NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|333108269|ref|NP_001193950|]
View 

protein shisa-8 isoform 1 precursor [Mus musculus]

Protein Classification

shisa family protein( domain architecture ID 10621415)

shisa family protein is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Shisa pfam13908
Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that ...
 55-181 3.50e-26

Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.


:

Pssm-ID: 464036  Cd Length: 187  Bit Score: 103.75  E-value: 3.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333108269   55 GDRCRGYYDVMGQWDPPFNCSSGVYSFCCGTCGYRFCCHDGPRRLDQSRCSNYDTpaWVQTGRPPARARD-TAAPRDPAR 133
Cdd:pfam13908   1 GEYCHGWFDSMGQWHEGFQCPERDATFCCGSCSLRYCCSDVLARLDQGTCTNDRR--WMETGKEPPEAPDsTAEPIYVPF 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 333108269  134 ERSHTAVYAVCGVAALLVLVGIGARLGL-----ERAHSPRARRTvTRTLTELL 181
Cdd:pfam13908  79 LALGLIVAIGGSVFVAFVIVGIFCATCCccclyKMCRRPRPVVT-TTTTTTVV 130
 
Name Accession Description Interval E-value
Shisa pfam13908
Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that ...
 55-181 3.50e-26

Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.


Pssm-ID: 464036  Cd Length: 187  Bit Score: 103.75  E-value: 3.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333108269   55 GDRCRGYYDVMGQWDPPFNCSSGVYSFCCGTCGYRFCCHDGPRRLDQSRCSNYDTpaWVQTGRPPARARD-TAAPRDPAR 133
Cdd:pfam13908   1 GEYCHGWFDSMGQWHEGFQCPERDATFCCGSCSLRYCCSDVLARLDQGTCTNDRR--WMETGKEPPEAPDsTAEPIYVPF 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 333108269  134 ERSHTAVYAVCGVAALLVLVGIGARLGL-----ERAHSPRARRTvTRTLTELL 181
Cdd:pfam13908  79 LALGLIVAIGGSVFVAFVIVGIFCATCCccclyKMCRRPRPVVT-TTTTTTVV 130
 
Name Accession Description Interval E-value
Shisa pfam13908
Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that ...
 55-181 3.50e-26

Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.


Pssm-ID: 464036  Cd Length: 187  Bit Score: 103.75  E-value: 3.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333108269   55 GDRCRGYYDVMGQWDPPFNCSSGVYSFCCGTCGYRFCCHDGPRRLDQSRCSNYDTpaWVQTGRPPARARD-TAAPRDPAR 133
Cdd:pfam13908   1 GEYCHGWFDSMGQWHEGFQCPERDATFCCGSCSLRYCCSDVLARLDQGTCTNDRR--WMETGKEPPEAPDsTAEPIYVPF 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 333108269  134 ERSHTAVYAVCGVAALLVLVGIGARLGL-----ERAHSPRARRTvTRTLTELL 181
Cdd:pfam13908  79 LALGLIVAIGGSVFVAFVIVGIFCATCCccclyKMCRRPRPVVT-TTTTTTVV 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH