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Conserved domains on  [gi|368711318|ref|NP_001243040|]
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immunoglobulin superfamily member 2 isoform 2 precursor [Homo sapiens]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 616-732 5.74e-09

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


:

Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 54.65  E-value: 5.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 616 VNSRSQVQELSINSNTDIECSILSRSNGNlqlAIIWYFSPVSTNASWLKILEMDQTNViktgdefhTPQRKQKFHTEKVS 695
Cdd:cd00099    1 VTQSPRSLSVQEGESVTLSCEVSSSFSST---YIYWYRQKPGQGPEFLIYLSSSKGKT--------KGGVPGRFSGSRDG 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 368711318 696 QDLFQLHILNVEDSDRGKYHCAVEEWLLS---TNGTWHKL 732
Cdd:cd00099   70 TSSFSLTISNLQPEDSGTYYCAVSESGGTdklTFGSGTRL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 233-331 1.34e-06

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


:

Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 48.10  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 233 AEGKPLELVCLVVSSGRDPQLQgiWFFNGTEIAHIDAGGVLGLKNDYKERASqGELQVSKLGPKAFSLKIFSLGPEDEGA 312
Cdd:cd00099   11 QEGESVTLSCEVSSSFSSTYIY--WYRQKPGQGPEFLIYLSSSKGKTKGGVP-GRFSGSRDGTSSFSLTISNLQPEDSGT 87

                         90       100
                 ....*....|....*....|..
gi 368711318 313 YRCVVAEVMKTRT---GSWQVL 331
Cdd:cd00099   88 YYCAVSESGGTDKltfGSGTRL 109
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 768-853 6.81e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 43.09  E-value: 6.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 768 VAIRCSLESVGSSATLYsvmWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHcyRSSSTDFVLKLHQVEMEDAGMYWC 847
Cdd:cd00099   16 VTLSCEVSSSFSSTYIY---WYRQKPGQGPEFLIYLSSSKGKTKGGVPGRFSGS--RDGTSSFSLTISNLQPEDSGTYYC 90


                 ....*.
gi 368711318 848 RVAEWQ 853
Cdd:cd00099   91 AVSESG 96
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 23-121 2.08e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.63  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318   23 EVTVQKGPLFRAEGYPVSIGCNVTGHQGPSeqhFQWsvylptnptqevqiisTKDaafsyavyTQRVRSGDVYVERVQGN 102
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPPT---ITW----------------YKN--------GEPISSGSTRSRSLSGS 55

                          90
                  ....*....|....*....
gi 368711318  103 SVLLHISKLQMKDAGEYEC 121
Cdd:pfam13927  56 NSTLTISNVTRSDAGTYTC 74
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 352-452 2.96e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


:

Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.24  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318  352 VMSTKNKQQVVWEGETLAFLCKAGGAESPlSVSWWHIprdqtqpefvagmgqdgivqlgasyGVPSYHGNTRLEKMDWAT 431
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPP-TITWYKN-------------------------GEPISSGSTRSRSLSGSN 56

                          90       100
                  ....*....|....*....|.
gi 368711318  432 FQLEITFTAITDSGTYECRVS 452
Cdd:pfam13927  57 STLTISNVTRSDAGTYTCVAS 77
 
Name Accession Description Interval E-value
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 616-732 5.74e-09

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 54.65  E-value: 5.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 616 VNSRSQVQELSINSNTDIECSILSRSNGNlqlAIIWYFSPVSTNASWLKILEMDQTNViktgdefhTPQRKQKFHTEKVS 695
Cdd:cd00099    1 VTQSPRSLSVQEGESVTLSCEVSSSFSST---YIYWYRQKPGQGPEFLIYLSSSKGKT--------KGGVPGRFSGSRDG 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 368711318 696 QDLFQLHILNVEDSDRGKYHCAVEEWLLS---TNGTWHKL 732
Cdd:cd00099   70 TSSFSLTISNLQPEDSGTYYCAVSESGGTdklTFGSGTRL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 233-331 1.34e-06

