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Conserved domains on  [gi|328550512|ref|NP_001192203|]
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homeobox protein Crxos isoform c [Mus musculus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 21)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  26464018|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain super family cl47488
Homeodomain;
20-61 2.66e-11

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 54.43  E-value: 2.66e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 328550512   20 FSWEQLSELEAYFKVEPYPDLQDRKIMATRLKLKEEQVEAWF 61
Cdd:pfam00046   7 FTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF 48
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
20-61 2.66e-11

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 54.43  E-value: 2.66e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 328550512   20 FSWEQLSELEAYFKVEPYPDLQDRKIMATRLKLKEEQVEAWF 61
Cdd:pfam00046   7 FTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF 48
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 18-64 7.27e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.40  E-value: 7.27e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 328550512  18 QKFSWEQLSELEAYFKVEPYPDLQDRKIMATRLKLKEEQVEAWFIQR 64
Cdd:cd00086    5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 18-64 1.02e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.33  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 328550512    18 QKFSWEQLSELEAYFKVEPYPDLQDRKIMATRLKLKEEQVEAWFIQR 64
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
20-61 2.66e-11

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 54.43  E-value: 2.66e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 328550512   20 FSWEQLSELEAYFKVEPYPDLQDRKIMATRLKLKEEQVEAWF 61
Cdd:pfam00046   7 FTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF 48
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 18-64 7.27e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.40  E-value: 7.27e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 328550512  18 QKFSWEQLSELEAYFKVEPYPDLQDRKIMATRLKLKEEQVEAWFIQR 64
Cdd:cd00086    5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNR 51
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 18-64 1.02e-09

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.33  E-value: 1.02e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 328550512    18 QKFSWEQLSELEAYFKVEPYPDLQDRKIMATRLKLKEEQVEAWFIQR 64
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNR 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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