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Conserved domains on  [gi|334186331|ref|NP_001190664|]
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Small nuclear ribonucleoprotein family protein [Arabidopsis thaliana]

Protein Classification

small nuclear ribonucleoprotein Sm D1( domain architecture ID 10109585)

small nuclear ribonucleoprotein D1 is part of the eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) which is assemble into a hetero-heptameric ring around the Sm site of the 2,2,7-trimethyl guanosine (m3G) capped U1, U2, U4 and U5 snRNAs (Sm snRNAs) forming the core of the snRNP particle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sm_D1 cd01724
Sm protein D1; The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a ...
 2-103 2.43e-56

Sm protein D1; The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a hetero-heptameric ring around the Sm site of the 2,2,7-trimethyl guanosine (m3G) capped U1, U2, U4 and U5 snRNAs (Sm snRNAs) forming the core of the snRNP particle. The snRNP particle, in turn, assembles with other components onto the pre-mRNA to form the spliceosome which is responsible for the excision of introns and the ligation of exons. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm subunit D1 heterodimerizes with subunit D2 and three such heterodimers form a hexameric ring structure with alternating D1 and D2 subunits. The D1 - D2 heterodimer also assembles into a heptameric ring containing DB, D3, E, F, and G subunits.


:

Pssm-ID: 212471  Cd Length: 92  Bit Score: 170.10  E-value: 2.43e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186331   2 KLVRFLMKLNNETVSIELKNGTIVHGTITdeytrfylnrGVDVSMNTHLKAVKLTLKGKNPVTLDHLSVRGNNIRYYILP 81
Cdd:cd01724    1 KLVRFLMKLSNETVTIELKNGTVVHGTIT----------GVDVSMNTHLKNVKLTLKGKNPVSLDTLSIRGNNIRYIILP 70

                         90       100
                 ....*....|....*....|..
gi 334186331  82 DSLNLETLLVEDTPRIKPKKPT 103
Cdd:cd01724   71 DSLNLDTLLVDDTPKAKAKKRA 92
 
Name Accession Description Interval E-value
Sm_D1 cd01724
Sm protein D1; The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a ...
 2-103 2.43e-56

Sm protein D1; The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a hetero-heptameric ring around the Sm site of the 2,2,7-trimethyl guanosine (m3G) capped U1, U2, U4 and U5 snRNAs (Sm snRNAs) forming the core of the snRNP particle. The snRNP particle, in turn, assembles with other components onto the pre-mRNA to form the spliceosome which is responsible for the excision of introns and the ligation of exons. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm subunit D1 heterodimerizes with subunit D2 and three such heterodimers form a hexameric ring structure with alternating D1 and D2 subunits. The D1 - D2 heterodimer also assembles into a heptameric ring containing DB, D3, E, F, and G subunits.


Pssm-ID: 212471  Cd Length: 92  Bit Score: 170.10  E-value: 2.43e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186331   2 KLVRFLMKLNNETVSIELKNGTIVHGTITdeytrfylnrGVDVSMNTHLKAVKLTLKGKNPVTLDHLSVRGNNIRYYILP 81
Cdd:cd01724    1 KLVRFLMKLSNETVTIELKNGTVVHGTIT----------GVDVSMNTHLKNVKLTLKGKNPVSLDTLSIRGNNIRYIILP 70

                         90       100
                 ....*....|....*....|..
gi 334186331  82 DSLNLETLLVEDTPRIKPKKPT 103
Cdd:cd01724   71 DSLNLDTLLVDDTPKAKAKKRA 92
LSM pfam01423
LSM domain; The LSM domain contains Sm proteins as well as other related LSM (Like Sm) ...
 5-80 1.52e-13

LSM domain; The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.


Pssm-ID: 426258  Cd Length: 66  Bit Score: 60.60  E-value: 1.52e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334186331    5 RFLMKLNNETVSIELKNGTIVHGTItdeytrfylnRGVDVSMNTHLKAVKLTLKGKNPVTLDHLSVRGNNIRYYIL 80
Cdd:pfam01423   1 KFLKKLLGKRVLVELKNGRELRGTL----------KGFDQFMNLVLDDVEETIKDGEVRKLGLVLIRGNNIVLISP 66
Sm smart00651
snRNP Sm proteins; small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA ...
 5-80 2.70e-13

snRNP Sm proteins; small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing


Pssm-ID: 197820 [Multi-domain]  Cd Length: 67  Bit Score: 60.20  E-value: 2.70e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334186331     5 RFLMKLNNETVSIELKNGTIVHGTItdeytrfylnRGVDVSMNTHLKAVKLTLK-GKNPVTLDHLSVRGNNIRYYIL 80
Cdd:smart00651   1 KFLKKLIGKRVLVELKNGREYRGTL----------KGFDQFMNLVLEDVEETVKdGEKKRKLGLVFIRGNNIVYIIL 67
LSM1 COG1958
Small nuclear ribonucleoprotein (snRNP) homolog [Transcription];
1-75 1.79e-05

Small nuclear ribonucleoprotein (snRNP) homolog [Transcription];


Pssm-ID: 441561  Cd Length: 71  Bit Score: 39.78  E-value: 1.79e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334186331   1 MKLVRFLMKLNNETVSIELKNGTIVHGTItdeytrfylnRGVDVSMNTHLKAVKLTLKGKNPVTLDHLSVRGNNI 75
Cdd:COG1958    3 ERPLKVLEKSLGKRVLVKLKDGREYRGKL----------KGYDQHMNLVLEDAEEIDDGEVVRKLGTVVIRGDNV 67
 
Name Accession Description Interval E-value
Sm_D1 cd01724
Sm protein D1; The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a ...
 2-103 2.43e-56

Sm protein D1; The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a hetero-heptameric ring around the Sm site of the 2,2,7-trimethyl guanosine (m3G) capped U1, U2, U4 and U5 snRNAs (Sm snRNAs) forming the core of the snRNP particle. The snRNP particle, in turn, assembles with other components onto the pre-mRNA to form the spliceosome which is responsible for the excision of introns and the ligation of exons. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm subunit D1 heterodimerizes with subunit D2 and three such heterodimers form a hexameric ring structure with alternating D1 and D2 subunits. The D1 - D2 heterodimer also assembles into a heptameric ring containing DB, D3, E, F, and G subunits.


Pssm-ID: 212471  Cd Length: 92  Bit Score: 170.10  E-value: 2.43e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186331   2 KLVRFLMKLNNETVSIELKNGTIVHGTITdeytrfylnrGVDVSMNTHLKAVKLTLKGKNPVTLDHLSVRGNNIRYYILP 81
Cdd:cd01724    1 KLVRFLMKLSNETVTIELKNGTVVHGTIT----------GVDVSMNTHLKNVKLTLKGKNPVSLDTLSIRGNNIRYIILP 70

                         90       100
                 ....*....|....*....|..
gi 334186331  82 DSLNLETLLVEDTPRIKPKKPT 103
Cdd:cd01724   71 DSLNLDTLLVDDTPKAKAKKRA 92
LSM pfam01423
LSM domain; The LSM domain contains Sm proteins as well as other related LSM (Like Sm) ...
 5-80 1.52e-13

LSM domain; The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.


Pssm-ID: 426258  Cd Length: 66  Bit Score: 60.60  E-value: 1.52e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334186331    5 RFLMKLNNETVSIELKNGTIVHGTItdeytrfylnRGVDVSMNTHLKAVKLTLKGKNPVTLDHLSVRGNNIRYYIL 80
Cdd:pfam01423   1 KFLKKLLGKRVLVELKNGRELRGTL----------KGFDQFMNLVLDDVEETIKDGEVRKLGLVLIRGNNIVLISP 66
Sm smart00651
snRNP Sm proteins; small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA ...
 5-80 2.70e-13

snRNP Sm proteins; small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing


Pssm-ID: 197820 [Multi-domain]  Cd Length: 67  Bit Score: 60.20  E-value: 2.70e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334186331     5 RFLMKLNNETVSIELKNGTIVHGTItdeytrfylnRGVDVSMNTHLKAVKLTLK-GKNPVTLDHLSVRGNNIRYYIL 80
Cdd:smart00651   1 KFLKKLIGKRVLVELKNGREYRGTL----------KGFDQFMNLVLEDVEETVKdGEKKRKLGLVFIRGNNIVYIIL 67
Sm_like cd00600
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to ...
 7-79 1.51e-08

Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm-like proteins exist in archaea as well as prokaryotes that form heptameric and hexameric ring structures similar to those found in eukaryotes.


Pssm-ID: 212462 [Multi-domain]  Cd Length: 63  Bit Score: 47.63  E-value: 1.51e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334186331   7 LMKLNNETVSIELKNGTIVHGTITdeytrfylnrGVDVSMNTHLKAVKLTLKGKNPVTLDHLSVRGNNIRYYI 79
Cdd:cd00600    1 LKDFIGKTVSVELKDGRVLTGTLV----------AFDKYMNLVLDDVVETGRDGKVRVLGLVLIRGSNIVSIR 63
Sm_D3 cd01721
Sm protein D3; The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a ...
 14-82 1.83e-08

Sm protein D3; The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a hetero-heptameric ring around the Sm site of the 2,2,7-trimethyl guanosine (m3G) capped U1, U2, U4 and U5 snRNAs (Sm snRNAs) forming the core of the snRNP particle. The snRNP particle, in turn, assembles with other components onto the pre-mRNA to form the spliceosome which is responsible for the excision of introns and the ligation of exons. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm subunit D3 heterodimerizes with subunit B and three such heterodimers form a hexameric ring structure with alternating B and D3 subunits. The D3 - B heterodimer also assembles into a heptameric ring containing D1, D2, E, F, and G subunits.


Pssm-ID: 212468  Cd Length: 70  Bit Score: 47.52  E-value: 1.83e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334186331  14 TVSIELKNGTIVHGTITDeytrfylnrgVDVSMNTHLKAVKLTLKGKNPVTLDHLSVRGNNIRYYILPD 82
Cdd:cd01721   12 IVTVELKTGEVYRGKLIE----------AEDNMNCQLKDVTVTARDGKVSKLEQVYIRGSQIRFIILPD 70
LSm10 cd01733
Like-Sm protein 10; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form ...
 3-77 3.83e-06

Like-Sm protein 10; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. LSm10 is an SmD1-like protein which is thought to bind U7 snRNA along with LSm11 and five other Sm subunits to form a 7-membered ring structure. LSm10 and the U7 snRNP of which it is a part are thought to play an important role in histone mRNA 3' processing.


Pssm-ID: 212480  Cd Length: 78  Bit Score: 41.76  E-value: 3.83e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334186331   3 LVRFLMKLNNETVSIELKNGTIVHGTITDeytrfylnrgVDVSMNTHLKAVKLT-LKGKNpVTLDHLSVRGNNIRY 77
Cdd:cd01733   10 LVCLLQALQGRVTTVELRNETSVRGIIDN----------VDGFMNITLSDATFTdRRGKQ-HHFDEFFVQGRNIRY 74
LSm4 cd01723
Like-Sm protein 4; The eukaryotic LSm proteins (LSm2-8 or LSm1-7) assemble into a ...
 11-84 1.48e-05

Like-Sm protein 4; The eukaryotic LSm proteins (LSm2-8 or LSm1-7) assemble into a hetero-heptameric ring around the 3'-terminus uridylation tag of the gamma-methyl triphosphate (gamma-m-P3) capped U6 snRNA. LSm2-8 form the core of the snRNP particle that, in turn, assembles with other components onto the pre-mRNA to form the spliceosome which is responsible for the excision of introns and the ligation of exons. LSm1-7 is involved in recognition of the 3' uridylation tag and recruitment of the decapping machinery. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet.


Pssm-ID: 212470 [Multi-domain]  Cd Length: 76  Bit Score: 40.25  E-value: 1.48e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334186331  11 NNETVSIELKNGTIVHGTITDeytrfylnrgVDVSMNTHLKAVKLTLK-GKNPVTLDHLSVRGNNIRYYILPDSL 84
Cdd:cd01723   10 QGHPVLVELKNGETYNGHLVN----------CDNWMNIHLKNVICTSKdGDRFWKMPECYIRGNTIKYLRLPDEV 74
LSM1 COG1958
Small nuclear ribonucleoprotein (snRNP) homolog [Transcription];
1-75 1.79e-05

Small nuclear ribonucleoprotein (snRNP) homolog [Transcription];


Pssm-ID: 441561  Cd Length: 71  Bit Score: 39.78  E-value: 1.79e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334186331   1 MKLVRFLMKLNNETVSIELKNGTIVHGTItdeytrfylnRGVDVSMNTHLKAVKLTLKGKNPVTLDHLSVRGNNI 75
Cdd:COG1958    3 ERPLKVLEKSLGKRVLVKLKDGREYRGKL----------KGYDQHMNLVLEDAEEIDDGEVVRKLGTVVIRGDNV 67
LSm2 cd01725
Like-Sm protein 2; The eukaryotic LSm proteins (LSm2-8 or LSm1-7) assemble into a ...
 6-96 9.51e-03

Like-Sm protein 2; The eukaryotic LSm proteins (LSm2-8 or LSm1-7) assemble into a hetero-heptameric ring around the 3'-terminus uridylation tag of the gamma-methyl triphosphate (gamma-m-P3) capped U6 snRNA. LSm2-8 form the core of the snRNP particle that, in turn, assembles with other components onto the pre-mRNA to form the spliceosome which is responsible for the excision of introns and the ligation of exons. LSm1-7 is involved in recognition of the 3' uridylation tag and recruitment of the decapping machinery. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet.


Pssm-ID: 212472  Cd Length: 89  Bit Score: 32.95  E-value: 9.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334186331   6 FLMKLNNETVSIELKNGTIVHGTITDeytrfylnrgVDVSMNTHLKAVKLTLKGKNP--VTLDHLSVRGNNIRYYILPDS 83
Cdd:cd01725    5 FFKTLVGKEVTVELKNDLSITGTLHS----------VDQYLNIKLTNISVNDPEKYPhlLSVKNCFIRGSVVRYVQLPAD 74

                         90
                 ....*....|...
gi 334186331  84 lNLETLLVEDTPR 96
Cdd:cd01725   75 -EVDTELLQDATR 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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