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Conserved domains on  [gi|334187707|ref|NP_001190318|]
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DNA/RNA polymerases superfamily protein [Arabidopsis thaliana]

Protein Classification

RPOL_N and RNA_pol domain-containing protein( domain architecture ID 13418561)

RPOL_N and RNA_pol domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RNA_pol pfam00940
DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.
620-1001 0e+00

DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.


:

Pssm-ID: 460006  Cd Length: 411  Bit Score: 678.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   620 RPMGISGLRWLKIHLANLYagGVDKLSLDGRLAFTENHLDDIFDSADRPLEGSRWWLQAEDPFQCLAVCISLTEALRSPS 699
Cdd:pfam00940    1 KPLGERGLRWLKIHLANLY--GFDKASLDERVAFVEDNLEDILDSAENPLDGRRWWLKAEDPWQCLAACFELANALRSPD 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   700 PETVLSHIPIHQDGSCNGLQHYAALGRDTLGAEAVNLVAGEKPADVYSGIATRVLDIMRRDADRDPEVfpealrARKLLN 779
Cdd:pfam00940   79 PEEYVSHLPVHQDGSCNGLQHYAALGGDEEGAKQVNLVPSDRPQDVYSGVAELVEEKIEKDAAKGNEI------AKLLKG 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   780 QVDRKLVKQTVMTSVYGVTYIGARDQIKRRLKERSDFGDEKEVFGAACYAAKVTLAAIDEMFQAARAIMRWFGECAKIIA 859
Cdd:pfam00940  153 KITRKVVKQTVMTNVYGVTFIGAREQIEKQLKEIGDFPGEEDLYKASSYLAKKIFDSIGELFTGAHEIQDWLGECAKRIA 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   860 SE------NETVRWTTPLGLPVVQPYHQMGTKLVKTSLQTLSLQ--HETDQVIVRRQRTAFPPNFIHSLDGSHMMMTAVA 931
Cdd:pfam00940  233 KSvppeqsMSPVIWTTPLGLPVVQPYRKSKKKQVKTNLQSVSISdpNDTDPVDKRKQLQAFPPNFIHSLDATHMMLTALA 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   932 CKRAGVCFAGVHDSFWTHACDVDKLNIILREKFVELYSQPILENLLESFEQSFPH-------------------LDFPPL 992
Cdd:pfam00940  313 CDEAGLTFAAVHDSFWTHACDVDEMNKILREQFVKLHSEDILERLREEFKERYKGslqlakipkdspltpvwlpLTFPEV 392

                   ....*....
gi 334187707   993 PERGDLDLK 1001
Cdd:pfam00940  393 PKKGDFDLN 401
PHA00452 super family cl42978
T3/T7-like RNA polymerase
174-1000 0e+00

T3/T7-like RNA polymerase


The actual alignment was detected with superfamily member PHA00452:

