BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  14 CYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggaaaa 93
Cdd:cd18207    1 SYTYQVSQHSADMLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGT-------------- 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 358424828  94 pgggaggSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQ 162
Cdd:cd18207   67 -------PRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQSNVQ 128

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 358424828 379 GEKPYSCPV--CGLRFKRKDRMSYHVR---------------SHDGSV--GKPYICQSCGKGFSRPDHLNGHIKQVH 436
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIFSakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  14 CYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggaaaa 93
Cdd:cd18207    1 SYTYQVSQHSADMLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGT-------------- 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 358424828  94 pgggaggSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQ 162
Cdd:cd18207   67 -------PRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQSNVQ 128

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828    42 DVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGaadggpadvggaaaapgggaggSRELEMHTISSKVFGDILDFA 121
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD----------------------KSEIYLDDVSPEDFRALLNFL 58

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 358424828   122 YTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQS 159
Cdd:smart00225  59 YTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKL 96

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 358424828 357 CEICGKIFRDVYHLNRHKLSHSGEKPYSCPVCGLRFKRKDRMS--YHVRSHDGS 408
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNN 89

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828 329 PRLGENGlPISEDPDGPRKRSRTRKQVACEI--CGKIFRDVYHLNRHKL---------------SHSG----EKPYSCPV 387
Cdd:COG5189  325 GKLAHGG-ERNIDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIfsakDKPYRCEV 403

                         90       100
                 ....*....|....*....|
gi 358424828 388 CGLRFKRKDRMSYHVR-SHD 406
Cdd:COG5189  404 CDKRYKNLNGLKYHRKhSHD 423

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 358424828   383 YSCPVCGLRFKRKDRMSYHVRSH 405
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  14 CYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggaaaa 93
Cdd:cd18207    1 SYTYQVSQHSADMLHNLNQQRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGT-------------- 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 358424828  94 pgggaggSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQ 162
Cdd:cd18207   67 -------PRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQSNVQ 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  40 FCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggaaaapggGAGGSRELEMHTISSKVFGDILD 119
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGM----------------------KESSSSEIELDDVSPEAFEALLD 58

                         90       100
                 ....*....|....*....|....
gi 358424828 120 FAYTSRIVVRLESFPELMTAAKFL 143
Cdd:cd18186   59 YIYTGELELSEENVEELLAAADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  21 RHSTEMLHNLNQQRKnGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggaaaapgggagg 100
Cdd:cd18256    2 KHASLILAQLNKLRG-QHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSK--------------------- 59

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 358424828 101 sRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIK 157
Cdd:cd18256   60 -DVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLK 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggaaaapggGAGGS 101
Cdd:cd18242    4 HAKSILNTMNSLRKSN-TLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEM----------------------SEKGK 60

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 358424828 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQE 154
Cdd:cd18242   61 SEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCE 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828   3 RVNDASCGPSGCYTYQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadg 82
Cdd:cd18267    4 RKSRASSGSMNIYLFHKSSYADSVLTHLNLLRQQR-LFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGL-------- 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 358424828  83 gpadvggaaaapggGAGGSRELEMH-TISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQS 159
Cdd:cd18267   75 --------------KESQDSEVNFHdSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKN 138

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADggpadvggaaaapgggaggs 101
Cdd:cd18326    8 HSSDILSSLNEQRTQG-LLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNV-------------------- 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 358424828 102 reLEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVI 156
Cdd:cd18326   67 --YEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828    42 DVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGaadggpadvggaaaapgggaggSRELEMHTISSKVFGDILDFA 121
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD----------------------KSEIYLDDVSPEDFRALLNFL 58

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 358424828   122 YTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQS 159
Cdd:smart00225  59 YTGKLDLPEENVEELLELADYLQIPGLVELCEEFLLKL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADggpadvggaaaapgggaggs 101
Cdd:cd18328    8 HSSEVLCSLNEQRHDG-LLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYV-------------------- 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 358424828 102 reLEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVI 156
Cdd:cd18328   67 --YEIDFVTPEALSAILEFAYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  21 RHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQlgdggaadggpadvggaaaapgggagG 100
Cdd:cd18332    1 RHSSDVLLNLNELRKRD-ILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGR--------------------------V 53

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 358424828 101 SRELEMHTISSKV----FGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIK 157
Cdd:cd18332   54 GEGVSVLTLPSGLeargFQLLLDFMYTSRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  15 YTYQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGpadvggaaaap 94
Cdd:cd18278    7 YVYESTVHCTNILLCLNDQRKQD-ILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLP----------- 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 358424828  95 gggaggsrelemHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEIC 152
Cdd:cd18278   75 ------------EEVTARGFGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSC 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  30 LNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAadggpadvggaaaapgggaggsRELEMHTI 109
Cdd:cd18240    8 FNELRLEG-KLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEK----------------------KVYKIPGV 64

