NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|325296973|ref|NP_001191674|]
View 

cadherin-16 isoform 3 precursor [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 342-445 1.63e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973 342 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 420
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 325296973 421 DlaGAEGGFSSTCEVEVAVTDINDH 445
Cdd:cd11304   76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-332 2.24e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.24e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325296973 264 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 332
Cdd:cd11304   28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-124 2.74e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.74e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325296973    47 PREGAEGQIVLSGDSGkATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 124
Cdd:smart00112   5 ADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 130-234 5.53e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 5.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973 130 IYRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQL 209
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*
gi 325296973 210 LVQVKDMGDQAsgHQATATVEVSII 234
Cdd:cd11304   71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 457-558 6.31e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 6.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973 457 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 536
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                         90       100
                 ....*....|....*....|....*..
gi 325296973 537 kLV-----GPGPGPGATATVTVLVERV 558
Cdd:cd11304   70 -LTvtatdGGGPPLSSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 568-640 6.06e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 6.06e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325296973 568 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQD 640
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATD 76
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 342-445 1.63e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973 342 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 420
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 325296973 421 DlaGAEGGFSSTCEVEVAVTDINDH 445
Cdd:cd11304   76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-332 2.24e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.24e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325296973 264 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 332
Cdd:cd11304   28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 264-334 2.19e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.19e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325296973   264 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 334
Cdd:smart00112   9 ENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-124 2.74e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.74e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325296973    47 PREGAEGQIVLSGDSGkATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 124
Cdd:smart00112   5 ADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 359-447 1.76e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973   359 SAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTLgVLPL--RAGQNILLLVLAMDlaGAEGGFSSTCEVE 436
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 325296973   437 VAVTDINDHAP 447
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-121 2.91e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 2.91e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 325296973  49 EGAEGQIV--LSGDSGkatEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 121
Cdd:cd11304   26 SGENGEVTysIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 130-234 5.53e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 5.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973 130 IYRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQL 209
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*
gi 325296973 210 LVQVKDMGDQAsgHQATATVEVSII 234
Cdd:cd11304   71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 457-558 6.31e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 6.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973 457 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 536
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                         90       100
                 ....*....|....*....|....*..
gi 325296973 537 kLV-----GPGPGPGATATVTVLVERV 558
Cdd:cd11304   70 -LTvtatdGGGPPLSSTATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
341-440 1.55e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973  341 PTVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSPEPedgveGRAFQVDPTSGSVTLGVlPLR--AGQNILLLVL 418
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDISTTK-PLDreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 325296973  419 AMDLAGaeGGFSSTCEVEVAVT 440
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
456-556 1.90e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973  456 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEVvvvvqSV 535
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRID--PDTGDISTT--KPLDRESIGEYEL-----TV 71

                          90       100
                  ....*....|....*....|.
gi 325296973  536 AKLVGPGPGPGATATVTVLVE 556
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 568-640 6.06e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 6.06e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325296973 568 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQD 640
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATD 76
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 150-234 1.48e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973   150 ASDRDEPgtANSDLRFHILSQAPaqpsPDMFQLEPRLGALALSpkgsTSLDHALERTYQLLVQVKDMGDQAsgHQATATV 229
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGPP--LSSTATV 69


                   ....*
gi 325296973   230 EVSII 234
Cdd:smart00112  70 TITVL 74
Cadherin pfam00028
Cadherin domain;
26-116 1.62e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 1.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973   26 SVEVPENY-GGNFPLYLTKLPlPREGAEGQIV---LSGDSGkateGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQ 101
Cdd:pfam00028   2 SASVPENApVGTEVLTVTATD-PDLGPNGRIFysiLGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 325296973  102 DGHVLWGPQPVLVHV 116
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
272-326 9.13e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 9.13e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 325296973  272 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLV 326
Cdd:pfam00028  36 LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
131-234 2.87e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 2.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973  131 YRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQLL 210
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....
gi 325296973  211 VQVKDMGDQASghQATATVEVSII 234
Cdd:pfam00028  71 VEATDSGGPPL--SSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 342-445 1.63e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973 342 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 420
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*
gi 325296973 421 DlaGAEGGFSSTCEVEVAVTDINDH 445
Cdd:cd11304   76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-332 2.24e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.24e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 325296973 264 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 332
Cdd:cd11304   28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 264-334 2.19e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.19e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 325296973   264 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 334
Cdd:smart00112   9 ENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-124 2.74e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.74e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 325296973    47 PREGAEGQIVLSGDSGkATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 124
Cdd:smart00112   5 ADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 359-447 1.76e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.22  E-value: 1.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973   359 SAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTLgVLPL--RAGQNILLLVLAMDlaGAEGGFSSTCEVE 436
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 325296973   437 VAVTDINDHAP 447
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-121 2.91e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 2.91e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 325296973  49 EGAEGQIV--LSGDSGkatEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 121
Cdd:cd11304   26 SGENGEVTysIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 130-234 5.53e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 5.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973 130 IYRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQL 209
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*
gi 325296973 210 LVQVKDMGDQAsgHQATATVEVSII 234
Cdd:cd11304   71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 457-558 6.31e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 6.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973 457 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 536
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                         90       100
                 ....*....|....*....|....*..
gi 325296973 537 kLV-----GPGPGPGATATVTVLVERV 558
Cdd:cd11304   70 -LTvtatdGGGPPLSSTATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
341-440 1.55e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973  341 PTVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSPEPedgveGRAFQVDPTSGSVTLGVlPLR--AGQNILLLVL 418
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDISTTK-PLDreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 325296973  419 AMDLAGaeGGFSSTCEVEVAVT 440
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
456-556 1.90e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 1.90e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973  456 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEVvvvvqSV 535
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRID--PDTGDISTT--KPLDRESIGEYEL-----TV 71

                          90       100
                  ....*....|....*....|.
gi 325296973  536 AKLVGPGPGPGATATVTVLVE 556
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 568-640 6.06e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 6.06e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 325296973 568 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQD 640
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATD 76
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 150-234 1.48e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973   150 ASDRDEPgtANSDLRFHILSQAPaqpsPDMFQLEPRLGALALSpkgsTSLDHALERTYQLLVQVKDMGDQAsgHQATATV 229
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGPP--LSSTATV 69


                   ....*
gi 325296973   230 EVSII 234
Cdd:smart00112  70 TITVL 74
Cadherin pfam00028
Cadherin domain;
26-116 1.62e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 1.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973   26 SVEVPENY-GGNFPLYLTKLPlPREGAEGQIV---LSGDSGkateGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQ 101
Cdd:pfam00028   2 SASVPENApVGTEVLTVTATD-PDLGPNGRIFysiLGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 325296973  102 DGHVLWGPQPVLVHV 116
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
272-326 9.13e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 9.13e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 325296973  272 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLV 326
Cdd:pfam00028  36 LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-121 2.19e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.87  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973  29 VPENYGGnfPLYLTKLPLPREGAEGQIV-LSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLW 107
Cdd:cd00031    6 AVEGRSR--GSFRVSIPTDLIASSGEIIkISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQ 83

                         90
                 ....*....|....
gi 325296973 108 GPQPVLVHVKDEND 121
Cdd:cd00031   84 TSSVFSIEVYDEND 97
Cadherin pfam00028
Cadherin domain;
131-234 2.87e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 2.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 325296973  131 YRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQLL 210
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....
gi 325296973  211 VQVKDMGDQASghQATATVEVSII 234
Cdd:pfam00028  71 VEATDSGGPPL--SSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 276-332 8.23e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.33  E-value: 8.23e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 325296973 276 PPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 332
Cdd:cd00031   41 LPSWLHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH