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Conserved domains on  [gi|339275839|ref|NP_001229853|]
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zinc finger protein 410 isoform a [Homo sapiens]

Protein Classification

COG5048 and zf-H2C2_2 domain-containing protein( domain architecture ID 11779481)

protein containing domains SFP1, COG5048, and zf-H2C2_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 1.41e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.41e-05
                          10        20
                  ....*....|....*....|....*.
gi 339275839  342 SLRKHLVVHSGEKPHQCQVCGKTFSQ 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 206-317 2.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 206 KTSSNGENVHlgSGDGQSKDSGPLPQV--EKKLKCTVEGCDRTFVWPAHFKYH-LKTHRNDRSFICPAEGCGKSFYVlqr 282
Cdd:COG5189  320 NSSSNGKLAH--GGERNIDTPSRMLKVkdGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSA--- 394

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 339275839 283 lkvhmrthnGEKPFMCHEsgCGKQFTTAGNLKNHR 317
Cdd:COG5189  395 ---------KDKPYRCEV--CDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-516 3.33e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 262 NDRSFICPaeGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYS 341
Cdd:COG5048   30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 342 SLRKHLVVHSGEKPHQCQVcgktfSQSGSRNVHMRKHHLQLgaagSQEQEQTAEPLMGSSLLEEASVPSK-NLVSMNSQP 420
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSH-----SLPPSSRDPQLPDLLSI----SNLRNNPLPGNNSSSVNTPQSNSLHpPLPANSLSK 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 421 SLGGESLNLPNTNSILGVDdeVLAEGSPRSLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQESLAPLPRLECSGAFSAH 500
Cdd:COG5048  179 DPSSNLSLLISSNVSTSIP--SSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250
                 ....*....|....*.
gi 339275839 501 CNLCLPGSSDSPASAS 516
Cdd:COG5048  257 ASESPRSSLPTASSQS 272
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 1.41e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.41e-05
                          10        20
                  ....*....|....*....|....*.
gi 339275839  342 SLRKHLVVHSGEKPHQCQVCGKTFSQ 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 206-317 2.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 206 KTSSNGENVHlgSGDGQSKDSGPLPQV--EKKLKCTVEGCDRTFVWPAHFKYH-LKTHRNDRSFICPAEGCGKSFYVlqr 282
Cdd:COG5189  320 NSSSNGKLAH--GGERNIDTPSRMLKVkdGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSA--- 394

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 339275839 283 lkvhmrthnGEKPFMCHEsgCGKQFTTAGNLKNHR 317
Cdd:COG5189  395 ---------KDKPYRCEV--CDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-516 3.33e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 262 NDRSFICPaeGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYS 341
Cdd:COG5048   30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 342 SLRKHLVVHSGEKPHQCQVcgktfSQSGSRNVHMRKHHLQLgaagSQEQEQTAEPLMGSSLLEEASVPSK-NLVSMNSQP 420
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSH-----SLPPSSRDPQLPDLLSI----SNLRNNPLPGNNSSSVNTPQSNSLHpPLPANSLSK 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 421 SLGGESLNLPNTNSILGVDdeVLAEGSPRSLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQESLAPLPRLECSGAFSAH 500
Cdd:COG5048  179 DPSSNLSLLISSNVSTSIP--SSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250
                 ....*....|....*.
gi 339275839 501 CNLCLPGSSDSPASAS 516
Cdd:COG5048  257 ASESPRSSLPTASSQS 272
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 296-320 2.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|....*
gi 339275839  296 FMCHEsgCGKQFTTAGNLKNHRRIH 320
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 1.41e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.41e-05
                          10        20
                  ....*....|....*....|....*.
gi 339275839  342 SLRKHLVVHSGEKPHQCQVCGKTFSQ 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 206-317 2.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 206 KTSSNGENVHlgSGDGQSKDSGPLPQV--EKKLKCTVEGCDRTFVWPAHFKYH-LKTHRNDRSFICPAEGCGKSFYVlqr 282
Cdd:COG5189  320 NSSSNGKLAH--GGERNIDTPSRMLKVkdGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSA--- 394

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 339275839 283 lkvhmrthnGEKPFMCHEsgCGKQFTTAGNLKNHR 317
Cdd:COG5189  395 ---------KDKPYRCEV--CDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-516 3.33e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 262 NDRSFICPaeGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGCGRSFAEYS 341
Cdd:COG5048   30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 342 SLRKHLVVHSGEKPHQCQVcgktfSQSGSRNVHMRKHHLQLgaagSQEQEQTAEPLMGSSLLEEASVPSK-NLVSMNSQP 420
Cdd:COG5048  108 SSLSSSSSNSNDNNLLSSH-----SLPPSSRDPQLPDLLSI----SNLRNNPLPGNNSSSVNTPQSNSLHpPLPANSLSK 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 421 SLGGESLNLPNTNSILGVDdeVLAEGSPRSLSSVPDVTHHLVTMQSGRQSYEVSVLTAVNPQESLAPLPRLECSGAFSAH 500
Cdd:COG5048  179 DPSSNLSLLISSNVSTSIP--SSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS 256

                        250
                 ....*....|....*.
gi 339275839 501 CNLCLPGSSDSPASAS 516
Cdd:COG5048  257 ASESPRSSLPTASSQS 272
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 356-378 4.77e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 4.77e-04
                          10        20
                  ....*....|....*....|...
gi 339275839  356 HQCQVCGKTFSQSGSRNVHMRKH 378
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
245-384 5.19e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 5.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 245 RTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRLKVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNH-----RRI 319
Cdd:COG5048  301 RSSPLTRHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPqslqqYKD 380

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 339275839 320 HTGEKPFLCEAQGCGRSFAEYSSLRKHLVVHSGEKPHQCqvcgKTFSQSGSRNVHMRKHHLQLGA 384
Cdd:COG5048  381 LKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNC----KNPPCSKSFNRHYNLIPHKKIH 441
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 292-380 9.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 339275839 292 GEKPFMCHESGCGKQFTTAGNLKNHrRIHTGEKPFLceaqgcgrsfAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSR 371
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKL----------HENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL 414


                 ....*....
gi 339275839 372 NVHMRKHHL 380
Cdd:COG5189  415 KYHRKHSHD 423
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 296-320 2.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|....*
gi 339275839  296 FMCHEsgCGKQFTTAGNLKNHRRIH 320
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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