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 48.10  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 233 AEGKPLELVCLVVSSGRDPQLQgiWFFNGTEIAHIDAGGVLGLKNDYKERASqGELQVSKLGPKAFSLKIFSLGPEDEGA 312
Cdd:cd00099   11 QEGESVTLSCEVSSSFSSTYIY--WYRQKPGQGPEFLIYLSSSKGKTKGGVP-GRFSGSRDGTSSFSLTISNLQPEDSGT 87

                         90       100
                 ....*....|....*....|..
gi 368711318 313 YRCVVAEVMKTRT---GSWQVL 331
Cdd:cd00099   88 YYCAVSESGGTDKltfGSGTRL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 768-853 6.81e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 43.09  E-value: 6.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 768 VAIRCSLESVGSSATLYsvmWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHcyRSSSTDFVLKLHQVEMEDAGMYWC 847
Cdd:cd00099   16 VTLSCEVSSSFSSTYIY---WYRQKPGQGPEFLIYLSSSKGKTKGGVPGRFSGS--RDGTSSFSLTISNLQPEDSGTYYC 90


                 ....*.
gi 368711318 848 RVAEWQ 853
Cdd:cd00099   91 AVSESG 96
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 23-121 2.08e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.63  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318   23 EVTVQKGPLFRAEGYPVSIGCNVTGHQGPSeqhFQWsvylptnptqevqiisTKDaafsyavyTQRVRSGDVYVERVQGN 102
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPPT---ITW----------------YKN--------GEPISSGSTRSRSLSGS 55

                          90
                  ....*....|....*....
gi 368711318  103 SVLLHISKLQMKDAGEYEC 121
Cdd:pfam13927  56 NSTLTISNVTRSDAGTYTC 74
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 352-452 2.96e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.24  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318  352 VMSTKNKQQVVWEGETLAFLCKAGGAESPlSVSWWHIprdqtqpefvagmgqdgivqlgasyGVPSYHGNTRLEKMDWAT 431
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPP-TITWYKN-------------------------GEPISSGSTRSRSLSGSN 56

                          90       100
                  ....*....|....*....|.
gi 368711318  432 FQLEITFTAITDSGTYECRVS 452
Cdd:pfam13927  57 STLTISNVTRSDAGTYTCVAS 77
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 761-850 1.70e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 38.98  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318  761 NVTEHREVAIRCSLESvGSSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGlRRHLHCYRSSStDFVLKLHQVEME 840
Cdd:pfam07686   7 TVALGGSVTLPCTYSS-SMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKG-RFSGRGDPSNG-DGSLTIQNLTLS 83

                          90
                  ....*....|
gi 368711318  841 DAGMYWCRVA 850
Cdd:pfam07686  84 DSGTYTCAVI 93
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 360-460 2.54e-03

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 38.79  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 360 QVVWEGETLAFLCKAGGAESPlSVSWWHIPR--DQTQPEFVAGMGQDGiVQLGASYgvpsyhgntrlekMDWATFQLEIT 437
Cdd:cd20940   10 QQRLVGDSVELHCEAVGSPIP-EIQWWFEGQepNEICSQLWDGARLDR-VHINATY-------------HQHATSTISID 74

                         90       100
                 ....*....|....*....|....
gi 368711318 438 FTAITDSGTYECRVS-EKSRNQAR 460
Cdd:cd20940   75 NLTEEDTGTYECRASnDPDRNHLT 98
IGv smart00406
Immunoglobulin V-Type;
768-847 3.29e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 37.36  E-value: 3.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318   768 VAIRCSLEsvGSSATLYSVMWYwnRENSGSKL-LVHLQHDGLLEYGEEGLRRHLHCYRSSS-TDFVLKLHQVEMEDAGMY 845
Cdd:smart00406   2 VTLSCKFS--GSTFSSYYVSWV--RQPPGKGLeWLGYIGSNGSSYYQESYKGRFTISKDTSkNDVSLTISNLRVEDTGTY 77


                   ..
gi 368711318   846 WC 847
Cdd:smart00406  78 YC 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 234-330 7.42e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 7.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318   234 EGKPLELVClVVSSGRDPQLQgiWFFNGTEiahidaggVLGLKNDYKERASQGElqvsklgpkaFSLKIFSLGPEDEGAY 313
Cdd:smart00410   8 EGESVTLSC-EASGSPPPEVT--WYKQGGK--------LLAESGRFSVSRSGST----------STLTISNVTPEDSGTY 66

                           90
                   ....*....|....*..
gi 368711318   314 RCVVAEVMKTRTGSWQV 330
Cdd:smart00410  67 TCAATNSSGSASSGTTL 83
 
Name Accession Description Interval E-value
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 616-732 5.74e-09

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 54.65  E-value: 5.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 616 VNSRSQVQELSINSNTDIECSILSRSNGNlqlAIIWYFSPVSTNASWLKILEMDQTNViktgdefhTPQRKQKFHTEKVS 695
Cdd:cd00099    1 VTQSPRSLSVQEGESVTLSCEVSSSFSST---YIYWYRQKPGQGPEFLIYLSSSKGKT--------KGGVPGRFSGSRDG 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 368711318 696 QDLFQLHILNVEDSDRGKYHCAVEEWLLS---TNGTWHKL 732
Cdd:cd00099   70 TSSFSLTISNLQPEDSGTYYCAVSESGGTdklTFGSGTRL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 233-331 1.34e-06

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 48.10  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 233 AEGKPLELVCLVVSSGRDPQLQgiWFFNGTEIAHIDAGGVLGLKNDYKERASqGELQVSKLGPKAFSLKIFSLGPEDEGA 312
Cdd:cd00099   11 QEGESVTLSCEVSSSFSSTYIY--WYRQKPGQGPEFLIYLSSSKGKTKGGVP-GRFSGSRDGTSSFSLTISNLQPEDSGT 87

                         90       100
                 ....*....|....*....|..
gi 368711318 313 YRCVVAEVMKTRT---GSWQVL 331
Cdd:cd00099   88 YYCAVSESGGTDKltfGSGTRL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 768-853 6.81e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 43.09  E-value: 6.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 768 VAIRCSLESVGSSATLYsvmWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHcyRSSSTDFVLKLHQVEMEDAGMYWC 847
Cdd:cd00099   16 VTLSCEVSSSFSSTYIY---WYRQKPGQGPEFLIYLSSSKGKTKGGVPGRFSGS--RDGTSSFSLTISNLQPEDSGTYYC 90


                 ....*.
gi 368711318 848 RVAEWQ 853
Cdd:cd00099   91 AVSESG 96
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 23-121 2.08e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.63  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318   23 EVTVQKGPLFRAEGYPVSIGCNVTGHQGPSeqhFQWsvylptnptqevqiisTKDaafsyavyTQRVRSGDVYVERVQGN 102
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPPT---ITW----------------YKN--------GEPISSGSTRSRSLSGS 55

                          90
                  ....*....|....*....
gi 368711318  103 SVLLHISKLQMKDAGEYEC 121
Cdd:pfam13927  56 NSTLTISNVTRSDAGTYTC 74
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 352-452 2.96e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.24  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318  352 VMSTKNKQQVVWEGETLAFLCKAGGAESPlSVSWWHIprdqtqpefvagmgqdgivqlgasyGVPSYHGNTRLEKMDWAT 431
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPP-TITWYKN-------------------------GEPISSGSTRSRSLSGSN 56

                          90       100
                  ....*....|....*....|.
gi 368711318  432 FQLEITFTAITDSGTYECRVS 452
Cdd:pfam13927  57 STLTISNVTRSDAGTYTCVAS 77
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 768-849 4.45e-04