Pssm-ID: 222797 [Multi-domain]  Cd Length: 807  Bit Score: 551.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  174 FQNLWRRQVKIETEEWERAAAEYMELLTDMCEQKLAPNLPYVKSLFLGWFEPLRDAIAKDQELYRLGKSKATYAHYLDQL 253
Cdd:PHA00452    2 GEDLAAEQLQLEEEAYGEGEERFRKALERQLEAGEADDNPVARRLLATLLPPVAEAIDAWKEEYKKRGRAAKARGLLRLV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  254 PADKISVITMHKLMGHLMTGGDNGCVKVVHAactVGDAIEQEIRICTFLDkkkkgddneesggvenetsmkEQDKLRKKV 333
Cdd:PHA00452   82 DPEVLAVITLKVTLDMLLSKETPTAQAVATA---IGRAIEDEIRFGRIED---------------------LNPKYFKKV 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  334 NELIKKQKLSAVRKILQ-------SHDY--TKPWIADVRAKVGSRLIELLvrtayIQSpadqqdNDLPDvrpaFVHTFKV 404
Cdd:PHA00452  138 VEYLKRSRTGSVYHIAFmmvveadMVLLgeWDPWPKEDYIHVGKWLLEAL-----IES------TGLVE----LVRHTGG 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  405 AKGSMnsgrkYGVIECDPLVRKGLEKSGRYA--VMP-YMPMLVPPLKWSGYDKGAYL-----FLTSYIMKTHGAKQqREA 476
Cdd:PHA00452  203 NGGKD-----HEYLELSEEAVELLQDIAAAAagISPmYQPMVVPPKPWTSIVGGGYHtegrrPLAPLVRKTKKALR-RYR 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  477 LKSAPKgqlqpVFEALDTLGSTKWRVNKRVLTVVDRIWSSGGcVADMVDRSDVPLPEKPDTEDEGI--LKKWKWEVKSAK 554
Cdd:PHA00452  277 QKQMPE-----VYKAVNALQNTAWRINKDVLAVVNEVVNWGP-VGDVLGIPRRPLPPKPEFLDENEeaFKAWKRAAAAWY 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  555 KVNSERHSQRCDTELKLSVARKMKDEEAFYYPHNMDFRGRAYPmPPHLNHLGSDLCRGVLEFAEGRPMGISGLRWLKIHL 634
Cdd:PHA00452  351 TKEKERVSKRRRLEFMLRVANKFADYKAIYFPYNMDWRGRVYA-VSMLNPQGSDLQKALLRFAEGKPLGKRGLYWLKVHG 429
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  635 ANLYagGVDKLSLDGRLAFTENHLDDIFDSADRPLeGSRWWLQAEDPFQCLAVCISLTEALRSPsPETVlSHIPIHQDGS 714
Cdd:PHA00452  430 ANCY--GVDKVTFDERAAWVDENHDNILAAAEDPL-NNTWWAEADSPLCFLAACFEYAAAVHSG-TSYV-SGLPVAMDGT 504
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  715 CNGLQHYAALGRDTLGAEAVNLVAGEKPADVYSGIATRVLDIMRRDADrDPEVFPEALRARKLLNQVDRKLVKQTVMTSV 794
Cdd:PHA00452  505 CSGLQHFSAMLRDEVGGRAVNLLPSDKPQDIYGIVAEVVNEKLERDAI-NGTDNTRALARLWLAYGITRSLTKRPVMTLP 583
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  795 YGVTYIGARDQIKRRLkERSDFGDEKE---VFGAACYAAKVTLAAIDEMFQAARAIMRWFGECAKIIASE-NETVRWTTP 870
Cdd:PHA00452  584 YGSTRFSCRDYILEDL-LQPGIDEGDGamfTNQAASYMAKLIWDAISETVPAAVEAMNWLQQAAKLLAAKgAEALHWTTP 662
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  871 LGLPVVQPYHQMGTKLVKTSL---QTLSLQHETDQVIVRRQRTAFPPNFIHSLDGSHMMMTAVACKRAGVC-FAGVHDSF 946
Cdd:PHA00452  663 TGFPVWQEYRKPEEKRVRLRLmgvARVQLYVNTDTIDARKHASGIAPNFVHSLDASHLRLTVVACAEKGIEsFAVIHDSF 742
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 334187707  947 WTHACDVDKLNIILREKFVELYSQP-ILENLLESFEQSFPHLDfPPLPERGDLDL 1000
Cdd:PHA00452  743 GTHAADADNLHRAIRETFVEMYEENdVLADFADQFGDQLQLKM-PELPEKGSLDL 796
 
Name Accession Description Interval E-value
RNA_pol pfam00940
DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.
620-1001 0e+00

DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.


Pssm-ID: 460006  Cd Length: 411  Bit Score: 678.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   620 RPMGISGLRWLKIHLANLYagGVDKLSLDGRLAFTENHLDDIFDSADRPLEGSRWWLQAEDPFQCLAVCISLTEALRSPS 699
Cdd:pfam00940    1 KPLGERGLRWLKIHLANLY--GFDKASLDERVAFVEDNLEDILDSAENPLDGRRWWLKAEDPWQCLAACFELANALRSPD 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   700 PETVLSHIPIHQDGSCNGLQHYAALGRDTLGAEAVNLVAGEKPADVYSGIATRVLDIMRRDADRDPEVfpealrARKLLN 779
Cdd:pfam00940   79 PEEYVSHLPVHQDGSCNGLQHYAALGGDEEGAKQVNLVPSDRPQDVYSGVAELVEEKIEKDAAKGNEI------AKLLKG 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   780 QVDRKLVKQTVMTSVYGVTYIGARDQIKRRLKERSDFGDEKEVFGAACYAAKVTLAAIDEMFQAARAIMRWFGECAKIIA 859
Cdd:pfam00940  153 KITRKVVKQTVMTNVYGVTFIGAREQIEKQLKEIGDFPGEEDLYKASSYLAKKIFDSIGELFTGAHEIQDWLGECAKRIA 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   860 SE------NETVRWTTPLGLPVVQPYHQMGTKLVKTSLQTLSLQ--HETDQVIVRRQRTAFPPNFIHSLDGSHMMMTAVA 931
Cdd:pfam00940  233 KSvppeqsMSPVIWTTPLGLPVVQPYRKSKKKQVKTNLQSVSISdpNDTDPVDKRKQLQAFPPNFIHSLDATHMMLTALA 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   932 CKRAGVCFAGVHDSFWTHACDVDKLNIILREKFVELYSQPILENLLESFEQSFPH-------------------LDFPPL 992
Cdd:pfam00940  313 CDEAGLTFAAVHDSFWTHACDVDEMNKILREQFVKLHSEDILERLREEFKERYKGslqlakipkdspltpvwlpLTFPEV 392

                   ....*....
gi 334187707   993 PERGDLDLK 1001
Cdd:pfam00940  393 PKKGDFDLN 401
PHA00452 PHA00452
T3/T7-like RNA polymerase
174-1000 0e+00

T3/T7-like RNA polymerase


Pssm-ID: 222797 [Multi-domain]  Cd Length: 807  Bit Score: 551.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  174 FQNLWRRQVKIETEEWERAAAEYMELLTDMCEQKLAPNLPYVKSLFLGWFEPLRDAIAKDQELYRLGKSKATYAHYLDQL 253
Cdd:PHA00452    2 GEDLAAEQLQLEEEAYGEGEERFRKALERQLEAGEADDNPVARRLLATLLPPVAEAIDAWKEEYKKRGRAAKARGLLRLV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  254 PADKISVITMHKLMGHLMTGGDNGCVKVVHAactVGDAIEQEIRICTFLDkkkkgddneesggvenetsmkEQDKLRKKV 333
Cdd:PHA00452   82 DPEVLAVITLKVTLDMLLSKETPTAQAVATA---IGRAIEDEIRFGRIED---------------------LNPKYFKKV 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  334 NELIKKQKLSAVRKILQ-------SHDY--TKPWIADVRAKVGSRLIELLvrtayIQSpadqqdNDLPDvrpaFVHTFKV 404
Cdd:PHA00452  138 VEYLKRSRTGSVYHIAFmmvveadMVLLgeWDPWPKEDYIHVGKWLLEAL-----IES------TGLVE----LVRHTGG 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  405 AKGSMnsgrkYGVIECDPLVRKGLEKSGRYA--VMP-YMPMLVPPLKWSGYDKGAYL-----FLTSYIMKTHGAKQqREA 476
Cdd:PHA00452  203 NGGKD-----HEYLELSEEAVELLQDIAAAAagISPmYQPMVVPPKPWTSIVGGGYHtegrrPLAPLVRKTKKALR-RYR 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  477 LKSAPKgqlqpVFEALDTLGSTKWRVNKRVLTVVDRIWSSGGcVADMVDRSDVPLPEKPDTEDEGI--LKKWKWEVKSAK 554
Cdd:PHA00452  277 QKQMPE-----VYKAVNALQNTAWRINKDVLAVVNEVVNWGP-VGDVLGIPRRPLPPKPEFLDENEeaFKAWKRAAAAWY 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  555 KVNSERHSQRCDTELKLSVARKMKDEEAFYYPHNMDFRGRAYPmPPHLNHLGSDLCRGVLEFAEGRPMGISGLRWLKIHL 634
Cdd:PHA00452  351 TKEKERVSKRRRLEFMLRVANKFADYKAIYFPYNMDWRGRVYA-VSMLNPQGSDLQKALLRFAEGKPLGKRGLYWLKVHG 429
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  635 ANLYagGVDKLSLDGRLAFTENHLDDIFDSADRPLeGSRWWLQAEDPFQCLAVCISLTEALRSPsPETVlSHIPIHQDGS 714
Cdd:PHA00452  430 ANCY--GVDKVTFDERAAWVDENHDNILAAAEDPL-NNTWWAEADSPLCFLAACFEYAAAVHSG-TSYV-SGLPVAMDGT 504
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  715 CNGLQHYAALGRDTLGAEAVNLVAGEKPADVYSGIATRVLDIMRRDADrDPEVFPEALRARKLLNQVDRKLVKQTVMTSV 794
Cdd:PHA00452  505 CSGLQHFSAMLRDEVGGRAVNLLPSDKPQDIYGIVAEVVNEKLERDAI-NGTDNTRALARLWLAYGITRSLTKRPVMTLP 583
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  795 YGVTYIGARDQIKRRLkERSDFGDEKE---VFGAACYAAKVTLAAIDEMFQAARAIMRWFGECAKIIASE-NETVRWTTP 870
Cdd:PHA00452  584 YGSTRFSCRDYILEDL-LQPGIDEGDGamfTNQAASYMAKLIWDAISETVPAAVEAMNWLQQAAKLLAAKgAEALHWTTP 662
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  871 LGLPVVQPYHQMGTKLVKTSL---QTLSLQHETDQVIVRRQRTAFPPNFIHSLDGSHMMMTAVACKRAGVC-FAGVHDSF 946
Cdd:PHA00452  663 TGFPVWQEYRKPEEKRVRLRLmgvARVQLYVNTDTIDARKHASGIAPNFVHSLDASHLRLTVVACAEKGIEsFAVIHDSF 742
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 334187707  947 WTHACDVDKLNIILREKFVELYSQP-ILENLLESFEQSFPHLDfPPLPERGDLDL 1000
Cdd:PHA00452  743 GTHAADADNLHRAIRETFVEMYEENdVLADFADQFGDQLQLKM-PELPEKGSLDL 796
RPO41 COG5108
Mitochondrial DNA-directed RNA polymerase [Transcription];
170-1000 2.27e-140

Mitochondrial DNA-directed RNA polymerase [Transcription];


Pssm-ID: 444054 [Multi-domain]  Cd Length: 826  Bit Score: 442.05  E-value: 2.27e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  170 GRTKFQNLWRRQVKIETEEWERAAAEYMELLTDMCEQKLAPNLPYVKSLFLGWFEPLRDAIAKDQELYRLGKS--KATYA 247
Cdd:COG5108     3 ARLDLTKPTARQIALEEEMAEAGRSRFVERIEKARKRGEESGTQYGRRIISDAVELLAEAIEATIDESSSGGAgnWHTAY 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  248 HYLDQLPADKISVITMHKLMGHLMTGgdngcVKVVHAACTVGDAIEQEIRICTFLDKKKKgddneesggvenetsmkEQD 327
Cdd:COG5108    83 AYLRELDAEVLAYLALRQCLDAVTQR-----HTLQAVAIRIASMVEDEVRGEAIREAFKD-----------------FYP 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  328 KLRKKvnelIKKQKLSAVRkilQSHDYTK----------PWIADVRAKVGSRLIELLVRTAYIQSPADQQD--NDLPdvr 395
Cdd:COG5108   141 RGKKK----IESRTSRAVR---YKDDFERrvknavakeeDWPVSDKIHVGFKLIELVVESTGLVEIARDTEgiNDTP--- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  396 pafvHTFKVAKGSMNSGRkygviecdplvrkglEKSGRYAVMP--YMPMLVPPLKWSGYDKGAYL---FLTSYIMKThGA 470
Cdd:COG5108   211 ----VFVRPTETTLEWIA---------------EANLRMAMLSpaYLPMVVPPRNWTTPFRGGYLsgeVRRLPLVKT-RN 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  471 KQQREALKSapkGQLQPVFEALDTLGSTKWRVNKRVLTVVDRIWSSGGCVAdMVDRSDVPLPEKPD-----TEDEGILKK 545
Cdd:COG5108   271 RKYLEELKN---GDMPEVYAAVNALQQTPWTINRYVLAVMKWLWERDLDLG-LPQREPITPPIKPEnrediTTNQVARKR 346
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  546 WKWEVKSAKKVNSERHSQRCDTELKLSVARKMKDEEAFYYPHNMDFRGRAYPMPPHLNHLGSDLCRGVLEFAEGRPMGIS 625
Cdd:COG5108   347 WKKAARKIYIANAKLCSKRVQFRRDLNEAERFSDYREFYFPYQLDFRGRVYAVPAFLNPQGQDHAKGLLMFADGKPIGDG 426
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  626 GLRWLKIHLANLYagGVDKLSLDGRLAFTENHLDDIFDSADRplEGSRWWLQAEDPFQCLAVCISLTEALRSPspETVLS 705
Cdd:COG5108   427 GAKWLAIHGANVW--GYDKASLEERVKWVEDNYEAILAAAAD--YVAEFWSKADKPWQFLAFCREWYGYDQHG--EGYVS 500
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  706 HIPIHQDGSCNGLQHYAALGRDTLGAEAVNLVAGEKPADVYSGIATRVLDIMRR---DADRDPEVFPEALR--ARKLLNQ 780
Cdd:COG5108   501 GLPIAMDGSCSGLQHYSAMLRDEVGGAAVNLVPSDKPQDIYAFVAEVDINLAQRigcPDELTTNEILNGIMdmAHNWLAF 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  781 -VDRKLVKQTVMTSVYGVTYIGARDQIKR----RLKERSD----FGDEKevFGAACYAAKVTLAAIDEMFQAARAIMRWF 851
Cdd:COG5108   581 gITRKVTKRNVMTLPYGSTEYGFRDQVREdmitRKKEEEGepfpFGGDG--FSAAMWLAKLIWDAIGEVVVAARRGMDWL 658
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  852 GECAKIIASENETVRWTTPLGLPVVQPYHQMGTKLVKTSLQT----LSLQHETDQVIVRRQRTAFPPNFIHSLDGSHMMM 927
Cdd:COG5108   659 QDLAGIAAKEGLPVIWTTPLGFPVMQDYRSSKARRINTTTRKvrvrLTLREEQDTIDKRKQKQGIAPNFVHSMDATHLMM 738
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  928 TAVACKRAGV-CFAGVHDSFWTHACDVDKLNIILREKFVELYSQpilENLLESFEQ------SFPHLDFPPLPERGDLDL 1000
Cdd:COG5108   739 TVNRSNEYGAsSFALVHDSFGTDAGSAELMLDCLRKAFIELYEE---SDVLEDFKSeiadmlSDDAYALPEVPKKGSLDV 815
RPOL_N pfam14700
DNA-directed RNA polymerase N-terminal; This is the N-terminal domain of DNA-directed RNA ...
180-497 1.82e-93

