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Conserved domains on  [gi|355390366|ref|NP_001238985|]
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lymphocyte antigen 6C1 isoform 2 precursor [Mus musculus]

Protein Classification

LU domain-containing protein( domain architecture ID 10439911)

LU domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-103 7.74e-33

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467071  Cd Length: 83  Bit Score: 111.27  E-value: 7.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355390366  25 QGLQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCLSFCPAGV----PIRDPNIRERTSCCSEDL 100
Cdd:cd23541    1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKNLyfleEILGTTVNVKTSCCKEDL 80


                 ...
gi 355390366 101 CNA 103
Cdd:cd23541   81 CNA 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-103 7.74e-33

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 111.27  E-value: 7.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355390366  25 QGLQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCLSFCPAGV----PIRDPNIRERTSCCSEDL 100
Cdd:cd23541    1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKNLyfleEILGTTVNVKTSCCKEDL 80


                 ...
gi 355390366 101 CNA 103
Cdd:cd23541   81 CNA 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-102 1.71e-15

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 66.79  E-value: 1.71e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 355390366   29 CYECYGVPiETSC-PAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCL-SFCPA--GVPIRDPNIRERTSCCSEDLCN 102
Cdd:pfam00021   1 CYSCLGVS-NEDClSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCArSSCPRllSDFINGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-108 1.01e-14

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 64.86  E-value: 1.01e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355390366    27 LQCYECYGVPiETSCP-AVTCRASDGFCIAQNIELIEDSqRRKLKTRQC--LSFCPA--GVPIRDPNIRERTSCCSEDLC 101
Cdd:smart00134   1 LQCYSCTGNP-DSSCSsEEECRSPDDVCLTVVAEVISDS-RGSVVYKGCatSPICPGshGYEINLTIAFLKVSCCQTDLC 78


                   ....*..
gi 355390366   102 NAAVPTA 108
Cdd:smart00134  79 NAAGPGA 85
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-103 7.74e-33

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 111.27  E-value: 7.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355390366  25 QGLQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCLSFCPAGV----PIRDPNIRERTSCCSEDL 100
Cdd:cd23541    1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKNLyfleEILGTTVNVKTSCCKEDL 80


                 ...
gi 355390366 101 CNA 103
Cdd:cd23541   81 CNA 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-102 1.71e-15

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 66.79  E-value: 1.71e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 355390366   29 CYECYGVPiETSC-PAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCL-SFCPA--GVPIRDPNIRERTSCCSEDLCN 102
Cdd:pfam00021   1 CYSCLGVS-NEDClSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCArSSCPRllSDFINGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-108 1.01e-14

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 64.86  E-value: 1.01e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355390366    27 LQCYECYGVPiETSCP-AVTCRASDGFCIAQNIELIEDSqRRKLKTRQC--LSFCPA--GVPIRDPNIRERTSCCSEDLC 101
Cdd:smart00134   1 LQCYSCTGNP-DSSCSsEEECRSPDDVCLTVVAEVISDS-RGSVVYKGCatSPICPGshGYEINLTIAFLKVSCCQTDLC 78


                   ....*..
gi 355390366   102 NAAVPTA 108
Cdd:smart00134  79 NAAGPGA 85
TFP_LU_ECD_Ly6L cd23551
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ...
 27-104 1.36e-08

extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467081  Cd Length: 86  Bit Score: 48.94  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355390366  27 LQCYECYGVPIETSCPAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCLSFCPAG------VPIRDPNIRERTSCCSEDL 100
Cdd:cd23551    2 LKCYQCFKVSSDEDCKPDQCAPSEIVCISNEVVLYVGTKVRVLISKRCAPRCPNTnsrcewSPGTQVIGSITRTCCSQSL 81


                 ....
gi 355390366 101 CNAA 104
Cdd:cd23551   82 CNRA 85
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 27-103 2.39e-03

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 35.00  E-value: 2.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 355390366  27 LQCYECYGVPIETSC-PAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCLSFCPAGVPIRDpNIRERTSCCSEDLCNA 103
Cdd:cd23575    3 LKCYTCVSAHSNSDClTETNCSSSDTYCKTLVASASGGSGSLTTITKWCASSCTPSTRTVE-GTKVTVSCCQTDLCNV 79
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 26-102 8.86e-03

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 33.59  E-value: 8.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355390366  26 GLQCYECYGVPIE----TSCPAVTCRASDGFCIAQNIELIEDSQRRKLKTRQCL--SFCPAGVpIRDPNIRERTSCCSED 99
Cdd:cd23563    3 GVECYSCVGNSRGacspSNAPVVRCYGAYSGCFDGNVTLTIGNVTLSLPVKGCVqdGDCTRES-KGGASVTLKGSCCSGN 81


                 ...
gi 355390366 100 LCN 102
Cdd:cd23563   82 LCN 84
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 27-102 9.85e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 33.23  E-value: 9.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 355390366  27 LQCYECYGVPIETSCPA----VTCRASDGFCIAQNIELIEDSQRrklKTRQCLSFCPAG----VPIRDPNIRERTSCCSE 98
Cdd:cd00117    1 LKCYQCNSSNDPNCCNSsptlVTCSSPETFCRKIVGKVGGGETL---VIRGCATECECGctecCSGTGTSGTTCTSCCDT 77


                 ....
gi 355390366  99 DLCN 102
Cdd:cd00117   78 DLCN 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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