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Conserved domains on  [gi|345478668|ref|NP_001230869|]
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phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 3 [Homo sapiens]

Protein Classification

ribose-phosphate diphosphokinase( domain architecture ID 11421473)

ribose-phosphate diphosphokinase catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form the the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP)

CATH:  3.40.50.2020
EC:  2.7.6.1
Gene Ontology:  GO:0002189|GO:0000287|GO:0004749|GO:0005524|GO:0009156|GO:0016301|GO:0016310|GO:0006015|GO:0009165
PubMed:  11751055|7593598

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 20-314 3.01e-87

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


:

Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 263.84  E-value: 3.01e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  20 LVLFSANSNsscMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTS 99
Cdd:COG0462    4 LKIFSGNAN---PELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 100 CAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEip 178
Cdd:COG0462   81 SARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 179 DYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIHpsleipmlipkekppitV 256
Cdd:COG0462  159 DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMN-----------------I 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 257 VGDVGGRIAIIV-------------------------------------------------VVVTNTIPHEVQKlQCPKI 287
Cdd:COG0462  206 IGDVEGKTCIIVddmidtggtlveaaealkeagaksvyaaathgvlsgpaverlenspideLVVTDTIPLPEEK-RCDKI 284

                        330       340
                 ....*....|....*....|....*..
gi 345478668 288 KTVDISMILSEAIRRIHNGESMSYLFR 314
Cdd:COG0462  285 KVLSVAPLLAEAIRRIHEGESVSSLFD 311
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 20-314 3.01e-87

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 263.84  E-value: 3.01e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  20 LVLFSANSNsscMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTS 99
Cdd:COG0462    4 LKIFSGNAN---PELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 100 CAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEip 178
Cdd:COG0462   81 SARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 179 DYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIHpsleipmlipkekppitV 256
Cdd:COG0462  159 DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMN-----------------I 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 257 VGDVGGRIAIIV-------------------------------------------------VVVTNTIPHEVQKlQCPKI 287
Cdd:COG0462  206 IGDVEGKTCIIVddmidtggtlveaaealkeagaksvyaaathgvlsgpaverlenspideLVVTDTIPLPEEK-RCDKI 284

                        330       340
                 ....*....|....*....|....*..
gi 345478668 288 KTVDISMILSEAIRRIHNGESMSYLFR 314
Cdd:COG0462  285 KVLSVAPLLAEAIRRIHEGESVSSLFD 311
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 179-314 9.04e-79

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 237.79  E-value: 9.04e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  179 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 258
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  259 DVGGRIAIIV-------------------------------------------------VVVTNTIPHEVQKLQCPKIKT 289
Cdd:pfam14572  80 DVGGRIAIIVddmiddvdsfvaaaellkergaykiyvmathgllssdaprlleaspideVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 345478668  290 VDISMILSEAIRRIHNGESMSYLFR 314
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
20-314 4.87e-77

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 237.71  E-value: 4.87e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  20 LVLFSANSNsscMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTS 99
Cdd:PRK01259   1 MKLFAGNAN---PELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 100 CAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEip 178
Cdd:PRK01259  78 SAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQK-- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 179 DYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIH---------------GEAQDAESDLVDGrhsppMV---------- 231
Cdd:PRK01259 156 NLENLVVV--SPdvGGVVRARALAKRLDADLAIIDkrrpranvsevmniiGDVEGRDCILVDD-----MIdtagtlckaa 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 232 --------RSVAAI--HPSLEIPMLIPKEKPPITvvgdvggriaiiVVVVTNTIPHEVQKLQCPKIKTVDISMILSEAIR 301
Cdd:PRK01259 229 ealkergaKSVYAYatHPVLSGGAIERIENSVID------------ELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIR 296

                        330
                 ....*....|...
gi 345478668 302 RIHNGESMSYLFR 314
Cdd:PRK01259 297 RISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 20-314 7.53e-73

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 227.16  E-value: 7.53e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668   20 LVLFSANSNSscmELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFII-QTVSKDVNTTIMELLIMVYACKT 98
Cdd:TIGR01251   1 MKIFSGSSNQ---ELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668   99 SCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEI 177
Cdd:TIGR01251  78 ASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  178 PDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDL--------VDGR----------------------HS 227
Cdd:TIGR01251 158 LD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRISATNEVevmnlvgdVEGKdvvivddiidtggtiakaaeilKS 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  228 PPMVR-SVAAIHPSLeipmlipkekppitvVGDVGGRIA---IIVVVVTNTIPHEVqklQCPKIKTVDISMILSEAIRRI 303
Cdd:TIGR01251 236 AGAKRvIAAATHGVF---------------SGPAIERIAnagVEEVIVTNTIPHEK---HKPKVSVISVAPLIAEAIRRI 297

                         330
                  ....*....|.
gi 345478668  304 HNGESMSYLFR 314
Cdd:TIGR01251 298 HNNESVSSLFD 308
FERM_F1_Myo10_like cd17110
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional ...
 8-80 7.75e-03

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X and similar proteins; Myosin-X, also termed myosin-10 (Myo10), is an untraditional member of myosin superfamily. It is an actin-based motor protein that plays a critical role in diverse cellular motile events, such as filopodia formation/extension, phagocytosis, cell migration, and mitotic spindle maintenance, as well as a number of disease states including cancer metastasis and pathogen infection. Myosin-X functions as an important regulator of cytoskeleton that modulates cell motilities in many different cellular contexts. It regulates neuronal radial migration through interacting with N-cadherin. Like other unconventional myosins, Myosin-X is composed of a conserved motor head, a neck region and a variable tail. The neck region consists of three IQ motifs (light chain-binding sites), and a predicted stalk of coiled coil. The tail contains three PEST regions, three PH domains, a MyTH4 domain, and a FERM domain. The FERM domain is made up of three sub-domains, F1, F2, and F3. This family corresponds to the F1 sub-domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N). Amoebozoan Dictyostelium discoideum myosin VII (DdMyo7) and uncharacterized pleckstrin homology domain-containing family H member 3 (PLEKHH3) are also included in this family. Like metazoan Myo10, DdMyo7 is essential for the extension of filopodia, plasma membrane protrusions filled with parallel bundles of F-actin.


Pssm-ID: 340630  Cd Length: 97  Bit Score: 35.44  E-value: 7.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 345478668   8 ELETKMNITKGGLVLFSANSNSSCMELSKKIAERLGVEMGK--VQVYqepnrETRVQIQESVRGKDVfIIQTVSK 80
Cdd:cd17110    3 ELTVTVTCQGGRTCKVAIDSWTTCGEVSKDLARRLGLERSRngFALF-----ETSGDIERALEAKTR-VVDVLSK 71
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 20-314 3.01e-87

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 263.84  E-value: 3.01e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  20 LVLFSANSNsscMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTS 99
Cdd:COG0462    4 LKIFSGNAN---PELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 100 CAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEip 178
Cdd:COG0462   81 SARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 179 DYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIHpsleipmlipkekppitV 256
Cdd:COG0462  159 DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMN-----------------I 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 257 VGDVGGRIAIIV-------------------------------------------------VVVTNTIPHEVQKlQCPKI 287
Cdd:COG0462  206 IGDVEGKTCIIVddmidtggtlveaaealkeagaksvyaaathgvlsgpaverlenspideLVVTDTIPLPEEK-RCDKI 284

                        330       340
                 ....*....|....*....|....*..
gi 345478668 288 KTVDISMILSEAIRRIHNGESMSYLFR 314
Cdd:COG0462  285 KVLSVAPLLAEAIRRIHEGESVSSLFD 311
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 179-314 9.04e-79

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 237.79  E-value: 9.04e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  179 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 258
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  259 DVGGRIAIIV-------------------------------------------------VVVTNTIPHEVQKLQCPKIKT 289
Cdd:pfam14572  80 DVGGRIAIIVddmiddvdsfvaaaellkergaykiyvmathgllssdaprlleaspideVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 345478668  290 VDISMILSEAIRRIHNGESMSYLFR 314
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
20-314 4.87e-77

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 237.71  E-value: 4.87e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  20 LVLFSANSNsscMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTS 99
Cdd:PRK01259   1 MKLFAGNAN---PELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 100 CAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEip 178
Cdd:PRK01259  78 SAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQK-- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 179 DYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIH---------------GEAQDAESDLVDGrhsppMV---------- 231
Cdd:PRK01259 156 NLENLVVV--SPdvGGVVRARALAKRLDADLAIIDkrrpranvsevmniiGDVEGRDCILVDD-----MIdtagtlckaa 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 232 --------RSVAAI--HPSLEIPMLIPKEKPPITvvgdvggriaiiVVVVTNTIPHEVQKLQCPKIKTVDISMILSEAIR 301
Cdd:PRK01259 229 ealkergaKSVYAYatHPVLSGGAIERIENSVID------------ELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIR 296

                        330
                 ....*....|...
gi 345478668 302 RIHNGESMSYLFR 314
Cdd:PRK01259 297 RISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 20-314 7.53e-73

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 227.16  E-value: 7.53e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668   20 LVLFSANSNSscmELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFII-QTVSKDVNTTIMELLIMVYACKT 98
Cdd:TIGR01251   1 MKIFSGSSNQ---ELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668   99 SCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEI 177
Cdd:TIGR01251  78 ASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  178 PDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDL--------VDGR----------------------HS 227
Cdd:TIGR01251 158 LD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKRRISATNEVevmnlvgdVEGKdvvivddiidtggtiakaaeilKS 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  228 PPMVR-SVAAIHPSLeipmlipkekppitvVGDVGGRIA---IIVVVVTNTIPHEVqklQCPKIKTVDISMILSEAIRRI 303
Cdd:TIGR01251 236 AGAKRvIAAATHGVF---------------SGPAIERIAnagVEEVIVTNTIPHEK---HKPKVSVISVAPLIAEAIRRI 297

                         330
                  ....*....|.
gi 345478668  304 HNGESMSYLFR 314
Cdd:TIGR01251 298 HNNESVSSLFD 308
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 32-314 7.72e-57

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 186.05  E-value: 7.72e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  32 MELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTSCAKSIIGVIPYF 111
Cdd:PLN02369   1 PALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 112 PYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSP 190
Cdd:PLN02369  81 GYARAdRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 191 ASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPpmvrsvaaiHPSLEipmlipkekpPITVVGDVGGRIAIIV-- 268
Cdd:PLN02369 161 GGVARARAFAKKL-----------SDAPLAIVDKRRQG---------HNVAE----------VMNLIGDVKGKVAIMVdd 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 269 -----------------------------------------------VVVTNTIPHEVQKlQCPKIKTVDISMILSEAIR 301
Cdd:PLN02369 211 midtagtitkgaallhqegarevyacathavfsppaierlssglfqeVIVTNTIPVSEKN-YFPQLTVLSVANLLGETIW 289

                        330
                 ....*....|...
gi 345478668 302 RIHNGESMSYLFR 314
Cdd:PLN02369 290 RVHDDCSVSSIFD 302
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
16-313 2.62e-56

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 185.00  E-value: 2.62e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  16 TKGGLVLFSANSNsscMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYA 95
Cdd:PRK02269   2 SYSDLKLFALSSN---KELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  96 CKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQ 174
Cdd:PRK02269  79 LKRASAESINVVMPYYGYARQdRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 175 EEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIH-----------------GEAQDAESDLVD------GR--HSPP 229
Cdd:PRK02269 159 RRGLVGDDVVVVSPDHGGVTRARKLAQFLKTPIAIIDkrrsvdkmntsevmniiGNVKGKKCILIDdmidtaGTicHAAD 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 230 MVRSVAAI-------HPSLEIPMLipkekppitvvgDVGGRIAIIVVVVTNTIPHEVQKLqCPKIKTVDISMILSEAIRR 302
Cdd:PRK02269 239 ALAEAGATevyasctHPVLSGPAL------------DNIQKSAIEKLVVLDTIYLPEERL-IDKIEQISIADLLGEAIIR 305

