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Conserved domains on  [gi|342187172|ref|NP_001230101|]
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isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial [Danio rerio]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
49-381 0e+00

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00175:

Pssm-ID: 444908  Cd Length: 333  Bit Score: 550.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172   49 GGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNSSSTSE-DDISNAIMAIRRNGVALKGNIETNHTMPpNHK 127
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKtEIPDEAVESIKRNKVALKGPLETPIGKG-GHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  128 SRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDIIIIRENTEGEYSSLEHESASGVVECLKIITRNNSLRIADYAFKLAR 207
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  208 EKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAGLVG 287
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  288 GPGLVPGANYGRDYAVFETATRNTGKSIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMNETRLHTVDIGGQ 367
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 342187172  368 GTTSEVVQSIMRII 381
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 49-381 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 550.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172   49 GGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNSSSTSE-DDISNAIMAIRRNGVALKGNIETNHTMPpNHK 127
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKtEIPDEAVESIKRNKVALKGPLETPIGKG-GHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  128 SRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDIIIIRENTEGEYSSLEHESASGVVECLKIITRNNSLRIADYAFKLAR 207
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  208 EKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAGLVG 287
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  288 GPGLVPGANYGRDYAVFETATRNTGKSIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMNETRLHTVDIGGQ 367
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 342187172  368 GTTSEVVQSIMRII 381
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 42-382 2.89e-126

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 368.04  E-value: 2.89e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  42 IPPPAKyGGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNSSStsEDDISNAIMAIRRNGVALKGNIETnhT 121
Cdd:PLN00123  22 MPRPGD-GAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGDM--KKVPEEVLESIRRNKVCLKGGLAT--P 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 122 MPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDIIIIRENTEGEYSSLEHESASGVVECLKIITRNNSLRIADY 201
Cdd:PLN00123  97 VGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKY 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 202 AFKLAREKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNV 281
Cdd:PLN00123 177 AFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANT 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 282 CAGLVGGPGLVPGANYGRDYAVFETATR--NTGK-SIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMNETR 358
Cdd:PLN00123 257 AAGIAGGTGVMPGGNVGADHAVFEQGASagNVGNeKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGK 336

                        330       340
                 ....*....|....*....|....
gi 342187172 359 LHTVDIGGQGTTSEVVQSIMRIIQ 382
Cdd:PLN00123 337 YRTKDLGGSSTTQEVVDAVIANLD 360
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 51-381 9.23e-115

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 338.14  E-value: 9.23e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  51 RHTVTLIPGDGIGPE-------LLNHVRELFRFscvpvDFEVVHVNSSSTS---------EDDISnaimAIRRNGVALKG 114
Cdd:COG0473    1 TYKIAVLPGDGIGPEvvaaalkVLEAAAERFGL-----DFEFEEADIGGAAydktgtplpDETLE----ALRKADAILLG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 115 NIETNHTmpPNHKS--RNNL-LRTSLDLYANVMHCQSLPGVQTRHK-----NIDIIIIRENTEGEYSSLEHESASG---- 182
Cdd:COG0473   72 AVGGPKW--DDGVRpeSGLLaLRKELDLYANLRPAKLYPGLPSPLKpeiveGIDLVIVRENTEGLYFGIGGRIGTGtgee 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 183 VVECLKIITRNNSLRIADYAFKLAReKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKP 262
Cdd:COG0473  150 VAIDTRVYTRKGIERIARYAFELAR-KRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNP 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 263 YQFDVMVMPNLYGNVVSNVCAGLVGGPGLVPGANYGRDY-AVFE----TATRntgksIANRNIANPTAMLLASCLMLDHL 337
Cdd:COG0473  229 EQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEpvhgSAPD-----IAGKGIANPIATILSAAMMLRHL 303

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 342187172 338 KLHDYANMIRSAILTTMNEtRLHTVDIGGQGTTSEVVQSIMRII 381
Cdd:COG0473  304 GEEEAADAIEAAVEKVLAE-GVRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
53-377 3.45e-87

