NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|334188460|ref|NP_001190559|]
View 

H[+]-ATPase 3 [Arabidopsis thaliana]

Protein Classification

plasma-membrane proton-efflux P-type ATPase( domain architecture ID 11492973)

plasma-membrane proton-efflux P-type ATPase generates the proton motive force across the plasma membrane that is necessary to activate most of the ion and metabolite transport

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
33-805 0e+00

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


:

Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 1156.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   33 GLSGAEGENRLQIFGPNKLEEKKESKLLKFLGFMWNPLSWVMEAAAIMAIALANgggkppdWQDFVGIVCLLVINSTISF 112
Cdd:TIGR01647   1 GLTSAEAKKRLAKYGPNELPEKKVSPLLKFLGFFWNPLSWVMEAAAIIAIALEN-------WVDFVIILGLLLLNATIGF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  113 VEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKG 192
Cdd:TIGR01647  74 IEENKAGNAVEALKQSLAPKARVLRDGKWQEIPASELVPGDVVRLKIGDIVPADCRLFEGDYIQVDQAALTGESLPVTKK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  193 PGEEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTN-QVGHFQKVLTAIGNFCICSIAVGIAIEIVVMYPIQRRHY 271
Cdd:TIGR01647 154 TGDIAYSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTEtGSGHLQKILSKIGLFLIVLIGVLVLIELVVLFFGRGESF 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  272 RDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLIEVYc 351
Cdd:TIGR01647 234 REGLQFALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEELAGMDILCSDKTGTLTLNKLSIDEILPFFN- 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  352 kGVEKDEVLLFAARASRVENQDAIDAAMVGMLADPKEARAGIREIHFLPFNPVDKRTALTFIDS-NGNWHRVSKGAPEQI 430
Cdd:TIGR01647 313 -GFDKDDVLLYAALASREEDQDAIDTAVLGSAKDLKEARDGYKVLEFVPFDPVDKRTEATVEDPeTGKRFKVTKGAPQVI 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  431 LDLCNARADLRKRVHSTIDKYAERGLRSLAVSRQtvpektkeSSGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKM 510
Cdd:TIGR01647 392 LDLCDNKKEIEEKVEEKVDELASRGYRALGVART--------DEEGRWHFLGLLPLFDPPRHDTKETIERARHLGVEVKM 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  511 ITGDQLAIAKETGRRLGMGSNMYPSSSLLGKhKDEAMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDG 590
Cdd:TIGR01647 464 VTGDHLAIAKETARRLGLGTNIYTADVLLKG-DNRDDLPSGLGEMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDG 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  591 VNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMLIALIWKF 670
Cdd:TIGR01647 543 VNDAPALKKADVGIAVAGATDAARSAADIVLTEPGLSVIVDAILESRKIFQRMKSYVIYRIAETIRIVFFFGLLILILNF 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  671 DFSPFMVLIIAILNDGTIMTISKDRVKPSPTPDSWKLKEIFATGVVLGGYMAIMTVVFFWAAYKTDFFPRTFHVRDLRGs 750
Cdd:TIGR01647 623 YFPPIMVVIIAILNDGTIMTIAYDNVKPSKLPQRWNLREVFTMSTVLGIYLVISTFLLLAIALDTTFFIDKFGLQLLHG- 701
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 334188460  751 ehEMMSALYLQVSIVSQALIFVTRSRSWSFTERPGYFLLIAFWVAQLIATAIAVY 805
Cdd:TIGR01647 702 --NLQSFIYLQVSISGHATIFVTRTHGFFWSERPGKLLFGAFVIAQIIATFIAVY 754
 
Name Accession Description Interval E-value
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
33-805 0e+00

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 1156.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   33 GLSGAEGENRLQIFGPNKLEEKKESKLLKFLGFMWNPLSWVMEAAAIMAIALANgggkppdWQDFVGIVCLLVINSTISF 112
Cdd:TIGR01647   1 GLTSAEAKKRLAKYGPNELPEKKVSPLLKFLGFFWNPLSWVMEAAAIIAIALEN-------WVDFVIILGLLLLNATIGF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  113 VEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKG 192
Cdd:TIGR01647  74 IEENKAGNAVEALKQSLAPKARVLRDGKWQEIPASELVPGDVVRLKIGDIVPADCRLFEGDYIQVDQAALTGESLPVTKK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  193 PGEEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTN-QVGHFQKVLTAIGNFCICSIAVGIAIEIVVMYPIQRRHY 271
Cdd:TIGR01647 154 TGDIAYSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTEtGSGHLQKILSKIGLFLIVLIGVLVLIELVVLFFGRGESF 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  272 RDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLIEVYc 351
Cdd:TIGR01647 234 REGLQFALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEELAGMDILCSDKTGTLTLNKLSIDEILPFFN- 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  352 kGVEKDEVLLFAARASRVENQDAIDAAMVGMLADPKEARAGIREIHFLPFNPVDKRTALTFIDS-NGNWHRVSKGAPEQI 430
Cdd:TIGR01647 313 -GFDKDDVLLYAALASREEDQDAIDTAVLGSAKDLKEARDGYKVLEFVPFDPVDKRTEATVEDPeTGKRFKVTKGAPQVI 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  431 LDLCNARADLRKRVHSTIDKYAERGLRSLAVSRQtvpektkeSSGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKM 510
Cdd:TIGR01647 392 LDLCDNKKEIEEKVEEKVDELASRGYRALGVART--------DEEGRWHFLGLLPLFDPPRHDTKETIERARHLGVEVKM 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  511 ITGDQLAIAKETGRRLGMGSNMYPSSSLLGKhKDEAMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDG 590
Cdd:TIGR01647 464 VTGDHLAIAKETARRLGLGTNIYTADVLLKG-DNRDDLPSGLGEMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDG 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  591 VNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMLIALIWKF 670
Cdd:TIGR01647 543 VNDAPALKKADVGIAVAGATDAARSAADIVLTEPGLSVIVDAILESRKIFQRMKSYVIYRIAETIRIVFFFGLLILILNF 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  671 DFSPFMVLIIAILNDGTIMTISKDRVKPSPTPDSWKLKEIFATGVVLGGYMAIMTVVFFWAAYKTDFFPRTFHVRDLRGs 750
Cdd:TIGR01647 623 YFPPIMVVIIAILNDGTIMTIAYDNVKPSKLPQRWNLREVFTMSTVLGIYLVISTFLLLAIALDTTFFIDKFGLQLLHG- 701
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 334188460  751 ehEMMSALYLQVSIVSQALIFVTRSRSWSFTERPGYFLLIAFWVAQLIATAIAVY 805
Cdd:TIGR01647 702 --NLQSFIYLQVSISGHATIFVTRTHGFFWSERPGKLLFGAFVIAQIIATFIAVY 754
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
33-840 0e+00

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 1106.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  33 GLSGAEGENRLQIFGPNKLEEKKESKLLKFLGFMWNPLSWVMEAAAIMAIAlangggkPPDWQDFVGIVCLLVINSTISF 112
Cdd:cd02076    1 GLTSEEAAKRLKEYGPNELPEKKENPILKFLSFFWGPIPWMLEAAAILAAA-------LGDWVDFAIILLLLLINAGIGF 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 113 VEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKG 192
Cdd:cd02076   74 IEERQAGNAVAALKKSLAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADARLLTGDALQVDQSALTGESLPVTKH 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 193 PGEEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQVGHFQKVLTAIGNFCICSIAVGIAIEIVVMYPIQRRhYR 272
Cdd:cd02076  154 PGDEAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVASAEEQGHLQKVLNKIGNFLILLALILVLIIVIVALYRHDP-FL 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 273 DGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLIevyCK 352
Cdd:cd02076  233 EILQFVLVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDKTGTLTLNKLSLDEPYS---LE 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 353 GVEKDEVLLFAARASRVENQDAIDAAMVGMLADPKEARAGIREIHFLPFNPVDKRTALTFIDSNGNWHRVSKGAPEQILD 432
Cdd:cd02076  310 GDGKDELLLLAALASDTENPDAIDTAILNALDDYKPDLAGYKQLKFTPFDPVDKRTEATVEDPDGERFKVTKGAPQVILE 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 433 LCNARADLRKRVHSTIDKYAERGLRSLAVSRQTVpektkessGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMIT 512
Cdd:cd02076  390 LVGNDEAIRQAVEEKIDELASRGYRSLGVARKED--------GGRWELLGLLPLFDPPRPDSKATIARAKELGVRVKMIT 461
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 513 GDQLAIAKETGRRLGMGSNMYPSSSLLGKHKDEAMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVN 592
Cdd:cd02076  462 GDQLAIAKETARQLGMGTNILSAERLKLGGGGGGMPGSELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVN 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 593 DAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMLIALIWKF-D 671
Cdd:cd02076  542 DAPALKKADVGIAVSGATDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYRIAETLRILVFFTLGILILNFyP 621
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 672 FSPFMVLIIAILNDGTIMTISKDRVKPSPTPDSWKLKEIFATGVVLGGYMAIMTVVFFWAAYKTDFFprtfhvRDLRGSE 751
Cdd:cd02076  622 LPLIMIVLIAILNDGATLTIAYDNVPPSPRPVRWNMPELLGIATVLGVVLTISSFLLLWLLDDQGWF------EDIVLSA 695
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 752 HEMMSALYLQVSIVSQALIFVTRSRSWSFTERPGYFLLIAFWVAQLIATAIAVYGNWEFArikGIGWGWAGVIWLYSIVF 831
Cdd:cd02076  696 GELQTILYLQLSISGHLTIFVTRTRGPFWRPRPSPLLFIAVVLTQILATLLAVYGWFMFA---GIGWGWALLVWIYALVW 772

                 ....*....
gi 334188460 832 YFPLDIMKF 840
Cdd:cd02076  773 FVVLDFVKL 781
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
18-843 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 613.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  18 IPIEEVFQQLKCSREGLSGAEGENRLQIFGPNKL-EEKKESKLLKFLGFMWNPL----------SWVMEaaaimaialan 86
Cdd:COG0474   11 LSAEEVLAELGTSEEGLSSEEAARRLARYGPNELpEEKKRSLLRRFLEQFKNPLilillaaaviSALLG----------- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  87 gggkppDWQDFVGIVCLLVINSTISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPAD 166
Cdd:COG0474   80 ------DWVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPAD 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 167 ARLLEGDPLKVDQSALTGESLPATKGPGEE------------VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQV 234
Cdd:COG0474  154 LRLLEAKDLQVDESALTGESVPVEKSADPLpedaplgdrgnmVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEE 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 235 -GHFQKVLTAIGNFCIcSIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITK 313
Cdd:COG0474  234 kTPLQKQLDRLGKLLA-IIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVR 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 314 RMTAIEEMAGMDVLCSDKTGTLTLNKLSVDK-----NLIEVYCKGVEK-DEVLLFAARAS------RVENQDAIDAAMVG 381
Cdd:COG0474  313 RLPAVETLGSVTVICTDKTGTLTQNKMTVERvytggGTYEVTGEFDPAlEELLRAAALCSdaqleeETGLGDPTEGALLV 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 382 MLA----DPKEARAGIREIHFLPFNPVDKRTALTFIDSNGNWHRVSKGAPEQILDLCNAR----------ADLRKRVHST 447
Cdd:COG0474  393 AAAkaglDVEELRKEYPRVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRVltgggvvpltEEDRAEILEA 472
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 448 IDKYAERGLRSLAVSRQTVPEKTKESSG---SPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGR 524
Cdd:COG0474  473 VEELAAQGLRVLAVAYKELPADPELDSEddeSDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIAR 552
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 525 RLGMGSNmyPSSSLLGKH----KDEAMAhipveDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKA 600
Cdd:COG0474  553 QLGLGDD--GDRVLTGAEldamSDEELA-----EAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPALKAA 625
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 601 DIGIAV-ADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFgFMLIALIWKFD--FSPFMV 677
Cdd:COG0474  626 DIGIAMgITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVL-SVLLASLLGLPlpLTPIQI 704
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 678 LIIAILNDGT-IMTISKDRVKPS-----PTPDSWKL--KEIFATGVVLGGYMAIMTVVFFWAAYKtdffprtfhvrdlRG 749
Cdd:COG0474  705 LWINLVTDGLpALALGFEPVEPDvmkrpPRWPDEPIlsRFLLLRILLLGLLIAIFTLLTFALALA-------------RG 771
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 750 SEHEMMSALYLQVSIVSQ-ALIFVTRSRSWSFTERPGY---FLLIAFWVAQLIATAIaVYGNWeFARIKG---IGWGWAG 822
Cdd:COG0474  772 ASLALARTMAFTTLVLSQlFNVFNCRSERRSFFKSGLFpnrPLLLAVLLSLLLQLLL-IYVPP-LQALFGtvpLPLSDWL 849
                        890       900
                 ....*....|....*....|.
gi 334188460 823 VIWLYSIVFYFPLDIMKFAIR 843
Cdd:COG0474  850 LILGLALLYLLLVELVKLLRR 870
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
13-646 7.10e-77

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 270.02  E-value: 7.10e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  13 VDLEKIPIEEVFQQLKCSREGLSGAEGENRLQIFGPNKLEEKKESKLLKFLgfmW----NP----------LSWVMEAAA 78
Cdd:PRK10517  47 LKAAVMPEEELWKTFDTHPEGLNEAEVESAREQHGENELPAQKPLPWWVHL---WvcyrNPfnilltilgaISYATEDLF 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  79 IMaialangggkppdwqdfvGIVCLLVINST-ISFVEENNAGNAAAALMAGLAPKTKVLR------DGKWSEQEASILVP 151
Cdd:PRK10517 124 AA------------------GVIALMVAISTlLNFIQEARSTKAADALKAMVSNTATVLRvindkgENGWLEIPIDQLVP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 152 GDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKGPGEE-------------VFSGSTCKQGEIEAVVIATGVH 218
Cdd:PRK10517 186 GDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFATTRqpehsnplecdtlCFMGTNVVSGTAQAVVIATGAN 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 219 TFFGKAAHLVDST-NQVGHFQKVLTAIGNFCICSIAVgiaieivvMYPIqrrhyrdgidnllVLLIGGI----------- 286
Cdd:PRK10517 266 TWFGQLAGRVSEQdSEPNAFQQGISRVSWLLIRFMLV--------MAPV-------------VLLINGYtkgdwweaalf 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 287 ---------PIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNlIEVYckGVEKD 357
Cdd:PRK10517 325 alsvavgltPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLENH-TDIS--GKTSE 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 358 EVLLFAARASRVEN--QDAIDAAMVGMLADPKEARAGI--REIHFLPFNpVDKRTALTFIDSNGNWHR-VSKGAPEQILD 432
Cdd:PRK10517 402 RVLHSAWLNSHYQTglKNLLDTAVLEGVDEESARSLASrwQKIDEIPFD-FERRRMSVVVAENTEHHQlICKGALEEILN 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 433 LC-NAR---------ADLRKRVHSTIDKYAERGLRSLAVSRQTVPEkTKESSGSPWE----FVGVLPLFDPPRHDSAETI 498
Cdd:PRK10517 481 VCsQVRhngeivpldDIMLRRIKRVTDTLNRQGLRVVAVATKYLPA-REGDYQRADEsdliLEGYIAFLDPPKETTAPAL 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 499 RRALDLGVNVKMITGDQLAIAKETGRRLGMGSNMYPSSSLLGKHKDEAMAHipvedLIEKADGFAGVFPEHKYEIVKKLQ 578
Cdd:PRK10517 560 KALKASGVTVKILTGDSELVAAKVCHEVGLDAGEVLIGSDIETLSDDELAN-----LAERTTLFARLTPMHKERIVTLLK 634
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334188460 579 ERKHICGMTGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNY 646
Cdd:PRK10517 635 REGHVVGFMGDGINDAPALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKY 702
E1-E2_ATPase pfam00122
E1-E2 ATPase;
131-308 1.83e-45

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 161.59  E-value: 1.83e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  131 PKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEA 210
Cdd:pfam00122   5 PTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEKKKGDMVYSGTVVVSGSAKA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  211 VVIATGVHTFFGKAAHLVDSTNQV-GHFQKVLTAIGNFCICsIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIPIA 289
Cdd:pfam00122  84 VVTATGEDTELGRIARLVEEAKSKkTPLQRLLDRLGKYFSP-VVLLIALAVFLLWLFVGGPPLRALLRALAVLVAACPCA 162
                         170
                  ....*....|....*....
gi 334188460  290 MPTVLSVTMAIGSHKLSQQ 308
Cdd:pfam00122 163 LPLATPLALAVGARRLAKK 181
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
12-75 1.36e-14

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 69.53  E-value: 1.36e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334188460    12 NVDLEKIPIEEVFQQLKCSRE-GLSGAEGENRLQIFGPNKLEE-KKESKLLKFLGFMWNPLSWVME 75
Cdd:smart00831   1 ELDWHALSLEEVLERLQTDLEkGLSSEEAARRLERYGPNELPPpKKTSPLLRFLRQFHNPLIYILL 66
 
Name Accession Description Interval E-value
ATPase-IIIA_H TIGR01647
plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton ...
33-805 0e+00

plasma-membrane proton-efflux P-type ATPase; This model describes the plasma membrane proton efflux P-type ATPase found in plants, fungi, protozoa, slime molds and archaea. The best studied representative is from yeast.