                        330
                 ....*....|.
gi 345478668 303 IHNGESMSYLF 313
Cdd:PRK02269 306 IHEKRPLSPLF 316
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 20-138 6.27e-54

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 171.83  E-value: 6.27e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668   20 LVLFSANSNsscMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTS 99
Cdd:pfam13793   1 LKIFSGNSN---PELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 345478668  100 CAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 138
Cdd:pfam13793  78 SAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
20-313 1.05e-52

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 175.89  E-value: 1.05e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  20 LVLFSANSNSScmeLSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTS 99
Cdd:PRK04923   7 LLVFSGNANKP---LAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 100 CAKSIIGVIPYFPYSKQ-CKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEI 177
Cdd:PRK04923  84 SAASVTAVIPYFGYSRQdRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADIWRAY 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 178 pDYRNAVIVAKSPASAKRAQSFAERL-------------RLGIAVIHGEAQDAE-------SDLVDGRHSppMVRSVAAI 237
Cdd:PRK04923 164 -GTDNLIVVSPDVGGVVRARAVAKRLddadlaiidkrrpRANVATVMNIIGDVQgktcvlvDDLVDTAGT--LCAAAAAL 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 345478668 238 --HPSLEIPMLIPKEKPPITVVGDVGGRIaIIVVVVTNTIPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 313
Cdd:PRK04923 241 kqRGALKVVAYITHPVLSGPAVDNINNSQ-LDELVVTDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 22-218 1.36e-51

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 173.00  E-value: 1.36e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  22 LFSANSNsscMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTSCA 101
Cdd:PRK02458  12 LFSLNSN---LEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRASA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 102 KSIIGVIPYFPYSKQCKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEIPDY 180
Cdd:PRK02458  89 NTVNVVLPYFGYARQDRIAKpREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCKKGLSG 168

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 345478668 181 RNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAE 218
Cdd:PRK02458 169 SDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSE 206
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 20-314 3.59e-51

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 172.23  E-value: 3.59e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  20 LVLFSANSNSScmeLSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTS 99
Cdd:PRK02812  22 LRLFSGSSNPA---LAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 100 CAKSIIGVIPYFPYSK-QCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEip 178
Cdd:PRK02812  99 SARQITAVIPYYGYARaDRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLASK-- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 179 DYRNAVIVAKSPASAKRAQSFAERLRlgiavihgeaqDAESDLVDGRHSPPMVRSVaaihpsleipmlipkekppITVVG 258
Cdd:PRK02812 177 NLEDIVVVSPDVGGVARARAFAKKLN-----------DAPLAIIDKRRQAHNVAEV-------------------LNVIG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 259 DVGGRIAIIV-------------------------------------------------VVVTNTIPHEvQKLQCPKIKT 289
Cdd:PRK02812 227 DVKGKTAILVddmidtggticegarllrkegakqvyacathavfsppaierlssglfeeVIVTNTIPVP-EERRFPQLKV 305

                        330       340
                 ....*....|....*....|....*
gi 345478668 290 VDISMILSEAIRRIHNGESMSYLFR 314
Cdd:PRK02812 306 LSVANMLGEAIWRIHEESSVSSMFR 330
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
34-313 4.57e-47

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 160.50  E-value: 4.57e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  34 LSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPY 113
Cdd:PRK03092   1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 114 SKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEIPDyRNAVIVAKSPAS 192
Cdd:PRK03092  81 ARQdKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDL-DNVTVVSPDAGR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 193 AKRAQSFAERLrlgiavihGEAqdaesdlvdgrhspPMvrsvAAIHPSLEIpmLIPKEKPPITVVGDVGGRIAIIV---- 268
Cdd:PRK03092 160 VRVAEQWADRL--------GGA--------------PL----AFIHKTRDP--TVPNQVVANRVVGDVEGRTCVLVddmi 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 269 ---------------------------------------------VVVTNTIPHEVQKlQCPKIKTVDISMILSEAIRRI 303
Cdd:PRK03092 212 dtggtiagavralkeagakdviiaathgvlsgpaaerlkncgareVVVTDTLPIPEEK-RFDKLTVLSIAPLLARAIREV 290