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 267.62  E-value: 3.45e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172   53 TVTLIPGDGIGPELLNHVRELFR--FSCVPVDFEVVHVNSSSTSEDDISNAI-----MAIRRNGVALKGNIETNHTMPPN 125
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKaaLEKAPLEFEFEERDVGGAAIDETGEPLpdetlEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  126 HKSRNNL--LRTSLDLYANVMHCQSLPG------VQTRHKNIDIIIIRENTEGEYSSLEHE---SASGVVECLKIITRNN 194
Cdd:pfam00180  81 VRPENGLlaLRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  195 SLRIADYAFKLAREKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLY 274
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  275 GNVVSNVCAGLVGGPGLVPGANYGRD-YAVFEtATRNTGKSIANRNIANPTAMLLASCLMLDH-LKLHDYANMIRSAILT 352
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANgFGIFE-PVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLK 319

                         330       340
                  ....*....|....*....|....*...
gi 342187172  353 TMNETRLhTVDIGGQGT---TSEVVQSI 377
Cdd:pfam00180 320 VLESGIR-TGDLAGSATyvsTSEFGEAV 346
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 49-381 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 550.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172   49 GGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNSSSTSE-DDISNAIMAIRRNGVALKGNIETNHTMPpNHK 127
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKtEIPDEAVESIKRNKVALKGPLETPIGKG-GHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  128 SRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDIIIIRENTEGEYSSLEHESASGVVECLKIITRNNSLRIADYAFKLAR 207
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  208 EKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAGLVG 287
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  288 GPGLVPGANYGRDYAVFETATRNTGKSIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMNETRLHTVDIGGQ 367
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 342187172  368 GTTSEVVQSIMRII 381
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 42-382 2.89e-126

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 368.04  E-value: 2.89e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  42 IPPPAKyGGRHTVTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNSSStsEDDISNAIMAIRRNGVALKGNIETnhT 121
Cdd:PLN00123  22 MPRPGD-GAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGDM--KKVPEEVLESIRRNKVCLKGGLAT--P 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 122 MPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDIIIIRENTEGEYSSLEHESASGVVECLKIITRNNSLRIADY 201
Cdd:PLN00123  97 VGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKY 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 202 AFKLAREKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNV 281
Cdd:PLN00123 177 AFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANT 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 282 CAGLVGGPGLVPGANYGRDYAVFETATR--NTGK-SIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMNETR 358
Cdd:PLN00123 257 AAGIAGGTGVMPGGNVGADHAVFEQGASagNVGNeKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGK 336

                        330       340
                 ....*....|....*....|....
gi 342187172 359 LHTVDIGGQGTTSEVVQSIMRIIQ 382
Cdd:PLN00123 337 YRTKDLGGSSTTQEVVDAVIANLD 360
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 5-377 4.24e-126

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 368.05  E-value: 4.24e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172   5 LTKALKPILGRQLGNTAKVFGAGVVSQRGKPTYSGRIipppakyggrhTVTLIPGDGIGPELLNHVRELFRFSCVPVDFE 84
Cdd:PLN00118   6 LRRLLGNRLAQILGASSSSSGAFSSSARAFSSSSTPI-----------TATLFPGDGIGPEIAESVKQVFTAAGVPIEWE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  85 VVHVnssSTSEDDISNAIM------AIRRNGVALKGNIETnhTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKN 158
Cdd:PLN00118  75 EHYV---GTTVDPRTGSFLtwesleSVRRNKVGLKGPMAT--PIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDD 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 159 IDIIIIRENTEGEYSSLEHESASGVVECLKIITRNNSLRIADYAFKLAREKGRRRVTAVHKANIMKLGDGLFLQCCKEVA 238
Cdd:PLN00118 150 VDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVA 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 239 SGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAGLVGGPGLVPGANYGRDYAVFETATRNTGKSIANR 318
Cdd:PLN00118 230 EKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGK 309

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 342187172 319 NIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMNETRLHTVDIGGQGTTSEVVQSI 377
Cdd:PLN00118 310 NLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAI 368
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 51-381 9.23e-115

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 338.14  E-value: 9.23e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  51 RHTVTLIPGDGIGPE-------LLNHVRELFRFscvpvDFEVVHVNSSSTS---------EDDISnaimAIRRNGVALKG 114
Cdd:COG0473    1 TYKIAVLPGDGIGPEvvaaalkVLEAAAERFGL-----DFEFEEADIGGAAydktgtplpDETLE----ALRKADAILLG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 115 NIETNHTmpPNHKS--RNNL-LRTSLDLYANVMHCQSLPGVQTRHK-----NIDIIIIRENTEGEYSSLEHESASG---- 182
Cdd:COG0473   72 AVGGPKW--DDGVRpeSGLLaLRKELDLYANLRPAKLYPGLPSPLKpeiveGIDLVIVRENTEGLYFGIGGRIGTGtgee 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 183 VVECLKIITRNNSLRIADYAFKLAReKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKP 262
Cdd:COG0473  150 VAIDTRVYTRKGIERIARYAFELAR-KRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNP 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 263 YQFDVMVMPNLYGNVVSNVCAGLVGGPGLVPGANYGRDY-AVFE----TATRntgksIANRNIANPTAMLLASCLMLDHL 337
Cdd:COG0473  229 EQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEpvhgSAPD-----IAGKGIANPIATILSAAMMLRHL 303

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 342187172 338 KLHDYANMIRSAILTTMNEtRLHTVDIGGQGTTSEVVQSIMRII 381
Cdd:COG0473  304 GEEEAADAIEAAVEKVLAE-GVRTPDLGGKAGTSEMGDAIIAAL 346
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 53-379 4.08e-109

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 323.59  E-value: 4.08e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  53 TVTLIPGDGIGPELLNH-VRELFRFSCvpvDFEVVHVNSSSTSEDD-----ISNAIMAIRRNGVALKGNIETnhTMPPNH 126
Cdd:PRK08997   4 TITVIPGDGIGPSIIDAtLKILDKLGC---DFEYEFADAGLTALEKhgellPQRTLDLIEKNKIALKGPLTT--PVGEGF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 127 KSRNNLLRTSLDLYANVMHCQSLPGVQTRHKNIDIIIIRENTEGEYSSLEHE-SASG-VVECLKIITRNNSLRIADYAFK 204
Cdd:PRK08997  79 TSINVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTvSEDGeTAEATSIITRKGAERIVRFAYE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 205 LAREKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAG 284
Cdd:PRK08997 159 LARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 285 LVGGPGLVPGANYGRDYAVFEtATRNTGKSIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMNETRLHTVDI 364
Cdd:PRK08997 239 LVGGLGMAPGANIGRDAAIFE-AVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDL 317

                        330
                 ....*....|....*
gi 342187172 365 GGQGTTSEVVQSIMR 379
Cdd:PRK08997 318 GGTHGTTDFTQAVID 332
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
54-374 1.32e-105

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 319.53  E-value: 1.32e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  54 VTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHV--------NSSSTSEDdisnAIMAIRRNGVALKGNIETnhtmpPN 125
Cdd:PRK09222   7 ITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIgekvykkgWTSGISPS----AWESIRRTKVLLKAPITT-----PQ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 126 ---HKSRNNLLRTSLDLYANVMHCQSL-PGVQTRHKNIDIIIIRENTEGEYSSLEHESASGVVECLKIITRNNSLRIADY 201
Cdd:PRK09222  78 gggYKSLNVTLRKTLGLYANVRPCVSYhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKIIRY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 202 AFKLAREKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNV 281
Cdd:PRK09222 158 AFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDI 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 282 CAGLVGGPGLVPGANYGRDYAVFEtATRNTGKSIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMnETRLHT 361
Cdd:PRK09222 238 AAEISGSVGLAGSANIGEEYAMFE-AVHGSAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTL-EDGIHT 315

                        330
                 ....*....|...
gi 342187172 362 VDIGGQGTTSEVV 374
Cdd:PRK09222 316 ADIYNEGVSKKKV 328
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
53-377 3.45e-87

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 267.62  E-value: 3.45e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172   53 TVTLIPGDGIGPELLNHVRELFR--FSCVPVDFEVVHVNSSSTSEDDISNAI-----MAIRRNGVALKGNIETNHTMPPN 125
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKaaLEKAPLEFEFEERDVGGAAIDETGEPLpdetlEACKKADAVLLGAVGGPKWDPAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  126 HKSRNNL--LRTSLDLYANVMHCQSLPG------VQTRHKNIDIIIIRENTEGEYSSLEHE---SASGVVECLKIITRNN 194
Cdd:pfam00180  81 VRPENGLlaLRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  195 SLRIADYAFKLAREKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLY 274
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  275 GNVVSNVCAGLVGGPGLVPGANYGRD-YAVFEtATRNTGKSIANRNIANPTAMLLASCLMLDH-LKLHDYANMIRSAILT 352
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANgFGIFE-PVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLK 319