Pssm-ID: 273731 [Multi-domain]  Cd Length: 754  Bit Score: 1156.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   33 GLSGAEGENRLQIFGPNKLEEKKESKLLKFLGFMWNPLSWVMEAAAIMAIALANgggkppdWQDFVGIVCLLVINSTISF 112
Cdd:TIGR01647   1 GLTSAEAKKRLAKYGPNELPEKKVSPLLKFLGFFWNPLSWVMEAAAIIAIALEN-------WVDFVIILGLLLLNATIGF 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  113 VEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKG 192
Cdd:TIGR01647  74 IEENKAGNAVEALKQSLAPKARVLRDGKWQEIPASELVPGDVVRLKIGDIVPADCRLFEGDYIQVDQAALTGESLPVTKK 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  193 PGEEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTN-QVGHFQKVLTAIGNFCICSIAVGIAIEIVVMYPIQRRHY 271
Cdd:TIGR01647 154 TGDIAYSGSTVKQGEAEAVVTATGMNTFFGKAAALVQSTEtGSGHLQKILSKIGLFLIVLIGVLVLIELVVLFFGRGESF 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  272 RDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLIEVYc 351
Cdd:TIGR01647 234 REGLQFALVLLVGGIPIAMPAVLSVTMAVGAAELAKKKAIVTRLTAIEELAGMDILCSDKTGTLTLNKLSIDEILPFFN- 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  352 kGVEKDEVLLFAARASRVENQDAIDAAMVGMLADPKEARAGIREIHFLPFNPVDKRTALTFIDS-NGNWHRVSKGAPEQI 430
Cdd:TIGR01647 313 -GFDKDDVLLYAALASREEDQDAIDTAVLGSAKDLKEARDGYKVLEFVPFDPVDKRTEATVEDPeTGKRFKVTKGAPQVI 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  431 LDLCNARADLRKRVHSTIDKYAERGLRSLAVSRQtvpektkeSSGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKM 510
Cdd:TIGR01647 392 LDLCDNKKEIEEKVEEKVDELASRGYRALGVART--------DEEGRWHFLGLLPLFDPPRHDTKETIERARHLGVEVKM 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  511 ITGDQLAIAKETGRRLGMGSNMYPSSSLLGKhKDEAMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDG 590
Cdd:TIGR01647 464 VTGDHLAIAKETARRLGLGTNIYTADVLLKG-DNRDDLPSGLGEMVEDADGFAEVFPEHKYEIVEILQKRGHLVGMTGDG 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  591 VNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMLIALIWKF 670
Cdd:TIGR01647 543 VNDAPALKKADVGIAVAGATDAARSAADIVLTEPGLSVIVDAILESRKIFQRMKSYVIYRIAETIRIVFFFGLLILILNF 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  671 DFSPFMVLIIAILNDGTIMTISKDRVKPSPTPDSWKLKEIFATGVVLGGYMAIMTVVFFWAAYKTDFFPRTFHVRDLRGs 750
Cdd:TIGR01647 623 YFPPIMVVIIAILNDGTIMTIAYDNVKPSKLPQRWNLREVFTMSTVLGIYLVISTFLLLAIALDTTFFIDKFGLQLLHG- 701
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 334188460  751 ehEMMSALYLQVSIVSQALIFVTRSRSWSFTERPGYFLLIAFWVAQLIATAIAVY 805
Cdd:TIGR01647 702 --NLQSFIYLQVSISGHATIFVTRTHGFFWSERPGKLLFGAFVIAQIIATFIAVY 754
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
33-840 0e+00

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 1106.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  33 GLSGAEGENRLQIFGPNKLEEKKESKLLKFLGFMWNPLSWVMEAAAIMAIAlangggkPPDWQDFVGIVCLLVINSTISF 112
Cdd:cd02076    1 GLTSEEAAKRLKEYGPNELPEKKENPILKFLSFFWGPIPWMLEAAAILAAA-------LGDWVDFAIILLLLLINAGIGF 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 113 VEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKG 192
Cdd:cd02076   74 IEERQAGNAVAALKKSLAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIVPADARLLTGDALQVDQSALTGESLPVTKH 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 193 PGEEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQVGHFQKVLTAIGNFCICSIAVGIAIEIVVMYPIQRRhYR 272
Cdd:cd02076  154 PGDEAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVASAEEQGHLQKVLNKIGNFLILLALILVLIIVIVALYRHDP-FL 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 273 DGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLIevyCK 352
Cdd:cd02076  233 EILQFVLVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDKTGTLTLNKLSLDEPYS---LE 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 353 GVEKDEVLLFAARASRVENQDAIDAAMVGMLADPKEARAGIREIHFLPFNPVDKRTALTFIDSNGNWHRVSKGAPEQILD 432
Cdd:cd02076  310 GDGKDELLLLAALASDTENPDAIDTAILNALDDYKPDLAGYKQLKFTPFDPVDKRTEATVEDPDGERFKVTKGAPQVILE 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 433 LCNARADLRKRVHSTIDKYAERGLRSLAVSRQTVpektkessGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMIT 512
Cdd:cd02076  390 LVGNDEAIRQAVEEKIDELASRGYRSLGVARKED--------GGRWELLGLLPLFDPPRPDSKATIARAKELGVRVKMIT 461
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 513 GDQLAIAKETGRRLGMGSNMYPSSSLLGKHKDEAMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVN 592
Cdd:cd02076  462 GDQLAIAKETARQLGMGTNILSAERLKLGGGGGGMPGSELIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVN 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 593 DAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMLIALIWKF-D 671
Cdd:cd02076  542 DAPALKKADVGIAVSGATDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYRIAETLRILVFFTLGILILNFyP 621
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 672 FSPFMVLIIAILNDGTIMTISKDRVKPSPTPDSWKLKEIFATGVVLGGYMAIMTVVFFWAAYKTDFFprtfhvRDLRGSE 751
Cdd:cd02076  622 LPLIMIVLIAILNDGATLTIAYDNVPPSPRPVRWNMPELLGIATVLGVVLTISSFLLLWLLDDQGWF------EDIVLSA 695
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 752 HEMMSALYLQVSIVSQALIFVTRSRSWSFTERPGYFLLIAFWVAQLIATAIAVYGNWEFArikGIGWGWAGVIWLYSIVF 831
Cdd:cd02076  696 GELQTILYLQLSISGHLTIFVTRTRGPFWRPRPSPLLFIAVVLTQILATLLAVYGWFMFA---GIGWGWALLVWIYALVW 772

                 ....*....
gi 334188460 832 YFPLDIMKF 840
Cdd:cd02076  773 FVVLDFVKL 781
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
18-843 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 613.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  18 IPIEEVFQQLKCSREGLSGAEGENRLQIFGPNKL-EEKKESKLLKFLGFMWNPL----------SWVMEaaaimaialan 86
Cdd:COG0474   11 LSAEEVLAELGTSEEGLSSEEAARRLARYGPNELpEEKKRSLLRRFLEQFKNPLilillaaaviSALLG----------- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  87 gggkppDWQDFVGIVCLLVINSTISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPAD 166
Cdd:COG0474   80 ------DWVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAPTARVLRDGKWVEIPAEELVPGDIVLLEAGDRVPAD 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 167 ARLLEGDPLKVDQSALTGESLPATKGPGEE------------VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQV 234
Cdd:COG0474  154 LRLLEAKDLQVDESALTGESVPVEKSADPLpedaplgdrgnmVFMGTLVTSGRGTAVVVATGMNTEFGKIAKLLQEAEEE 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 235 -GHFQKVLTAIGNFCIcSIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITK 313
Cdd:COG0474  234 kTPLQKQLDRLGKLLA-IIALVLAALVFLIGLLRGGPLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVR 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 314 RMTAIEEMAGMDVLCSDKTGTLTLNKLSVDK-----NLIEVYCKGVEK-DEVLLFAARAS------RVENQDAIDAAMVG 381
Cdd:COG0474  313 RLPAVETLGSVTVICTDKTGTLTQNKMTVERvytggGTYEVTGEFDPAlEELLRAAALCSdaqleeETGLGDPTEGALLV 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 382 MLA----DPKEARAGIREIHFLPFNPVDKRTALTFIDSNGNWHRVSKGAPEQILDLCNAR----------ADLRKRVHST 447
Cdd:COG0474  393 AAAkaglDVEELRKEYPRVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRVltgggvvpltEEDRAEILEA 472
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 448 IDKYAERGLRSLAVSRQTVPEKTKESSG---SPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGR 524
Cdd:COG0474  473 VEELAAQGLRVLAVAYKELPADPELDSEddeSDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIAR 552
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 525 RLGMGSNmyPSSSLLGKH----KDEAMAhipveDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKA 600
Cdd:COG0474  553 QLGLGDD--GDRVLTGAEldamSDEELA-----EAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDGVNDAPALKAA 625
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 601 DIGIAV-ADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFgFMLIALIWKFD--FSPFMV 677
Cdd:COG0474  626 DIGIAMgITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVL-SVLLASLLGLPlpLTPIQI 704
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 678 LIIAILNDGT-IMTISKDRVKPS-----PTPDSWKL--KEIFATGVVLGGYMAIMTVVFFWAAYKtdffprtfhvrdlRG 749
Cdd:COG0474  705 LWINLVTDGLpALALGFEPVEPDvmkrpPRWPDEPIlsRFLLLRILLLGLLIAIFTLLTFALALA-------------RG 771
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 750 SEHEMMSALYLQVSIVSQ-ALIFVTRSRSWSFTERPGY---FLLIAFWVAQLIATAIaVYGNWeFARIKG---IGWGWAG 822
Cdd:COG0474  772 ASLALARTMAFTTLVLSQlFNVFNCRSERRSFFKSGLFpnrPLLLAVLLSLLLQLLL-IYVPP-LQALFGtvpLPLSDWL 849
                        890       900
                 ....*....|....*....|.
gi 334188460 823 VIWLYSIVFYFPLDIMKFAIR 843
Cdd:COG0474  850 LILGLALLYLLLVELVKLLRR 870
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
135-667 2.25e-119

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 375.12  E-value: 2.25e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  135 VLRDGkWSEQEASILVPGDIVSIKLGDIIPADARLLEGDpLKVDQSALTGESLPATK---GPGEEVFSGSTCKQGEIEAV 211
Cdd:TIGR01494  39 VLRNG-WKEISSKDLVPGDVVLVKSGDTVPADGVLLSGS-AFVDESSLTGESLPVLKtalPDGDAVFAGTINFGGTLIVK 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  212 VIATGVHTFFGKAAHLVDSTNQ-VGHFQKVLTAIGNF---CICSIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIP 287
Cdd:TIGR01494 117 VTATGILTTVGKIAVVVYTGFStKTPLQSKADKFENFifiLFLLLLALAVFLLLPIGGWDGNSIYKAILRALAVLVIAIP 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  288 IAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLIevyCKGVEKDEVLLFAARAS 367
Cdd:TIGR01494 197 CALPLAVSVALAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVII---IGGVEEASLALALLAAS 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  368 RVE-NQDAIDAAMVGmLADPKEARAGIRE----IHFLPFNPVDKRTALTFIDSNGNWHRVSKGAPEQILDLCNARADLRK 442
Cdd:TIGR01494 274 LEYlSGHPLERAIVK-SAEGVIKSDEINVeykiLDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERCNNENDYDE 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  443 RVHStidkYAERGLRSLAVSRQTVPEktkessgsPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKET 522
Cdd:TIGR01494 353 KVDE----YARQGLRVLAFASKKLPD--------DLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAI 420
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  523 GRRLGMgsnmypsssllgkhkdeamahipvedliekaDGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADI 602
Cdd:TIGR01494 421 AKELGI-------------------------------DVFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADV 469
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334188460  603 GIAVADAtDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMLIALI 667
Cdd:TIGR01494 470 GIAMGSG-DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVI 533
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
33-686 5.56e-114

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 365.01  E-value: 5.56e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  33 GLSGAEGENRLQIFGPNKLEE-KKESKLLKFLGFMWNPLSWVMEAAAIMAIALANgggkppdWQDFVGIVCLLVINSTIS 111
Cdd:cd02089    1 GLSEEEAERRLAKYGPNELVEkKKRSPWKKFLEQFKDFMVIVLLAAAVISGVLGE-------YVDAIVIIAIVILNAVLG 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 112 FVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATK 191
Cdd:cd02089   74 FVQEYKAEKALAALKKMSAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLRVEESSLTGESEPVEK 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 192 GP----------GEE---VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDST-NQVGHFQKVLTAIGNFcICSIAVGIA 257
Cdd:cd02089  154 DAdtlleedvplGDRknmVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEETeEEKTPLQKRLDQLGKR-LAIAALIIC 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 258 IEIVVMYPIQRrhyRDGIDNLLV---LLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGT 334
Cdd:cd02089  233 ALVFALGLLRG---EDLLDMLLTavsLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSVICSDKTGT 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 335 LTLNKLSVDKnlieVYCKGvEKDEVLLFAArasrvenqdaidAAMVGMlaDPKEARAGIREIHFLPFNPVDKRTAlTFID 414
Cdd:cd02089  310 LTQNKMTVEK----IYTIG-DPTETALIRA------------ARKAGL--DKEELEKKYPRIAEIPFDSERKLMT-TVHK 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 415 SNGNWHRVSKGAPEQILDLCNARAD----------LRKRVHSTIDKYAERGLRSLAVSRQTVPEKTKESSGSPWE---FV 481
Cdd:cd02089  370 DAGKYIVFTKGAPDVLLPRCTYIYIngqvrplteeDRAKILAVNEEFSEEALRVLAVAYKPLDEDPTESSEDLENdliFL 449
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 482 GVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSNmypsssllgkhKDEAM-----AHIPVEDL- 555
Cdd:cd02089  450 GLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILED-----------GDKALtgeelDKMSDEELe 518
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 556 --IEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVA-DATDAARGASDIVLTEPGLSVIISA 632
Cdd:cd02089  519 kkVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGiTGTDVAKEAADMILTDDNFATIVAA 598
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 334188460 633 VLTSRAIFQRMKNYTIYAVSITIRIVFGfMLIALI--WKFDFSPFMVLIIAILNDG 686
Cdd:cd02089  599 VEEGRTIYDNIRKFIRYLLSGNVGEILT-MLLAPLlgWPVPLLPIQLLWINLLTDG 653
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
33-663 1.62e-110

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 360.04  E-value: 1.62e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  33 GLSGAEGENRLQIFGPNKLEEKK-ESKLLKFLGFMWNPLSWVMEAAAIMAIALANgggkppdWQDFVGIVCLLVINSTIS 111
Cdd:cd02080    1 GLTSEEAAERLERYGPNRLPEKKtKSPLLRFLRQFNNPLIYILLAAAVVTAFLGH-------WVDAIVIFGVVLINAIIG 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 112 FVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATK 191
Cdd:cd02080   74 YIQEGKAEKALAAIKNMLSPEATVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIEARNLQIDESALTGESVPVEK 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 192 --GPGEE----------VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDS--------TNQVGHFQKVLTAIgnfcics 251
Cdd:cd02080  154 qeGPLEEdtplgdrknmAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEveqlatplTRQIAKFSKALLIV------- 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 252 IAVGIAIEIVVMYpiQRRHYR--DGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCS 329
Cdd:cd02080  227 ILVLAALTFVFGL--LRGDYSlvELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLGSVTVICS 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 330 DKTGTLTLNKLSVDKnlIEVYCkgveKDEVLLFAARASRVENqDAIDAAM--VGMLA--DPKEARAGIREIHFLPFNPVD 405
Cdd:cd02080  305 DKTGTLTRNEMTVQA--IVTLC----NDAQLHQEDGHWKITG-DPTEGALlvLAAKAglDPDRLASSYPRVDKIPFDSAY 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 406 KRTALTFIDSNGNWHRVsKGAPEQILDLCNARADL-------RKRVHSTIDKYAERGLRSLAVSRQTVPEKTKESS---- 474
Cdd:cd02080  378 RYMATLHRDDGQRVIYV-KGAPERLLDMCDQELLDggvspldRAYWEAEAEDLAKQGLRVLAFAYREVDSEVEEIDhadl 456
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 475 GSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSNmypSSSLLGKHkdeaMAHIPVED 554
Cdd:cd02080  457 EGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLGLGDG---KKVLTGAE----LDALDDEE 529
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 555 LIEKADG---FAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVA-DATDAARGASDIVLTEPGLSVII 630
Cdd:cd02080  530 LAEAVDEvdvFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGiKGTEVAKEAADMVLADDNFATIA 609
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|.
gi 334188460 631 SAVLTSRAIFQRMKNYTIY--------AVSITIRIVFGFML 663
Cdd:cd02080  610 AAVEEGRRVYDNLKKFILFtlptnlgeGLVIIVAILFGVTL 650
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
33-780 1.31e-105

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 345.39  E-value: 1.31e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  33 GLSGAEGENRLQIFGPNKLE-EKKESKLLKFLGFMWNPLSWVMeaAAIMAIALANGGGKPPDWQDFVGIVCLLV---INS 108
Cdd:cd02077    1 GLTNEEAEERLEKYGPNEIShEKFPSWFKLLLKAFINPFNIVL--LVLALVSFFTDVLLAPGEFDLVGALIILLmvlISG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 109 TISFVEENNAGNAAAALMAGLAPKTKVLRDG-KWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESL 187
Cdd:cd02077   79 LLDFIQEIRSLKAAEKLKKMVKNTATVIRDGsKYMEIPIDELVPGDIVYLSAGDMIPADVRIIQSKDLFVSQSSLTGESE 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 188 PATK--GPGEE-----------VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQVGHFQKvltaignfCICSIAV 254
Cdd:cd02077  159 PVEKhaTAKKTkdesileleniCFMGTNVVSGSALAVVIATGNDTYFGSIAKSITEKRPETSFDK--------GINKVSK 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 255 GIAIEIVVMYPIqrrhyrdgidnllVLLIGGI--------------------PIAMPTVLSVTMAIGSHKLSQQGAITKR 314
Cdd:cd02077  231 LLIRFMLVMVPV-------------VFLINGLtkgdwleallfalavavgltPEMLPMIVTSNLAKGAVRMSKRKVIVKN 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 315 MTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNL-IEvyckGVEKDEVLLFAARASRVEN--QDAIDAAMV--GMLADPKEA 389
Cdd:cd02077  298 LNAIQNFGAMDILCTDKTGTLTQDKIVLERHLdVN----GKESERVLRLAYLNSYFQTglKNLLDKAIIdhAEEANANGL 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 390 RAGIREIHFLPFNPVDKRTALTFIDSNGNWHRVSKGAPEQILDLC----------NARADLRKRVHSTIDKYAERGLRSL 459
Cdd:cd02077  374 IQDYTKIDEIPFDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCthvevngevvPLTDTLREKILAQVEELNREGLRVL 453
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 460 AVSRQTVPEKTKESSGSPWE---FVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSNMYPSS 536
Cdd:cd02077  454 AIAYKKLPAPEGEYSVKDEKeliLIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGLDINRVLTG 533
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 537 SLLGKHKDEAMAHIpvedlIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADATDAARGA 616
Cdd:cd02077  534 SEIEALSDEELAKI-----VEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALRQADVGISVDSAVDIAKEA 608
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 617 SDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGfMLIALIWkFDFSPFMVLIIAILN---DGTIMTISK 693
Cdd:cd02077  609 ADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASSNFGNVFS-VLVASAF-LPFLPMLPIQLLLQNllyDFSQLAIPF 686
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 694 DRVKPSPT--PDSWKLKEIFATGVVLGGYMAIMTVVFFWAAYKtdffprTFHVRDLrGSEHEMMSALYLqVSIVSQAL-I 770
Cdd:cd02077  687 DNVDEEFLkkPQKWDIKNIGRFMIWIGPISSIFDILTFLVMWF------VFKANTA-ASQALFQTGWFI-EGLLTQTLvV 758
                        810
                 ....*....|
gi 334188460 771 FVTRSRSWSF 780
Cdd:cd02077  759 HMIRTEKIPF 768
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
42-686 3.86e-89

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 302.01  E-value: 3.86e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  42 RLQIFGPNKLEEKKESKLLK-FLGFMWNPLSWVMEAAAIMAIALANgggkppdWQDFVGIVCLLVINSTISFVEENNAGN 120
Cdd:cd02085    1 RRKLHGPNEFKVEDEEPLWKkYLEQFKNPLILLLLGSAVVSVVMKQ-------YDDAVSITVAILIVVTVAFVQEYRSEK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 121 AAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATK--------- 191
Cdd:cd02085   74 SLEALNKLVPPECHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKttevipkas 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 192 -GPGEE----VFSGSTCKQGEIEAVVIATGVHTFFG---KAAH--------LVDSTNQVGhfqKVLTAIgNFCIcsIAVg 255
Cdd:cd02085  154 nGDLTTrsniAFMGTLVRCGHGKGIVIGTGENSEFGevfKMMQaeeapktpLQKSMDKLG---KQLSLY-SFII--IGV- 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 256 iaieIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTL 335
Cdd:cd02085  227 ----IMLIGWLQGKNLLEMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTL 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 336 TLNKLSVDKnlieVYCKGVEKDEVLlfaaRASRVENQDAIDAAMV-GMLADPKEARAGIREIHFLPFNPVDKRTALTFID 414
Cdd:cd02085  303 TKNEMTVTK----IVTGCVCNNAVI----RNNTLMGQPTEGALIAlAMKMGLSDIRETYIRKQEIPFSSEQKWMAVKCIP 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 415 SNGNWHR---VSKGAPEQILDLC-------NARADLRKRVHSTIDKYAER----GLRSLAVSRQTVPEKTKessgspweF 480
Cdd:cd02085  375 KYNSDNEeiyFMKGALEQVLDYCttynssdGSALPLTQQQRSEINEEEKEmgskGLRVLALASGPELGDLT--------F 446
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 481 VGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSnmyPSSSLLGKHKDEAMAHIPVEDLIEKAD 560
Cdd:cd02085  447 LGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYS---PSLQALSGEEVDQMSDSQLASVVRKVT 523
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 561 GFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVA-DATDAARGASDIVLTEPGLSVIISAVLTSRAI 639
Cdd:cd02085  524 VFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIAMGrTGTDVCKEAADMILVDDDFSTILAAIEEGKGI 603
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|.
gi 334188460 640 FQRMKNYTIYAVSITIRivfGFMLIALIWKFDF-SPF---MVLIIAILNDG 686
Cdd:cd02085  604 FYNIKNFVRFQLSTSIA---ALSLIALSTLFNLpNPLnamQILWINIIMDG 651
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
96-653 4.63e-88

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 294.71  E-value: 4.63e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  96 DFVGIVCLLVINSTISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQE--ASILVPGDIVSIKLGDIIPADARLLEGD 173
Cdd:cd07539   59 DAVLIVGVLTVNAVIGGVQRLRAERALAALLAQQQQPARVVRAPAGRTQTvpAESLVPGDVIELRAGEVVPADARLLEAD 138
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 174 PLKVDQSALTGESLPATKG----PGEE-------VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQVGHFQKVLT 242
Cdd:cd07539  139 DLEVDESALTGESLPVDKQvaptPGAPladracmLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVAPVETATGVQAQLR 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 243 AIGN-FCICSIAVG---IAIEIVVMYPIqRRHYRDGIDnllvLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAI 318
Cdd:cd07539  219 ELTSqLLPLSLGGGaavTGLGLLRGAPL-RQAVADGVS----LAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTV 293
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 319 EEMAGMDVLCSDKTGTLTLNKLSVdknlievyckgvekdevllfaarasrvenqdaidaamvGMLADPkearagireIHF 398
Cdd:cd07539  294 EALGRVDTICFDKTGTLTENRLRV--------------------------------------VQVRPP---------LAE 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 399 LPFNPvDKRTALTFIDSNGNWHRVS-KGAPEQILDLCNAR----------ADLRKRVHSTIDKYAERGLRSLAVSRQTV- 466
Cdd:cd07539  327 LPFES-SRGYAAAIGRTGGGIPLLAvKGAPEVVLPRCDRRmtggqvvpltEADRQAIEEVNELLAGQGLRVLAVAYRTLd 405
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 467 --PEKTKESSGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGM-GSNMYPSSSLLGKHK 543
Cdd:cd07539  406 agTTHAVEAVVDDLELLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGLpRDAEVVTGAELDALD 485
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 544 DEAMahipvEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAV-ADATDAARGASDIVLT 622
Cdd:cd07539  486 EEAL-----TGLVADIDVFARVSPEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVgARGSDAAREAADLVLT 560
                        570       580       590
                 ....*....|....*....|....*....|.
gi 334188460 623 EPGLSVIISAVLTSRAIFQRMKNytiyAVSI 653
Cdd:cd07539  561 DDDLETLLDAVVEGRTMWQNVRD----AVHV 587
ATPase-IIA2_Ca TIGR01522
golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
18-730 1.74e-85

golgi membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the golgi membrane of fungi and animals, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the former of which is modelled by TIGR01116.


Pssm-ID: 130585 [Multi-domain]  Cd Length: 884  Bit Score: 293.66  E-value: 1.74e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   18 IPIEEVFQQLKCSRE-GLSGA-EGENRLQIFGPNKLE-EKKESKLLKFLG-FMWNPLSWVMEAAAIMAIALANgggkppd 93
Cdd:TIGR01522   7 LSVEETCSKLQTDLQnGLNSSqEASHRRAFHGWNEFDvEEDESLWKKFLSqFVKNPLILLLIASAVISVFMGN------- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   94 WQDFVGIVCLLVINSTISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGD 173
Cdd:TIGR01522  80 IDDAVSITLAILIVVTVGFVQEYRSEKSLEALNKLVPPECHLIREGKLEHVLASTLVPGDLVCLSVGDRVPADLRIVEAV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  174 PLKVDQSALTGESLPATK----------GPGEE----VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQVGH-FQ 238
Cdd:TIGR01522 160 DLSIDESNLTGETTPVSKvtapipaatnGDLAErsniAFMGTLVRCGHGKGIVVGTGSNTEFGAVFKMMQAIEKPKTpLQ 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  239 KVLTAIGNFCICSIAVGIAIeIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAI 318
Cdd:TIGR01522 240 KSMDLLGKQLSLVSFGVIGV-ICLVGWFQGKDWLEMFTISVSLAVAAIPEGLPIIVTVTLALGVLRMSKKRAIVRKLPSV 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  319 EEMAGMDVLCSDKTGTLTLNKLSVDK---------------------------NLIEVYCKGVEKdeVLLFAA--RASRV 369
Cdd:TIGR01522 319 ETLGSVNVICSDKTGTLTKNHMTVTKiwtsdglhtmlnavslnqfgevivdgdVLHGFYTVAVSR--ILEAGNlcNNAKF 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  370 ENQDAI------DAAMVGMLA-----DPKEARAGIREihfLPFNPVDKRTALTFIDSNGNWHRVS-KGAPEQILDLCNA- 436
Cdd:TIGR01522 397 RNEADTllgnptDVALIELLMkfgldDLRETYIRVAE---VPFSSERKWMAVKCVHRQDRSEMCFmKGAYEQVLKYCTYy 473
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  437 ----------RADLRKRVHSTIDKYAERGLRSLAVSRQtvPEKTKESsgspweFVGVLPLFDPPRHDSAETIRRALDLGV 506
Cdd:TIGR01522 474 qkkdgktltlTQQQRDVIQEEAAEMASAGLRVIAFASG--PEKGQLT------FLGLVGINDPPRPGVKEAVTTLITGGV 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  507 NVKMITGDQLAIAKETGRRLGMGSNmyPSSSLLGKHKDEaMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGM 586
Cdd:TIGR01522 546 RIIMITGDSQETAVSIARRLGMPSK--TSQSVSGEKLDA-MDDQQLSQIVPKVAVFARASPEHKMKIVKALQKRGDVVAM 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  587 TGDGVNDAPALKKADIGIAVAD-ATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRivfGFMLIA 665
Cdd:TIGR01522 623 TGDGVNDAPALKLADIGVAMGQtGTDVAKEAADMILTDDDFATILSAIEEGKGIFNNIKNFITFQLSTSVA---ALSLIA 699
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  666 LIWKFDF----SPFMVLIIAILNDGT------IMTISKDRVKPSPTPDSWK------LKEIFATGVVLggymAIMTVVFF 729
Cdd:TIGR01522 700 LATLMGFpnplNAMQILWINILMDGPpaqslgVEPVDKDVMRKPPRPRNDKiltkdlIKKILVSAIII----VVGTLFVF 775

                  .
gi 334188460  730 W 730
Cdd:TIGR01522 776 V 776
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
33-680 5.09e-82

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 278.56  E-value: 5.09e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  33 GLSGAEGENRLQIFGPNKLEEKKESKLLKFLgfmWNPLSWVMEAAAIMAIALANGGGKPPDWQDFVGIVcllVINSTISF 112
Cdd:cd07538    1 GLTEAEARRRLESGGKNELPQPKKRTLLASI---LDVLREPMFLLLLAAALIYFVLGDPREGLILLIFV---VVIIAIEV 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 113 VEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKG 192
Cdd:cd07538   75 VQEWRTERALEALKNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDDLGVDESTLTGESVPVWKR 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 193 PGEE------------VFSGSTCKQGEIEAVVIATGVHTFFGK----AAHLVDS----TNQVGHFQKVLtAIGNFCICSI 252
Cdd:cd07538  155 IDGKamsapggwdknfCYAGTLVVRGRGVAKVEATGSRTELGKigksLAEMDDEptplQKQTGRLVKLC-ALAALVFCAL 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 253 avgiaieIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKT 332
Cdd:cd07538  234 -------IVAVYGVTRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKT 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 333 GTLTLNKLSVdknlievyckgvekdevllfaarasrvenqdaidaamvgmladpKEARAGIREihfLPFNPvDKRTALTF 412
Cdd:cd07538  307 GTLTKNQMEV--------------------------------------------VELTSLVRE---YPLRP-ELRMMGQV 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 413 IDSNGNWHRVSKGAPEQILDLCNARADLRKRVHSTIDKYAERGLRSLAV-----SRQTVPEKTKESSgspWEFVGVLPLF 487
Cdd:cd07538  339 WKRPEGAFAAAKGSPEAIIRLCRLNPDEKAAIEDAVSEMAGEGLRVLAVaacriDESFLPDDLEDAV---FIFVGLIGLA 415
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 488 DPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMG-SNMYPSSSLLGKHKDEAMAhipveDLIEKADGFAGVF 566
Cdd:cd07538  416 DPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGLDnTDNVITGQELDAMSDEELA-----EKVRDVNIFARVV 490
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 567 PEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVAD-ATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKN 645
Cdd:cd07538  491 PEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAMGKrGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKK 570
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|.
gi 334188460 646 YTIYAVSITIRIvFGFMLIALIWKFD--FSP----FMVLII 680
Cdd:cd07538  571 AITYVFAIHVPI-AGLALLPPLLGLPplLFPvhvvLLELII 610
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
326-689 2.01e-80

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 263.54  E-value: 2.01e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 326 VLCSDKTGTLTLNKLSVdknlievyckgvekdevllfaarasrvenqdaidaamvgmladpkeARAGIREIhflPFNPVD 405
Cdd:cd01431    1 VICSDKTGTLTKNGMTV----------------------------------------------TKLFIEEI---PFNSTR 31
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 406 KRTAlTFIDSNGNWHRVSKGAPEQILDLCNARADL--RKRVHSTIDKYAERGLRSLAV-SRQTVPEKTKESSGSPWEFVG 482
Cdd:cd01431   32 KRMS-VVVRLPGRYRAIVKGAPETILSRCSHALTEedRNKIEKAQEESAREGLRVLALaYREFDPETSKEAVELNLVFLG 110
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 483 VLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSNMYPSSSLLGkhkDEAMAHIPVEDLIEKADGF 562
Cdd:cd01431  111 LIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGIDTKASGVILGEE---ADEMSEEELLDLIAKVAVF 187
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 563 AGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVA-DATDAARGASDIVLTEPGLSVIISAVLTSRAIFQ 641
Cdd:cd01431  188 ARVTPEQKLRIVKALQARGEVVAMTGDGVNDAPALKQADVGIAMGsTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYD 267
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 334188460 642 RMKNYTIYAVSITIRIVFGFML-IALIWKFDFSPFMVLIIAILNDGTIM 689
Cdd:cd01431  268 NIKKNITYLLANNVAEVFAIALaLFLGGPLPLLAFQILWINLVTDLIPA 316
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
33-680 3.43e-80

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 279.73  E-value: 3.43e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  33 GLSGAEGENRLQIFGPNKLEEKKESKLLK-FLGFMWNPLSWVMEAAAIMAIALAngggkppDWQDFVGIVCLLVINSTIS 111
Cdd:cd02086    1 GLTNDEAERRLKEYGENELEGDTGVSAWKiLLRQVANAMTLVLIIAMALSFAVK-------DWIEGGVIAAVIALNVIVG 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 112 FVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATK 191
Cdd:cd02086   74 FIQEYKAEKTMDSLRNLSSPNAHVIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIETKNFETDEALLTGESLPVIK 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 192 ------------GPGEE---VFSGSTCKQGEIEAVVIATGVHTFFGK-AAHLVDSTNQVGHFQKVLTAIGNFCICSIAVG 255
Cdd:cd02086  154 daelvfgkeedvSVGDRlnlAYSSSTVTKGRAKGIVVATGMNTEIGKiAKALRGKGGLISRDRVKSWLYGTLIVTWDAVG 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 256 IAIEIVVMYPIQRRhyrdgIDNLLVLL-------------------------------IGGIPIAMPTVLSVTMAIGSHK 304
Cdd:cd02086  234 RFLGTNVGTPLQRK-----LSKLAYLLffiavilaiivfavnkfdvdneviiyaialaISMIPESLVAVLTITMAVGAKR 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 305 LSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDK--------NLIEVyckgVEKDEVLLFAARASRVENQDAID 376
Cdd:cd02086  309 MVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVRQvwipaalcNIATV----FKDEETDCWKAHGDPTEIALQVF 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 377 AAMVGM--LADPKEARAGIREIHFLPFNPVDKRTALTFID-SNGNWHRVSKGAPEQILDLCNARADL----------RKR 443
Cdd:cd02086  385 ATKFDMgkNALTKGGSAQFQHVAEFPFDSTVKRMSVVYYNnQAGDYYAYMKGAVERVLECCSSMYGKdgiiplddefRKT 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 444 VHSTIDKYAERGLRSLAVSRQTVPE--KTKESSGSP----------WEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMI 511
Cdd:cd02086  465 IIKNVESLASQGLRVLAFASRSFTKaqFNDDQLKNItlsradaesdLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHML 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 512 TGDQ----LAIAKETG---RRLGMGSNMYPSSSLLGKHKDEAMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHIC 584
Cdd:cd02086  545 TGDHpgtaKAIAREVGilpPNSYHYSQEIMDSMVMTASQFDGLSDEEVDALPVLPLVIARCSPQTKVRMIEALHRRKKFC 624
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 585 GMTGDGVNDAPALKKADIGIAV-ADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVfGFML 663
Cdd:cd02086  625 AMTGDGVNDSPSLKMADVGIAMgLNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQV-ILLL 703
                        730       740
                 ....*....|....*....|....
gi 334188460 664 IALIWK-------FDFSPFMVLII 680
Cdd:cd02086  704 IGLAFKdedglsvFPLSPVEILWI 727
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
19-729 8.56e-79

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 274.82  E-value: 8.56e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   19 PIEEVFQQLKCSREGLSGAEGENRLQIFGPNKL-EEKKESKLLKFLGFMWNPLSWVMEAAAIMAIALANGGGkppdwqdf 97
Cdd:TIGR01524  19 GKETLLRKLGVHETGLTNVEVTERLAEFGPNQTvEEKKVPNLRLLIRAFNNPFIYILAMLMGVSYLTDDLEA-------- 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   98 VGIVCLLVINSTI-SFVEENNAGNAAAALMAGLAPKTKVLR------DGKWSEQEASILVPGDIVSIKLGDIIPADARLL 170
Cdd:TIGR01524  91 TVIIALMVLASGLlGFIQESRAERAAYALKNMVKNTATVLRvinengNGSMDEVPIDALVPGDLIELAAGDIIPADARVI 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  171 EGDPLKVDQSALTGESLPATK-------------GPGEEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQVGHF 237
Cdd:TIGR01524 171 SARDLFINQSALTGESLPVEKfvedkrardpeilERENLCFMGTNVLSGHAQAVVLATGSSTWFGSLAIAATERRGQTAF 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  238 QKVLTAIGNFCICSIAVGIAIeIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTA 317
Cdd:TIGR01524 251 DKGVKSVSKLLIRFMLVMVPV-VLMINGLMKGDWLEAFLFALAVAVGLTPEMLPMIVSSNLAKGAINMSKKKVIVKELSA 329
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  318 IEEMAGMDVLCSDKTGTLTLNKLSVDKNLievYCKGVEKDEVLLFAARASRVEN--QDAIDAAMVGMLAD--PKEARAGI 393
Cdd:TIGR01524 330 IQNFGAMDILCTDKTGTLTQDKIELEKHI---DSSGETSERVLKMAWLNSYFQTgwKNVLDHAVLAKLDEsaARQTASRW 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  394 REIHFLPFNPVDKRTALTFIDSNGNWHRVSKGAPEQILDLCNAR----------ADLRKRVHSTIDKYAERGLRSLAVSR 463
Cdd:TIGR01524 407 KKVDEIPFDFDRRRLSVVVENRAEVTRLICKGAVEEMLTVCTHKrfggavvtlsESEKSELQDMTAEMNRQGIRVIAVAT 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  464 QTVP------EKTKESSgspWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSNMYPSSS 537
Cdd:TIGR01524 487 KTLKvgeadfTKTDEEQ---LIIEGFLGFLDPPKESTKEAIAALFKNGINVKVLTGDNEIVTARICQEVGIDANDFLLGA 563
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  538 LLGKHKDEAMAHipvedLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADATDAARGAS 617
Cdd:TIGR01524 564 DIEELSDEELAR-----ELRKYHIFARLTPMQKSRIIGLLKKAGHTVGFLGDGINDAPALRKADVGISVDTAADIAKEAS 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  618 DIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFMLI-ALIWKFDFSPFMVLIIAILNDGTIMTISKDRV 696
Cdd:TIGR01524 639 DIILLEKSLMVLEEGVIEGRNTFGNILKYLKMTASSNFGNVFSVLVAsAFIPFLPMLSLHLLIQNLLYDFSQLTLPWDKM 718
                         730       740       750
                  ....*....|....*....|....*....|....*
gi 334188460  697 KPS--PTPDSWKLKEIFATGVVLGGYMAIMTVVFF 729
Cdd:TIGR01524 719 DREflKKPHQWEQKGMGRFMLCIGPVSSIFDIATF 753
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
13-646 7.10e-77

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 270.02  E-value: 7.10e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  13 VDLEKIPIEEVFQQLKCSREGLSGAEGENRLQIFGPNKLEEKKESKLLKFLgfmW----NP----------LSWVMEAAA 78
Cdd:PRK10517  47 LKAAVMPEEELWKTFDTHPEGLNEAEVESAREQHGENELPAQKPLPWWVHL---WvcyrNPfnilltilgaISYATEDLF 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  79 IMaialangggkppdwqdfvGIVCLLVINST-ISFVEENNAGNAAAALMAGLAPKTKVLR------DGKWSEQEASILVP 151
Cdd:PRK10517 124 AA------------------GVIALMVAISTlLNFIQEARSTKAADALKAMVSNTATVLRvindkgENGWLEIPIDQLVP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 152 GDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKGPGEE-------------VFSGSTCKQGEIEAVVIATGVH 218
Cdd:PRK10517 186 GDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKFATTRqpehsnplecdtlCFMGTNVVSGTAQAVVIATGAN 265
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 219 TFFGKAAHLVDST-NQVGHFQKVLTAIGNFCICSIAVgiaieivvMYPIqrrhyrdgidnllVLLIGGI----------- 286
Cdd:PRK10517 266 TWFGQLAGRVSEQdSEPNAFQQGISRVSWLLIRFMLV--------MAPV-------------VLLINGYtkgdwweaalf 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 287 ---------PIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNlIEVYckGVEKD 357
Cdd:PRK10517 325 alsvavgltPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIVLENH-TDIS--GKTSE 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 358 EVLLFAARASRVEN--QDAIDAAMVGMLADPKEARAGI--REIHFLPFNpVDKRTALTFIDSNGNWHR-VSKGAPEQILD 432
Cdd:PRK10517 402 RVLHSAWLNSHYQTglKNLLDTAVLEGVDEESARSLASrwQKIDEIPFD-FERRRMSVVVAENTEHHQlICKGALEEILN 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 433 LC-NAR---------ADLRKRVHSTIDKYAERGLRSLAVSRQTVPEkTKESSGSPWE----FVGVLPLFDPPRHDSAETI 498
Cdd:PRK10517 481 VCsQVRhngeivpldDIMLRRIKRVTDTLNRQGLRVVAVATKYLPA-REGDYQRADEsdliLEGYIAFLDPPKETTAPAL 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 499 RRALDLGVNVKMITGDQLAIAKETGRRLGMGSNMYPSSSLLGKHKDEAMAHipvedLIEKADGFAGVFPEHKYEIVKKLQ 578
Cdd:PRK10517 560 KALKASGVTVKILTGDSELVAAKVCHEVGLDAGEVLIGSDIETLSDDELAN-----LAERTTLFARLTPMHKERIVTLLK 634
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334188460 579 ERKHICGMTGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNY 646
Cdd:PRK10517 635 REGHVVGFMGDGINDAPALRAADIGISVDGAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKY 702
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
97-686 9.87e-77