DNA-directed RNA polymerase N-terminal; This is the N-terminal domain of DNA-directed RNA polymerase. This domain has a role in interaction with regions of upstream promoter DNA and the nascent RNA chain, leading to the processivity of the enzyme. In order to make mRNA transcripts the RNA polymerase undergoes a transition from the initiation phase (which only makes short fragments of RNA) to an elongation phase. This domain undergoes a structural change in the transition from initiation to elongation phase. The structural change results in abolition of the promoter binding site, creation of a channel accommodating the heteroduplex in the active site and formation of an exit tunnel which the RNA transcript passes through after peeling off the heteroduplex.


Pssm-ID: 464270  Cd Length: 286  Bit Score: 299.14  E-value: 1.82e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   180 RQVKIETEEWERAAAEYMELLTDMCEQKLAPNLP-YVKSLFLGWFEPLRDAIAKDQELYRLGKSK---------ATYAHY 249
Cdd:pfam14700    1 RQLRLERDSVEAAVERWREEFEELQKRGLNTNLPkSLNALLWQWYEALLPAIKEEIELLKAAEAKpkktkdkerCEYGPY 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   250 LDQLPADKISVITMHKLMGHLMTGGDNGCVKVVHAACTVGDAIEQEIRIctfldkkkkgddneesggvenetsmkeqDKL 329
Cdd:pfam14700   81 LRLLPPEKLAAITILELLSLLSTGGVDKGMKVSRLAISIGKAVEDEYRA----------------------------QQL 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   330 RKKVNELIKKQKLsavrkilqshdytkPWIADVRAKVGSRLIELLVRTAYIQSPADQQDNDLPDVR--PAFVHTFkvakg 407
Cdd:pfam14700  133 LKKEKKKIKKKKI--------------PWPQEVRAKVGAVLLSLLIETAKVPVTAEDPETGEKVIQpqPAFYHSY----- 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   408 SMNSGRKYGVIECDPLVRKGL-EKSGRYAVMP-YMPMLVPPLKWSGYDKGAYLFLTSYIMKTHGAKQQREALKSAPK-GQ 484
Cdd:pfam14700  194 QYKRGKKVGVIKPHPELVKLLlREPARDTLTPrHLPMLVPPKPWTSYNKGGYLLSPSKLMRTKDGDEQRAYLKAASErGD 273
                          330
                   ....*....|...
gi 334187707   485 LQPVFEALDTLGS 497
Cdd:pfam14700  274 LDQVFDGLDVLGN 286
 
Name Accession Description Interval E-value
RNA_pol pfam00940
DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.
620-1001 0e+00

DNA-dependent RNA polymerase; This is a family of single chain RNA polymerases.


Pssm-ID: 460006  Cd Length: 411  Bit Score: 678.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   620 RPMGISGLRWLKIHLANLYagGVDKLSLDGRLAFTENHLDDIFDSADRPLEGSRWWLQAEDPFQCLAVCISLTEALRSPS 699
Cdd:pfam00940    1 KPLGERGLRWLKIHLANLY--GFDKASLDERVAFVEDNLEDILDSAENPLDGRRWWLKAEDPWQCLAACFELANALRSPD 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   700 PETVLSHIPIHQDGSCNGLQHYAALGRDTLGAEAVNLVAGEKPADVYSGIATRVLDIMRRDADRDPEVfpealrARKLLN 779
Cdd:pfam00940   79 PEEYVSHLPVHQDGSCNGLQHYAALGGDEEGAKQVNLVPSDRPQDVYSGVAELVEEKIEKDAAKGNEI------AKLLKG 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   780 QVDRKLVKQTVMTSVYGVTYIGARDQIKRRLKERSDFGDEKEVFGAACYAAKVTLAAIDEMFQAARAIMRWFGECAKIIA 859
Cdd:pfam00940  153 KITRKVVKQTVMTNVYGVTFIGAREQIEKQLKEIGDFPGEEDLYKASSYLAKKIFDSIGELFTGAHEIQDWLGECAKRIA 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   860 SE------NETVRWTTPLGLPVVQPYHQMGTKLVKTSLQTLSLQ--HETDQVIVRRQRTAFPPNFIHSLDGSHMMMTAVA 931
Cdd:pfam00940  233 KSvppeqsMSPVIWTTPLGLPVVQPYRKSKKKQVKTNLQSVSISdpNDTDPVDKRKQLQAFPPNFIHSLDATHMMLTALA 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   932 CKRAGVCFAGVHDSFWTHACDVDKLNIILREKFVELYSQPILENLLESFEQSFPH-------------------LDFPPL 992
Cdd:pfam00940  313 CDEAGLTFAAVHDSFWTHACDVDEMNKILREQFVKLHSEDILERLREEFKERYKGslqlakipkdspltpvwlpLTFPEV 392

                   ....*....
gi 334187707   993 PERGDLDLK 1001
Cdd:pfam00940  393 PKKGDFDLN 401
PHA00452 PHA00452
T3/T7-like RNA polymerase
174-1000 0e+00

T3/T7-like RNA polymerase


Pssm-ID: 222797 [Multi-domain]  Cd Length: 807  Bit Score: 551.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  174 FQNLWRRQVKIETEEWERAAAEYMELLTDMCEQKLAPNLPYVKSLFLGWFEPLRDAIAKDQELYRLGKSKATYAHYLDQL 253
Cdd:PHA00452    2 GEDLAAEQLQLEEEAYGEGEERFRKALERQLEAGEADDNPVARRLLATLLPPVAEAIDAWKEEYKKRGRAAKARGLLRLV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  254 PADKISVITMHKLMGHLMTGGDNGCVKVVHAactVGDAIEQEIRICTFLDkkkkgddneesggvenetsmkEQDKLRKKV 333
Cdd:PHA00452   82 DPEVLAVITLKVTLDMLLSKETPTAQAVATA---IGRAIEDEIRFGRIED---------------------LNPKYFKKV 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  334 NELIKKQKLSAVRKILQ-------SHDY--TKPWIADVRAKVGSRLIELLvrtayIQSpadqqdNDLPDvrpaFVHTFKV 404
Cdd:PHA00452  138 VEYLKRSRTGSVYHIAFmmvveadMVLLgeWDPWPKEDYIHVGKWLLEAL-----IES------TGLVE----LVRHTGG 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  405 AKGSMnsgrkYGVIECDPLVRKGLEKSGRYA--VMP-YMPMLVPPLKWSGYDKGAYL-----FLTSYIMKTHGAKQqREA 476
Cdd:PHA00452  203 NGGKD-----HEYLELSEEAVELLQDIAAAAagISPmYQPMVVPPKPWTSIVGGGYHtegrrPLAPLVRKTKKALR-RYR 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  477 LKSAPKgqlqpVFEALDTLGSTKWRVNKRVLTVVDRIWSSGGcVADMVDRSDVPLPEKPDTEDEGI--LKKWKWEVKSAK 554
Cdd:PHA00452  277 QKQMPE-----VYKAVNALQNTAWRINKDVLAVVNEVVNWGP-VGDVLGIPRRPLPPKPEFLDENEeaFKAWKRAAAAWY 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  555 KVNSERHSQRCDTELKLSVARKMKDEEAFYYPHNMDFRGRAYPmPPHLNHLGSDLCRGVLEFAEGRPMGISGLRWLKIHL 634
Cdd:PHA00452  351 TKEKERVSKRRRLEFMLRVANKFADYKAIYFPYNMDWRGRVYA-VSMLNPQGSDLQKALLRFAEGKPLGKRGLYWLKVHG 429
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  635 ANLYagGVDKLSLDGRLAFTENHLDDIFDSADRPLeGSRWWLQAEDPFQCLAVCISLTEALRSPsPETVlSHIPIHQDGS 714
Cdd:PHA00452  430 ANCY--GVDKVTFDERAAWVDENHDNILAAAEDPL-NNTWWAEADSPLCFLAACFEYAAAVHSG-TSYV-SGLPVAMDGT 504
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  715 CNGLQHYAALGRDTLGAEAVNLVAGEKPADVYSGIATRVLDIMRRDADrDPEVFPEALRARKLLNQVDRKLVKQTVMTSV 794
Cdd:PHA00452  505 CSGLQHFSAMLRDEVGGRAVNLLPSDKPQDIYGIVAEVVNEKLERDAI-NGTDNTRALARLWLAYGITRSLTKRPVMTLP 583
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  795 YGVTYIGARDQIKRRLkERSDFGDEKE---VFGAACYAAKVTLAAIDEMFQAARAIMRWFGECAKIIASE-NETVRWTTP 870
Cdd:PHA00452  584 YGSTRFSCRDYILEDL-LQPGIDEGDGamfTNQAASYMAKLIWDAISETVPAAVEAMNWLQQAAKLLAAKgAEALHWTTP 662
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  871 LGLPVVQPYHQMGTKLVKTSL---QTLSLQHETDQVIVRRQRTAFPPNFIHSLDGSHMMMTAVACKRAGVC-FAGVHDSF 946
Cdd:PHA00452  663 TGFPVWQEYRKPEEKRVRLRLmgvARVQLYVNTDTIDARKHASGIAPNFVHSLDASHLRLTVVACAEKGIEsFAVIHDSF 742
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 334187707  947 WTHACDVDKLNIILREKFVELYSQP-ILENLLESFEQSFPHLDfPPLPERGDLDL 1000
Cdd:PHA00452  743 GTHAADADNLHRAIRETFVEMYEENdVLADFADQFGDQLQLKM-PELPEKGSLDL 796
RPO41 COG5108
Mitochondrial DNA-directed RNA polymerase [Transcription];
170-1000 2.27e-140

Mitochondrial DNA-directed RNA polymerase [Transcription];


Pssm-ID: 444054 [Multi-domain]  Cd Length: 826  Bit Score: 442.05  E-value: 2.27e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  170 GRTKFQNLWRRQVKIETEEWERAAAEYMELLTDMCEQKLAPNLPYVKSLFLGWFEPLRDAIAKDQELYRLGKS--KATYA 247
Cdd:COG5108     3 ARLDLTKPTARQIALEEEMAEAGRSRFVERIEKARKRGEESGTQYGRRIISDAVELLAEAIEATIDESSSGGAgnWHTAY 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  248 HYLDQLPADKISVITMHKLMGHLMTGgdngcVKVVHAACTVGDAIEQEIRICTFLDKKKKgddneesggvenetsmkEQD 327
Cdd:COG5108    83 AYLRELDAEVLAYLALRQCLDAVTQR-----HTLQAVAIRIASMVEDEVRGEAIREAFKD-----------------FYP 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  328 KLRKKvnelIKKQKLSAVRkilQSHDYTK----------PWIADVRAKVGSRLIELLVRTAYIQSPADQQD--NDLPdvr 395
Cdd:COG5108   141 RGKKK----IESRTSRAVR---YKDDFERrvknavakeeDWPVSDKIHVGFKLIELVVESTGLVEIARDTEgiNDTP--- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  396 pafvHTFKVAKGSMNSGRkygviecdplvrkglEKSGRYAVMP--YMPMLVPPLKWSGYDKGAYL---FLTSYIMKThGA 470
Cdd:COG5108   211 ----VFVRPTETTLEWIA---------------EANLRMAMLSpaYLPMVVPPRNWTTPFRGGYLsgeVRRLPLVKT-RN 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  471 KQQREALKSapkGQLQPVFEALDTLGSTKWRVNKRVLTVVDRIWSSGGCVAdMVDRSDVPLPEKPD-----TEDEGILKK 545
Cdd:COG5108   271 RKYLEELKN---GDMPEVYAAVNALQQTPWTINRYVLAVMKWLWERDLDLG-LPQREPITPPIKPEnrediTTNQVARKR 346
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  546 WKWEVKSAKKVNSERHSQRCDTELKLSVARKMKDEEAFYYPHNMDFRGRAYPMPPHLNHLGSDLCRGVLEFAEGRPMGIS 625
Cdd:COG5108   347 WKKAARKIYIANAKLCSKRVQFRRDLNEAERFSDYREFYFPYQLDFRGRVYAVPAFLNPQGQDHAKGLLMFADGKPIGDG 426
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  626 GLRWLKIHLANLYagGVDKLSLDGRLAFTENHLDDIFDSADRplEGSRWWLQAEDPFQCLAVCISLTEALRSPspETVLS 705
Cdd:COG5108   427 GAKWLAIHGANVW--GYDKASLEERVKWVEDNYEAILAAAAD--YVAEFWSKADKPWQFLAFCREWYGYDQHG--EGYVS 500
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  706 HIPIHQDGSCNGLQHYAALGRDTLGAEAVNLVAGEKPADVYSGIATRVLDIMRR---DADRDPEVFPEALR--ARKLLNQ 780
Cdd:COG5108   501 GLPIAMDGSCSGLQHYSAMLRDEVGGAAVNLVPSDKPQDIYAFVAEVDINLAQRigcPDELTTNEILNGIMdmAHNWLAF 580
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  781 -VDRKLVKQTVMTSVYGVTYIGARDQIKR----RLKERSD----FGDEKevFGAACYAAKVTLAAIDEMFQAARAIMRWF 851
Cdd:COG5108   581 gITRKVTKRNVMTLPYGSTEYGFRDQVREdmitRKKEEEGepfpFGGDG--FSAAMWLAKLIWDAIGEVVVAARRGMDWL 658
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  852 GECAKIIASENETVRWTTPLGLPVVQPYHQMGTKLVKTSLQT----LSLQHETDQVIVRRQRTAFPPNFIHSLDGSHMMM 927
Cdd:COG5108   659 QDLAGIAAKEGLPVIWTTPLGFPVMQDYRSSKARRINTTTRKvrvrLTLREEQDTIDKRKQKQGIAPNFVHSMDATHLMM 738
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707  928 TAVACKRAGV-CFAGVHDSFWTHACDVDKLNIILREKFVELYSQpilENLLESFEQ------SFPHLDFPPLPERGDLDL 1000
Cdd:COG5108   739 TVNRSNEYGAsSFALVHDSFGTDAGSAELMLDCLRKAFIELYEE---SDVLEDFKSeiadmlSDDAYALPEVPKKGSLDV 815
RPOL_N pfam14700
DNA-directed RNA polymerase N-terminal; This is the N-terminal domain of DNA-directed RNA ...
180-497 1.82e-93

