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Conserved domains on  [gi|345478666|ref|NP_001230865|]
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phosphoribosyl pyrophosphate synthase-associated protein 2 isoform 2 [Homo sapiens]

Protein Classification

phosphoribosyl pyrophosphate synthase-associated protein( domain architecture ID 11226557)

phosphoribosyl pyrophosphate synthase-associated protein seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 139-323 4.61e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


:

Pssm-ID: 434046  Cd Length: 184  Bit Score: 322.92  E-value: 4.61e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  139 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 218
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  219 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKT 298
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 345478666  299 VDISMILSEAIRRIHNGESMSYLFR 323
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 20-98 4.01e-23

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 92.10  E-value: 4.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666   20 LVLFSANSNsscMELSKKIAE----------------------------------------DVNTTIMELLIMVYACKTS 59
Cdd:pfam13793   1 LKIFSGNSN---PELAEKIAKrlgiplgkatvsrfsdgeiyvrieesvrgkdvfiiqstcpPVNDNLMELLIMIDALKRA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 345478666   60 CAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 98
Cdd:pfam13793  78 SAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 139-323 4.61e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 322.92  E-value: 4.61e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  139 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 218
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  219 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKT 298
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 345478666  299 VDISMILSEAIRRIHNGESMSYLFR 323
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 42-323 2.97e-79

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 243.81  E-value: 2.97e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:COG0462   63 VNDNLMELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPV 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIH 198
Cdd:COG0462  143 DHLYAAPLLADYIKSK--DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMN 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 199 PSLEIpmlipKEKPPItVVGDV---GGriaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAI 275
Cdd:COG0462  205 IIGDV-----EGKTCI-IVDDMidtGG--------------TLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPI 264

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 345478666 276 DEVVVTNTIPHEVQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:COG0462  265 DELVVTDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
42-323 8.25e-73

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 227.31  E-value: 8.25e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK01259  60 TNDNLMELLIMIDALKRASAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPV 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSVaaih 198
Cdd:PRK01259 140 DNLYGSPILLEDIKQK--NLENLVVV--SPdvGGVVRARALAKRLDADLAII------------DKRRPRANVSEV---- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 199 psleipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEV 278
Cdd:PRK01259 200 ---------------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDEL 264

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 345478666 279 VVTNTIPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:PRK01259 265 VVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 42-323 1.76e-72

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 226.39  E-value: 1.76e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666   42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:TIGR01251  61 VNDNLMELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPV 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  121 DNLRASPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAIhps 200
Cdd:TIGR01251 141 DNLYASPVLAEYLKKKILD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEVMNL--- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  201 leipmlipkekppitvVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVV 280
Cdd:TIGR01251 205 ----------------VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIV 268

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 345478666  281 TNTIPHEVqklQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:TIGR01251 269 TNTIPHEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 20-98 4.01e-23

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 92.10  E-value: 4.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666   20 LVLFSANSNsscMELSKKIAE----------------------------------------DVNTTIMELLIMVYACKTS 59
Cdd:pfam13793   1 LKIFSGNSN---PELAEKIAKrlgiplgkatvsrfsdgeiyvrieesvrgkdvfiiqstcpPVNDNLMELLIMIDALKRA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 345478666   60 CAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 98
Cdd:pfam13793  78 SAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 125-283 5.61e-03

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 36.60  E-value: 5.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 125 ASPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAihpsleip 204
Cdd:cd06223    1 AGRLLAEEIREDLLE--PDVVVGILRGGLPLAAALARALGLPLAFIRKE-----------RKGPGRTPSEPY-------- 59

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 345478666 205 mlipkeKPPITVVGDVGGRIAIIvddiiddvDSFLAAAETLKERGAYKIFVMATHGLLSSDAprRIEESAIDEVVVTNT 283
Cdd:cd06223   60 ------GLELPLGGDVKGKRVLLvddviatgGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 139-323 4.61e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 322.92  E-value: 4.61e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  139 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 218
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  219 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKT 298
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 345478666  299 VDISMILSEAIRRIHNGESMSYLFR 323
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 42-323 2.97e-79