                        330
                 ....*....|
gi 345478668 304 HNGESMSYLF 313
Cdd:PRK03092 291 FEDGSVTSLF 300
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 21-313 2.98e-46

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 161.96  E-value: 2.98e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  21 VLFSANSNSscmELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTSC 100
Cdd:PTZ00145 121 ILFSGSSNP---LLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRAS 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 101 AKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFF--NIPVDNLRASPFLLQYIQEEi 177
Cdd:PTZ00145 198 AKKITAVIPYYGYARQdRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFgpRVPVDNLEAQLIGLDYFTKK- 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 178 pDYRNAVIVAKSPASAKRAQSFAERL------RLGIAV---------------IHGEAQDAESDLVDG------------ 224
Cdd:PTZ00145 277 -DLYKPVIVSPDAGGVYRARKFQDGLnhrgisDCGIAMlikqrtkpneiekmdLVGNVYDSDVIIVDDmidtsgtlceaa 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 225 ----RHSPPMVRSVAAiHPSLEIPMLIPKEKPPITvvgdvggriaiiVVVVTNTIPHEVQKLQCPKIKTVDISMILSEAI 300
Cdd:PTZ00145 356 kqlkKHGARRVFAFAT-HGLFSGPAIERIEASPLE------------EVVVTDTVKSNKNIDSCKKITKLSVSVLVADAI 422

                        330
                 ....*....|...
gi 345478668 301 RRIHNGESMSYLF 313
Cdd:PTZ00145 423 RRIHQKESLNDLF 435
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 12-313 1.25e-40

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 144.67  E-value: 1.25e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  12 KMNITKGGLVLFSAnsnSSCMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLI 91
Cdd:PRK00553   2 HLSIDKSNHVIFSL---SKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  92 MVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLL 170
Cdd:PRK00553  79 AIDALKRGSAKSITAILPYYGYARQdRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 171 QYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIH---------------GEAQDAESDLVDGrhsppMVRSVA 235
Cdd:PRK00553 159 SRVLELL-GKKDLVVVSPDYGGVKRARLIAESLELPLAIIDkrrpkhnvaesinvlGEVKNKNCLIVDD-----MIDTGG 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 236 AIhpsLEIPMLIPKEKPPITVVGDVGG---------------RIAIIVVVVTNTIPHEVQKlQCPKIKTVDISMILSEAI 300
Cdd:PRK00553 233 TV---IAAAKLLKKQKAKKVCVMATHGlfnknaiqlfdeafkKKLIDKLFVSNSIPQTKFE-KKPQFKVVDLAHLYEEVL 308

                        330
                 ....*....|...
gi 345478668 301 RRIHNGESMSYLF 313
Cdd:PRK00553 309 LCYANGGSISAIY 321
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 29-203 5.93e-27

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 106.92  E-value: 5.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  29 SSCMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDvNTTIMELLIMVYACKTSCAKSIIGVI 108
Cdd:PRK00934   6 SASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKSITLVI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 109 PYFPYSKQCKMRKRG-SIVSKLLASMMcKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEeipDYRNAVIVA 187
Cdd:PRK00934  85 PYLGYARQDKRFKPGePISARAIAKII-SAYYDRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGD---KLDDPLVLA 160

                        170
                 ....*....|....*.
gi 345478668 188 KSPASAKRAQSFAERL 203
Cdd:PRK00934 161 PDKGALELAKEAAEIL 176
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 56-225 2.50e-15

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 75.76  E-value: 2.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  56 NRETRVQIQESVRGKDVFIIQTVS--------------KDVNTTIMELLIMVYACKTScAKSIIGVIPYFPYSKQCKMRK 121
Cdd:PRK06827  64 NGEAKGEILESVRGKDIYILQDVGnysvtynmfgeknhMSPDDHFQDLKRTIDAIRGK-ARRITVIMPFLYESRQHKRKG 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 122 RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIP-VDNLRASPFLLQYIQEEIPDYR----NAVIVAKSPASAKRA 196
Cdd:PRK06827 143 RESLDCALALQELEELGVDNIITFDAHDPRIENAIPLMgFENLYPSYQIIKALLKNEKDLEidkdHLMVISPDTGAMDRA 222

                        170       180
                 ....*....|....*....|....*....
gi 345478668 197 QSFAERLRLGIAVIHGEaQDaESDLVDGR 225
Cdd:PRK06827 223 KYYASVLGVDLGLFYKR-RD-YSRVVNGR 249
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
33-211 1.88e-12

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 66.50  E-value: 1.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  33 ELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDvNTTIMELLIMVYACKTSCAKSIIGVIPYFP 112
Cdd:PRK07199  13 AAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCSLDRP-DEKLLPLLFAAEAARELGARRVGLVAPYLA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668 113 YSKQCKMRKRGSIVS-----KLLAsmmckAGLTHLITMD--LHQ-KEIQGFFNIPVDNLRASPFLLQYIQEEIPDyrnAV 184
Cdd:PRK07199  92 YMRQDIAFHPGEAISqrhfaRLLS-----GSFDRLVTVDphLHRyPSLSEVYPIPAVVLSAAPAIAAWIRAHVPR---PL 163

                        170       180
                 ....*....|....*....|....*..
gi 345478668 185 IVAKSPASAKRAQSFAERLRLGIAVIH 211
Cdd:PRK07199 164 LIGPDEESEQWVAAVAERAGAPHAVLR 190
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 65-199 8.80e-04

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 40.44  E-value: 8.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478668  65 ESVRGKDVFIIQTVSKdvNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVSKL-LASM-----MCKAG 138
Cdd:PLN02297  62 HGIRGQHVAFLASFSS--PAVIFEQLSVIYALPKLFVASFTLVLPFFPTGTSERVEREGDVATAFtLARIlsnipISRGG 139

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 345478668 139 LTHLITMDLHQKEIQGFFNipvDNLRAS-----PFLLQYIQeEIPDYRNAVIVAKSPASAKRAQSF 199
Cdd:PLN02297 140 PTSLVIFDIHALQERFYFG---DNVLPCfesgiPLLKKRLQ-QLPDSDNIVIAFPDDGAWKRFHKQ 201
FERM_F1_Myo10_like cd17110
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional ...
 8-80 7.75e-03

FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X and similar proteins; Myosin-X, also termed myosin-10 (Myo10), is an untraditional member of myosin superfamily. It is an actin-based motor protein that plays a critical role in diverse cellular motile events, such as filopodia formation/extension, phagocytosis, cell migration, and mitotic spindle maintenance, as well as a number of disease states including cancer metastasis and pathogen infection. Myosin-X functions as an important regulator of cytoskeleton that modulates cell motilities in many different cellular contexts. It regulates neuronal radial migration through interacting with N-cadherin. Like other unconventional myosins, Myosin-X is composed of a conserved motor head, a neck region and a variable tail. The neck region consists of three IQ motifs (light chain-binding sites), and a predicted stalk of coiled coil. The tail contains three PEST regions, three PH domains, a MyTH4 domain, and a FERM domain. The FERM domain is made up of three sub-domains, F1, F2, and F3. This family corresponds to the F1 sub-domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N). Amoebozoan Dictyostelium discoideum myosin VII (DdMyo7) and uncharacterized pleckstrin homology domain-containing family H member 3 (PLEKHH3) are also included in this family. Like metazoan Myo10, DdMyo7 is essential for the extension of filopodia, plasma membrane protrusions filled with parallel bundles of F-actin.


Pssm-ID: 340630  Cd Length: 97  Bit Score: 35.44  E-value: 7.75e-03
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                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 345478668   8 ELETKMNITKGGLVLFSANSNSSCMELSKKIAERLGVEMGK--VQVYqepnrETRVQIQESVRGKDVfIIQTVSK 80
Cdd:cd17110    3 ELTVTVTCQGGRTCKVAIDSWTTCGEVSKDLARRLGLERSRngFALF-----ETSGDIERALEAKTR-VVDVLSK 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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