                         330       340
                  ....*....|....*....|....*...
gi 342187172  353 TMNETRLhTVDIGGQGT---TSEVVQSI 377
Cdd:pfam00180 320 VLESGIR-TGDLAGSATyvsTSEFGEAV 346
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 52-381 2.87e-83

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 257.37  E-value: 2.87e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  52 HTVTLIPGDGIGPELLNHVRELFRfsCVPVDFEVVHVNSSSTseddisnaimAIRRNGVALKgnietNHTMPPNHKSRNN 131
Cdd:PRK14025   2 HKICVIEGDGIGKEVVPAALHVLE--ATGLPFEFVYAEAGDE----------VFEKTGKALP-----EETIEAAKEADAV 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 132 L--------------LRTSLDLYANVMHCQSLPGVQTRHKNIDIIIIRENTEGEYSSLEHESASGVVECLKIITRNNSLR 197
Cdd:PRK14025  65 LfgaagetaadvivkLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASER 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 198 IADYAFKLAREK----GRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNL 273
Cdd:PRK14025 145 IFRFAFEMAKRRkkmgKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 274 YGNVVSNVCAGLVGGPGLVPGANYGRDYAVFEtATRNTGKSIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTT 353
Cdd:PRK14025 225 FGDILSDGAAGLVGGLGLAPSANIGDKYGLFE-PVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEV 303

                        330       340
                 ....*....|....*....|....*...
gi 342187172 354 MNEtRLHTVDIGGQGTTSEVVQSIMRII 381
Cdd:PRK14025 304 LAL-GLTTPDLGGNLSTMEMAEEVAKRV 330
ICDH_alpha TIGR02924
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ...
 54-374 3.69e-82

isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]


Pssm-ID: 274353 [Multi-domain]  Cd Length: 473  Bit Score: 258.92  E-value: 3.69e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172   54 VTLIPGDGIGPELLNHVRELFRFSCVPVDFEVVHVNSSSTSED---DISNAIMA-IRRNGVALKGNIETNHTmpPNHKSR 129
Cdd:TIGR02924   3 ITVAYGDGIGPEIMEAVLLILKEAEAPIDIETIEIGEKVYKKGwpsGISPSSWEsIRRTKVLLKAPITTPQG--GGHKSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  130 NNLLRTSLDLYANVMHCQSL-PGVQTRHKNIDIIIIRENTEGEYSSLEHESASGVVECLKIITRNNSLRIADYAFKLARE 208
Cdd:TIGR02924  81 NVTLRKTLGLYANIRPCVSYhPFIETKSPNLNIVIVRENEEDLYTGIEYRQTPDTYECTKLITRSGSEKICRYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  209 KGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAGLVGG 288
Cdd:TIGR02924 161 HNRKKVTCLTKDNIMKMTDGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYGDILSDVAAEISGS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  289 PGLVPGANYGRDYAVFEtATRNTGKSIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMnETRLHTVDIGGQG 368
Cdd:TIGR02924 241 VGLAGSANIGEEYAMFE-AVHGSAPDIAGQNIANPSGLLNAAIQMLVHIGQSDIAQLIYNAWLKTL-EDGVHTADIYNEK 318


                  ....*.
gi 342187172  369 TTSEVV 374
Cdd:TIGR02924 319 TSKQKV 324
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 52-384 3.98e-57

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 190.70  E-value: 3.98e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  52 HTVTLIPGDGIGPE-------LLNHVRELFRFscvpvDFEvvhvnsssTSEDDISNAimAIRRNGVALkgnieTNHTM-- 122
Cdd:PRK00772   3 YKIAVLPGDGIGPEvmaeavkVLDAVAEKFGF-----DFE--------FEEALVGGA--AIDAHGVPL-----PEETLea 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 123 --------------------PPNHKSRNNLL--RTSLDLYANVMHCQSLPGVQT-------RHKNIDIIIIRENTEGEYS 173
Cdd:PRK00772  63 craadavllgavggpkwdnlPPDVRPERGLLalRKELGLFANLRPAKLYPGLADasplkpeIVAGLDILIVRELTGGIYF 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 174 --------SLEHESAsgvVECLkIITRNNSLRIADYAFKLAReKGRRRVTAVHKANIMKlGDGLFLQCCKEVASGYPDIE 245
Cdd:PRK00772 143 geprgregLGGEERA---FDTM-VYTREEIERIARVAFELAR-KRRKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVE 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 246 FENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAGLVGGPGLVPGANYGRD-YAVFETAtrntGKS---IANRNIA 321
Cdd:PRK00772 217 LSHMYVDNAAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPI----HGSapdIAGKGIA 292