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 40.46  E-value: 4.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 768 VAIRCSLESVGSSATLYsvmwyWNRENSGSKLLVHLQhdgllEYGEEGLRRHLHCYRSSSTdFVLKLHQVEMEDAGMYWC 847
Cdd:cd05716   15 VTIQCPYPPKYASSRKY-----WCKWGSEGCQTLVSS-----EGVVPGGRISLTDDPDNGV-FTVTLNQLRKEDAGWYWC 83


                 ..
gi 368711318 848 RV 849
Cdd:cd05716   84 GV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 19-140 1.50e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 38.98  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318   19 IGQREVTVqkgplfrAEGYPVSIGCNVTGHQGPSEQHFQWSVYLPTNPTQEVQIISTKDaafsyavYTQRVRSGDVYVER 98
Cdd:pfam07686   1 QTPREVTV-------ALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYSNG-------SEEGVKKGRFSGRG 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 368711318   99 -VQGNSVLLHISKLQMKDAGEYECHTPNtdeKYYGSYSAKTNL 140
Cdd:pfam07686  67 dPSNGDGSLTIQNLTLSDSGTYTCAVIP---SGEGVFGKGTRL 106
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 761-850 1.70e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 38.98  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318  761 NVTEHREVAIRCSLESvGSSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGlRRHLHCYRSSStDFVLKLHQVEME 840
Cdd:pfam07686   7 TVALGGSVTLPCTYSS-SMSEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKG-RFSGRGDPSNG-DGSLTIQNLTLS 83

                          90
                  ....*....|
gi 368711318  841 DAGMYWCRVA 850
Cdd:pfam07686  84 DSGTYTCAVI 93
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 360-460 2.54e-03

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 38.79  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318 360 QVVWEGETLAFLCKAGGAESPlSVSWWHIPR--DQTQPEFVAGMGQDGiVQLGASYgvpsyhgntrlekMDWATFQLEIT 437
Cdd:cd20940   10 QQRLVGDSVELHCEAVGSPIP-EIQWWFEGQepNEICSQLWDGARLDR-VHINATY-------------HQHATSTISID 74

                         90       100
                 ....*....|....*....|....
gi 368711318 438 FTAITDSGTYECRVS-EKSRNQAR 460
Cdd:cd20940   75 NLTEEDTGTYECRASnDPDRNHLT 98
IGv smart00406
Immunoglobulin V-Type;
768-847 3.29e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 37.36  E-value: 3.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318   768 VAIRCSLEsvGSSATLYSVMWYwnRENSGSKL-LVHLQHDGLLEYGEEGLRRHLHCYRSSS-TDFVLKLHQVEMEDAGMY 845
Cdd:smart00406   2 VTLSCKFS--GSTFSSYYVSWV--RQPPGKGLeWLGYIGSNGSSYYQESYKGRFTISKDTSkNDVSLTISNLRVEDTGTY 77


                   ..
gi 368711318   846 WC 847
Cdd:smart00406  78 YC 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 762-849 4.54e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 4.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318   762 VTEHREVAIRCSLesvgSSATLYSVMWYWNRENsgskllvhlqhdgLLEYGEEGLRRHlhcyrsSSTDFVLKLHQVEMED 841
Cdd:smart00410   6 VKEGESVTLSCEA----SGSPPPEVTWYKQGGK-------------LLAESGRFSVSR------SGSTSTLTISNVTPED 62


                   ....*...
gi 368711318   842 AGMYWCRV 849
Cdd:smart00410  63 SGTYTCAA 70
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 234-330 7.42e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 7.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 368711318   234 EGKPLELVClVVSSGRDPQLQgiWFFNGTEiahidaggVLGLKNDYKERASQGElqvsklgpkaFSLKIFSLGPEDEGAY 313
Cdd:smart00410   8 EGESVTLSC-EASGSPPPEVT--WYKQGGK--------LLAESGRFSVSRSGST----------STLTISNVTPEDSGTY 66

                           90
                   ....*....|....*..
gi 368711318   314 RCVVAEVMKTRTGSWQV 330
Cdd:smart00410  67 TCAATNSSGSASSGTTL 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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