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 264.53  E-value: 9.87e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  97 FVGIVCllvINSTISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLK 176
Cdd:cd02609   61 FLGVII---VNTVIGIVQEIRAKRQLDKLSILNAPKVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLE 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 177 VDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVVIATGVHTFFGKAA-----------HLVDSTNQVghfQKVLTAIg 245
Cdd:cd02609  138 VDESLLTGESDLIPKKAGDKLLSGSFVVSGAAYARVTAVGAESYAAKLTleakkhklinsELLNSINKI---LKFTSFI- 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 246 nfcicSIAVGIAIEIVVMYpiqRRH--YRDGIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAG 323
Cdd:cd02609  214 -----IIPLGLLLFVEALF---RRGggWRQAVVSTVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQELYSIETLAR 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 324 MDVLCSDKTGTLTLNKLSVDKNLIEVYCKGVEKDEVLLFAARASRVEN--QDAIDAAMVGmlADPKEARAGIreihflPF 401
Cdd:cd02609  286 VDVLCLDKTGTITEGKMKVERVEPLDEANEAEAAAALAAFVAASEDNNatMQAIRAAFFG--NNRFEVTSII------PF 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 402 NPVDKRTALTFiDSNGNWHRvskGAPEQILdlcnarADLRKRVHSTIDKYAERGLRSLAVSRQTVpEKTKESSGSPWEFV 481
Cdd:cd02609  358 SSARKWSAVEF-RDGGTWVL---GAPEVLL------GDLPSEVLSRVNELAAQGYRVLLLARSAG-ALTHEQLPVGLEPL 426
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 482 GVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGM-GSNMYPSSSLLGkhKDEAMAhipveDLIEKAD 560
Cdd:cd02609  427 ALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAGLeGAESYIDASTLT--TDEELA-----EAVENYT 499
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 561 GFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIf 640
Cdd:cd02609  500 VFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMASGSDATRQVAQVVLLDSDFSALPDVVFEGRRV- 578
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 334188460 641 qrMKNYTIYAVSITIRIVFGFML----IALIWKFDFSPFMVLIIAILNDG 686
Cdd:cd02609  579 --VNNIERVASLFLVKTIYSVLLalicVITALPFPFLPIQITLISLFTIG 626
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
92-744 1.40e-76

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 269.34  E-value: 1.40e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   92 PDWQDFVGIVCLLVINSTISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLE 171
Cdd:TIGR01116  34 TAFVEPFVILLILVANAIVGVWQERNAEKAIEALKEYESEHAKVLRDGRWSVIKAKDLVPGDIVELAVGDKVPADIRVLS 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  172 GDPLKVDQSALTGESLPATKG----PGEE---------VFSGSTCKQGEIEAVVIATGVHTFFGK-AAHLVDSTNQVGHF 237
Cdd:TIGR01116 114 LKTLRVDQSILTGESVSVNKHtesvPDERavnqdkknmLFSGTLVVAGKARGVVVRTGMSTEIGKiRDEMRAAEQEDTPL 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  238 QKVLTAIGNFC------ICSIAVGIAIEIVVMYPIQRRHYRDGIDNLLV---LLIGGIPIAMPTVLSVTMAIGSHKLSQQ 308
Cdd:TIGR01116 194 QKKLDEFGELLskviglICILVWVINIGHFNDPALGGGWIQGAIYYFKIavaLAVAAIPEGLPAVITTCLALGTRKMAKK 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  309 GAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSV----------------------------------------DKNLIE 348
Cdd:TIGR01116 274 NAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVckvvaldpsssslnefcvtgttyapeggvikddgpvaggqDAGLEE 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  349 V-YCKGVEKDEVLLFAARASRVENQ-DAIDAAM-------------VGMLADPKEA-------RAGIREIHFLPFNPvDK 406
Cdd:TIGR01116 354 LaTIAALCNDSSLDFNERKGVYEKVgEATEAALkvlvekmglpatkNGVSSKRRPAlgcnsvwNDKFKKLATLEFSR-DR 432
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  407 RTALTFIDSNGNWHRVSKGAPEQILDLCN-----------ARADLRKRVHSTIDKYAER-GLRSLAVSRQTVPEKTKESS 474
Cdd:TIGR01116 433 KSMSVLCKPSTGNKLFVKGAPEGVLERCThilngdgravpLTDKMKNTILSVIKEMGTTkALRCLALAFKDIPDPREEDL 512
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  475 G----------SPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGM--GSNMYPSSSLLGKH 542
Cdd:TIGR01116 513 LsdpanfeaieSDLTFIGVVGMLDPPRPEVADAIEKCRTAGIRVIMITGDNKETAEAICRRIGIfsPDEDVTFKSFTGRE 592
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  543 KDEaMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADATDAARGASDIVLT 622
Cdd:TIGR01116 593 FDE-MGPAKQRAACRSAVLFSRVEPSHKSELVELLQEQGEIVAMTGDGVNDAPALKKADIGIAMGSGTEVAKEASDMVLA 671
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  623 EPGLSVIISAVLTSRAIFQRMKNYTIYAVSITI-RIVFGFMLIALIWKFDFSPFMVLIIAILNDGTIMTI------SKDR 695
Cdd:TIGR01116 672 DDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIgEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATAlgfnppDKDI 751
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|.
gi 334188460  696 V-KPSPTPDSWKLKE-IFATGVVLGGYMAIMTVVFFWAAYKTDFFPRTFHV 744
Cdd:TIGR01116 752 MwKPPRRPDEPLITGwLFFRYLVVGVYVGLATVGGFVWWYLLTHFTGCDED 802
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
19-730 3.60e-71

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 254.91  E-value: 3.60e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  19 PIEEVFQQLKCSRE-GLSGAEGENRLQIFGPNKL--EEKK----------ESKLLKFL------GFMwnpLSWVMEAAAI 79
Cdd:cd02083    4 TVEEVLAYFGVDPTrGLSDEQVKRRREKYGPNELpaEEGKslwelvleqfDDLLVRILllaaiiSFV---LALFEEGEEG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  80 maialangggkppdWQDFVG---IVCLLVINSTISFVEENNAGNAAAALMAGLAPKTKVLRDGK-WSEQEASILVPGDIV 155
Cdd:cd02083   81 --------------VTAFVEpfvILLILIANAVVGVWQERNAEKAIEALKEYEPEMAKVLRNGKgVQRIRARELVPGDIV 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 156 SIKLGDIIPADARLLE--GDPLKVDQSALTGESLPATKG----PGEE---------VFSGSTCKQGEIEAVVIATGVHTF 220
Cdd:cd02083  147 EVAVGDKVPADIRIIEikSTTLRVDQSILTGESVSVIKHtdvvPDPRavnqdkknmLFSGTNVAAGKARGVVVGTGLNTE 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 221 FGKAAHLVDSTNQVGH-FQKVLTAIGNFcicsIAVGIAIEIVVMYPIQRRHYRD----------GIDNLLV---LLIGGI 286
Cdd:cd02083  227 IGKIRDEMAETEEEKTpLQQKLDEFGEQ----LSKVISVICVAVWAINIGHFNDpahggswikgAIYYFKIavaLAVAAI 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 287 PIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDK-----------NLIEVYCKGV- 354
Cdd:cd02083  303 PEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRmfildkveddsSLNEFEVTGSt 382
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 355 ----------------EKDEVLLFAARASRVENQDAID----------------AA---MVGMLADPKEARAG-IREIHF 398
Cdd:cd02083  383 yapegevfkngkkvkaGQYDGLVELATICALCNDSSLDyneskgvyekvgeateTAltvLVEKMNVFNTDKSGlSKRERA 462
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 399 LPFNPV-----DKRTALTF--------------IDSNGNwHRVSKGAPEQILDLCN-ARADLRKRVHST----------I 448
Cdd:cd02083  463 NACNDVieqlwKKEFTLEFsrdrksmsvycsptKASGGN-KLFVKGAPEGVLERCThVRVGGGKVVPLTaaikililkkV 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 449 DKYAERGLRSLAVSRQTVPEKTKE------SSGSPWE----FVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAI 518
Cdd:cd02083  542 WGYGTDTLRCLALATKDTPPKPEDmdledsTKFYKYEtdltFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGT 621
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 519 AKETGRRLGMGSNM--YPSSSLLGKHKDEamahIPVEDLIE---KADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVND 593
Cdd:cd02083  622 AEAICRRIGIFGEDedTTGKSYTGREFDD----LSPEEQREacrRARLFSRVEPSHKSKIVELLQSQGEITAMTGDGVND 697
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 594 APALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITI-RIVFGFMLIALIWKFDF 672
Cdd:cd02083  698 APALKKAEIGIAMGSGTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIgEVVSIFLTAALGLPEAL 777
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334188460 673 SPFMVLIIAILNDG-------------TIMTiskdrvKPSPTPD-----SWklkeIFATGVVLGGYMAIMTV-VFFW 730
Cdd:cd02083  778 IPVQLLWVNLVTDGlpatalgfnppdlDIMK------KPPRKPDeplisGW----LFFRYLAIGTYVGLATVgAFAW 844
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
40-641 2.88e-70

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 247.89  E-value: 2.88e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  40 ENRLQIFGPNKLEEKKESKLLKFlgfMWNPLSWVMEAA---------AIMAIALANGGGKPPDWQDFVGI-VCLLVINST 109
Cdd:cd02081    2 EHRREVYGKNEIPPKPPKSFLQL---VWEALQDPTLIIlliaaivslGLGFYTPFGEGEGKTGWIEGVAIlVAVILVVLV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 110 ISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPA 189
Cdd:cd02081   79 TAGNDYQKEKQFRKLNSKKEDQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLKIDESSLTGESDPI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 190 TKGPGEE-----VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTNQV-----GHFQKVLTAIGNF-CICSIAVGIA- 257
Cdd:cd02081  159 KKTPDNQipdpfLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAENEEktplqEKLTKLAVQIGKVgLIVAALTFIVl 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 258 -IEIVVMYPIQ--RRHYRDGIDNLLVLLIGGIPI---AMPT--VLSVTM--AIGSHKLSQQGAITKRMTAIEEMAGMDVL 327
Cdd:cd02081  239 iIRFIIDGFVNdgKSFSAEDLQEFVNFFIIAVTIivvAVPEglPLAVTLslAYSVKKMMKDNNLVRHLDACETMGNATAI 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 328 CSDKTGTLTLNKLSVDKNLIevyckGvEKDEV--LLFAARasrvenqdaidaamVGMLADPKEARAGIREIHFLPFNPVD 405
Cdd:cd02081  319 CSDKTGTLTQNRMTVVQGYI-----G-NKTECalLGFVLE--------------LGGDYRYREKRPEEKVLKVYPFNSAR 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 406 KRTALTFIDSNGNWHRVSKGAPEQILDLCN-----------ARADLRKRVHSTIDKYAERGLRSLAVSRQTVPEKTKESS 474
Cdd:cd02081  379 KRMSTVVRLKDGGYRLYVKGASEIVLKKCSyilnsdgevvfLTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSPDEEPTA 458
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 475 GSPWE----------FVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSNMYPSSSLLGK--- 541
Cdd:cd02081  459 ERDWDdeediesdltFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGLVLEGKefr 538
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 542 ----HKDEAMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADA-TDAARGA 616
Cdd:cd02081  539 elidEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDSGEVVAVTGDGTNDAPALKKADVGFAMGIAgTEVAKEA 618
                        650       660
                 ....*....|....*....|....*
gi 334188460 617 SDIVLTEPGLSVIISAVLTSRAIFQ 641
Cdd:cd02081  619 SDIILLDDNFSSIVKAVMWGRNVYD 643
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
19-640 2.86e-69

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 248.40  E-value: 2.86e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  19 PIEEVFQQLKCSREGLSGAEGENRLQIFGPNKL-EEKKESKLLKFLGFMWNPLSWVMEAAAIMAIALANG----GGKPPD 93
Cdd:PRK15122  31 SLEETLANLNTHRQGLTEEDAAERLQRYGPNEVaHEKPPHALVQLLQAFNNPFIYVLMVLAAISFFTDYWlplrRGEETD 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  94 WQDFVGIVCLLVINSTISFVEENNAGNAAAALMAGLAPKTKVLR----DGKWSEQEASI--LVPGDIVSIKLGDIIPADA 167
Cdd:PRK15122 111 LTGVIIILTMVLLSGLLRFWQEFRSNKAAEALKAMVRTTATVLRrghaGAEPVRREIPMreLVPGDIVHLSAGDMIPADV 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 168 RLLEGDPLKVDQSALTGESLP--------------ATKGPGEEV---------FSGSTCKQGEIEAVVIATGVHTFFGKA 224
Cdd:PRK15122 191 RLIESRDLFISQAVLTGEALPvekydtlgavagksADALADDEGslldlpnicFMGTNVVSGTATAVVVATGSRTYFGSL 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 225 AHLVDSTNQVGHFQKVLTAIGNFCICSIavgiaieiVVMYPIqrrhyrdgidnllVLLIGGI------------------ 286
Cdd:PRK15122 271 AKSIVGTRAQTAFDRGVNSVSWLLIRFM--------LVMVPV-------------VLLINGFtkgdwleallfalavavg 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 287 --PIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLievYCKGVEKDEVLLFAA 364
Cdd:PRK15122 330 ltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEHHL---DVSGRKDERVLQLAW 406
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 365 RASRVEN--QDAIDAAMV--GMLADPKEARAGIREIHFLPFNPVDKRTALTFIDSNGNWHRVSKGAPEQILDLCNARAD- 439
Cdd:PRK15122 407 LNSFHQSgmKNLMDQAVVafAEGNPEIVKPAGYRKVDELPFDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAVATHVRDg 486
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 440 ---------LRKRVHSTIDKYAERGLRSLAVSRQTVPE---KTKESSGSPWEFV--GVLPLFDPPRHDSAETIRRALDLG 505
Cdd:PRK15122 487 dtvrpldeaRRERLLALAEAYNADGFRVLLVATREIPGgesRAQYSTADERDLVirGFLTFLDPPKESAAPAIAALRENG 566
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 506 VNVKMITGDQLAIAKETGRRLGMGsnmyPSSSLLGKhKDEAMAHIPVEDLIEKADGFAGVFPEHKYEIVKKLQERKHICG 585
Cdd:PRK15122 567 VAVKVLTGDNPIVTAKICREVGLE----PGEPLLGT-EIEAMDDAALAREVEERTVFAKLTPLQKSRVLKALQANGHTVG 641
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 334188460 586 MTGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIF 640
Cdd:PRK15122 642 FLGDGINDAPALRDADVGISVDSGADIAKESADIILLEKSLMVLEEGVIKGRETF 696
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
131-644 7.74e-69

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 243.51  E-value: 7.74e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 131 PKT-KVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIE 209
Cdd:COG2217  212 PKTaRVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS-VDESMLTGESLPVEKTPGDEVFAGTINLDGSLR 290
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 210 AVVIATGVHTFFGKAAHLV-DSTNQVGHFQKVLTAI-GNFCIcsIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIggip 287
Cdd:COG2217  291 VRVTKVGSDTTLARIIRLVeEAQSSKAPIQRLADRIaRYFVP--AVLAIAALTFLVWLLFGGDFSTALYRAVAVLV---- 364
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 288 IAMPT--VLSVTMAI--GSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVdknlIEVYC-KGVEKDEVLLF 362
Cdd:COG2217  365 IACPCalGLATPTAImvGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEV----TDVVPlDGLDEDELLAL 440
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 363 AArasRVENQ------DAIDAAmvgmladpkearAGIREIHFLpfnPVDKRTALT------FIDSngnwHRVSKGAPEQI 430
Cdd:COG2217  441 AA---ALEQGsehplaRAIVAA------------AKERGLELP---EVEDFEAIPgkgveaTVDG----KRVLVGSPRLL 498
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 431 LDLcnaRADLRKRVHSTIDKYAERGLRSLAVSRQTvpektkessgspwEFVGVLPLFDPPRHDSAETIRRALDLGVNVKM 510
Cdd:COG2217  499 EEE---GIDLPEALEERAEELEAEGKTVVYVAVDG-------------RLLGLIALADTLRPEAAEAIAALKALGIRVVM 562
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 511 ITGDQLAIAKETGRRLGMgsnmypsssllgkhkDEAmahipvedliekadgFAGVFPEHKYEIVKKLQERKHICGMTGDG 590
Cdd:COG2217  563 LTGDNERTAEAVARELGI---------------DEV---------------RAEVLPEDKAAAVRELQAQGKKVAMVGDG 612
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 334188460 591 VNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMK 644
Cdd:COG2217  613 INDAPALAAADVGIAMGSGTDVAIEAADIVLMRDDLRGVPDAIRLSRATMRIIR 666
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
32-839 1.87e-60

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 224.12  E-value: 1.87e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460    32 EGLSGAEGENRLQIFGPNKLEEKKESKLLKFLgfmwnpLSWVMEAAAIMAIALANGGGKPPDWQDFVGIVCLLVINSTIS 111
Cdd:TIGR01523   25 EGLTHDEAQHRLKEVGENRLEADSGIDAKAML------LHQVCNAMCMVLIIAAAISFAMHDWIEGGVISAIIALNILIG 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   112 FVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATK 191
Cdd:TIGR01523   99 FIQEYKAEKTMDSLKNLASPMAHVIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIETKNFDTDEALLTGESLPVIK 178
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   192 ------GPGEEV---------FSGSTCKQGEIEAVVIATGVHTFFGKAA---------------------------HLVD 229
Cdd:TIGR01523  179 dahatfGKEEDTpigdrinlaFSSSAVTKGRAKGICIATALNSEIGAIAaglqgdgglfqrpekddpnkrrklnkwILKV 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   230 STNQVGHF---------QKVLTAIGNFCICsIAVGIAIeiVVMYPiQRRHYRDGIDNLLVLL-IGGIPIAMPTVLSVTMA 299
Cdd:TIGR01523  259 TKKVTGAFlglnvgtplHRKLSKLAVILFC-IAIIFAI--IVMAA-HKFDVDKEVAIYAICLaISIIPESLIAVLSITMA 334
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   300 IGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKL-----------------SVDKN--------LI------- 347
Cdd:TIGR01523  335 MGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMiarqiwiprfgtisidnSDDAFnpnegnvsGIprfspye 414
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   348 -----------------EVYCKGVEKDEVL-LFA--------ARASRVENQDAIDAAMVGmlADPKE------------- 388
Cdd:TIGR01523  415 yshneaadqdilkefkdELKEIDLPEDIDMdLFIklletaalANIATVFKDDATDCWKAH--GDPTEiaihvfakkfdlp 492
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   389 -------------------------ARAGIREIHFL---PFNPVDKRTALTFIDSNGNWHRV-SKGAPEQILDLCNA--- 436
Cdd:TIGR01523  493 hnaltgeedllksnendqsslsqhnEKPGSAQFEFIaefPFDSEIKRMASIYEDNHGETYNIyAKGAFERIIECCSSsng 572
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   437 -------------RADLRKRVHStidkYAERGLRSLAVS---------------RQTVPEKTKESSgspWEFVGVLPLFD 488
Cdd:TIGR01523  573 kdgvkispledcdRELIIANMES----LAAEGLRVLAFAsksfdkadnnddqlkNETLNRATAESD---LEFLGLIGIYD 645
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   489 PPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLG-MGSNMYP------SSSLLGKHKDEAMAHIPVEDLIEKADG 561
Cdd:TIGR01523  646 PPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGiIPPNFIHdrdeimDSMVMTGSQFDALSDEEVDDLKALCLV 725
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   562 FAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVA-DATDAARGASDIVLTEPGLSVIISAVLTSRAIF 640
Cdd:TIGR01523  726 IARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGIAMGiNGSDVAKDASDIVLSDDNFASILNAIEEGRRMF 805
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   641 QRMKNYTIYAVSITIRIVFgFMLIALIWK-------FDFSPFMVL-IIAILNDGTIMTISKDRVKPS----PTPDS---- 704
Cdd:TIGR01523  806 DNIMKFVLHLLAENVAEAI-LLIIGLAFRdengksvFPLSPVEILwCIMITSCFPAMGLGLEKAAPDlmdrLPHDNevgi 884
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   705 --WKL-KEIFATGVVLGGY-MAIMTVVFFW-----AAYKTDffpRTFH--VRDL---RGSEHEMMS--ALYLQVSIVSQA 768
Cdd:TIGR01523  885 fqKELiIDMFAYGFFLGGScLASFTGILYGfgsgnLGHDCD---AHYHagCNDVfkaRSAAFATMTfcALILAVEVKDFD 961
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   769 LIFVtRSRSWSFTERPGYFLLIAFWVAQLIATAIAVYGNWEFARI------------KGIGWGWaGVIWLYSIVFYFPLD 836
Cdd:TIGR01523  962 NSFF-NLHGIPDGDSNFKEFFHSIVENKFLAWAIAFAAVSAFPTIyipvinddvfkhKPIGAEW-GLAAAATIAFFFGAE 1039

                   ...
gi 334188460   837 IMK 839
Cdd:TIGR01523 1040 IWK 1042
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
133-668 4.72e-59

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 212.11  E-value: 4.72e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  133 TKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVV 212
Cdd:TIGR01525  58 RVLQGDGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVEKKEGDEVFAGTINGDGSLTIRV 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  213 IATGVHTFFGKAAHLV-DSTNQVGHFQKVLTAIGNFCICSIaVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMp 291
Cdd:TIGR01525 137 TKLGEDSTLAQIVELVeEAQSSKAPIQRLADRIASYYVPAV-LAIALLTFVVWLALGALWREALYRALTVLVVACPCAL- 214
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  292 tVLSVTMAI--GSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKnliEVYCKGVEKDEVL-LFAARASR 368
Cdd:TIGR01525 215 -GLATPVAIlvAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVD---IEPLDDASEEELLaLAAALEQS 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  369 VEN------QDAIDAAMVGMLADPKEARAGIReihflpfnpvdkrtaltfIDSNGNWHRVSK-GAPEQILDLCNARADLR 441
Cdd:TIGR01525 291 SSHplaraiVRYAKERGLELPPEDVEEVPGKG------------------VEATVDGGREVRiGNPRFLGNRELAIEPIS 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  442 kRVHSTIDKYAERGLRSLAVSRQTvpektkessgspwEFVGVLPLFDPPRHDSAETIRRALDLGV-NVKMITGDQLAIAK 520
Cdd:TIGR01525 353 -ASPDLLNEGESQGKTVVFVAVDG-------------ELLGVIALRDQLRPEAKEAIAALKRAGGiKLVMLTGDNRSAAE 418
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  521 ETGRRLGMGSNMYpsssllgkhkdeamahipvedliekadgfAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKA 600
Cdd:TIGR01525 419 AVAAELGIDDEVH-----------------------------AELLPEDKLAIVKKLQEEGGPVAMVGDGINDAPALAAA 469
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334188460  601 DIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMK-NYTIYAVSITIRIVFGFMLIALIW 668
Cdd:TIGR01525 470 DVGIAMGSGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKqNLAWALGYNLVAIPLAAGGLLPLW 538
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
5-681 1.11e-58

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 218.12  E-value: 1.11e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460    5 LEDIVNE-NVDLEKIPIEEVFQQLKCSRE-GLSGAEGENRLQIFGPNKLEEKKES-KLLKFLGFMWNPLS---WVMEAAA 78
Cdd:TIGR01106   6 LDELKKEvEMDDHKLSLDELERKYGTDLSkGLSAARAAEILARDGPNALTPPPTTpEWVKFCRQLFGGFSmllWIGAILC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   79 IMAIALANGGGKPPDWQD-FVGIVCLLV--INSTISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIV 155
Cdd:TIGR01106  86 FLAYGIQASTEEEPQNDNlYLGVVLSAVviITGCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVVVGDLV 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  156 SIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKGPG----------EEVFSGSTCKQGEIEAVVIATGVHTFFGKAA 225
Cdd:TIGR01106 166 EVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthenpletrNIAFFSTNCVEGTARGIVVNTGDRTVMGRIA 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  226 HLVDSTN--------QVGHFQKVLTAignfcicsIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMPTVLSVT 297
Cdd:TIGR01106 246 SLASGLEngktpiaiEIEHFIHIITG--------VAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVC 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  298 MAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSV-----DKNLIEVYC----KGVEKDE---------- 358
Cdd:TIGR01106 318 LTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVahmwfDNQIHEADTtedqSGVSFDKssatwlalsr 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  359 VLLFAARASRVENQDAI---------DAAMVGML-------ADPKEARAGIREIHFLPFNPVDKR--TALTFIDSNGNWH 420
Cdd:TIGR01106 398 IAGLCNRAVFKAGQENVpilkravagDASESALLkcielclGSVMEMRERNPKVVEIPFNSTNKYqlSIHENEDPRDPRH 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  421 -RVSKGAPEQILDLCNA----------RADLRKRVHSTIDKYAERGLRSLAVSRQTVPEKT--------KESSGSPWE-- 479
Cdd:TIGR01106 478 lLVMKGAPERILERCSSilihgkeqplDEELKEAFQNAYLELGGLGERVLGFCHLYLPDEQfpegfqfdTDDVNFPTDnl 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  480 -FVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSNmypsssllGKHKDEAMAH---IPVEDL 555
Cdd:TIGR01106 558 cFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISE--------GNETVEDIAArlnIPVSQV 629
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  556 IEKADG----------------------------FAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVA 607
Cdd:TIGR01106 630 NPRDAKacvvhgsdlkdmtseqldeilkyhteivFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMG 709
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334188460  608 DA-TDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRivfgfmlialiwkfDFSPFMVLIIA 681
Cdd:TIGR01106 710 IAgSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIP--------------EITPFLIFIIA 770
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
1-658 1.27e-58

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 217.72  E-value: 1.27e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460    1 MASGLEDIVNENVDL-EKI-PIEEVFQQLKCS-REGLSG--AEGENRLQIFGPNKLEEKKEsklLKFLGFMWNPLSWVM- 74
Cdd:TIGR01517  24 ILTDLTDIFKKAMPLyEKLgGAEGIATKLKTDlNEGVRLssSTLERREKVYGKNELPEKPP---KSFLQIVWAALSDQTl 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   75 -----------EAAAIMAIALANGGGKPPDWQDFVGIVCLLVINSTISFVEENNAGNA-AAALMAGLAPKTKVLRDGkwS 142
Cdd:TIGR01517 101 illsvaavvslVLGLYVPSVGEDKADTETGWIEGVAILVSVILVVLVTAVNDYKKELQfRQLNREKSAQKIAVIRGG--Q 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  143 EQEASI--LVPGDIVSIKLGDIIPADARLLEGDPLKVDQSALTGESLPATKGPGEEVF--SGSTCKQGEIEAVVIATGVH 218
Cdd:TIGR01517 179 EQQISIhdIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIKKGPVQDPFllSGTVVNEGSGRMLVTAVGVN 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  219 TFFGKaahLVDSTNQVG--------HFQKVLTAIGNF----CICSIAVGIAIEIVVMYPIQRRHYRDGID-----NLLVL 281
Cdd:TIGR01517 259 SFGGK---LMMELRQAGeeetplqeKLSELAGLIGKFgmgsAVLLFLVLSLRYVFRIIRGDGRFEDTEEDaqtflDHFII 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  282 LIGGIPIAMPTV--LSVTMAI--GSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLIEVYCKGVEKD 357
Cdd:TIGR01517 336 AVTIVVVAVPEGlpLAVTIALaySMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDE 415
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  358 EVLLFAARASRVENQDAI-----------------------DAAMVGML-------ADPKEARAGIREIHFLPFNPVDKR 407
Cdd:TIGR01517 416 IVLRNLPAAVRNILVEGIslnssseevvdrggkrafigsktECALLDFGlllllqsRDVQEVRAEEKVVKIYPFNSERKF 495
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  408 TALTFIDSNGNWHRVSKGAPEQILDLCNAR-----------ADLRKRVHSTIDKYAERGLRSLAV---SRQTVPEKTKES 473
Cdd:TIGR01517 496 MSVVVKHSGGKYREFRKGASEIVLKPCRKRldsngeatpisEDDKDRCADVIEPLASDALRTICLayrDFAPEEFPRKDY 575
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  474 SGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMgsnMYPSSSLLGKHKDEAMAHIPVE 553
Cdd:TIGR01517 576 PNKGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGI---LTFGGLAMEGKEFRSLVYEEMD 652
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  554 DLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADA-TDAARGASDIVLTEPGLSVIISA 632
Cdd:TIGR01517 653 PILPKLRVLARSSPLDKQLLVLMLKDMGEVVAVTGDGTNDAPALKLADVGFSMGISgTEVAKEASDIILLDDNFASIVRA 732
                         730       740       750
                  ....*....|....*....|....*....|.
gi 334188460  633 VLTSRAIFQRMKNY-----TIYAVSITIRIV 658
Cdd:TIGR01517 733 VKWGRNVYDNIRKFlqfqlTVNVVAVILTFV 763
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
132-644 1.07e-56

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 206.68  E-value: 1.07e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 132 KTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAV 211
Cdd:cd02079  126 TATVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEKGAGDTVFAGTINLNGPLTIE 204
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 212 VIATGVHTFFGKAAHLVDST-NQVGHFQKVLTAI-GNFC--ICSIAVGIAIeivvMYPIQRRHYRDGIDNLLVLLIGGIP 287
Cdd:cd02079  205 VTKTGEDTTLAKIIRLVEEAqSSKPPLQRLADRFaRYFTpaVLVLAALVFL----FWPLVGGPPSLALYRALAVLVVACP 280
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 288 ----IAMPTVLSVtmaiGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKnlIEVYcKGVEKDEVLlfa 363
Cdd:cd02079  281 calgLATPTAIVA----GIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTE--IEPL-EGFSEDELL--- 350
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 364 ARASRVENQD------AIDAAMVGMLADPKEArAGIREI-HFLPFNPVDKRTALtfidsngnwhrvskgapeqildLCNA 436
Cdd:cd02079  351 ALAAALEQHSehplarAIVEAAEEKGLPPLEV-EDVEEIpGKGISGEVDGREVL----------------------IGSL 407
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 437 RADLRKRVHSTIDKYAERG-LRSLAVSRQTvpektkessgspwEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQ 515
Cdd:cd02079  408 SFAEEEGLVEAADALSDAGkTSAVYVGRDG-------------KLVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDN 474
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 516 LAIAKETGRRLGMgsnmypsssllgkhkDEAmahipvedliekadgFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAP 595
Cdd:cd02079  475 EAAAQAVAKELGI---------------DEV---------------HAGLLPEDKLAIVKALQAEGGPVAMVGDGINDAP 524
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 334188460 596 ALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMK 644
Cdd:cd02079  525 ALAQADVGIAMGSGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIK 573
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
131-644 4.31e-56

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 205.79  E-value: 4.31e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 131 PKT-KVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIE 209
Cdd:cd02094  138 PKTaRVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPGDKVIGGTINGNGSLL 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 210 AVVIATGVHTFFGKAAHLVDSTnQVGH--FQK-----------------VLTAIGNFCIC-SIAVGIAIEIVVMypiqrr 269
Cdd:cd02094  217 VRATRVGADTTLAQIIRLVEEA-QGSKapIQRladrvsgvfvpvviaiaILTFLVWLLLGpEPALTFALVAAVA------ 289
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 270 hyrdgidnllVLLIG---GIPIAMPTVLSVtmaiGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSV-DKN 345
Cdd:cd02094  290 ----------VLVIAcpcALGLATPTAIMV----GTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVtDVV 355
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 346 LIEvyckGVEKDEVLLFAARasrVENQDA--IDAAMVgmladpkeARAGIREIhflPFNPVDKRTALTF--IDSNGNWHR 421
Cdd:cd02094  356 PLP----GDDEDELLRLAAS---LEQGSEhpLAKAIV--------AAAKEKGL---ELPEVEDFEAIPGkgVRGTVDGRR 417
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 422 VSKGAPEQILDLCNARADLrkrvHSTIDKYAERGLRSLAVSRqtvpektkessgsPWEFVGVLPLFDPPRHDSAETIRRA 501
Cdd:cd02094  418 VLVGNRRLMEENGIDLSAL----EAEALALEEEGKTVVLVAV-------------DGELAGLIAVADPLKPDAAEAIEAL 480
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 502 LDLGVNVKMITGDQLAIAKETGRRLGmgsnmypsssllgkhkdeamahipvedlIEKAdgFAGVFPEHKYEIVKKLQERK 581
Cdd:cd02094  481 KKMGIKVVMLTGDNRRTARAIAKELG----------------------------IDEV--IAEVLPEDKAEKVKKLQAQG 530
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334188460 582 HICGMTGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMK 644
Cdd:cd02094  531 KKVAMVGDGINDAPALAQADVGIAIGSGTDVAIESADIVLMRGDLRGVVTAIDLSRATMRNIK 593
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
33-681 9.84e-56

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 208.74  E-value: 9.84e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  33 GLSGAEGENRLQIFGPNKLE-EKKESKLLKFLGFMWNPLS---WV----------MEAAAimaialangGGKPPDWQDFV 98
Cdd:cd02608    1 GLTSARAAEILARDGPNALTpPPTTPEWVKFCKQLFGGFSmllWIgailcflaygIQAAT---------EEEPSNDNLYL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  99 GIVCLLVINST--ISFVEENNAGNAAAALMAGLAPKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLK 176
Cdd:cd02608   72 GIVLAAVVIVTgcFSYYQEAKSSKIMDSFKNMVPQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCK 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 177 VDQSALTGESLPATKGP---GEE-------VFSGSTCKQGEIEAVVIATGVHTFFGKAAHLVDSTN--------QVGHFQ 238
Cdd:cd02608  152 VDNSSLTGESEPQTRSPeftHENpletkniAFFSTNCVEGTARGIVINTGDRTVMGRIATLASGLEvgktpiarEIEHFI 231
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 239 KVLTAIGNFcicsiaVGIAIEIVVMypIQRRHYRDGIdnllVLLIgGIPIA------MPTVlSVTMAIGSHKLSQQGAIT 312
Cdd:cd02608  232 HIITGVAVF------LGVSFFILSL--ILGYTWLEAV----IFLI-GIIVAnvpeglLATV-TVCLTLTAKRMARKNCLV 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 313 KRMTAIEEMAGMDVLCSDKTGTLTLNKLSV-----DKNLIEVYC----KGVEKDE-------VLLFAARASRVE---NQD 373
Cdd:cd02608  298 KNLEAVETLGSTSTICSDKTGTLTQNRMTVahmwfDNQIHEADTtedqSGASFDKssatwlaLSRIAGLCNRAEfkaGQE 377
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 374 AI---------DAAMVGML-------ADPKEARAGIREIHFLPFNPVDKRTALTFIDSNGNWHR---VSKGAPEQILDLC 434
Cdd:cd02608  378 NVpilkrdvngDASESALLkcielscGSVMEMRERNPKVAEIPFNSTNKYQLSIHENEDPGDPRyllVMKGAPERILDRC 457
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 435 NA----------RADLRKRVHS---TIDKYAER--GLRSLAVSRQTVPEKTK---ESSGSPWE---FVGVLPLFDPPRHD 493
Cdd:cd02608  458 STilingkeqplDEEMKEAFQNaylELGGLGERvlGFCHLYLPDDKFPEGFKfdtDEVNFPTEnlcFVGLMSMIDPPRAA 537
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 494 SAETIRRALDLGVNVKMITGDQ----LAIAKETGrrlgmgsnmypsssllgkhkdeamahIPVedliekadgFAGVFPEH 569
Cdd:cd02608  538 VPDAVGKCRSAGIKVIMVTGDHpitaKAIAKGVG--------------------------IIV---------FARTSPQQ 582
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 570 KYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADA-TDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTI 648
Cdd:cd02608  583 KLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAgSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIA 662
                        730       740       750
                 ....*....|....*....|....*....|...
gi 334188460 649 YAVSITIRivfgfmlialiwkfDFSPFMVLIIA 681
Cdd:cd02608  663 YTLTSNIP--------------EITPFLIFIIA 681
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
135-687 1.26e-54

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 200.19  E-value: 1.26e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 135 VLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVVIA 214
Cdd:cd07550  104 VERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEKREGDLVFASTVVEEGQLVIRAER 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 215 TGVHTFFGKAAHLVDSTNQV-GHFQKVLTAIGNFCIC-SIAVGIAIEIVVmypiqrRHYRDGIDNLLVLLIGGIPIAMPT 292
Cdd:cd07550  183 VGRETRAARIAELIEQSPSLkARIQNYAERLADRLVPpTLGLAGLVYALT------GDISRAAAVLLVDFSCGIRLSTPV 256
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 293 VLSVTMAIGSHKlsqqGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKnlIEVYCKGVEKDEVLLFAARASRVENQ 372
Cdd:cd07550  257 AVLSALNHAARH----GILVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTA--IITFDGRLSEEDLLYLAASAEEHFPH 330
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 373 dAIDAAMVgmladpKEARAgiREIHFLPFNPVDKRTALTfIDSNGNWHRVSKGAP-----EQILDLCNARADLRKRVHST 447
Cdd:cd07550  331 -PVARAIV------REAEE--RGIEHPEHEEVEYIVGHG-IASTVDGKRIRVGSRhfmeeEEIILIPEVDELIEDLHAEG 400
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 448 idkyaeRGLRSLAVSRqtvpektkessgspwEFVGVLPLFDPPRHDSAETIRRALDLGV-NVKMITGDQLAIAKETGRRL 526
Cdd:cd07550  401 ------KSLLYVAIDG---------------RLIGVIGLSDPLRPEAAEVIARLRALGGkRIIMLTGDHEQRARALAEQL 459
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 527 GMGSNmypsssllgkhkdeamahipvedliekadgFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAV 606
Cdd:cd07550  460 GIDRY------------------------------HAEALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADVGISM 509
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 607 ADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMK-NYTIYAVSITIRIVFGFMlialiwkFDFSPfmvLIIAILND 685
Cdd:cd07550  510 RGGTDIARETADVVLLEDDLRGLAEAIELARETMALIKrNIALVVGPNTAVLAGGVF-------GLLSP---ILAAVLHN 579

                 ..
gi 334188460 686 GT 687
Cdd:cd07550  580 GT 581
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
135-684 3.67e-51

