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Conserved domains on  [gi|357197163|ref|NP_001239407|]
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zinc transporter 6 isoform 1 [Mus musculus]

Protein Classification

cation diffusion facilitator family transporter( domain architecture ID 1750094)

cation diffusion facilitator (CDF) family transporter facilitates the active efflux of one or more from a variety of metal cations including Zn, Cd, Ni, Co, Mn, and Cu

Gene Ontology:  GO:0008324
PubMed:  25896018|17448255
TCDB:  2.A.4

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CzcD super family cl40534
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
83-325 2.14e-23

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG1230:

Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 99.81  E-value: 2.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163  83 LISYWVMMRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALSFNLFTMLSIRn 162
Cdd:COG1230   64 LFAYRLARRPADARFTFGYKRAEILAALANALLLLVVAGYILYEAIQRLFNPPPVAGGGMLVVAVIGLVVNLVSAWLLH- 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163 163 kpfayvseaastswlQEHVADLSrslcglipgLSSIFLprmnpFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIAL 242
Cdd:COG1230  143 ---------------RGSKHDLN---------LRGAYL-----HVLADALGSVAVIVAALVILFTGWTWLDPLLSLLIAL 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163 243 MTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVS 322
Cdd:COG1230  194 LILRSAWGLLRESLRILLEGVPDGI--DLEEVRAALEALPGVADVHDLHVWSLSSGENALTAHVVVDDGADADAILDEIR 271

                 ...
gi 357197163 323 NRL 325
Cdd:COG1230  272 ELL 274
 
Name Accession Description Interval E-value
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
83-325 2.14e-23

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 99.81  E-value: 2.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163  83 LISYWVMMRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALSFNLFTMLSIRn 162
Cdd:COG1230   64 LFAYRLARRPADARFTFGYKRAEILAALANALLLLVVAGYILYEAIQRLFNPPPVAGGGMLVVAVIGLVVNLVSAWLLH- 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163 163 kpfayvseaastswlQEHVADLSrslcglipgLSSIFLprmnpFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIAL 242
Cdd:COG1230  143 ---------------RGSKHDLN---------LRGAYL-----HVLADALGSVAVIVAALVILFTGWTWLDPLLSLLIAL 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163 243 MTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVS 322
Cdd:COG1230  194 LILRSAWGLLRESLRILLEGVPDGI--DLEEVRAALEALPGVADVHDLHVWSLSSGENALTAHVVVDDGADADAILDEIR 271

                 ...
gi 357197163 323 NRL 325
Cdd:COG1230  272 ELL 274
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
43-260 9.25e-21

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 89.64  E-value: 9.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163   43 LCTGFLLMWCSSTNSIALTAYTYLTIFDLFSLfffslITCLISYWVMMRKPSPVYSFGFERLEVLAVFASTVLAQLGALF 122
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISS-----LLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163  123 ILKESAERFLE-QPEIHTGRLLVGTFVALSFNLFTMLSIRNKPFAYvseaastswlqehvadlsrslcglipglSSIFLP 201
Cdd:pfam01545  76 LLYESIQRLLSpGEEIDPGLALILALVSLLVNLFLLLYLRRAARRI----------------------------RSPALK 127
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 357197163  202 RMNPFVLIDLAGAFALCITYMLIEINNYFA---VDTASAIAIALMTFGTMYPMSVYSGKVLL 260
Cdd:pfam01545 128 ADALHALSDVLASLGVLISALLIYLGPITGgllADPLASLLIGLLILYTALRLLKESLSILL 189
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
83-313 1.11e-19

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 88.43  E-value: 1.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163   83 LISYWVMMRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLE-QPEIHTGRLLVGTFVALSFNLFtMLSIR 161
Cdd:TIGR01297  36 LLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEAIERLINpEPEIDGGTMLIVAIVGLIVNLI-LALYL 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163  162 NKPFAYVSEAASTSWLQEHVADLSRSLCGLIPGLSSIFlprmnpfvlidlagafalcitymlieinNYFAVDTASAIAIA 241
Cdd:TIGR01297 115 HRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIYF----------------------------GWHWADPIAALLIS 166
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 357197163  242 LMTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDAN 313
Cdd:TIGR01297 167 LLILYTAFRLLKESINVLLDAAPDEE--DLEEIKKAILSIPGVKGVHDLHIWRIGPGKLFLDVHVVVDPDLD 236
 
Name Accession Description Interval E-value
CzcD COG1230
Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];
83-325 2.14e-23

Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism];