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 243.81  E-value: 2.97e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:COG0462   63 VNDNLMELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPV 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIH 198
Cdd:COG0462  143 DHLYAAPLLADYIKSK--DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMN 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 199 PSLEIpmlipKEKPPItVVGDV---GGriaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAI 275
Cdd:COG0462  205 IIGDV-----EGKTCI-IVDDMidtGG--------------TLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPI 264

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 345478666 276 DEVVVTNTIPHEVQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:COG0462  265 DELVVTDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
42-323 8.25e-73

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 227.31  E-value: 8.25e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK01259  60 TNDNLMELLIMIDALKRASAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPV 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSVaaih 198
Cdd:PRK01259 140 DNLYGSPILLEDIKQK--NLENLVVV--SPdvGGVVRARALAKRLDADLAII------------DKRRPRANVSEV---- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 199 psleipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEV 278
Cdd:PRK01259 200 ---------------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDEL 264

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 345478666 279 VVTNTIPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:PRK01259 265 VVTDSIPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 42-323 1.76e-72

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 226.39  E-value: 1.76e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666   42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:TIGR01251  61 VNDNLMELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPV 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  121 DNLRASPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAIhps 200
Cdd:TIGR01251 141 DNLYASPVLAEYLKKKILD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEVMNL--- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  201 leipmlipkekppitvVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVV 280
Cdd:TIGR01251 205 ----------------VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIV 268

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 345478666  281 TNTIPHEVqklQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:TIGR01251 269 TNTIPHEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
43-322 8.70e-53

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 176.27  E-value: 8.70e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  43 NTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK04923  67 AENLMELLVLIDALKRASAASVTAVIPYFGYSRQdRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPV 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPPMVRSVaaihps 200
Cdd:PRK04923 147 DNVYASPLLLADIWRAY-GTDNLIVVSPDVGGVVRARAVAKRL-----------DDADLAIIDKRRPRANVATV------ 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 201 leipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVV 280
Cdd:PRK04923 209 -------------MNIIGDVQGKTCVLVDDLVDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVV 275

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 345478666 281 TNTIPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 322
Cdd:PRK04923 276 TDTIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
38-322 6.11e-51

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 171.51  E-value: 6.11e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  38 IAEDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFF 116
Cdd:PRK02269  61 TSSPVNDNLMEILIMVDALKRASAESINVVMPYYGYARQdRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFF 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 117 NIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSppmvrsvaa 196
Cdd:PRK02269 141 DIPVDHLMGAPLIADYFDRRGLVGDDVVVVSPDHGGVTRARKLAQFLKTPIAII------------DKRRS--------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 197 ihpslEIPMLIPKekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAID 276
Cdd:PRK02269 200 -----VDKMNTSE---VMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAGATEVYASCTHPVLSGPALDNIQKSAIE 271

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 345478666 277 EVVVTNTIPHEVQKLqCPKIKTVDISMILSEAIRRIHNGESMSYLF 322
Cdd:PRK02269 272 KLVVLDTIYLPEERL-IDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 42-323 3.23e-50

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 169.10  E-value: 3.23e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PLN02369  51 ANENLMELLIMIDACRRASAKRITAVIPYFGYARAdRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPV 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPpmvrsvaaiHPS 200
Cdd:PLN02369 131 DHVYGQPVILDYLASKTISSPDLVVVSPDVGGVARARAFAKKL-----------SDAPLAIVDKRRQG---------HNV 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 201 LEipmlipkekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVV 280
Cdd:PLN02369 191 AE----------VMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAVFSPPAIERLSSGLFQEVIV 260

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 345478666 281 TNTIPHEVQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:PLN02369 261 TNTIPVSEKN-YFPQLTVLSVANLLGETIWRVHDDCSVSSIFD 302
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
42-322 1.68e-49

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 167.05  E-value: 1.68e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK03092  49 INKWLMEQLIMIDALKRASAKRITVVLPFYPYARQdKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPV 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEIPDyRNAVIVAKSPASAKRAQSFAERLrlgiavihGEAqdaesdlvdgrhspPMvrsvAAIHPS 200
Cdd:PRK03092 129 DHLFAMPLLADYVRDKYDL-DNVTVVSPDAGRVRVAEQWADRL--------GGA--------------PL----AFIHKT 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 201 LEIpmLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVV 280
Cdd:PRK03092 182 RDP--TVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHGVLSGPAAERLKNCGAREVVV 259

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 345478666 281 TNTIPHEVQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLF 322
Cdd:PRK03092 260 TDTLPIPEEK-RFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 42-323 5.62e-48

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 164.14  E-value: 5.62e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSK-QCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK02812  81 VNDHLMELLIMVDACRRASARQITAVIPYYGYARaDRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPC 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEipDYRNAVIVAKSPASAKRAQSFAERLRlgiavihgeaqDAESDLVDGRHSPPMVRSVaaihps 200
Cdd:PRK02812 161 DHVYGSPVLLDYLASK--NLEDIVVVSPDVGGVARARAFAKKLN-----------DAPLAIIDKRRQAHNVAEV------ 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 201 leipmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVV 280
Cdd:PRK02812 222 -------------LNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLFEEVIV 288

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 345478666 281 TNTIPHEvQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:PRK02812 289 TNTIPVP-EERRFPQLKVLSVANMLGEAIWRIHEESSVSSMFR 330
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 42-323 2.97e-45

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 156.82  E-value: 2.97e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK02458  69 VNDHLWELLIMIDACKRASANTVNVVLPYFGYARQDRIAKpREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPV 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDlvDGrhsppmvrsvaaihps 200
Cdd:PRK02458 149 DNLFTVPLFAKHYCKKGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSERE--EG---------------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 201 leipmlipkekppiTVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVV 280
Cdd:PRK02458 211 --------------YIIGDVAGKKAILIDDILNTGKTFAEAAKIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILV 276

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 345478666 281 TNTIpheVQKLQCPK-IKTVDISMILSEAIRRIHNGESMSYLFR 323
Cdd:PRK02458 277 TDSV---ATKERVPKnVTYLSASELIADAIIRIHERKPLSPLFA 317
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 42-322 6.55e-45

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 158.88  E-value: 6.55e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFN--I 118
Cdd:PTZ00145 179 VNENLIELLLMISTCRRASAKKITAVIPYYGYARQdRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprV 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 119 PVDNLRASPFLLQYIQEEipDYRNAVIVAKSPASAKRAQSFAERLrlgiavIHGEAQDAEsdlvdgrhsppmvrsvaaih 198
Cdd:PTZ00145 259 PVDNLEAQLIGLDYFTKK--DLYKPVIVSPDAGGVYRARKFQDGL------NHRGISDCG-------------------- 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 199 psleIPMLI-----PKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEES 273
Cdd:PTZ00145 311 ----IAMLIkqrtkPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEAS 386

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 345478666 274 AIDEVVVTNTIPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 322
Cdd:PTZ00145 387 PLEEVVVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDLF 435
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 42-322 3.94e-42

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 148.91  E-value: 3.94e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPV 120
Cdd:PRK00553  69 VNDSLMELLIAIDALKRGSAKSITAILPYYGYARQdRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPV 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSvaaihps 200
Cdd:PRK00553 149 DILRTYHVFLSRVLELL-GKKDLVVVSPDYGGVKRARLIAESLELPLAII------------DKRRPKHNVAE------- 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 201 leipmlipkekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEES----AID 276
Cdd:PRK00553 209 ------------SINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFDEAfkkkLID 276

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 345478666 277 EVVVTNTIPHEVQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLF 322
Cdd:PRK00553 277 KLFVSNSIPQTKFE-KKPQFKVVDLAHLYEEVLLCYANGGSISAIY 321
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 43-291 1.88e-27