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 189.46  E-value: 3.67e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  135 VLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVVIA 214
Cdd:TIGR01512  59 RLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVLSGTSS-VDESALTGESVPVEKAPGDEVFAGAINLDGVLTIEVTK 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  215 TGVHTFFGKAAHLV-DSTNQVGHFQKVLTAIGNFCICSIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIPIAMptV 293
Cdd:TIGR01512 138 LPADSTIAKIVNLVeEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALVPPLLGAGPFLEWIYRALVLLVVASPCAL--V 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  294 LSVTMAI--GSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKnliEVYCKGVEKDEVLlfaARASRVEN 371
Cdd:TIGR01512 216 ISAPAAYlsAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTD---VHPADGHSESEVL---RLAAAAEQ 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  372 Q------DAIDAAMVGMLADP--KEARA----GIREIhflpfnpVDKRTALTfidSNGNWHRVSKGApeQILDLCNARAD 439
Cdd:TIGR01512 290 GsthplaRAIVDYARARELAPpvEDVEEvpgeGVRAV-------VDGGEVRI---GNPRSLSEAVGA--SIAVPESAGKT 357
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  440 LrkrVHSTIDKyaerglrslavsrqtvpektkessgspwEFVGVLPLFDPPRHDSAETIRRALDLGV-NVKMITGDQLAI 518
Cdd:TIGR01512 358 I---VLVARDG----------------------------TLLGYIALSDELRPDAAEAIAELKALGIkRLVMLTGDRRAV 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  519 AKETGRRLGMgsnmypsssllgkhkDEAmahipvedliekadgFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALK 598
Cdd:TIGR01512 407 AEAVARELGI---------------DEV---------------HAELLPEDKLEIVKELREKAGPVAMVGDGINDAPALA 456
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  599 KADIGIAV-ADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMK-NYTIYAVSITIRIVFGFMLIALIWKFDFSPFM 676
Cdd:TIGR01512 457 AADVGIAMgASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKqNVVIALGIILVLILLALFGVLPLWLAVLGHEG 536

                  ....*...
gi 334188460  677 VLIIAILN 684
Cdd:TIGR01512 537 STVLVILN 544
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
133-664 6.14e-51

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 189.02  E-value: 6.14e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  133 TKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPlKVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVV 212
Cdd:TIGR01511  94 TLLTKDGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVGDPVIAGTVNGTGSLVVRA 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  213 IATGVHTFFGKAAHLVD----STNQVGHFQKVLTAIgnFCICSIAVGIAIEIVVMYPIQRrhyrdgidNLLVLLIG---G 285
Cdd:TIGR01511 173 TATGEDTTLAQIVRLVRqaqqSKAPIQRLADKVAGY--FVPVVIAIALITFVIWLFALEF--------AVTVLIIAcpcA 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  286 IPIAMPTVLsvtmAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVdknlievyckgvekdevllfaar 365
Cdd:TIGR01511 243 LGLATPTVI----AVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTV----------------------- 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  366 asrvenqdaidaamvgmladpkearagireIHFLPFNPVDKRTALTFIDS--NGNWHRVSKG----APEQILDLCNA--- 436
Cdd:TIGR01511 296 ------------------------------TDVHVFGDRDRTELLALAAAleAGSEHPLAKAivsyAKEKGITLVTVsdf 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  437 RADLRKRVHSTIDKYAERGLRSLAVSRQTVPEKTKESSGS-------PWEFVGVLPLFDPPRHDSAETIRRALDLGVNVK 509
Cdd:TIGR01511 346 KAIPGIGVEGTVEGTKIQLGNEKLLGENAIKIDGKAGQGStvvlvavNGELAGVFALEDQLRPEAKEVIQALKRRGIEPV 425
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  510 MITGDQLAIAKETGRRLGMgsnmypsssllgkhkdeamahipvedliekaDGFAGVFPEHKYEIVKKLQERKHICGMTGD 589
Cdd:TIGR01511 426 MLTGDNRKTAKAVAKELGI-------------------------------DVRAEVLPDDKAALIKKLQEKGPVVAMVGD 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  590 GVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKN-------YTIYAVSITIRIVFGFM 662
Cdd:TIGR01511 475 GINDAPALAQADVGIAIGAGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKQnllwafgYNVIAIPIAAGVLYPIG 554

                  ..
gi 334188460  663 LI 664
Cdd:TIGR01511 555 IL 556
E1-E2_ATPase pfam00122
E1-E2 ATPase;
131-308 1.83e-45

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 161.59  E-value: 1.83e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  131 PKTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEA 210
Cdd:pfam00122   5 PTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEKKKGDMVYSGTVVVSGSAKA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  211 VVIATGVHTFFGKAAHLVDSTNQV-GHFQKVLTAIGNFCICsIAVGIAIEIVVMYPIQRRHYRDGIDNLLVLLIGGIPIA 289
Cdd:pfam00122  84 VVTATGEDTELGRIARLVEEAKSKkTPLQRLLDRLGKYFSP-VVLLIALAVFLLWLFVGGPPLRALLRALAVLVAACPCA 162
                         170
                  ....*....|....*....
gi 334188460  290 MPTVLSVTMAIGSHKLSQQ 308
Cdd:pfam00122 163 LPLATPLALAVGARRLAKK 181
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
131-663 1.55e-43

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 168.25  E-value: 1.55e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 131 PKT-KVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIE 209
Cdd:cd07552  130 PKTaHLVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGESKPVEKKPGDEVIGGSVNGNGTLE 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 210 AVVIATGVHTFFGKAAHLV-DSTNQVGHFQK-------------VLTAIGNFCICSIA--VGIAIEIVVMypiqrrhyrd 273
Cdd:cd07552  209 VKVTKTGEDSYLSQVMELVaQAQASKSRAENladkvagwlfyiaLGVGIIAFIIWLILgdLAFALERAVT---------- 278
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 274 gidnllVLLIG---GIPIAMPTVLSVTMAIGSHklsqQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVdkNLIEVY 350
Cdd:cd07552  279 ------VLVIAcphALGLAIPLVVARSTSIAAK----NGLLIRNREALERARDIDVVLFDKTGTLTEGKFGV--TDVITF 346
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 351 CKgVEKDEVLLFAARasrVENQDA--IDAAMVGMLADPKEARAGIREIHFLPFNPvdkrtaltfIDSNGNWHRVSKGAPE 428
Cdd:cd07552  347 DE-YDEDEILSLAAA---LEAGSEhpLAQAIVSAAKEKGIRPVEVENFENIPGVG---------VEGTVNGKRYQVVSPK 413
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 429 QIldlcnARADLRKRvHSTIDKYAERGLRSLAVSRQTvpektkessgspwEFVGVLPLFDPPRHDSAETIRRALDLGVNV 508
Cdd:cd07552  414 YL-----KELGLKYD-EELVKRLAQQGNTVSFLIQDG-------------EVIGAIALGDEIKPESKEAIRALKAQGITP 474
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 509 KMITGDQLAIAKETGRRLGMgsnmypsssllgkhkdeamahipvedliekADGFAGVFPEHKYEIVKKLQERKHICGMTG 588
Cdd:cd07552  475 VMLTGDNEEVAQAVAEELGI------------------------------DEYFAEVLPEDKAKKVKELQAEGKKVAMVG 524
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 589 DGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKN-------YTIYAVSITIRIV--F 659
Cdd:cd07552  525 DGVNDAPALAQADVGIAIGAGTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMKQnlwwgagYNVIAIPLAAGVLapI 604

                 ....
gi 334188460 660 GFML 663
Cdd:cd07552  605 GIIL 608
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
133-666 2.90e-43

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 167.04  E-value: 2.90e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 133 TKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPlKVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVV 212
Cdd:cd07551  115 RRIQRDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEKTPGDEVFAGTINGSGALTVRV 193
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 213 IATGVHTFFGKAAHLVDSTNQvgHFQKVLTAIGNF-CICSIAVGIAIE--IVVMYPIQRRHYRDGIDNLLVLLIGGIPIA 289
Cdd:cd07551  194 TKLSSDTVFAKIVQLVEEAQS--EKSPTQSFIERFeRIYVKGVLLAVLllLLLPPFLLGWTWADSFYRAMVFLVVASPCA 271
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 290 -----MPTVLSvtmAIGShkLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVdKNLIevYCKGVEKDEVLLFAA 364
Cdd:cd07551  272 lvastPPATLS---AIAN--AARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRV-TDVI--PAEGVDEEELLQVAA 343
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 365 RASRVENQdAIDAAMVgmladpKEARAgiREIHFLPFNPVDKRTA--LTFIDSNGNWHrvsKGAPEQIldlcnARADLRK 442
Cdd:cd07551  344 AAESQSEH-PLAQAIV------RYAEE--RGIPRLPAIEVEAVTGkgVTATVDGQTYR---IGKPGFF-----GEVGIPS 406
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 443 RVHSTIDKYAERGLRSLAVSRQTVpektkessgspweFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKET 522
Cdd:cd07551  407 EAAALAAELESEGKTVVYVARDDQ-------------VVGLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAV 473
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 523 GRRLGMgsnmypsssllgkhkDEAmahipvedliekadgFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADI 602
Cdd:cd07551  474 AKELGI---------------DEV---------------VANLLPEDKVAIIRELQQEYGTVAMVGDGINDAPALANADV 523
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334188460 603 GIAVADATDAARGASDIVLTEPGLSVIISAVLTSRA----IFQrmkNYTIYAVSITIRIV---FGFMLIAL 666
Cdd:cd07551  524 GIAMGAGTDVALETADVVLMKDDLSKLPYAIRLSRKmrriIKQ---NLIFALAVIALLIVanlFGLLNLPL 591
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
135-676 1.49e-42

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 168.70  E-value: 1.49e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   135 VLRDGKWSEQEASILVPGDIVSIKL--GDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEE---------------- 196
Cdd:TIGR01657  233 VIRNGKWVTIASDELVPGDIVSIPRpeEKTMPCDSVLLSGSCI-VNESMLTGESVPVLKFPIPDngdddedlflyetskk 311
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   197 --VFSG-------STCKQGEIEAVVIATGVHTFFGKAAH-LVDSTNQVGHFQKVLTAIGNFCICSIAVGIAIEIVVMYPI 266
Cdd:TIGR01657  312 hvLFGGtkilqirPYPGDTGCLAIVVRTGFSTSKGQLVRsILYPKPRVFKFYKDSFKFILFLAVLALIGFIYTIIELIKD 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   267 QRRHYRDGIDNLLVLLIgGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSV---- 342
Cdd:TIGR01657  392 GRPLGKIILRSLDIITI-VVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDLrgvq 470
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   343 --------DKNLIEVyCKGVEKDEVLLFAARAS--RVENQ---DAIDAAMV---------------------GMLADPKE 388
Cdd:TIGR01657  471 glsgnqefLKIVTED-SSLKPSITHKALATCHSltKLEGKlvgDPLDKKMFeatgwtleeddesaeptsilaVVRTDDPP 549
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   389 ARAGIreIHFLPFNPVDKRTA-LTFIDSNGNWHRVSKGAPEQILDLCNaRADLRKRVHSTIDKYAERGLRSLAVSRQTVP 467
Cdd:TIGR01657  550 QELSI--IRRFQFSSALQRMSvIVSTNDERSPDAFVKGAPETIQSLCS-PETVPSDYQEVLKSYTREGYRVLALAYKELP 626
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   468 EKT--------KESSGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSN-------- 531
Cdd:TIGR01657  627 KLTlqkaqdlsRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVNPsntlilae 706
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   532 ----------------------------------MYPSSSLLGKHKDEAM---------AHIP--VEDLIEKADGFAGVF 566
Cdd:TIGR01657  707 aeppesgkpnqikfevidsipfastqveipyplgQDSVEDLLASRYHLAMsgkafavlqAHSPelLLRLLSHTTVFARMA 786
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460   567 PEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAV--ADATDAARGASDIVLTEPGLSVII---SAVLTSRAIFQ 641
Cdd:TIGR01657  787 PDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLseAEASVAAPFTSKLASISCVPNVIRegrCALVTSFQMFK 866
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 334188460   642 RMKNYT-IYAVSITIRIVFG-------FMLIALIWKFDFSPFM 676
Cdd:TIGR01657  867 YMALYSlIQFYSVSILYLIGsnlgdgqFLTIDLLLIFPVALLM 909
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
131-638 6.76e-41

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 159.88  E-value: 6.76e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 131 PKT-KVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPlKVDQSALTGESLPATKGPGEEVFSGSTCKQGEIE 209
Cdd:cd07546   98 PETaLREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKAAGDKVFAGSINVDGVLR 176
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 210 AVVIATGVHTFFGKAAHLVDSTNQ--------VGHFQKVLT-AIgnfcicsiaVGIAIEIVVMYPI------QRRHYRDg 274
Cdd:cd07546  177 IRVTSAPGDNAIDRILHLIEEAEErrapierfIDRFSRWYTpAI---------MAVALLVIVVPPLlfgadwQTWIYRG- 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 275 idnlLVLLIGGIPIAMptVLSVTMAIGShKLS---QQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVdknlIEVYC 351
Cdd:cd07546  247 ----LALLLIGCPCAL--VISTPAAITS-GLAaaaRRGALIKGGAALEQLGRVTTVAFDKTGTLTRGKPVV----TDVVP 315
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 352 KGVEKDEVLLfaARASRVENQDAidaamvGMLADPKEARAGIREihfLPFNPVDKRTALT--FIDSNGNWHRVSKGAPEQ 429
Cdd:cd07546  316 LTGISEAELL--ALAAAVEMGSS------HPLAQAIVARAQAAG---LTIPPAEEARALVgrGIEGQVDGERVLIGAPKF 384
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 430 ildlcnARADLRKRVHSTIDKYAERGLRSLAVSRQTVPektkessgspwefVGVLPLFDPPRHDSAETIRRALDLGVNVK 509
Cdd:cd07546  385 ------AADRGTLEVQGRIAALEQAGKTVVVVLANGRV-------------LGLIALRDELRPDAAEAVAELNALGIKAL 445
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 510 MITGDQLAIAKETGRRLGMgsnmypsssllgkhkdeamahipvedliekaDGFAGVFPEHKYEIVKKLQERKHIcGMTGD 589
Cdd:cd07546  446 MLTGDNPRAAAAIAAELGL-------------------------------DFRAGLLPEDKVKAVRELAQHGPV-AMVGD 493
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 334188460 590 GVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRA 638
Cdd:cd07546  494 GINDAPAMKAASIGIAMGSGTDVALETADAALTHNRLGGVAAMIELSRA 542
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
131-685 1.27e-40

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 159.12  E-value: 1.27e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 131 PKTK-VLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIE 209
Cdd:cd07545   95 PKTAlVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIVRGESS-VNQAAITGESLPVEKGVGDEVFAGTLNGEGALE 173
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 210 AVVIATGVHTFFGKAAHLVDSTNQ--------VGHFQKVLTAIgnfcICSIAVGIAIEIVVMYPIQrrhYRDGIDNLLVL 281
Cdd:cd07545  174 VRVTKPAEDSTIARIIHLVEEAQAeraptqafVDRFARYYTPV----VMAIAALVAIVPPLFFGGA---WFTWIYRGLAL 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 282 LIGGIPIAM--PTVLSVTMAIGShkLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKnlIEVYcKGVEKDEV 359
Cdd:cd07545  247 LVVACPCALviSTPVSIVSAIGN--AARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTD--VVVL-GGQTEKEL 321
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 360 LLFAArASRVENQDAIDAAMVGmladpKEARAGIreihflPFNPVDKRTALT------FIDSN----GNwHRVSKgapEQ 429
Cdd:cd07545  322 LAIAA-ALEYRSEHPLASAIVK-----KAEQRGL------TLSAVEEFTALTgrgvrgVVNGTtyyiGS-PRLFE---EL 385
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 430 ILDLCNAradlrkrVHSTIDKYAERGLRSLAVsrqtvpektkessGSPWEFVGVLPLFDPPRHDSAETIRRALDLGV-NV 508
Cdd:cd07545  386 NLSESPA-------LEAKLDALQNQGKTVMIL-------------GDGERILGVIAVADQVRPSSRNAIAALHQLGIkQT 445
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 509 KMITGDQLAIAKETGrrlgmgsnmypsssllgkhkdeamAHIPVEDLiekadgFAGVFPEHKYEIVKKLQERKHICGMTG 588
Cdd:cd07545  446 VMLTGDNPQTAQAIA------------------------AQVGVSDI------RAELLPQDKLDAIEALQAEGGRVAMVG 495
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 589 DGVNDAPALKKADIGIAVADA-TDAARGASDIVLTEPGLSVIISAVLTSRaifqrmKNYTIYAVSITIRIvfGFMLIALI 667
Cdd:cd07545  496 DGVNDAPALAAADVGIAMGAAgTDTALETADIALMGDDLRKLPFAVRLSR------KTLAIIKQNIAFAL--GIKLIALL 567
                        570
                 ....*....|....*...
gi 334188460 668 wkFDFSPFMVLIIAILND 685
Cdd:cd07545  568 --LVIPGWLTLWMAVFAD 583
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
134-648 2.16e-40

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 160.11  E-value: 2.16e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 134 KVLRDGKWSEQEASILVPGDIVSIKL-GDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEE---------------- 196
Cdd:cd07542   90 RVIRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGSCI-VNESMLTGESVPVTKTPLPDesndslwsiysiedhs 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 197 ---VFSGSTC------KQGEIEAVVIATGVHTFFGKaahLVDS-----------TNQVGHFQKVLTAIGnfcicsiAVGI 256
Cdd:cd07542  169 khtLFCGTKViqtrayEGKPVLAVVVRTGFNTTKGQ---LVRSilypkpvdfkfYRDSMKFILFLAIIA-------LIGF 238
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 257 AIEIVVMYPIQRRHYRDGIDNLLVLLIGgIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEeMAGM-DVLCSDKTGTL 335
Cdd:cd07542  239 IYTLIILILNGESLGEIIIRALDIITIV-VPPALPAALTVGIIYAQSRLKKKGIFCISPQRIN-ICGKiNLVCFDKTGTL 316
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 336 TLNKLSV---------DKNLIEVYCKGVEKDEVL----LFAARA-----SRVENQ---DAIDAAMVgmladpkEARAGIR 394
Cdd:cd07542  317 TEDGLDLwgvrpvsgnNFGDLEVFSLDLDLDSSLpngpLLRAMAtchslTLIDGElvgDPLDLKMF-------EFTGWSL 389
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 395 EI-HFLPFNPVDKR-TALTFIDSNGNWHRVSKGAPEQILDLCNARAdLRKRVHSTIDKYAERGLRSLAVSRQTVPEKT-- 470
Cdd:cd07542  390 EIlRQFPFSSALQRmSVIVKTPGDDSMMAFTKGAPEMIASLCKPET-VPSNFQEVLNEYTKQGFRVIALAYKALESKTwl 468
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 471 -----KESSGSPWEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSnmyPSSSL----LGK 541
Cdd:cd07542  469 lqklsREEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVARECGMIS---PSKKVilieAVK 545
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 542 HKDEAMAHIPVEDLIeKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIAVADAtdAARGASDIVL 621
Cdd:cd07542  546 PEDDDSASLTWTLLL-KGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVGISLSEA--EASVAAPFTS 622
                        570       580       590
                 ....*....|....*....|....*....|....
gi 334188460 622 TEPGLS----VII---SAVLTSRAIFQRMKNYTI 648
Cdd:cd07542  623 KVPDIScvptVIKegrAALVTSFSCFKYMALYSL 656
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
135-665 5.23e-40