Pssm-ID: 440843 [Multi-domain]  Cd Length: 294  Bit Score: 99.81  E-value: 2.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163  83 LISYWVMMRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALSFNLFTMLSIRn 162
Cdd:COG1230   64 LFAYRLARRPADARFTFGYKRAEILAALANALLLLVVAGYILYEAIQRLFNPPPVAGGGMLVVAVIGLVVNLVSAWLLH- 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163 163 kpfayvseaastswlQEHVADLSrslcglipgLSSIFLprmnpFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIAL 242
Cdd:COG1230  143 ---------------RGSKHDLN---------LRGAYL-----HVLADALGSVAVIVAALVILFTGWTWLDPLLSLLIAL 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163 243 MTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVS 322
Cdd:COG1230  194 LILRSAWGLLRESLRILLEGVPDGI--DLEEVRAALEALPGVADVHDLHVWSLSSGENALTAHVVVDDGADADAILDEIR 271

                 ...
gi 357197163 323 NRL 325
Cdd:COG1230  272 ELL 274
Cation_efflux pfam01545
Cation efflux family; Members of this family are integral membrane proteins, that are found to ...
43-260 9.25e-21

Cation efflux family; Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.


Pssm-ID: 426316 [Multi-domain]  Cd Length: 189  Bit Score: 89.64  E-value: 9.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163   43 LCTGFLLMWCSSTNSIALTAYTYLTIFDLFSLfffslITCLISYWVMMRKPSPVYSFGFERLEVLAVFASTVLAQLGALF 122
Cdd:pfam01545   1 LLALVKLAAGLLTGSLALLADAVHSLIDLISS-----LLALLALRLSRKPPDERFPFGHGRLEPLAALVVGILLLGGGVF 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163  123 ILKESAERFLE-QPEIHTGRLLVGTFVALSFNLFTMLSIRNKPFAYvseaastswlqehvadlsrslcglipglSSIFLP 201
Cdd:pfam01545  76 LLYESIQRLLSpGEEIDPGLALILALVSLLVNLFLLLYLRRAARRI----------------------------RSPALK 127
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 357197163  202 RMNPFVLIDLAGAFALCITYMLIEINNYFA---VDTASAIAIALMTFGTMYPMSVYSGKVLL 260
Cdd:pfam01545 128 ADALHALSDVLASLGVLISALLIYLGPITGgllADPLASLLIGLLILYTALRLLKESLSILL 189
CDF TIGR01297
cation diffusion facilitator family transporter; This model describes a broadly distributed ...
83-313 1.11e-19

cation diffusion facilitator family transporter; This model describes a broadly distributed family of transporters, a number of which have been shown to transport divalent cations of cobalt, cadmium and/or zinc. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273544 [Multi-domain]  Cd Length: 268  Bit Score: 88.43  E-value: 1.11e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163   83 LISYWVMMRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLE-QPEIHTGRLLVGTFVALSFNLFtMLSIR 161
Cdd:TIGR01297  36 LLALRISRRPADERHPFGHGRAEILAALLNGLFLVVVALFILYEAIERLINpEPEIDGGTMLIVAIVGLIVNLI-LALYL 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163  162 NKPFAYVSEAASTSWLQEHVADLSRSLCGLIPGLSSIFlprmnpfvlidlagafalcitymlieinNYFAVDTASAIAIA 241
Cdd:TIGR01297 115 HRVGHRLGSLALRAAALHVLSDALSSVGVLIGALLIYF----------------------------GWHWADPIAALLIS 166
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 357197163  242 LMTFGTMYPMSVYSGKVLLQTTPPHVigQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDAN 313
Cdd:TIGR01297 167 LLILYTAFRLLKESINVLLDAAPDEE--DLEEIKKAILSIPGVKGVHDLHIWRIGPGKLFLDVHVVVDPDLD 236
FieF COG0053
Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];
83-321 5.38e-04

Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism];


Pssm-ID: 439823 [Multi-domain]  Cd Length: 284  Bit Score: 41.63  E-value: 5.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163  83 LISYWVMMRKPSPVYSFGFERLEVLA-VFASTVLAqLGALFILKESAERFLE-QPEIHTGRLLVGTFVALSFNLFTMLSI 160
Cdd:COG0053   49 LLGLRLAAKPADEEHPYGHGKAEYLAsLIVAVLIL-LAGLFILYEAIERLLHpEPVEPSGLGLAVLLISIVVNEALARYL 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163 161 RNKPFAYVSEAASTSWLqEHVADLsrslcglipgLSSIflprmnpFVLIDLAGAFALcitymlieinNYFAVDTASAIAI 240
Cdd:COG0053  128 RRVGKKTGSPALKADAL-HDRSDA----------LTSL-------GVLIGLLLALLT----------GWPWLDPIAAILI 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 357197163 241 ALMTFGTMYPMSVYSGKVLL-QTTPPHVIGQLDKLIREVstlDGVLEVrneHfwtlgfgslagsvHVRIRRDANEQMVLA 319
Cdd:COG0053  180 GLLILKVAYKLARESLSLLMdEALDEELVERIRAIILSV---PGVIGV---H-------------DLRTRKSGPRIFVDL 240

                 ..
gi 357197163 320 HV 321
Cdd:COG0053  241 HI 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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