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 342187172 322 NPTAMLLASCLMLDH-LKLHDYANMIRSAILTTMNEtRLHTVDI---GGQGTTSEVVQSIMRIIQSG 384
Cdd:PRK00772 293 NPIATILSAAMMLRYsLGLEEAADAIEAAVEKVLAQ-GYRTADIaegGGKVSTSEMGDAILAALAEG 358
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 54-381 4.47e-46

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 161.42  E-value: 4.47e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172   54 VTLIPGDGIGPEL-------LNHVRELFRFScvpVDFEvvhvnssstsEDDISNAimAIRRNGV-----ALKGNIETN-- 119
Cdd:TIGR00169   2 IAVLPGDGIGPEVmaqalkvLKAVAERFGLK---FEFE----------EHLIGGA--AIDATGQplpeeTLKGCKEADav 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  120 ----------HTMPPNHKSRNNLL--RTSLDLYANVMHCQSLPGVQTRH-------KNIDIIIIRENTEGEYSSLEHE-S 179
Cdd:TIGR00169  67 llgavggpkwDNLPRDQRPEQGLLklRKSLDLFANLRPAKVFPGLEDLSplkeeiaKGVDFVVVRELTGGIYFGEPKGrE 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  180 ASGVVECLKIITRNNSLRIADYAFKLAReKGRRRVTAVHKANIMKLGDgLFLQCCKEVASGYPDIEFENMIVDNTTMQLV 259
Cdd:TIGR00169 147 GEGEAWDTEVYTVPEIERIARVAFEMAR-KRRKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLV 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  260 SKPYQFDVMVMPNLYGNVVSNVCAGLVGGPGLVPGANYGRD-YAVFETAtRNTGKSIANRNIANPTAMLLASCLMLDH-L 337
Cdd:TIGR00169 225 KSPTQFDVVVTSNLFGDILSDEASVITGSLGMLPSASLGSDgFGLFEPV-HGSAPDIAGKGIANPIAQILSAAMLLRYsF 303

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 342187172  338 KLHDYANMIRSAILTTMNETRlHTVDIGGQGTTSEVVQSIMRII 381
Cdd:TIGR00169 304 NLEEAADAIEAAVKKVLAEGY-RTPDLGSSATTAVGTAEMGEEL 346
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 53-383 1.22e-44

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 157.58  E-value: 1.22e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  53 TVTLIPGDGIGPE-------LLNHVREL-----FRFSCVPVDFEVVHVNSSSTSED--DISNAIMAIRRNGValkGNIEt 118
Cdd:PRK08194   5 KIAVIPGDGVGKEvvpaavrVLKAVAEVhgglkFEFTEFPWSCEYYLEHGEMMPEDglEQLKQFDAIFLGAV---GNPK- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 119 nhtMPPNHKSRNNLL---RTSLDLYANVMHCQSLPGVQ---TRHKNIDIIIIRENTEGEYSSL-------EHEsasgVVE 185
Cdd:PRK08194  81 ---LVPDHISLWGLLikiRREFEQVINIRPAKQLRGIKsplANPKDFDLLVVRENSEGEYSEVggrihrgEDE----IAI 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 186 CLKIITRNNSLRIADYAFKLAREKgRRRVTAVHKAN----IMKLGDGLFlqccKEVASGYPDIEFENMIVDNTTMQLVSK 261
Cdd:PRK08194 154 QNAVFTRKGTERAMRYAFELAAKR-RKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAFFVTR 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 262 PYQFDVMVMPNLYGNVVSNVCAGLVGGPGLVPGAN---YGRDYAVFEtATRNTGKSIANRNIANPTAMLLASCLMLDHLK 338
Cdd:PRK08194 229 PEEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANinvNGKYPSMFE-PVHGSAPDIAGKGIANPIGQIWTAKLMLDHFG 307

