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Conserved domains on  [gi|355390368|ref|NP_001238986|]
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lymphocyte antigen 6C1 isoform 3 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP super family cl45932
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 25-65 3.00e-15

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


The actual alignment was detected with superfamily member cd23541:

Pssm-ID: 480272  Cd Length: 83  Bit Score: 63.89  E-value: 3.00e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 355390368 25 QGLQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEGSH 65
Cdd:cd23541   1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQ 41
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-65 3.00e-15

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 63.89  E-value: 3.00e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 355390368 25 QGLQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEGSH 65
Cdd:cd23541   1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQ 41
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-66 9.67e-05

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 36.75  E-value: 9.67e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 355390368  29 CYECYGVPiETSC-PAVTCRASDGFCIAQNIELIEGSHS 66
Cdd:pfam00021  1 CYSCLGVS-NEDClSEVTCPLSDGQCVTTTLELPEGNLR 38
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-68 1.05e-03

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 34.43  E-value: 1.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 355390368   27 LQCYECYGVPiETSCP-AVTCRASDGFCIAQNIELIEGSHSNL 68
Cdd:smart00134  1 LQCYSCTGNP-DSSCSsEEECRSPDDVCLTVVAEVISDSRGSV 42
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-65 3.00e-15

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 63.89  E-value: 3.00e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 355390368 25 QGLQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEGSH 65
Cdd:cd23541   1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQ 41
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-66 9.67e-05

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 36.75  E-value: 9.67e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 355390368  29 CYECYGVPiETSC-PAVTCRASDGFCIAQNIELIEGSHS 66
Cdd:pfam00021  1 CYSCLGVS-NEDClSEVTCPLSDGQCVTTTLELPEGNLR 38
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-68 1.05e-03

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 34.43  E-value: 1.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 355390368   27 LQCYECYGVPiETSCP-AVTCRASDGFCIAQNIELIEGSHSNL 68
Cdd:smart00134  1 LQCYSCTGNP-DSSCSsEEECRSPDDVCLTVVAEVISDSRGSV 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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