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 108.46  E-value: 1.88e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  43 NTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMcKAGLTHLITMDLHQKEIQGFFNIPVD 121
Cdd:PRK00934  59 DENLVELLLLIDALRDEGAKSITLVIPYLGYARQDKRFKPGePISARAIAKII-SAYYDRIITINIHEPSILEFFPIPFI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 122 NLRASPFLLQYIQEeipDYRNAVIVAKSPASAKRAQSFAERLrlGIAVIHGEAQdaesdlvdgRHSPPMVRsvaaIHPSl 201
Cdd:PRK00934 138 NLDAAPLIAEYIGD---KLDDPLVLAPDKGALELAKEAAEIL--GCEYDYLEKT---------RISPTEVE----IAPK- 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 202 EIpmlipkekppitvvgDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVT 281
Cdd:PRK00934 199 NL---------------DVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVT 263

                        250
                 ....*....|
gi 345478666 282 NTIPHEVQKL 291
Cdd:PRK00934 264 DTLESEVSKI 273
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 20-98 4.01e-23

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 92.10  E-value: 4.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666   20 LVLFSANSNsscMELSKKIAE----------------------------------------DVNTTIMELLIMVYACKTS 59
Cdd:pfam13793   1 LKIFSGNSN---PELAEKIAKrlgiplgkatvsrfsdgeiyvrieesvrgkdvfiiqstcpPVNDNLMELLIMIDALKRA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 345478666   60 CAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 98
Cdd:pfam13793  78 SAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 42-324 8.53e-19

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 86.16  E-value: 8.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  42 VNTTIMELLIMVYACKTScAKSIIGVIPYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIP-V 120
Cdd:PRK06827 104 PDDHFQDLKRTIDAIRGK-ARRITVIMPFLYESRQHKRKGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLMgF 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 121 DNLRASPFLLQYIQEEIPDYR----NAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaQDaESDLVDGRHsppmvrsvaa 196
Cdd:PRK06827 183 ENLYPSYQIIKALLKNEKDLEidkdHLMVISPDTGAMDRAKYYASVLGVDLGLFYKR-RD-YSRVVNGRN---------- 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 197 ihpsleipmlipkekpPITVV----GDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLsSDAPRRI-- 270
Cdd:PRK06827 251 ----------------PIVAHeflgRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAKKIIVAATFGFF-TNGLEKFdk 313

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 345478666 271 --EESAIDEVVVTNTIPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFRN 324
Cdd:PRK06827 314 ayEEGYFDRIIGTNLVYHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLSKLLDP 369
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
43-311 1.49e-10

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 61.11  E-value: 1.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666  43 NTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVS-----KLLAsmmckAGLTHLITMD--LHQ-KEIQG 114
Cdd:PRK07199  62 DEKLLPLLFAAEAARELGARRVGLVAPYLAYMRQDIAFHPGEAISqrhfaRLLS-----GSFDRLVTVDphLHRyPSLSE 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 115 FFNIPVDNLRASPFLLQYIQEEIPDyrnAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSV 194
Cdd:PRK07199 137 VYPIPAVVLSAAPAIAAWIRAHVPR---PLLIGPDEESEQWVAAVAERAGAPHAVLRKT-----------RHGD---RDV 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 195 AaihpsLEIPMLIPKEKPPITVVGDV--GGRiaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEE 272
Cdd:PRK07199 200 E-----ISLPDAAPWAGRTPVLVDDIvsTGR-------------TLIEAARQLRAAGAASPDCVVVHALFAGDAYSALAA 261

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 345478666 273 SAIDEVVVTNTIPHEVQklqcpkikTVDISMILSEAIRR 311
Cdd:PRK07199 262 AGIARVVSTDTVPHPSN--------AISLAPLLAEALRR 292
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 125-283 5.61e-03

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 36.60  E-value: 5.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 345478666 125 ASPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAihpsleip 204
Cdd:cd06223    1 AGRLLAEEIREDLLE--PDVVVGILRGGLPLAAALARALGLPLAFIRKE-----------RKGPGRTPSEPY-------- 59

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 345478666 205 mlipkeKPPITVVGDVGGRIAIIvddiiddvDSFLAAAETLKERGAYKIFVMATHGLLSSDAprRIEESAIDEVVVTNT 283
Cdd:cd06223   60 ------GLELPLGGDVKGKRVLLvddviatgGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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