TMCO1, a ER calcium load-activated calcium channel. Archaeal members may function as insertases of the archaeal plasma membrane.


Pssm-ID: 396507  Cd Length: 169  Bit Score: 130.86  E-value: 4.27e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371872799   11 SGITWVLVYRT--DKYKRLKAEVEKQSKKLEkkketitESAGRQQKKKIERQEEKLKNNNRDLSMVRMKSMFAIGFCFTA 88
Cdd:pfam01956  32 ELLQKLLIDRKkmEKYKKRMKEFQKRARELR-------KNGDKLSLKKFEKRQEELMEDQKEMMMDMMKPNFAIMIPQIP 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 371872799   89 LMGMFNSIFDGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLA 153
Cdd:pfam01956 105 IMFWINYFFSGFVVAKLPFPLTGRFKGMLQRGLDGLDVTWVSSISWYFLCSFGLSQVIRKLLGIA 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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