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Conserved domains on  [gi|358439536|ref|NP_001240616|]
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MICOS complex subunit Mic60 isoform 4 [Mus musculus]

Protein Classification

MICOS complex subunit MIC60( domain architecture ID 12101363)

MICOS complex subunit MIC60 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-697 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


:

Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 591.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  123 LPVAQSQKTKGDTPASAAGDTLSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVTLQTITAQNAAV 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVAEEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESATAVAKEAKDDAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  203 QAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITA 282
Cdd:pfam09731 157 QAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  283 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMtGKLSTDDLNSLIAHAHRR 362
Cdd:pfam09731 217 APETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKED-NLLSNDDLNSLIAHAHRE 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  363 IDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQA 438
Cdd:pfam09731 296 IDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQA 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  439 AAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 518
Cdd:pfam09731 375 EAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQ 443

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  519 QLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAM 598
Cdd:pfam09731 444 QLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSL 523

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  599 IDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKE 678
Cdd:pfam09731 524 IDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKE 599

                         650
                  ....*....|....*....
gi 358439536  679 ARMTLETKQIVEILTAYAS 697
Cdd:pfam09731 600 ARRRLEVQQALELLQAEAA 618
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-697 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 591.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  123 LPVAQSQKTKGDTPASAAGDTLSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVTLQTITAQNAAV 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVAEEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESATAVAKEAKDDAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  203 QAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITA 282
Cdd:pfam09731 157 QAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  283 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMtGKLSTDDLNSLIAHAHRR 362
Cdd:pfam09731 217 APETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKED-NLLSNDDLNSLIAHAHRE 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  363 IDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQA 438
Cdd:pfam09731 296 IDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQA 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  439 AAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 518
Cdd:pfam09731 375 EAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQ 443

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  519 QLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAM 598
Cdd:pfam09731 444 QLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSL 523

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  599 IDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKE 678
Cdd:pfam09731 524 IDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKE 599

                         650
                  ....*....|....*....
gi 358439536  679 ARMTLETKQIVEILTAYAS 697
Cdd:pfam09731 600 ARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 228-528 7.62e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 7.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536 228 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 307
Cdd:COG1196  232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536 308 akvvsqyHELVVQARDDFRKELDSItpditpgwkgmtgklsTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK 387
Cdd:COG1196  304 -------IARLEERRRELEERLEEL----------------EEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536 388 HKLEEKRtfdSAVAKALEHHRSEIQAEQDRKVEEVRDAME-----NEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 462
Cdd:COG1196  361 AEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAELEEEE 437

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 358439536 463 GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQshAVAEEEARKAHQLWLSVEALK 528
Cdd:COG1196  438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA--ELLEELAEAAARLLLLLEAEA 501
PTZ00121 PTZ00121
MAEBL; Provisional
 197-520 4.30e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 4.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  197 AQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALK--ERRKAVDEA----------ADALLKAKEELEK---M 261
Cdd:PTZ00121 1344 AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKkaEEKKKADEAkkkaeedkkkADELKKAAAAKKKadeA 1423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  262 KTIIEDAKKREIAGAtphiTAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDdfRKELDSITPditpgwK 341
Cdd:PTZ00121 1424 KKKAEEKKKADEAKK----KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEE--AKKADEAKK------K 1491

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  342 GMTGKLSTDDLNSlIAHAHRRIDQLNRELAQQKATEKQHIElalEKHKLEEKRTFDSaVAKALEHHRSE--IQAEQDRKV 419
Cdd:PTZ00121 1492 AEEAKKKADEAKK-AAEAKKKADEAKKAEEAKKADEAKKAE---EAKKADEAKKAEE-KKKADELKKAEelKKAEEKKKA 1566

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  420 EEVRDAMENEMRTQLRRQAAAHTDHLR--DVLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARL 497
Cdd:PTZ00121 1567 EEAKKAEEDKNMALRKAEEAKKAEEARieEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEK 1646

                         330       340       350
                  ....*....|....*....|....*....|....
gi 358439536  498 RGIEQ-----------AVQSHAVAEEEARKAHQL 520
Cdd:PTZ00121 1647 KKAEElkkaeeenkikAAEEAKKAEEDKKKAEEA 1680
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 173-506 3.70e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.44  E-value: 3.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   173 TTALAKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRK 242
Cdd:TIGR02168  624 GVLVVDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEK 698