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 358424828 110 SSKVFGDILDFAYTSRIVVRLESFPELMTAA-KFLLMRSVIEICQEVIKQ 158
Cdd:cd18240   65 SPEMMELIIEYAYTRTVPITAENVEELLPAAdQFNIMGIVKACCDFLEDQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggPADVGGAAAAPGGGAGGS 101
Cdd:cd18195    1 HAGALLLQLNEQRLRG-LFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPL---------PLGAAAVAAAPGATQSPE 70

                         90       100
                 ....*....|....*....|....*..
gi 358424828 102 RELEMHTISSKVFGDILDFAYTSRIVV 128
Cdd:cd18195   71 RVLELPGVKAGVFSDVLNFIYSSRVAL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggaaaapggGAGGS 101
Cdd:cd18254    5 HPDCVLTHLNTLRKQC-MFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGL----------------------RESLD 61

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 358424828 102 RELEMH-TISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQS 159
Cdd:cd18254   62 STVNFHdSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKN 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSaqlgdggaadggpadvggaaaapgggAGGS 101
Cdd:cd18232    1 HSVKVLQALNKQREEG-QYCDATLDVGGRVFKAHWSVLACCSHFFQSLYG--------------------------DGTS 53

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 358424828 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQ 153
Cdd:cd18232   54 GSVVLPESFAEVFGLLLDFFYTGELALTRENRDRVLLAAKELRVPEAVELCQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  15 YTYQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDggaadggpadvggaaaap 94
Cdd:cd18277    3 FAYESSVHSTNVLLSLNDQRKKD-VLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADA------------------ 63

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 358424828  95 gggaggsrELEM---HTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEIC 152
Cdd:cd18277   64 --------ELNItlpEEVTVKGFEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggaaaapggGAGGS 101
Cdd:cd18235    4 HTQKAFDVMNELRKQN-LLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDL----------------------SESRA 60

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 358424828 102 RELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQE 154
Cdd:cd18235   61 NRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  18 QVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQlgdggaadggpadvggaaaapggg 97
Cdd:cd18222    4 EIPDFSNSVLSHLNQLRMQG-RLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLN------------------------ 58

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 358424828  98 aggsrelEMHTIS------SKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQI 163
Cdd:cd18222   59 -------EMSTVSisviknPTVFEQLLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILEGIHFKI 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  22 HSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggaaaapgggagGS 101
Cdd:cd18194    6 HSRQLLQCLREQRSQG-FLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRL-------------------------DK 59

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 358424828 102 RE---LEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQ 153
Cdd:cd18194   60 RDlvrLNSDIVTAPAFGLLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  20 SRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggaaaapggGAG 99
Cdd:cd18237    2 AKLLADFMGVMNNMRKQK-TLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNM----------------------TES 58

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 358424828 100 GSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18237   59 KSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  17 YQVSRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLgdggaadggpadvggaaaapgg 96
Cdd:cd18266    3 YRWADHSNLVLQGLNEQRQRG-LFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGM---------------------- 59

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 358424828  97 GAGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18266   60 REAHQKEVELVGASYIGLKAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLEN 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  20 SRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFES-VFSAQLGdggaadggpadvggaaaapggga 98
Cdd:cd18216    1 PSHATQLLLQLNNQRTKG-FLCDVIIVVENSLFRAHKNVLAASSGYFKSlVLHDNLI----------------------- 56

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 358424828  99 ggsrELEMHTISSKVFGDILDFAYTSRIVVRLE---SFPELMTAAKFLLMRSVIEICQEVIKQ 158
Cdd:cd18216   57 ----HLDQDMVSPTVFQQILDFIYTGKLLDSLFeepNLSEVLAAANYLQLPDLAALCRSKLKR 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  20 SRHSTEMLHNLNQQRKNGgRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAqlgdggaadggpadvggaaaapgggag 99
Cdd:cd18219    2 TQYSGSLLKSLNEQRGHG-LFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSV--------------------------- 53

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 358424828 100 GSRELEMHTISSKVFGDILDFAYTSRIV-VRLESFPELMTAAKFL 143
Cdd:cd18219   54 AGQVVELNFIRADIFAEILNYIYSSKIVrVRSDLLEELIKSGQLL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358424828  41 CDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGpadvggaaaapgggaggsrelemHTISSKVFGDILDF 120
Cdd:cd18955    2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLVITLP-----------------------EEVTVKGFEPLLQF 58

                         90       100       110
                 ....*....|....*....|....*....|..
gi 358424828 121 AYTSRIVVRLESFPELMTAAKFLLMRSVIEIC 152
Cdd:cd18955   59 AYTAKLLLSKENVLEVCRCAEFLGVHNIEKAC 90