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 342187172 339 LHDYAnmirSAILTTMNETR---LHTVDIGGQGTTSEVVQSIMRIIQS 383
Cdd:PRK08194 308 EEELG----SHLLDVIEDVTedgIKTPDIGGRATTDEVTDEIISRLKK 351
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 101-383 1.24e-41

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 151.03  E-value: 1.24e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 101 AIMAIRRNGVALKGNIETnhtmpPN---HKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKN---IDIIIIRENTEGEYSS 174
Cdd:COG0538   78 TAEAIKEYGVGIKGPLTT-----PVgggWRSLNVTIRQILDLYVCRRPVRYFKGVPSPVKHpekVDIVIFRENTEDIYAG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 175 LE-------------------------HESASGVVecLKIITRNNSLRIADYAFKLAREKGRRRVTAVHKANIMKLGDGL 229
Cdd:COG0538  153 IEwkagspealkliffledemgvtvirFPEDSGIG--IKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGA 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 230 FLQCCKEVA-SGYPD-------------------IEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAGLVGGP 289
Cdd:COG0538  231 FKDWGYEVAeEEFGDkfitegpwekykgpkpagkIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGL 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 290 GLVPGANYGRDY-AVFE----TATRntgksIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMNETRLhTVD- 363
Cdd:COG0538  311 GIAPGANIGDDGgAEFEathgTAPK-----YAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKV-TYDl 384

                        330       340
                 ....*....|....*....|....*
gi 342187172 364 ---IGGQG--TTSEVVQSIMRIIQS 383
Cdd:COG0538  385 arlMEGATelSTSEFGDAIIENLDK 409
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 57-373 4.47e-41

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 148.15  E-value: 4.47e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  57 IPGDGIGPEL-------LNHVRE-LFRFSCVPVDF--EVVHVNSSSTSEDDISnaimAIRRNGVALKGNIeTNHTMPPNH 126
Cdd:PRK03437  10 IPGDGIGPEVvaealkvLDAVAAgGPGVETTEYDLgaRRYLRTGETLPDSVLA----ELRQHDAILLGAI-GDPSVPSGV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 127 KSRNNLLRT--SLDLYANVMHCQSLPGVQTRHKN---IDIIIIRENTEGEYSS--------LEHESASGVveclKIITRN 193
Cdd:PRK03437  85 LERGLLLKLrfALDHYVNLRPSKLYPGVTSPLAGpgdIDFVVVREGTEGPYTGnggalrvgTPHEVATEV----SVNTAF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 194 NSLRIADYAFKLAREKGRRRVTAVHKANIMKLGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKPYQFDVMVMPNL 273
Cdd:PRK03437 161 GVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTDNL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 274 YGNVVSNVCAGLVGGPGLVPGANY---GRDYAVFEtATRNTGKSIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAI 350
Cdd:PRK03437 241 FGDIITDLAAAVTGGIGLAASGNInptGTNPSMFE-PVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARIEAAV 319

                        330       340
                 ....*....|....*....|...
gi 342187172 351 LTTMNEtrlhtvDIGGQGTTSEV 373
Cdd:PRK03437 320 EADLAE------RGKMGRSTAEV 336
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
57-364 1.39e-40

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 148.44  E-value: 1.39e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  57 IPGDGIGPELLNHVRELfrfscvpVDFEV------------VHVNSSSTSEDDISN-----AIMAIRRNGVALKGNIETn 119
Cdd:PRK06451  29 VEGDGIGPEITHAAMKV-------INKAVekaygsdreikwVEVLAGDKAEKLTGNrfpkeSEELIEKYRVLLKGPLET- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 120 hTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKN---IDIIIIRENTEGEYSSLEH----ESASGVVECL----- 187
Cdd:PRK06451 101 -PIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPLKNpekIDLIIFRENTDDLYRGIEYpydsEEAKKIRDFLrkelg 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 188 -----------KIITRNNSLRIADYAFKLAREKGRRRVTAVHKANIMKLGDGLFLQCCKEVA------------------ 238
Cdd:PRK06451 180 veveddtgigiKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVAlkefrdyvvteeevtkny 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 239 SGYPD---IEFENMIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAGLVGGPGLVPGANYGRDYAVFEtATRNTGKSI 315
Cdd:PRK06451 260 NGVPPsgkVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE-AIHGTAPKY 338

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 342187172 316 ANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAILTTMNETRLhTVDI 364
Cdd:PRK06451 339 AGKNVANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKV-TQDL 386
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 104-350 1.14e-29

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 118.63  E-value: 1.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 104 AIRRNGVALKGNIETnhtmpP---NHKSRNNLLRTSLDLYA---NVMHCQSLPGVQTRHKNIDIIIIRENTEGEYSSLEH 177
Cdd:PRK07006  84 LIREYRVAIKGPLTT-----PvggGIRSLNVALRQELDLYVclrPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEW 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 178 ESASGVVECL-----------------------KIITRNNSLRIADYAFKLAREKGRRRVTAVHKANIMKLGDGLFLQCC 234
Cdd:PRK07006 159 KAGSAEAKKVikflqeemgvkkirfpetsgigiKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWG 238

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 235 KEVA---------SGYPDIEFEN-----------MIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAGLVGGPGLVPG 294
Cdd:PRK07006 239 YQLAeeefgdeliDGGPWDKIKNpetgkeiivkdSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPG 318

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 342187172 295 ANYGRDYAVFEtATRNTGKSIANRNIANPTAMLLASCLMLDHLKLHDYANMIRSAI 350
Cdd:PRK07006 319 ANINDGHAIFE-ATHGTAPKYAGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSM 373
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 51-388 3.73e-27

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 111.32  E-value: 3.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172  51 RHTVTLIPGDGIGPELLNHVREL-----------FRFSCVPV-----DFEVVHVNSSSTSEDDISNAIMAIRRNGVALKG 114
Cdd:PLN02329  46 RYNIALLPGDGIGPEVISVAKNVlqkagslegleFDFQEMPVggaalDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDK 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 115 NieTNHTMPPNHKSRnnlLRTSLDLYANVMHCQSLPGV-------QTRHKNIDIIIIRENTEGEYSSLE-----HESASG 182
Cdd:PLN02329 126 N--EKHLRPEMALFY---LRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYFGEPrgitiNENGEE 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 183 VVECLKIITRNNSLRIADYAFKLAREKgRRRVTAVHKANIMKlGDGLFLQCCKEVASGYPDIEFENMIVDNTTMQLVSKP 262
Cdd:PLN02329 201 VGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDP 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 263 YQFDVMVMPNLYGNVVSNVCAGLVGGPGLVPGANYGRDYAVFETATRNTGKSIANRNIANPTAMLLASCLMLDH-LKLHD 341
Cdd:PLN02329 279 KQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEK 358

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 342187172 342 YANMIRSAILTTMNETrLHTVDIGGQGTT----SEVVQSIMRIIQSGGPLT 388
Cdd:PLN02329 359 AAKRIEDAVVDALNKG-FRTGDIYSPGNKlvgcKEMGEEVLKSVDSKVPAT 408
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
102-350 1.69e-24

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 104.41  E-value: 1.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 102 IMAIRRNGVALKGNIETnhTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQTRHKN---IDIIIIRENTEGEYSSLEHE 178
Cdd:PRK07362  91 LEAIREYGVAIKGPLTT--PIGGGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNpekLDVIVYRENTEDIYMGIEWE 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 179 SASGVVECL----------------------------KIITRNNSLRIADYAFKLAR--EKGRRRVTAVHKANIMKLGDG 228
Cdd:PRK07362 169 AGDEIGDKLikhlneevipaspelgkrqiplgsgigiKPVSKTGSQRHIRRAIEHALrlPGDKRHVTLVHKGNIMKYTEG 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 229 LFL-------------QCCKEVAS-------GYPDIEFEN---------------------------------------- 248
Cdd:PRK07362 249 AFRdwgyelattefrdECVTERESwilsnkeKNPNISIEDnarmiepgydsltpekkaaicaevkevldsiwsshgngkw 328

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342187172 249 --------MIVDNTTMQLVSKPYQFDVMVMPNLYGNVVSNVCAGLVGGPGLVPGANYGRDYAVFEtATRNTGKSIANRNI 320
Cdd:PRK07362 329 kekvlvddRIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFE-ATHGTAPKHAGLDR 407

                        330       340       350
                 ....*....|....*....|....*....|
gi 342187172 321 ANPTAMLLASCLMLDHLKLHDYANMIRSAI 350
Cdd:PRK07362 408 INPGSVILSGVMMLEYLGWQEAADLITKGL 437
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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