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   243 AVDEAADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 322
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   323 DDFRKELDSITPDITpgwkgmTGKLSTDDLNSLIAHAHRRIDQLNRELAQQK-----------ATEKQHIELALEK---- 387
Cdd:TIGR02168  778 AEAEAEIEELEAQIE------QLKEELKALREALDELRAELTLLNEEAANLRerleslerriaATERRLEDLEEQIeels 851

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   388 -------HKLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKV 451
Cdd:TIGR02168  852 edieslaAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LEL 929

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 358439536   452 QEQELKYEFEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 506
Cdd:TIGR02168  930 RLEGLEVRIDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-697 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 591.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  123 LPVAQSQKTKGDTPASAAGDTLSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVTLQTITAQNAAV 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVAEEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESATAVAKEAKDDAI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  203 QAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKREIAGATPHITA 282
Cdd:pfam09731 157 QAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQSEEEAAPPLLDA 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  283 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMtGKLSTDDLNSLIAHAHRR 362
Cdd:pfam09731 217 APETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKED-NLLSNDDLNSLIAHAHRE 295

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  363 IDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQA 438
Cdd:pfam09731 296 IDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQA 374

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  439 AAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 518
Cdd:pfam09731 375 EAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQ 443

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  519 QLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAM 598
Cdd:pfam09731 444 QLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSL 523

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  599 IDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKE 678
Cdd:pfam09731 524 IDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKE 599

                         650
                  ....*....|....*....
gi 358439536  679 ARMTLETKQIVEILTAYAS 697
Cdd:pfam09731 600 ARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 228-528 7.62e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.10  E-value: 7.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536 228 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 307
Cdd:COG1196  232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536 308 akvvsqyHELVVQARDDFRKELDSItpditpgwkgmtgklsTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK 387
Cdd:COG1196  304 -------IARLEERRRELEERLEEL----------------EEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL 360

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536 388 HKLEEKRtfdSAVAKALEHHRSEIQAEQDRKVEEVRDAME-----NEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 462
Cdd:COG1196  361 AEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAELEEEE 437

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 358439536 463 GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQshAVAEEEARKAHQLWLSVEALK 528
Cdd:COG1196  438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA--ELLEELAEAAARLLLLLEAEA 501
PTZ00121 PTZ00121
MAEBL; Provisional
 197-520 4.30e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 4.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  197 AQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALK--ERRKAVDEA----------ADALLKAKEELEK---M 261
Cdd:PTZ00121 1344 AAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKkaEEKKKADEAkkkaeedkkkADELKKAAAAKKKadeA 1423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  262 KTIIEDAKKREIAGAtphiTAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDdfRKELDSITPditpgwK 341
Cdd:PTZ00121 1424 KKKAEEKKKADEAKK----KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEE--AKKADEAKK------K 1491

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  342 GMTGKLSTDDLNSlIAHAHRRIDQLNRELAQQKATEKQHIElalEKHKLEEKRTFDSaVAKALEHHRSE--IQAEQDRKV 419
Cdd:PTZ00121 1492 AEEAKKKADEAKK-AAEAKKKADEAKKAEEAKKADEAKKAE---EAKKADEAKKAEE-KKKADELKKAEelKKAEEKKKA 1566

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  420 EEVRDAMENEMRTQLRRQAAAHTDHLR--DVLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARL 497
Cdd:PTZ00121 1567 EEAKKAEEDKNMALRKAEEAKKAEEARieEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEK 1646

                         330       340       350
                  ....*....|....*....|....*....|....
gi 358439536  498 RGIEQ-----------AVQSHAVAEEEARKAHQL 520
Cdd:PTZ00121 1647 KKAEElkkaeeenkikAAEEAKKAEEDKKKAEEA 1680
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
228-451 2.83e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 2.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  228 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKR----EIAGATPHITAAEGRLHNmiVDLDNVVKKVQA 303
Cdd:COG4913   692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRleaaEDLARLELRALLEERFAA--ALGDAVERELRE 769

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  304 A------QSEAKVVSQYHELV--------------------VQARDDFRKELDSITPDITPG----WKGMTGKLSTDDLN 353
Cdd:COG4913   770 NleeridALRARLNRAEEELEramrafnrewpaetadldadLESLPEYLALLDRLEEDGLPEyeerFKELLNENSIEFVA 849

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  354 SL-------IAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAM 426
Cdd:COG4913   850 DLlsklrraIREIKERIDPLNDSLKRIPFGPGRYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEARFAALKRLI 929