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 157.10  E-value: 5.23e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 135 VLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVVIA 214
Cdd:cd07544  114 RLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKRPGDRVMSGAVNGDSALTMVATK 192
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 215 TGVHTFFGKAAHLVDST-NQVGHFQKVLTAIGN-FCICSIAVGIAIEIVVMYPIQrrhyrdgidnLLVLLIGGIPIamPT 292
Cdd:cd07544  193 LAADSQYAGIVRLVKEAqANPAPFVRLADRYAVpFTLLALAIAGVAWAVSGDPVR----------FAAVLVVATPC--PL 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 293 VLSVTMAI--GSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKNLIEvycKGVEKDEVLLFAARASRvE 370
Cdd:cd07544  261 ILAAPVAIvsGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDVVPA---PGVDADEVLRLAASVEQ-Y 336
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 371 NQDAIDAAMVgmladpKEARAgiREIHFLPFNPVDKRTALTfIDSNGNWHRVSKGAPEQILDLCNARADLRKRVHSTIDK 450
Cdd:cd07544  337 SSHVLARAIV------AAARE--RELQLSAVTELTEVPGAG-VTGTVDGHEVKVGKLKFVLARGAWAPDIRNRPLGGTAV 407
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 451 YaerglrslaVSRQTvpektkessgspwEFVGVLPLFDPPRHDSAETIRRALDLGVN-VKMITGDQLAIAKETGRRLGMg 529
Cdd:cd07544  408 Y---------VSVDG-------------KYAGAITLRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGI- 464
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 530 snmypsssllgkhkdeamahipvedliekADGFAGVFPEHKYEIVKKLQERkHICGMTGDGVNDAPALKKADIGIAV-AD 608
Cdd:cd07544  465 -----------------------------DEVRAELLPEDKLAAVKEAPKA-GPTIMVGDGVNDAPALAAADVGIAMgAR 514
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 334188460 609 ATDAARGASDIVLTEPGLSVIISAVltsrAIFQRMKNYTIYAVSITIRIVFGFMLIA 665
Cdd:cd07544  515 GSTAASEAADVVILVDDLDRVVDAV----AIARRTRRIALQSVLIGMALSIIGMLIA 567
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
94-721 1.45e-36

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 148.51  E-value: 1.45e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  94 WQDFVGIVCLLVINSTISfVEENNAGNAAAALMAGLAPKTKVLRDG-KWSEQEASILVPGDIVSIKL-GDIIPADARLLE 171
Cdd:cd02082   50 VYYAITVVFMTTINSLSC-IYIRGVMQKELKDACLNNTSVIVQRHGyQEITIASNMIVPGDIVLIKRrEVTLPCDCVLLE 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 172 GDpLKVDQSALTGESLPATKGPGEE-----------------VFSGSTCKQ-----GEI-EAVVIATGVHTFFGKAAHLV 228
Cdd:cd02082  129 GS-CIVTEAMLTGESVPIGKCQIPTdshddvlfkyesskshtLFQGTQVMQiippeDDIlKAIVVRTGFGTSKGQLIRAI 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 229 ---DSTNQVGHFQKVLtaignFCICSIAVGIAIEIVVMY-----PIQRrhYRDGIDNLLVLLIGgIPIAMPTVLSVTMAI 300
Cdd:cd02082  208 lypKPFNKKFQQQAVK-----FTLLLATLALIGFLYTLIrlldiELPP--LFIAFEFLDILTYS-VPPGLPMLIAITNFV 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 301 GSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSV--------DKNL--IEVYCKGVEKDEVLLFAARAS--R 368
Cdd:cd02082  280 GLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDLigyqlkgqNQTFdpIQCQDPNNISIEHKLFAICHSltK 359
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 369 VENQ---DAIDAAM---VGMLADPKE---------ARAGIREIHFLPFNPVDKRTA-----LTFIDSNGNWHRVSKGAPE 428
Cdd:cd02082  360 INGKllgDPLDVKMaeaSTWDLDYDHeakqhysksGTKRFYIIQVFQFHSALQRMSvvakeVDMITKDFKHYAFIKGAPE 439
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 429 QILDLCNARADLRKRVHSTIDKyaeRGLRSLAVSRQTVPEKT--------KESSGSPWEFVGVLPLFDPPRHDSAETIRR 500
Cdd:cd02082  440 KIQSLFSHVPSDEKAQLSTLIN---EGYRVLALGYKELPQSEidafldlsREAQEANVQFLGFIIYKNNLKPDTQAVIKE 516
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 501 ALDLGVNVKMITGDQLAIAKETGRRLGMgsnMYPSSSLLGKH----KDEAMAHIPVEdLIEKADGFAGVFPEHKYEIVKK 576
Cdd:cd02082  517 FKEACYRIVMITGDNPLTALKVAQELEI---INRKNPTIIIHllipEIQKDNSTQWI-LIIHTNVFARTAPEQKQTIIRL 592
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 577 LQERKHICGMTGDGVNDAPALKKADIGIAVADATdaARGASDIVLTEPGLSVIISAVLTSRAI----FQRMKNYTIYAvs 652
Cdd:cd02082  593 LKESDYIVCMCGDGANDCGALKEADVGISLAEAD--ASFASPFTSKSTSISCVKRVILEGRVNlstsVEIFKGYALVA-- 668
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334188460 653 itIRIVFGFMLIALIWKfDFSPFMVLIIAILNDGTIMTISKdrvKPSPTPDSWKLKE-----IFATGVVLGGYM 721
Cdd:cd02082  669 --LIRYLSFLTLYYFYS-SYSSSGQMDWQLLAAGYFLVYLR---LGCNTPLKKLEKDdnlfsIYNVTSVLFGFT 736
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
134-620 1.47e-35

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 144.33  E-value: 1.47e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 134 KVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFS---GSTCKQGEIEA 210
Cdd:cd02078   99 RLRNDGKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGVAS-VDESAITGESAPVIRESGGDRSSvtgGTKVLSDRIKV 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 211 VVIATGVHTFFGKAAHLVDSTNQvghfQKVLTAIG-NFCICSIAVGIAIEIVVMYPIQrrHYRDG---IDNLLVLLIGGI 286
Cdd:cd02078  178 RITANPGETFLDRMIALVEGASR----QKTPNEIAlTILLVGLTLIFLIVVATLPPFA--EYSGApvsVTVLVALLVCLI 251
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 287 PIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTL-NKLSVDknLIEVycKGVEKDEVLLFAAR 365
Cdd:cd02078  252 PTTIGGLLSAIGIAGMDRLLRFNVIAKSGRAVEAAGDVDTLLLDKTGTITLgNRQATE--FIPV--GGVDEKELADAAQL 327
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 366 ASRV----ENQDAIDAA--MVGMLADPkearaGIREIHFLPFNPvdkRTALTFIDSNGNwHRVSKGAPEQILDLCNARA- 438
Cdd:cd02078  328 ASLAdetpEGRSIVILAkqLGGTERDL-----DLSGAEFIPFSA---ETRMSGVDLPDG-TEIRKGAVDAIRKYVRSLGg 398
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 439 DLRKRVHSTIDKYAERGLRSLAVSRQTvpektkessgspwEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQ--- 515
Cdd:cd02078  399 SIPEELEAIVEEISKQGGTPLVVAEDD-------------RVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNplt 465
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 516 -LAIAKETGrrlgmgsnmypsssllgkhkdeamahipVEDLIEKADgfagvfPEHKYEIVKKLQERKHICGMTGDGVNDA 594
Cdd:cd02078  466 aAAIAAEAG----------------------------VDDFLAEAK------PEDKLELIRKEQAKGKLVAMTGDGTNDA 511
                        490       500
                 ....*....|....*....|....*.
gi 334188460 595 PALKKADIGIAVADATDAARGASDIV 620
Cdd:cd02078  512 PALAQADVGVAMNSGTQAAKEAGNMV 537
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
135-684 3.72e-35

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 142.37  E-value: 3.72e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 135 VLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVVIA 214
Cdd:cd07548  113 LKRNNELKDVKPEEVQIGDIIVVKPGEKIPLDGVVLKGESF-LDTSALTGESVPVEVKEGSSVLAGFINLNGVLEIKVTK 191
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 215 TGVHTFFGKAAHLV-DSTNQVGHFQKVLTAIGNFcICSIAVGIAIEIVVMYPI--QRRHYRDGIDNLLVLLIGGIPIAMp 291
Cdd:cd07548  192 PFKDSAVAKILELVeNASARKAPTEKFITKFARY-YTPIVVFLALLLAVIPPLfsPDGSFSDWIYRALVFLVISCPCAL- 269
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 292 tVLSVTMA--IGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVDKnlIEVYcKGVEKDEVLLFAARASRV 369
Cdd:cd07548  270 -VISIPLGyfGGIGAASRKGILIKGSNYLEALSQVKTVVFDKTGTLTKGVFKVTE--IVPA-PGFSKEELLKLAALAESN 345
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 370 ENQ---DAIDAAMVGMLaDPKEARA-------GIREIhflpfnpVDKRTALTfidsnGNwhrvskgapEQILDLCNARAD 439
Cdd:cd07548  346 SNHpiaRSIQKAYGKMI-DPSEIEDyeeiaghGIRAV-------VDGKEILV-----GN---------EKLMEKFNIEHD 403
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 440 LRKRVHSTIdkYAERGLRslavsrqtvpektkessgspweFVGVLPLFDPPRHDSAETIRRALDLGV-NVKMITGDQLAI 518
Cdd:cd07548  404 EDEIEGTIV--HVALDGK----------------------YVGYIVISDEIKEDAKEAIKGLKELGIkNLVMLTGDRKSV 459
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 519 AKETGRRLGMGSNmypsssllgkhkdeamahipvedliekadgFAGVFPEHKYEIVKKLQER-KHICGMTGDGVNDAPAL 597
Cdd:cd07548  460 AEKVAKKLGIDEV------------------------------YAELLPEDKVEKVEELKAEsKGKVAFVGDGINDAPVL 509
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 598 KKADIGIAV-ADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSI-TIRIVFGFMLIALIWKFDFSPF 675
Cdd:cd07548  510 ARADVGIAMgGLGSDAAIEAADVVLMNDEPSKVAEAIKIARKTRRIVWQNIILALGVkAIVLILGALGLATMWEAVFADV 589

                 ....*....
gi 334188460 676 MVLIIAILN 684
Cdd:cd07548  590 GVALLAILN 598
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
133-655 3.11e-31

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 130.55  E-value: 3.11e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 133 TKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVV 212
Cdd:cd02092  129 QRLQADGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPVTVAPGDLVQAGAMNLSGPLRLRA 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 213 IATGVHTFFGKAAHLVDSTNQ------------------VGHFQKVLTAIGnFCICSIAVGIAIEIVVMypiqrrhyrdg 274
Cdd:cd02092  208 TAAGDDTLLAEIARLMEAAEQgrsryvrladraarlyapVVHLLALLTFVG-WVAAGGDWRHALLIAVA----------- 275
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 275 idnllVLLIG---GIPIAMPTVlsVTMAIGshKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVdKNLIEVyc 351
Cdd:cd02092  276 -----VLIITcpcALGLAVPAV--QVVASG--RLFRRGVLVKDGTALERLAEVDTVVFDKTGTLTLGSPRL-VGAHAI-- 343
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 352 kgveKDEVLLFAARASRVENQDAIDAamvgmLADPKEARA----GIREIHflpfnpvdkrtaltfidsngnwhrvSKGap 427
Cdd:cd02092  344 ----SADLLALAAALAQASRHPLSRA-----LAAAAGARPveldDAREVP-------------------------GRG-- 387
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 428 eqildlcnaradlrkrVHSTIDKYAER-GLRSLAVSRQTVPEKTKESSGSPWEFVGVLPLFDPPRHDSAETIRRALDLGV 506
Cdd:cd02092  388 ----------------VEGRIDGARVRlGRPAWLGASAGVSTASELALSKGGEEAARFPFEDRPRPDAREAISALRALGL 451
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 507 NVKMITGDQLAIAKETGRRLGmgsnmypsssllgkhkdeamahipVEDLIekadgfAGVFPEHKYEIVKKLQERKHICGM 586
Cdd:cd02092  452 SVEILSGDREPAVRALARALG------------------------IEDWR------AGLTPAEKVARIEELKAQGRRVLM 501
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334188460 587 TGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKN-------YTIYAVSITI 655
Cdd:cd02092  502 VGDGLNDAPALAAAHVSMAPASAVDASRSAADIVFLGDSLAPVPEAIEIARRARRLIRQnfalaigYNVIAVPLAI 577
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
134-620 2.70e-29

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 124.99  E-value: 2.70e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  134 KVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDPlKVDQSALTGESLPATKGPGEEVFS---GSTCKQGEIEA 210
Cdd:TIGR01497 109 LLRDDGAIDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGVA-SVDESAITGESAPVIKESGGDFASvtgGTRILSDWLVV 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  211 VVIATGVHTFFGKAAHLVDSTNQvghfQKVLTAIG-NFCICSIAVGIAIEIVVMYPIQrrHYRD---GIDNLLVLLIGGI 286
Cdd:TIGR01497 188 ECTANPGETFLDRMIALVEGAQR----RKTPNEIAlTILLIALTLVFLLVTATLWPFA--AYGGnaiSVTVLVALLVCLI 261
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  287 PIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTL-NKLSVDknLIEVycKGVEKDEVLLFAAR 365
Cdd:TIGR01497 262 PTTIGGLLSAIGIAGMDRVLGFNVIATSGRAVEACGDVDTLLLDKTGTITLgNRLASE--FIPA--QGVDEKTLADAAQL 337
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  366 ASRVEnqDAIDAAMVGMLADpkeaRAGIRE-------IHFLPFNpVDKRTALTFIDsngNWHRVSKGAPEQILDLCNAR- 437
Cdd:TIGR01497 338 ASLAD--DTPEGKSIVILAK----QLGIREddvqslhATFVEFT-AQTRMSGINLD---NGRMIRKGAVDAIKRHVEANg 407
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  438 ADLRKRVHSTIDKYAERGLRSLAVSRQTvpektkessgspwEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQ-- 515
Cdd:TIGR01497 408 GHIPTDLDQAVDQVARQGGTPLVVCEDN-------------RIYGVIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNrl 474
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  516 --LAIAKETGrrlgmgsnmypsssllgkhkdeamahipVEDLIEKADgfagvfPEHKYEIVKKLQERKHICGMTGDGVND 593
Cdd:TIGR01497 475 taAAIAAEAG----------------------------VDDFIAEAT------PEDKIALIRQEQAEGKLVAMTGDGTND 520
                         490       500
                  ....*....|....*....|....*..
gi 334188460  594 APALKKADIGIAVADATDAARGASDIV 620
Cdd:TIGR01497 521 APALAQADVGVAMNSGTQAAKEAANMV 547
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
135-613 3.48e-29

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 125.19  E-value: 3.48e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 135 VLRDGKWSEQEASILVPGDIVSI---KLGDIIPADARLLEGdPLKVDQSALTGESLPATKGPGEEV-------------- 197
Cdd:cd07543   90 VYRDGKWVPISSDELLPGDLVSIgrsAEDNLVPCDLLLLRG-SCIVNEAMLTGESVPLMKEPIEDRdpedvldddgddkl 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 198 ---FSGSTCKQ-------------GEIEAVVIATGVHTFFGKAAH-LVDSTNQVghfqkvlTAigNfcicSIAVGIAIEI 260
Cdd:cd07543  169 hvlFGGTKVVQhtppgkgglkppdGGCLAYVLRTGFETSQGKLLRtILFSTERV-------TA--N----NLETFIFILF 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 261 VVMYPIQRRHY--RDGIDN-------LL--VLLIGG-IPIAMPTVLSvtMAIGShklsQQGAITKRMTAIEE-----MAG 323
Cdd:cd07543  236 LLVFAIAAAAYvwIEGTKDgrsryklFLecTLILTSvVPPELPMELS--LAVNT----SLIALAKLYIFCTEpfripFAG 309
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 324 -MDVLCSDKTGTLTLNKLSVDKnlievyCKGVEKDEvllFAARASRVENQDAIDA-----AMVGML-----ADPKEARA- 391
Cdd:cd07543  310 kVDICCFDKTGTLTSDDLVVEG------VAGLNDGK---EVIPVSSIEPVETILVlaschSLVKLDdgklvGDPLEKATl 380
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 392 ---------------------GIREIHFLPFNPVDKR-----TALTFIDSNGNWHRVSKGAPEQILdlcNARADLRKRVH 445
Cdd:cd07543  381 eavdwtltkdekvfprskktkGLKIIQRFHFSSALKRmsvvaSYKDPGSTDLKYIVAVKGAPETLK---SMLSDVPADYD 457
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 446 STIDKYAERGLRSLAV--------SRQTVPEKTKESSGSPWEFVGVLpLFDPP-RHDSAETIRRALDLGVNVKMITGDQL 516
Cdd:cd07543  458 EVYKEYTRQGSRVLALgykelghlTKQQARDYKREDVESDLTFAGFI-VFSCPlKPDSKETIKELNNSSHRVVMITGDNP 536
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 517 AIAKETGRRLGMGSNmyPSSSLLGKHKDEAMAHipveDLIEKADGFAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPA 596
Cdd:cd07543  537 LTACHVAKELGIVDK--PVLILILSEEGKSNEW----KLIPHVKVFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGA 610
                        570       580
                 ....*....|....*....|
gi 334188460 597 LKKADIGIAV---ADATDAA 613
Cdd:cd07543  611 LKHAHVGVALlklGDASIAA 630
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
134-662 4.54e-29

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 124.43  E-value: 4.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 134 KVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGdPLKVDQSALTGESLPATKGPG---EEVFSGSTCKQGEIEA 210
Cdd:PRK14010 108 RIKQDGSYEMIDASDLKKGHIVRVATGEQIPNDGKVIKG-LATVDESAITGESAPVIKESGgdfDNVIGGTSVASDWLEV 186
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 211 VVIATGVHTFFGKAAHLVDST------NQVGHFQKVLTaignFCICSIAVgiaieIVVMYPIQR-RHYRDGIDNLLVLLI 283
Cdd:PRK14010 187 EITSEPGHSFLDKMIGLVEGAtrkktpNEIALFTLLMT----LTIIFLVV-----ILTMYPLAKfLNFNLSIAMLIALAV 257
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 284 GGIPIAMPTVLSVTMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTL-NKLSVDknLIEVYCKGVEKdevLLF 362
Cdd:PRK14010 258 CLIPTTIGGLLSAIGIAGMDRVTQFNILAKSGRSVETCGDVNVLILDKTGTITYgNRMADA--FIPVKSSSFER---LVK 332
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 363 AARASRVENqDAIDAAMVGMLADPKEARAGIREIHFLPFNPVDKRTALTFidSNgnwHRVSKGAPEQILD-LCNARADLR 441
Cdd:PRK14010 333 AAYESSIAD-DTPEGRSIVKLAYKQHIDLPQEVGEYIPFTAETRMSGVKF--TT---REVYKGAPNSMVKrVKEAGGHIP 406
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 442 KRVHSTIDKYAERGLRSLAVSRQTVpektkessgspweFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKE 521
Cdd:PRK14010 407 VDLDALVKGVSKKGGTPLVVLEDNE-------------ILGVIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAAT 473
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 522 TGRRLGMgsnmypsssllgkhkDEAMAHIPvedliekadgfagvfPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKAD 601
Cdd:PRK14010 474 IAKEAGV---------------DRFVAECK---------------PEDKINVIREEQAKGHIVAMTGDGTNDAPALAEAN 523
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334188460 602 IGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMKNYTIYAVSITIRIVFGFM 662
Cdd:PRK14010 524 VGLAMNSGTMSAKEAANLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDIAKYFAIL 584
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
135-638 6.33e-29

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 124.33  E-value: 6.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 135 VLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLegDPL-KVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVVI 213
Cdd:PRK11033 247 RLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLL--SPFaSFDESALTGESIPVERATGEKVPAGATSVDRLVTLEVL 324
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 214 ATGVHTFFGKAAHLVDSTNQ--------VGHFQKVLTAIgnFCICSIAVGIAIEIVVMYPIQRRHYRdgidNLLVLLIgG 285
Cdd:PRK11033 325 SEPGASAIDRILHLIEEAEErrapierfIDRFSRIYTPA--IMLVALLVILVPPLLFAAPWQEWIYR----GLTLLLI-G 397
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 286 IPIAMptVLSVTMAIGS--HKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVdknlIEVY-CKGVEKDEVLLF 362
Cdd:PRK11033 398 CPCAL--VISTPAAITSglAAAARRGALIKGGAALEQLGRVTTVAFDKTGTLTEGKPQV----TDIHpATGISESELLAL 471
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 363 AArasrvenqdAIDAAMVGMLADPKEARAGIREIhFLPfnPVDKRTALTFIDSNG--NWHRVSKGAPEQILDLCNAradl 440
Cdd:PRK11033 472 AA---------AVEQGSTHPLAQAIVREAQVRGL-AIP--EAESQRALAGSGIEGqvNGERVLICAPGKLPPLADA---- 535
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 441 rkrVHSTIDKYAERGlrslavsrQTVPEKTKESsgspwEFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQ----L 516
Cdd:PRK11033 536 ---FAGQINELESAG--------KTVVLVLRND-----DVLGLIALQDTLRADARQAISELKALGIKGVMLTGDNpraaA 599
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 517 AIAKEtgrrLGMgsnmypsssllgkhkdeamahipvedliekaDGFAGVFPEHKYEIVKKLQERKHIcGMTGDGVNDAPA 596
Cdd:PRK11033 600 AIAGE----LGI-------------------------------DFRAGLLPEDKVKAVTELNQHAPL-AMVGDGINDAPA 643
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 334188460 597 LKKADIGIAVADATDAARGASDIVLTEPGLSVIISAVLTSRA 638
Cdd:PRK11033 644 MKAASIGIAMGSGTDVALETADAALTHNRLRGLAQMIELSRA 685
copA PRK10671
copper-exporting P-type ATPase CopA;
151-644 9.07e-26

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 114.45  E-value: 9.07e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 151 PGDIVSIKLGDIIPADARLLEGDPLkVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVVIATGVHTFFGKAAHLV-- 228
Cdd:PRK10671 343 PGMLLRLTTGDRVPVDGEITQGEAW-LDEAMLTGEPIPQQKGEGDSVHAGTVVQDGSVLFRASAVGSHTTLSRIIRMVrq 421
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 229 --DSTNQVGHFQKVLTAIgnfcICSIAVGIA-IEIVVMY---PIQRRHYRdgidnlLVLLIGGIPIAMPTVLSVT--MAI 300
Cdd:PRK10671 422 aqSSKPEIGQLADKISAV----FVPVVVVIAlVSAAIWYffgPAPQIVYT------LVIATTVLIIACPCALGLAtpMSI 491
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 301 --GSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKLSVdknlIEVYC-KGVEKDEVLLFAArasrvenqdAIDA 377
Cdd:PRK10671 492 isGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLTEGKPQV----VAVKTfNGVDEAQALRLAA---------ALEQ 558
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 378 AMVGMLADPKEARAGIREihfLPfnPVDK-RTaltfIDSNGnwhrVSKGAPEQILDLCNARADLRKRVHST-----IDKY 451
Cdd:PRK10671 559 GSSHPLARAILDKAGDMT---LP--QVNGfRT----LRGLG----VSGEAEGHALLLGNQALLNEQQVDTKaleaeITAQ 625
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 452 AERGLRS--LAVSRQTVpektkessgspwefvGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQL----AIAKETGrr 525
Cdd:PRK10671 626 ASQGATPvlLAVDGKAA---------------ALLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPttanAIAKEAG-- 688
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 526 lgmgsnmypsssllgkhkdeamahipVEDLIekadgfAGVFPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKADIGIA 605
Cdd:PRK10671 689 --------------------------IDEVI------AGVLPDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIA 736
                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 334188460 606 VADATDAARGASDIVLTEPGLSVIISAVLTSRAIFQRMK 644
Cdd:PRK10671 737 MGGGSDVAIETAAITLMRHSLMGVADALAISRATLRNMK 775
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
149-691 1.50e-25

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 112.61  E-value: 1.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 149 LVPGDIVSIKLGDIIPADARLLEgDPLKVDQSALTGESLPATKGPGEEVFSGSTCKQGEIEAVVIATGVHTFFG------ 222
Cdd:cd07553  146 IKSGDVYLVASGQRVPVDGKLLS-EQASIDMSWLTGESLPRIVERGDKVPAGTSLENQAFEIRVEHSLAESWSGsilqkv 224
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 223 -----KAAHLVDSTNQVGH-FQKVLTAIGnfcICSIAVGIAIEIVVmypiqrrhyrdGIDNLLVLLIGGIPIAMPTVLSV 296
Cdd:cd07553  225 eaqeaRKTPRDLLADKIIHyFTVIALLIA---VAGFGVWLAIDLSI-----------ALKVFTSVLIVACPCALALATPF 290
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 297 TMAIGSHKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLNKlsvdKNLIEVYCKGVekDEVLLFAARASRVENQDAID 376
Cdd:cd07553  291 TDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGK----SSFVMVNPEGI--DRLALRAISAIEAHSRHPIS 364
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 377 AAMVGMLADPKEARAGIREIHFLPFNPVDkrtaltfIDSNGNWHRVSKgapeqildLCNARADLRKRVHSTIDKYAergl 456
Cdd:cd07553  365 RAIREHLMAKGLIKAGASELVEIVGKGVS-------GNSSGSLWKLGS--------APDACGIQESGVVIARDGRQ---- 425
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 457 rslavsrqtvpektkessgspwefVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMGSnmypss 536
Cdd:cd07553  426 ------------------------LLDLSFNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVGDSLGLDP------ 475
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 537 sllgkhkdeamahipvedliekADGFAGVFPEHKYEIVKKLQERKHIcgMTGDGVNDAPALKKADIGIAVADATDAARGA 616
Cdd:cd07553  476 ----------------------RQLFGNLSPEEKLAWIESHSPENTL--MVGDGANDALALASAFVGIAVAGEVGVSLEA 531
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334188460 617 SDIVLTEPGLSVIISAVLTSRaifqrmKNYTIYAVSITIRIVFGFMLIALIWKFDFSPFMVLIIAILNDGTIMTI 691
Cdd:cd07553  532 ADIYYAGNGIGGIRDLLTLSK------QTIKAIKGLFAFSLLYNLVAIGLALSGWISPLVAAILMPLSSITILGI 600
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
12-75 1.36e-14

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 69.53  E-value: 1.36e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334188460    12 NVDLEKIPIEEVFQQLKCSRE-GLSGAEGENRLQIFGPNKLEE-KKESKLLKFLGFMWNPLSWVME 75
Cdd:smart00831   1 ELDWHALSLEEVLERLQTDLEkGLSSEEAARRLERYGPNELPPpKKTSPLLRFLRQFHNPLIYILL 66
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
17-75 2.09e-12

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 62.96  E-value: 2.09e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334188460   17 KIPIEEVFQQLKCSRE-GLSGAEGENRLQIFGPNKL-EEKKESKLLKFLGFMWNPLSWVME 75
Cdd:pfam00690   3 ALSVEEVLKKLGTDLEkGLTEAEAEKRLKKYGPNELpEKKPKSLWKLFLRQFKDPLIIILL 63
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
132-621 1.66e-11

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 68.35  E-value: 1.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 132 KTKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLL---EGDPL-KVDQSALTGES-------LPATKGPGEEV--- 197
Cdd:cd02073   84 PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLsssEPDGLcYVETANLDGETnlkirqaLPETALLLSEEdla 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 198 -FSGS-TCKQ-------------------------------------GEIEAVVIATGVHTffgKAAhlvdsTNQVG--- 235
Cdd:cd02073  164 rFSGEiECEQpnndlytfngtlelnggrelplspdnlllrgctlrntEWVYGVVVYTGHET---KLM-----LNSGGtpl 235
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 236 ---HFQKVLTA--IGNFCI-CSIAVGIAIEIVVMypiQRRHYRDGIDNLLVLLIGGIPIAMPTVLS-------------- 295
Cdd:cd02073  236 krsSIEKKMNRfiIAIFCIlIVMCLISAIGKGIW---LSKHGRDLWYLLPKEERSPALEFFFDFLTfiilynnlipisly 312
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 296 VTM----AIGS----------HKLSQQGAITKRMTAIEEMAGMDVLCSDKTGTLTLN-----KLSVDKNLIEVY-----C 351
Cdd:cd02073  313 VTIevvkFLQSffinwdldmyDEETDTPAEARTSNLNEELGQVEYIFSDKTGTLTENimefkKCSINGVDYGFFlalalC 392
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 352 KGVE----------------KDEV-LLFAARAS--RVENQDAidaAMVGMLADPKEARAGIreIHFLPFNPVDKRTALTF 412
Cdd:cd02073  393 HTVVpekddhpgqlvyqassPDEAaLVEAARDLgfVFLSRTP---DTVTINALGEEEEYEI--LHILEFNSDRKRMSVIV 467
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 413 IDSNGNWHRVSKGAPEQILDLCnaRADLRKRVHST---IDKYAERGLRSLAVSRQTVPEKTKESsgspW----------- 478
Cdd:cd02073  468 RDPDGRILLYCKGADSVIFERL--SPSSLELVEKTqehLEDFASEGLRTLCLAYREISEEEYEE----Wnekydeastal 541
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 479 ------------------EFVGVLPLFDPPRHDSAETIRRALDLGVNVKMITGDQlaiaKETGRRLGMGSNMYPSSS--- 537
Cdd:cd02073  542 qnreelldevaeeiekdlILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDK----QETAINIGYSCRLLSEDMenl 617
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 538 -LL--GKHKDEAMAHIPVEDLIEKADGFAGVF-----PEHKYEIVKKLQERKHicGMT---GDGVNDAPALKKADIGIAV 606
Cdd:cd02073  618 aLVidGKTLTYALDPELERLFLELALKCKAVIccrvsPLQKALVVKLVKKSKK--AVTlaiGDGANDVSMIQEAHVGVGI 695
                        650
                 ....*....|....*..
gi 334188460 607 A--DATDAARgASDIVL 621
Cdd:cd02073  696 SgqEGMQAAR-ASDYAI 711
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
406-601 3.93e-10

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 60.29  E-value: 3.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  406 KRTALTFIDSNGNWHRVSKGAPEQILDLCNARADLRKRVHSTIDKYAERgLRSLAVSRQTVPEKTKESSGSPWEFVGVLP 485
Cdd:pfam00702  16 EPVVTEAIAELASEHPLAKAIVAAAEDLPIPVEDFTARLLLGKRDWLEE-LDILRGLVETLEAEGLTVVLVELLGVIALA 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  486 LFDPPRHDSAETIRRALDLGVNVKMITGDQLAIAKETGRRLGMgsnmypsssllgkhKDEAMAHIPVEDliekaDGFAGV 565
Cdd:pfam00702  95 DELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGL--------------DDYFDVVISGDD-----VGVGKP 155
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 334188460  566 FPEHKYEIVKKLQERKHICGMTGDGVNDAPALKKAD 601
Cdd:pfam00702 156 KPEIYLAALERLGVKPEEVLMVGDGVNDIPAAKAAG 191
HAD_Pase cd07514
phosphatase, similar to Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PCPase), ...
588-624 4.23e-06

phosphatase, similar to Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PCPase), and Pyrococcus horikoshii PH1421, a magnesium-dependent phosphatase; belongs to the haloacid dehalogenase-like superfamily; Thermoplasma acidophilum TA0175 phosphoglycolate phosphatase (PGPase) catalyzes the magnesium-dependent dephosphorylation of phosphoglycolate. This family also includes Pyrococcus horikoshii OT3 PH1421, a magnesium-dependent phosphatase. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319816 [Multi-domain]  Cd Length: 139  Bit Score: 47.20  E-value: 4.23e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 334188460 588 GDGVNDAPALKKADIGIAVADATDAARGASDIVLTEP 624
Cdd:cd07514   90 GDSENDIEMFKVAGFKVAVANADEELKEAADYVTDAS 126
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
133-344 2.68e-05

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 48.17  E-value: 2.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 133 TKVLRDGKWSEQEASILVPGDIVSIKLGDIIPADARLLEGDP------LKVDQsaLTGES-------LPATKGPGEEV-- 197
Cdd:cd07541   83 EKLTVRGETVEIPSSDIKVGDLIIVEKNQRIPADMVLLRTSEksgscfIRTDQ--LDGETdwklriaVPCTQKLPEEGil 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 198 -----------------FSGSTCKQGEIE------------AVVIA----TGVHTFFGKAAHLVDSTNQVGHFQKVLTAI 244
Cdd:cd07541  161 nsisavyaeapqkdihsFYGTFTINDDPTseslsventlwaNTVVAsgtvIGVVVYTGKETRSVMNTSQPKNKVGLLDLE 240
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 245 GNF---CICSIAVGIAIEIVVMYPIQRRHYRDgIDNLLVLLIGGIPIAMPTVLSVTMAIGSHKLSQ----QGAITKRMTA 317
Cdd:cd07541  241 INFltkILFCAVLALSIVMVALQGFQGPWYIY-LFRFLILFSSIIPISLRVNLDMAKIVYSWQIEHdkniPGTVVRTSTI 319
                        250       260
                 ....*....|....*....|....*..
gi 334188460 318 IEEMAGMDVLCSDKTGTLTLNKLSVDK 344
Cdd:cd07541  320 PEELGRIEYLLSDKTGTLTQNEMVFKK 346
HAD_KDO-like cd01630
haloacid dehalogenase-like (HAD) hydrolase, similar to Escherichia coli ...
498-625 1.59e-04

haloacid dehalogenase-like (HAD) hydrolase, similar to Escherichia coli 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) phosphatase KdsC, and rainbow trout N-acylneuraminate cytidylyltransferase; KDO 8-P phosphatase catalyzes the hydrolysis of KDO 8-P to KDO (3-deoxy-D-manno-octulosonate) and inorganic phosphate and is the last enzyme in the KDO biosynthetic pathway. KDO is an 8-carbon sugar that links the lipid A and polysaccharide moieties of the lipopolysaccharide region in Gram-negative bacteria. An interruption in KDO biosynthesis leads to the accumulation of lipid A precursors and subsequent arrest in cell growth. The KDO biosynthesis pathway involves five sequential enzymatic reactions. This family also includes rainbow trout CMP-sialic acid synthetase which effectively converts both deaminoneuraminic acid (KDN, 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) and N-acetylneuraminic acid (Neu5Ac) to CMP-KDN and CMP-Neu5Ac, respectively. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319769 [Multi-domain]  Cd Length: 146  Bit Score: 42.89  E-value: 1.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 498 IRRALDLGVNVKMITGDQLAIAKETGRRLGmgsnmypsssllgkhkdeamahipVEDLiekadgFAGVfpEHKYEIVKKL 577
Cdd:cd01630   37 IKLLQKSGIEVAIITGRQSEAVRRRAKELG------------------------IEDL------FQGV--KDKLEALEEL 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 334188460 578 QER-----KHICGMtGDGVNDAPALKKADIGIAVADATDAARGASDIVLTEPG 625
Cdd:cd01630   85 LEKlglsdEEVAYM-GDDLPDLPVMKRVGLSVAPADAHPEVREAADYVTRARG 136
PRK01158 PRK01158
phosphoglycolate phosphatase; Provisional
588-624 9.86e-04

phosphoglycolate phosphatase; Provisional


Pssm-ID: 234910 [Multi-domain]  Cd Length: 230  Bit Score: 41.88  E-value: 9.86e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 334188460 588 GDGVNDAPALKKADIGIAVADATDAARGASDIVLTEP 624
Cdd:PRK01158 180 GDSENDLEMFEVAGFGVAVANADEELKEAADYVTEKS 216
COG4087 COG4087
Soluble P-type ATPase [General function prediction only];
545-624 1.23e-03

Soluble P-type ATPase [General function prediction only];


Pssm-ID: 443263 [Multi-domain]  Cd Length: 156  Bit Score: 40.53  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 545 EAMAHIPVE-DLIEKADGfagvfPEHKYEIVKKLQERKHICgmTGDGVNDAPALKKADIGIAVADATDAARGA---SDIV 620
Cdd:COG4087   61 KELAGLPVElHILPSGDQ-----AEEKLEFVEKLGAETTVA--IGNGRNDVLMLKEAALGIAVIGPEGASVKAllaADIV 133

                 ....
gi 334188460 621 LTEP 624
Cdd:COG4087  134 VKSI 137
SPP-subfamily TIGR01482
sucrose-phosphate phosphatase subfamily; This model includes both the members of the SPP ...
574-620 2.93e-03

sucrose-phosphate phosphatase subfamily; This model includes both the members of the SPP equivalog model (TIGR01485), encompassing plants and cyanobacteria, as well as those archaeal sequences which are the closest relatives (TIGR01487). It remains to be shown whether these archaeal sequences catalyze the same reaction as SPP.


Pssm-ID: 273650 [Multi-domain]  Cd Length: 225  Bit Score: 40.14  E-value: 2.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 334188460  574 VKKLQERKHICG----MTGDGVNDAPALKKADIGIAVADATDAARGASDIV 620
Cdd:TIGR01482 154 VKKLKEKLGIKPgetlVCGDSENDIDLFEVPGFGVAVANAQPELKEWADYV 204
serB TIGR00338
phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction ...
555-631 4.07e-03

phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction 3-phospho-serine + H2O = L-serine + phosphate. It catalyzes the last of three steps in the biosynthesis of serine from D-3-phosphoglycerate. Note that this enzyme acts on free phosphoserine, not on phosphoserine residues of phosphoproteins. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273022 [Multi-domain]  Cd Length: 219  Bit Score: 39.65  E-value: 4.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460  555 LIEKADGFAG------VFPEHKYEIVKKLQERKHI----CGMTGDGVNDAPALKKADIGIAVaDATDAARGASDIVLTEP 624
Cdd:TIGR00338 132 LEVEDGKLTGlvegpiVDASYKGKTLLILLRKEGIspenTVAVGDGANDLSMIKAAGLGIAF-NAKPKLQQKADICINKK 210

                  ....*..
gi 334188460  625 GLSVIIS 631
Cdd:TIGR00338 211 DLTDILP 217
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
569-620 5.47e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 39.53  E-value: 5.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 334188460  569 HKYEIVKKLQERKHICG---MT-GDGVNDAPALKKADIGIAVADATDAARGASDIV 620
Cdd:pfam08282 187 SKGTALKALAKHLNISLeevIAfGDGENDIEMLEAAGLGVAMGNASPEVKAAADYV 242
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
496-620 7.74e-03

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 38.58  E-value: 7.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334188460 496 ETIRRALDLGVNVKMITGDQLAIAKETGRRLGM-----GSN----MYPSSSLLgkhKDEAMAHIPVEDLIEKADGF---- 562
Cdd:COG0561   26 EALRRLREKGIKVVIATGRPLRSALPLLEELGLddpliTSNgaliYDPDGEVL---YERPLDPEDVREILELLREHglhl 102
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334188460 563 ---------------AGVfpeHKYEIVKKLQER-----KHICGMtGDGVNDAPALKKADIGIAVADATDAARGASDIV 620
Cdd:COG0561  103 qvvvrsgpgfleilpKGV---SKGSALKKLAERlgippEEVIAF-GDSGNDLEMLEAAGLGVAMGNAPPEVKAAADYV 176
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
569-620 7.90e-03

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 39.17  E-value: 7.90e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 334188460  569 HKYEIVKKLQERKHI----CGMTGDGVNDAPALKKADIGIAVADATDAARGASDIV 620
Cdd:TIGR00099 188 SKGSALQSLAEALGIsledVIAFGDGMNDIEMLEAAGYGVAMGNADEELKALADYV 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH