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Conserved domains on  [gi|341926171|ref|NP_001230098|]
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pre T-cell antigen receptor alpha isoform 3 precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTCRA super family cl48267
Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature ...
 34-121 8.03e-45

Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation. This protein contains an immunoglobulin domain.


The actual alignment was detected with superfamily member pfam15028:

Pssm-ID: 464455  Cd Length: 127  Bit Score: 146.93  E-value: 8.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341926171   34 GPIWFSAGNGSALDAFTYGPSPATDGTWTNLAHLSLPSEELASWEPLVCHTGPGAEGHSRSTQPMHLSGEASTARTCPQE 113
Cdd:pfam15028  40 SPIWFSAGNGSALDAFTYGPSPATDGTWTSLAQLSLPSEELAAWEPLVCHTGPGAGGHGRSTQPLQLSGEASTARTCPQE 119


                  ....*...
gi 341926171  114 PLRGTPGG 121
Cdd:pfam15028 120 PLAGTQAQ 127
 
Name Accession Description Interval E-value
PTCRA pfam15028
Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature ...
 34-121 8.03e-45

Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation. This protein contains an immunoglobulin domain.


Pssm-ID: 464455  Cd Length: 127  Bit Score: 146.93  E-value: 8.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341926171   34 GPIWFSAGNGSALDAFTYGPSPATDGTWTNLAHLSLPSEELASWEPLVCHTGPGAEGHSRSTQPMHLSGEASTARTCPQE 113
Cdd:pfam15028  40 SPIWFSAGNGSALDAFTYGPSPATDGTWTSLAQLSLPSEELAAWEPLVCHTGPGAGGHGRSTQPLQLSGEASTARTCPQE 119


                  ....*...
gi 341926171  114 PLRGTPGG 121
Cdd:pfam15028 120 PLAGTQAQ 127
 
Name Accession Description Interval E-value
PTCRA pfam15028
Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature ...
 34-121 8.03e-45

Pre-T-cell antigen receptor; The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation. This protein contains an immunoglobulin domain.


Pssm-ID: 464455  Cd Length: 127  Bit Score: 146.93  E-value: 8.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 341926171   34 GPIWFSAGNGSALDAFTYGPSPATDGTWTNLAHLSLPSEELASWEPLVCHTGPGAEGHSRSTQPMHLSGEASTARTCPQE 113
Cdd:pfam15028  40 SPIWFSAGNGSALDAFTYGPSPATDGTWTSLAQLSLPSEELAAWEPLVCHTGPGAGGHGRSTQPLQLSGEASTARTCPQE 119


                  ....*...
gi 341926171  114 PLRGTPGG 121
Cdd:pfam15028 120 PLAGTQAQ 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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