                         250       260
                  ....*....|....*....|....*.
gi 358439536  427 EnemrtQLRRQAAAHTDH-LRDVLKV 451
Cdd:COG4913   930 E-----RLRSEEEESDRRwRARVLDV 950
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 173-506 3.70e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.44  E-value: 3.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   173 TTALAKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRK 242
Cdd:TIGR02168  624 GVLVVDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEK 698

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   243 AVDEAADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 322
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   323 DDFRKELDSITPDITpgwkgmTGKLSTDDLNSLIAHAHRRIDQLNRELAQQK-----------ATEKQHIELALEK---- 387
Cdd:TIGR02168  778 AEAEAEIEELEAQIE------QLKEELKALREALDELRAELTLLNEEAANLRerleslerriaATERRLEDLEEQIeels 851

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   388 -------HKLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKV 451
Cdd:TIGR02168  852 edieslaAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LEL 929

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 358439536   452 QEQELKYEFEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 506
Cdd:TIGR02168  930 RLEGLEVRIDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 400-519 3.49e-05

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 44.27  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  400 VAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAhtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRS 479
Cdd:pfam15346  24 VEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREA---------ELEEERRKEEEERKKREELERILEENNRKI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 358439536  480 QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 519
Cdd:pfam15346  95 EEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQ 134
PTZ00121 PTZ00121
MAEBL; Provisional
 212-520 1.56e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  212 LKTAMDNSEIAGEKKSAQWRTVEGALK--ERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIAGAtphitaaegrlhn 289
Cdd:PTZ00121 1283 LKKAEEKKKADEAKKAEEKKKADEAKKkaEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAK------------- 1349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  290 mivdldnvvKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITpditpgwKGMTGKLSTDDLNSLIAHAHRRIDQLNRE 369
Cdd:PTZ00121 1350 ---------AEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAK-------KKAEEKKKADEAKKKAEEDKKKADELKKA 1413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  370 LAQQKATEKQhielaleKHKLEEKRTFDSAVAKAlehhrseiqaEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVL 449
Cdd:PTZ00121 1414 AAAKKKADEA-------KKKAEEKKKADEAKKKA----------EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAK 1476

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 358439536  450 KVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSftldintayARLRGIEQAVQS-HAVAEEEARKAHQL 520
Cdd:PTZ00121 1477 KKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKA---------DEAKKAEEAKKAdEAKKAEEAKKADEA 1539
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 350-518 1.91e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.06  E-value: 1.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   350 DDLNSLIAHAHRRIDQLNREL--AQQKATEKQ-HIELALEKH-----KLEEKRTFDSAVAKALEHHRSEIQ------AEQ 415
Cdd:TIGR02169  691 SSLQSELRRIENRLDELSQELsdASRKIGEIEkEIEQLEQEEeklkeRLEELEEDLSSLEQEIENVKSELKeleariEEL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   416 DRKVEEVRDAMEN-----------EMRTQLRRQAAAHTDhLRDVLKVQEQEL-KYEFEQGLSEKLSEQELEFRRRSQEQM 483
Cdd:TIGR02169  771 EEDLHKLEEALNDlearlshsripEIQAELSKLEEEVSR-IEARLREIEQKLnRLTLEKEYLEKEIQELQEQRIDLKEQI 849

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 358439536   484 DSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 518
Cdd:TIGR02169  850 KSIEKEIENLNGKKEELEEELEELEAALRDLESRL 884
PTZ00121 PTZ00121
MAEBL; Provisional
 197-520 1.96e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 1.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  197 AQNAAVQAVKAHsNILKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEK---MKTIIEDAKKREI 273
Cdd:PTZ00121 1449 AKKKAEEAKKAE-EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadeAKKAEEAKKADEA 1527

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  274 AGATPHITAAEGRLHNMIVDLDNV-----------VKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKG 342
Cdd:PTZ00121 1528 KKAEEAKKADEAKKAEEKKKADELkkaeelkkaeeKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKM 1607

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  343 MTGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEkrtfDSAVAKALEHHRSEiqaEQDRKVEEV 422
Cdd:PTZ00121 1608 KAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE----ENKIKAAEEAKKAE---EDKKKAEEA 1680

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  423 RDAMENEMrtqlrrqaaahtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSftldintAYARLRGIEQ 502
Cdd:PTZ00121 1681 KKAEEDEK-------------------KAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA-------EEENKIKAEE 1734

                         330
                  ....*....|....*...
gi 358439536  503 AVQShavAEEEARKAHQL 520
Cdd:PTZ00121 1735 AKKE---AEEDKKKAEEA 1749
PTZ00121 PTZ00121
MAEBL; Provisional
 361-537 6.41e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 6.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  361 RRIDQLNR-ELAQQKATEKQHIElalEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQaa 439
Cdd:PTZ00121 1224 KKAEAVKKaEEAKKDAEEAKKAE---EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKA-- 1298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  440 ahtdhlRDVLKVQEQELKYEfEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARlRGIEQAVQSHAVAEEEARKAHQ 519
Cdd:PTZ00121 1299 ------EEKKKADEAKKKAE-EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEAEAAEEKAEAAE 1370

                         170
                  ....*....|....*...
gi 358439536  520 LWLSVEALKYSMKTSSAE 537
Cdd:PTZ00121 1371 KKKEEAKKKADAAKKKAE 1388
COG4223 COG4223
Uncharacterized conserved protein [Function unknown];
464-698 7.49e-04

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443367 [Multi-domain]  Cd Length: 259  Bit Score: 41.96  E-value: 7.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536 464 LSEKLSEQELEFRRRSQEQMDsftLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSaemptiPL 543
Cdd:COG4223   39 LEARLAALRAALAAAREAVAA---AAAAALEARLAALEAKAAAPEAEAAAAARAAALALAAAALRAAVERGQ------PF 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536 544 GSAVEAIRVNCSDNEFTQALTAAippesLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLlfppk 623
Cdd:COG4223  110 AAELAALEALAPDAPALAALAAF-----AATGVPTLAALRAEFPAAARAALAAARAPEADASWLDRLLAFARSLV----- 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 358439536 624 QLKPPAElyPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASA 698
Cdd:COG4223  180 TVRRVGP--VEGDDPDAILARAEAALAAGDLAGALAELEALPEAAQAAAAPWIAKAEARLAADAALQALAAQALA 252
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
357-500 8.68e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 8.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  357 AHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEkrtfDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMR----- 431
Cdd:COG4913   647 REALQRLAEYSWDEIDVASAEREIAELEAELERLDA----SSDDLAALEEQLEELEAELEELEEELDELKGEIGRlekel 722

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  432 TQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSE-KLSEQELEFRRRSQEQMDSFTLDINTAYARLRGI 500
Cdd:COG4913   723 EQAEEELDELQDRLEAAEDLARLELRALLEERFAAaLGDAVERELRENLEERIDALRARLNRAEEELERA 792
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 369-541 1.30e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  369 ELAQQKATEKQHIELALEKHKLEEKRtfdsavaKALEHHRSeiQAEQDRKVEEVRDAMENEMRTqlRRQAAAHTDHLRDV 448
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERKR-------KKLELEKE--KRDRKRAEEQRRKILEKELEE--RKQAMIEEERKRKL 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  449 LKVQEQELK---YEFEQ---GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRgiEQAVQSHAVAEEEARKAHQLWL 522
Cdd:pfam17380 518 LEKEMEERQkaiYEEERrreAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMER--EREMMRQIVESEKARAEYEATT 595

                         170       180
                  ....*....|....*....|.
gi 358439536  523 SVEALK--YSMKTSSAEMPTI 541
Cdd:pfam17380 596 PITTIKpiYRPRISEYQPPDV 616
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 171-471 1.30e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.13  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   171 SETTALAKSLEDAlNRTSSVTLQTITAQnaAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADA 250
Cdd:pfam12128  664 SEKDKKNKALAER-KDSANERLNSLEAQ--LKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAA 740

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   251 L-LKAKEELEKMKTiiedAKKREIAGATPHitaaEGRLHNMIVDLDNVVKKV-QAAQSEAKVVSQ---YHELVVQARDDF 325
Cdd:pfam12128  741 RrSGAKAELKALET----WYKRDLASLGVD----PDVIAKLKREIRTLERKIeRIAVRRQEVLRYfdwYQETWLQRRPRL 812

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   326 RKELDSITPDITPgwkgmtgklSTDDLNSLIAHAHRRIDQLNRELaqqKATEKQHIELALEKHKLeekRTFDSAVAKALE 405
Cdd:pfam12128  813 ATQLSNIERAISE---------LQQQLARLIADTKLRRAKLEMER---KASEKQQVRLSENLRGL---RCEMSKLATLKE 877

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   406 HHRSE----IQAEQDRKVEEVRDAMENEMrtqlrRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQ 471
Cdd:pfam12128  878 DANSEqaqgSIGERLAQLEDLKLKRDYLS-----ESVKKYVEHFKNVIADHSGSGLAETWESLREEDHYQ 942
PTZ00121 PTZ00121
MAEBL; Provisional
 116-486 1.50e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  116 EVMKDSKLPVAQSQKTKGDTPASAAGDTLSVPAPAVQHEDTIKT---ECPNTNEGKSTSETTALAKSLE---------DA 183
Cdd:PTZ00121 1395 EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkaeEAKKADEAKKKAEEAKKAEEAKkkaeeakkaDE 1474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  184 LNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALK-ERRKAVDEAADALLKAK-EELEKM 261
Cdd:PTZ00121 1475 AKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKaEEAKKADEAKKAEEKKKaDELKKA 1554

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  262 ktiiEDAKKREIAGATPHITAAEGRlHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPgwK 341
Cdd:PTZ00121 1555 ----EELKKAEEKKKAEEAKKAEED-KNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELK--K 1627

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  342 GMTGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALE-KHKLEEKRTFDSAVAKALEHHRSEiqAEQDRKVE 420
Cdd:PTZ00121 1628 AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEdKKKAEEAKKAEEDEKKAAEALKKE--AEEAKKAE 1705

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  421 EVRDAMENEMRT--QLRRQAAAHTDHLRDVLKVQEQ------ELKYE----------------------------FEQGL 464
Cdd:PTZ00121 1706 ELKKKEAEEKKKaeELKKAEEENKIKAEEAKKEAEEdkkkaeEAKKDeeekkkiahlkkeeekkaeeirkekeavIEEEL 1785

                         410       420
                  ....*....|....*....|..
gi 358439536  465 SEKLSEQELEFRRRSQEQMDSF 486
Cdd:PTZ00121 1786 DEEDEKRRMEVDKKIKDIFDNF 1807
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 364-482 2.89e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 41.11  E-value: 2.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536   364 DQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHtd 443
Cdd:TIGR00618  256 LKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAH-- 333

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 358439536   444 hlrdvlkvQEQELKYEFEQGLSEKLSEQELEFRRRSQEQ 482
Cdd:TIGR00618  334 --------VKQQSSIEEQRRLLQTLHSQEIHIRDAHEVA 364
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 326-481 3.13e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 40.18  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536  326 RKELDSITPDITPGWKGMTGKLSTDDLNslIAHAHRRIDQLNRELaqqKATEKQHIELALEKHKLEEKRTFDSAVAKALE 405
Cdd:pfam15905 165 RNKLEAKMKEVMAKQEGMEGKLQVTQKN--LEHSKGKVAQLEEKL---VSTEKEKIEEKSETEKLLEYITELSCVSEQVE 239

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 358439536  406 HHRSEIQaeqdrKVEEVRDAMENEMRTqLRRQAAAHTDHLRDVLKVQEQELKyEFEQGLSEKLSEQELEFRRRSQE 481
Cdd:pfam15905 240 KYKLDIA-----QLEELLKEKNDEIES-LKQSLEEKEQELSKQIKDLNEKCK-LLESEKEELLREYEEKEQTLNAE 308
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 233-422 9.81e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 38.37  E-value: 9.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536 233 VEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAkKREIAgatphitaaegRLHNMIVDLDNVVKKVQAAQSEAKVVS 312
Cdd:COG1579   22 LEHRLKELPAELAELEDELAALEARLEAAKTELEDL-EKEIK-----------RLELEIEEVEARIKKYEEQLGNVRNNK 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 358439536 313 QYHELvvqarddfRKELDSITPDItpgwkgmtgklstDDLNSLIAHAHRRIDQLNRELAQQKAtekqhiELALEKHKLEE 392
Cdd:COG1579   90 EYEAL--------QKEIESLKRRI-------------SDLEDEILELMERIEELEEELAELEA------ELAELEAELEE 142

                        170       180       190
                 ....*....|....*....|....*....|.
gi 358439536 393 KRT-FDSAVAKaLEHHRSEIQAEQDRKVEEV 422
Cdd:COG1579  143 KKAeLDEELAE-LEAELEELEAEREELAAKI 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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