DNA-directed RNA polymerase N-terminal; This is the N-terminal domain of DNA-directed RNA polymerase. This domain has a role in interaction with regions of upstream promoter DNA and the nascent RNA chain, leading to the processivity of the enzyme. In order to make mRNA transcripts the RNA polymerase undergoes a transition from the initiation phase (which only makes short fragments of RNA) to an elongation phase. This domain undergoes a structural change in the transition from initiation to elongation phase. The structural change results in abolition of the promoter binding site, creation of a channel accommodating the heteroduplex in the active site and formation of an exit tunnel which the RNA transcript passes through after peeling off the heteroduplex.


Pssm-ID: 464270  Cd Length: 286  Bit Score: 299.14  E-value: 1.82e-93
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   180 RQVKIETEEWERAAAEYMELLTDMCEQKLAPNLP-YVKSLFLGWFEPLRDAIAKDQELYRLGKSK---------ATYAHY 249
Cdd:pfam14700    1 RQLRLERDSVEAAVERWREEFEELQKRGLNTNLPkSLNALLWQWYEALLPAIKEEIELLKAAEAKpkktkdkerCEYGPY 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   250 LDQLPADKISVITMHKLMGHLMTGGDNGCVKVVHAACTVGDAIEQEIRIctfldkkkkgddneesggvenetsmkeqDKL 329
Cdd:pfam14700   81 LRLLPPEKLAAITILELLSLLSTGGVDKGMKVSRLAISIGKAVEDEYRA----------------------------QQL 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   330 RKKVNELIKKQKLsavrkilqshdytkPWIADVRAKVGSRLIELLVRTAYIQSPADQQDNDLPDVR--PAFVHTFkvakg 407
Cdd:pfam14700  133 LKKEKKKIKKKKI--------------PWPQEVRAKVGAVLLSLLIETAKVPVTAEDPETGEKVIQpqPAFYHSY----- 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187707   408 SMNSGRKYGVIECDPLVRKGL-EKSGRYAVMP-YMPMLVPPLKWSGYDKGAYLFLTSYIMKTHGAKQQREALKSAPK-GQ 484
Cdd:pfam14700  194 QYKRGKKVGVIKPHPELVKLLlREPARDTLTPrHLPMLVPPKPWTSYNKGGYLLSPSKLMRTKDGDEQRAYLKAASErGD 273
                          330
                   ....*....|...
gi 334187707   485 LQPVFEALDTLGS 497
Cdd:pfam14700  274 LDQVFDGLDVLGN 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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