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Conserved domains on  [gi|334185889|ref|NP_001190054|]
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tonoplast monosaccharide transporter3 [Arabidopsis thaliana]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
510-707 5.80e-68

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17315:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 365  Bit Score: 227.84  E-value: 5.80e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 510 RALMVGVGLQILQQFAGINGVMYYTPQILEETGvsslltnlgisAESASLLISALTTLLMLPCILVSMRLMDVTGRRSLM 589
Cdd:cd17315  179 RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAG-----------GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLL 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 590 LSTIPILILSLVTLVIGSLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDII 669
Cdd:cd17315  248 LIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFI 327
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 334185889 670 VTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPE 707
Cdd:cd17315  328 VGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
10-193 1.12e-65

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17315:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 365  Bit Score: 222.06  E-value: 1.12e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  10 AAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIV 89
Cdd:cd17315    1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  90 MFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMSLQESPSWRLMLGV 169
Cdd:cd17315   81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFAL 160
                        170       180
                 ....*....|....*....|....
gi 334185889 170 LSIPSIaYFVLAAFFLPESPRWLV 193
Cdd:cd17315  161 AAVPAL-LQLLLMFFLPESRALLV 183
 
Name Accession Description Interval E-value
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
510-707 5.80e-68

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 227.84  E-value: 5.80e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 510 RALMVGVGLQILQQFAGINGVMYYTPQILEETGvsslltnlgisAESASLLISALTTLLMLPCILVSMRLMDVTGRRSLM 589
Cdd:cd17315  179 RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAG-----------GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLL 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 590 LSTIPILILSLVTLVIGSLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDII 669
Cdd:cd17315  248 LIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFI 327
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 334185889 670 VTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPE 707
Cdd:cd17315  328 VGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
10-193 1.12e-65

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 222.06  E-value: 1.12e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  10 AAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIV 89
Cdd:cd17315    1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  90 MFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMSLQESPSWRLMLGV 169
Cdd:cd17315   81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFAL 160
                        170       180
                 ....*....|....*....|....
gi 334185889 170 LSIPSIaYFVLAAFFLPESPRWLV 193
Cdd:cd17315  161 AAVPAL-LQLLLMFFLPESRALLV 183
Sugar_tr pfam00083
Sugar (and other) transporter;
7-219 1.69e-46

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 171.69  E-value: 1.69e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889    7 VALAAAIGNMLQGWDNATIAGAVIYIK--KEFHLEKE-------PKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLI 77
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIDffKNFGLSKSvsslaalSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   78 LSSVLYFLSSIVMFWSP---NVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFG 154
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334185889  155 MSL-QESPSWRLMLGVLSIPSIAYFVLaAFFLPESPRWLVSKGRMDEARQVLQRLRGREDVSGELA 219
Cdd:pfam00083 161 LNKtSNSDGWRIPLGLQLVPALLLIIG-LLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELD 225
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
4-244 3.12e-40

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 154.42  E-value: 3.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889    4 VVLVALAAAIGNMLQGWDNATIAGAV--IYIKKEFHLEKEPKIE----GLIVAMSLIGATLITTFSGPVSDKVGRRSMLI 77
Cdd:TIGR00879  26 VALLSLIAAIGGLMFGYDTGVIGGALalPAFEFKFTSANSDSYSsslwGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLL 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   78 LSSVLYFLSSIVMFWSPN---VYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFG 154
Cdd:TIGR00879 106 IIALLFVIGAILMGLAAFalsVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSG 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  155 MSLQESPS-WRLMLGVLSIPSIAYFVLaAFFLPESPRWLVSKGRMDEARQVLQRLRGREDVsgELALLVEGLGVGKDTSI 233
Cdd:TIGR00879 186 KVSLNNTLgWRIPLGLQLIPAGLLFLG-LFFLPESPRWLVGKGRVEEARKSLARLRGTSGE--DKELLDELELIDIKRSI 262
                         250
                  ....*....|.
gi 334185889  234 EEYVIGPDNEE 244
Cdd:TIGR00879 263 EKRSVQPSWGS 273
Sugar_tr pfam00083
Sugar (and other) transporter;
484-720 6.03e-39

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 150.11  E-value: 6.03e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  484 KGETAMLPKEVKDGPG-WRELKE-PGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVS-SLLTNLGISAesasll 560
Cdd:pfam00083 225 DEIKDSLEAGQEAEKAsWKELFStKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSdSFLVTIIVGV------ 298
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  561 ISALTTLlmlpcilVSMRLMDVTGRRSLMLstIPILILSLVTLVIGSLVNLG---GSINALISTASVTVYLSCFVMGFGA 637
Cdd:pfam00083 299 VNFVFTF-------IAIFLVDRFGRRPLLL--LGAAGMAICFVILGIVALLGvskSDWAGIVAIVFIALFIAFFAMGWGP 369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  638 IPNILCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVIS 717
Cdd:pfam00083 370 VPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEID 449

                  ...
gi 334185889  718 EFF 720
Cdd:pfam00083 450 ELF 452
xylE PRK10077
D-xylose transporter XylE; Provisional
2-232 1.66e-36

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 143.68  E-value: 1.66e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   2 RSVVLVALAAAIGNMLQGWDNATIAGAVIYIKKEFhleKEPK---------IEGLIVAMSLIGATLITTFSGPVSDKVGR 72
Cdd:PRK10077   8 SYIFSITLVATLGGLLFGYDTAVISGTVESLNTVF---VAPQnlsesaansLLGFCVASALIGCIIGGALGGYCSNRFGR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  73 RSMLILSSVLYFLSSI------VMFWSPN----VYVLLFA--RLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFC 140
Cdd:PRK10077  85 RDSLKIAAVLFFISALgsawpeFGFTSIGpdntGYVPEFViyRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 141 GSGGMFLSYCLVFGMSLQESPS------WRLMLGVLSIPSiAYFVLAAFFLPESPRWLVSKGRMDEARQVLQRLRGREDV 214
Cdd:PRK10077 165 IIFGQLVVYFVNYFIARSGDASwlntdgWRYMFASEAIPA-LLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLA 243
                        250
                 ....*....|....*...
gi 334185889 215 SGELALLVEGLGVGKDTS 232
Cdd:PRK10077 244 TQALQEIKHSLDHGRKTG 261
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
498-716 1.44e-33

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 135.16  E-value: 1.44e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  498 PGWRELK--EPGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVS---SLLTNLGISAesasllISALTTLlmlpc 572
Cdd:TIGR00879 269 PSWGSLFssTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVStdhAFLVSIIVGA------VNFAFTF----- 337
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  573 ilVSMRLMDVTGRRSLMLstIPILILSLVTLVIG----SLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFP 648
Cdd:TIGR00879 338 --VAIFLVDRFGRRPLLL--IGAAGMAICLFVLGilgaSFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFP 413
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334185889  649 TSVRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVI 716
Cdd:TIGR00879 414 LSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
1-193 7.62e-26

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 108.36  E-value: 7.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   1 MRSVVLVALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSS 80
Cdd:COG0477    9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGAS--SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  81 VLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYclVFGMSLQES 160
Cdd:COG0477   87 LLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP--LLGGLLVAA 164
                        170       180       190
                 ....*....|....*....|....*....|...
gi 334185889 161 PSWRLMLGVLSIPSIAYFVLaAFFLPESPRWLV 193
Cdd:COG0477  165 LGWRWIFLINAPLGLLALVL-RLRLPESRGLLL 196
xylE PRK10077
D-xylose transporter XylE; Provisional
512-714 5.50e-25

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 109.01  E-value: 5.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 512 LMVGVGLQILQQFAGINGVMYYTPQILEETGVSSlltnlgisaeSASLLISALTTLLMLPCILVSMRLMDVTGRRSLMLs 591
Cdd:PRK10077 272 IVIGVMLSVFQQFVGINVVLYYAPEIFKTLGAST----------DIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQI- 340
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 592 tIPILILSLVTLVIGSLvnLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDIIVT 671
Cdd:PRK10077 341 -IGALGMAIGMFSLGTA--FYTQAPGIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVS 417
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 334185889 672 YTLPVMLKSIGIAGVF------GIYAIVCAVAWVFVYLKVPETKGMPLE 714
Cdd:PRK10077 418 WTFPMMDKNSWLVAHFhngfsyWIYGCMGVLAALFMWKFVPETKGKTLE 466
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
524-709 7.33e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 58.34  E-value: 7.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 524 FAGINGVMYYTPQILEETgvsslltnLGISAESASLLISALTtLLMLPCILVSMRLMDVTGRRSlmlsTIPILILSLVTL 603
Cdd:COG2271  193 YFALYGFLTWLPTYLVEV--------RGLSLAQAGLLLSLPF-LAGIVGSLLGGWLSDRLGRRR----KLVLAIGLLLAA 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 604 VIGSLVNLGGSINALISTASVtvyLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIGI 683
Cdd:COG2271  260 LALLLLALLPSPALAIALLFL---AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
                        170       180
                 ....*....|....*....|....*.
gi 334185889 684 AGVFGIYAIVCAVAWVFVYLKVPETK 709
Cdd:COG2271  337 QAAFLLLAALALLAALLALLLLRETR 362
 
Name Accession Description Interval E-value
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
510-707 5.80e-68

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 227.84  E-value: 5.80e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 510 RALMVGVGLQILQQFAGINGVMYYTPQILEETGvsslltnlgisAESASLLISALTTLLMLPCILVSMRLMDVTGRRSLM 589
Cdd:cd17315  179 RALLVGVGLQLLQQLTGINAVMYYAPTIFKSAG-----------GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLL 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 590 LSTIPILILSLVTLVIGSLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDII 669
Cdd:cd17315  248 LIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFI 327
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 334185889 670 VTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPE 707
Cdd:cd17315  328 VGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
10-193 1.12e-65

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 222.06  E-value: 1.12e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  10 AAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIV 89
Cdd:cd17315    1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  90 MFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMSLQESPSWRLMLGV 169
Cdd:cd17315   81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFAL 160
                        170       180
                 ....*....|....*....|....
gi 334185889 170 LSIPSIaYFVLAAFFLPESPRWLV 193
Cdd:cd17315  161 AAVPAL-LQLLLMFFLPESRALLV 183
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
6-197 2.60e-48

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 175.06  E-value: 2.60e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   6 LVALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFL 85
Cdd:cd17359    1 LISLVAALGGLLFGYDTGVINGALPFLQTDFNLT--PFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  86 SSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCL------VFGMSLQE 159
Cdd:cd17359   79 SALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVnylianAGGADWLG 158
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 334185889 160 SPSWRLMLGVLSIPSIAYFVLaAFFLPESPRWLVSKGR 197
Cdd:cd17359  159 AEGWRWMLGLEAIPAILFLLG-MLFIPESPRWLVSKGK 195
Sugar_tr pfam00083
Sugar (and other) transporter;
7-219 1.69e-46

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 171.69  E-value: 1.69e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889    7 VALAAAIGNMLQGWDNATIAGAVIYIK--KEFHLEKE-------PKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLI 77
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIDffKNFGLSKSvsslaalSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   78 LSSVLYFLSSIVMFWSP---NVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFG 154
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334185889  155 MSL-QESPSWRLMLGVLSIPSIAYFVLaAFFLPESPRWLVSKGRMDEARQVLQRLRGREDVSGELA 219
Cdd:pfam00083 161 LNKtSNSDGWRIPLGLQLVPALLLIIG-LLFLPESPRWLVEKGRLEEAREVLAKLRGVPDVDRELD 225
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
499-714 5.88e-41

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 155.81  E-value: 5.88e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 499 GWRELKEPGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVsslltnlGISAESASLLISALttllMLPCILVSMR 578
Cdd:cd17358  228 SFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGS-------GLDPNTATIIIGVV----QVVGTLVATL 296
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 579 LMDVTGRRSLMLstIPILILSLVTLVIG-----SLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRG 653
Cdd:cd17358  297 LVDRLGRRPLLL--VSAIGMGIGLLALGlyfylQEHGALLSSVSWLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKG 374
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185889 654 LCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLE 714
Cdd:cd17358  375 LAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPETKGKSLE 435
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
4-244 3.12e-40

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 154.42  E-value: 3.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889    4 VVLVALAAAIGNMLQGWDNATIAGAV--IYIKKEFHLEKEPKIE----GLIVAMSLIGATLITTFSGPVSDKVGRRSMLI 77
Cdd:TIGR00879  26 VALLSLIAAIGGLMFGYDTGVIGGALalPAFEFKFTSANSDSYSsslwGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLL 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   78 LSSVLYFLSSIVMFWSPN---VYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFG 154
Cdd:TIGR00879 106 IIALLFVIGAILMGLAAFalsVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSG 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  155 MSLQESPS-WRLMLGVLSIPSIAYFVLaAFFLPESPRWLVSKGRMDEARQVLQRLRGREDVsgELALLVEGLGVGKDTSI 233
Cdd:TIGR00879 186 KVSLNNTLgWRIPLGLQLIPAGLLFLG-LFFLPESPRWLVGKGRVEEARKSLARLRGTSGE--DKELLDELELIDIKRSI 262
                         250
                  ....*....|.
gi 334185889  234 EEYVIGPDNEE 244
Cdd:TIGR00879 263 EKRSVQPSWGS 273
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
509-707 3.45e-40

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 151.95  E-value: 3.45e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 509 KRALMVGVGLQILQQFAGINGVMYYTPQILEETGVSslltnlgisaESASLLISALTTLLMLPCILVSMRLMDVTGRRSL 588
Cdd:cd17359  195 KPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFS----------ENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPL 264
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 589 MLSTIPILILSLVTLVIGSLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDI 668
Cdd:cd17359  265 LLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANF 344
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 334185889 669 IVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPE 707
Cdd:cd17359  345 LVSLTFPILLAAFGLAFTFLIFAVICVLAFLFVWKFVPE 383
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
506-707 1.93e-39

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 149.34  E-value: 1.93e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 506 PGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVSSLLTnlgisaesaSLLISALTTLLMLPCILVSMRLMDVTGR 585
Cdd:cd17360  182 PSTRRALIVGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQN---------AIWLSLIVAGTNFIFTIVGMYLIDKFGR 252
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 586 RSLMLSTIPILILSLVTLVIGSLVnlggsinalistASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWI 665
Cdd:cd17360  253 RKLLLISLFGVIVALVVLAVWLAL------------VGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWV 320
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 334185889 666 CDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPE 707
Cdd:cd17360  321 FNLLVSQTFLTLTQAIGPYGTFLLFAGLAVLGLIFIYFCVPE 362
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
10-191 3.58e-39

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 148.57  E-value: 3.58e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  10 AAAIGNMLQGWDNATIAGAVIYIKKEF-HLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSI 88
Cdd:cd17360    1 FAGIGGFLFGYDTGVISGALLYIKDDLgEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  89 VMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMSLQESpSWRLMLG 168
Cdd:cd17360   81 VMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPG-GWRWMLG 159
                        170       180
                 ....*....|....*....|...
gi 334185889 169 VLSIPSIAYFVLaAFFLPESPRW 191
Cdd:cd17360  160 LAAVPAVLQFIG-LLFLPESPRW 181
Sugar_tr pfam00083
Sugar (and other) transporter;
484-720 6.03e-39

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 150.11  E-value: 6.03e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  484 KGETAMLPKEVKDGPG-WRELKE-PGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVS-SLLTNLGISAesasll 560
Cdd:pfam00083 225 DEIKDSLEAGQEAEKAsWKELFStKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSdSFLVTIIVGV------ 298
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  561 ISALTTLlmlpcilVSMRLMDVTGRRSLMLstIPILILSLVTLVIGSLVNLG---GSINALISTASVTVYLSCFVMGFGA 637
Cdd:pfam00083 299 VNFVFTF-------IAIFLVDRFGRRPLLL--LGAAGMAICFVILGIVALLGvskSDWAGIVAIVFIALFIAFFAMGWGP 369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  638 IPNILCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVIS 717
Cdd:pfam00083 370 VPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEID 449

                  ...
gi 334185889  718 EFF 720
Cdd:pfam00083 450 ELF 452
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
50-219 6.19e-38

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 146.95  E-value: 6.19e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  50 AMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEI 129
Cdd:cd17358   48 SLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNV 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 130 RGLLNTFPQFCGSGGMFLSYCLVFGMslqespSWRLMLGVLSIPSIAYFVLaAFFLPESPRWLVSKGRMDEARQVLQRLR 209
Cdd:cd17358  128 RGALGSLNQLLVNIGILLGYVLGSFL------PWRTLALIGAIPPVVFLIL-LFFIPESPRWLAKKGREEEAEKSLQFLR 200
                        170
                 ....*....|.
gi 334185889 210 GRE-DVSGELA 219
Cdd:cd17358  201 GKDaDISKEAA 211
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
496-716 1.11e-37

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 145.19  E-value: 1.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 496 DGPGWRelkePGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVSSlltnlGISAESASLLIsALTTLLMlpcILV 575
Cdd:cd17362  181 PSPRWQ----GNYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGFSA-----ASDATLVSVGL-GVFKLLM---TIV 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 576 SMRLMDVTGRRSLMLSTIPILILSLVTL-VIGSLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGL 654
Cdd:cd17362  248 AVLLVDKLGRRPLLLGGVSGMVVSLFLLaAYNLFVQMGPAGLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGR 327
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334185889 655 CITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVI 716
Cdd:cd17362  328 AIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKGLSLEEI 389
xylE PRK10077
D-xylose transporter XylE; Provisional
2-232 1.66e-36

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 143.68  E-value: 1.66e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   2 RSVVLVALAAAIGNMLQGWDNATIAGAVIYIKKEFhleKEPK---------IEGLIVAMSLIGATLITTFSGPVSDKVGR 72
Cdd:PRK10077   8 SYIFSITLVATLGGLLFGYDTAVISGTVESLNTVF---VAPQnlsesaansLLGFCVASALIGCIIGGALGGYCSNRFGR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  73 RSMLILSSVLYFLSSI------VMFWSPN----VYVLLFA--RLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFC 140
Cdd:PRK10077  85 RDSLKIAAVLFFISALgsawpeFGFTSIGpdntGYVPEFViyRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 141 GSGGMFLSYCLVFGMSLQESPS------WRLMLGVLSIPSiAYFVLAAFFLPESPRWLVSKGRMDEARQVLQRLRGREDV 214
Cdd:PRK10077 165 IIFGQLVVYFVNYFIARSGDASwlntdgWRYMFASEAIPA-LLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGNTLA 243
                        250
                 ....*....|....*...
gi 334185889 215 SGELALLVEGLGVGKDTS 232
Cdd:PRK10077 244 TQALQEIKHSLDHGRKTG 261
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
11-198 1.16e-33

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 133.30  E-value: 1.16e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  11 AAIGNMLQGWDNATIAGAVIYIKKEFHLEkEPKIEGLIVAM---SLIGATLittfSGPVSDKVGRRSMLILSSVLYFLSS 87
Cdd:cd17437    2 ASLNSILLGYDIGVMSGAVIFIKEDLKIS-DVQEEVLIGSLniiSLVGSLA----AGRTSDWIGRRYTIALAALIFFVGA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  88 IVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMS-LQESPSWRLM 166
Cdd:cd17437   77 LLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSgLPLHVGWRLM 156
                        170       180       190
                 ....*....|....*....|....*....|..
gi 334185889 167 LGVLSIPSIaYFVLAAFFLPESPRWLVSKGRM 198
Cdd:cd17437  157 LGVGAVPSL-FLAIGVLAMPESPRWTPAVRRM 187
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
498-716 1.44e-33

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 135.16  E-value: 1.44e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  498 PGWRELK--EPGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVS---SLLTNLGISAesasllISALTTLlmlpc 572
Cdd:TIGR00879 269 PSWGSLFssTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVStdhAFLVSIIVGA------VNFAFTF----- 337
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  573 ilVSMRLMDVTGRRSLMLstIPILILSLVTLVIG----SLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFP 648
Cdd:TIGR00879 338 --VAIFLVDRFGRRPLLL--IGAAGMAICLFVLGilgaSFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFP 413
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334185889  649 TSVRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVI 716
Cdd:TIGR00879 414 LSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
46-213 9.52e-31

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 126.22  E-value: 9.52e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWS---PNVYVLLFARLLDGFGIGLAVTLVPIYIS 122
Cdd:cd17357   52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 123 ETAPSEIRGLLNTFPQFCGSGGMFLSycLVFGMS--LQESPSWRLMLGVLSIPSIAyFVLAAFFLPESPRWLV-SKGRMD 199
Cdd:cd17357  132 EISPSELRGALGSLTQIGVTLGILLG--QVFGLPsvLGTETLWPYLLFFPGIPALL-QLAALPFFPESPKFLLiSKGDEE 208
                        170
                 ....*....|....
gi 334185889 200 EARQVLQRLRGRED 213
Cdd:cd17357  209 EAEKSLKFLRGIED 222
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
11-191 4.04e-30

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 123.23  E-value: 4.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  11 AAIGNMLQGWDNATIAGAVIYIKKEFHLEKE-----PKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFL 85
Cdd:cd17362    2 PALGGLLFGYDIGATSGALLSITSPALSGTDwynlsSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  86 SSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYclVFGMSLQESPS-WR 164
Cdd:cd17362   82 GSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGY--VSGYAFADVVGgWR 159
                        170       180
                 ....*....|....*....|....*..
gi 334185889 165 LMLGVLSIPSIAyFVLAAFFLPESPRW 191
Cdd:cd17362  160 YMYGLAAPPALL-LGIGMWFLPPSPRW 185
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
6-192 2.43e-29

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 121.20  E-value: 2.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   6 LVALAAAIGNMLQGWDNATIAGAV--IYIKKEFHLEKEPKI-----EGLIVAMSLIGATLITTFSGPVSDKVGRRSMLIL 78
Cdd:cd17356    1 LLCAFVSLGGFLFGYDTGSISGILnmKSFQKYFADNTGTYYpsssrQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  79 SSVLYFLSSIVMFWS-PNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMS- 156
Cdd:cd17356   81 GCVIYIIGAIIQVAAiGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHk 160
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 334185889 157 LQESPSWRLMLGVLSIPSIAYFVlAAFFLPESPRWL 192
Cdd:cd17356  161 LDGSAQWRIPLGLQIVWGLLLLI-GMFFLPESPRWL 195
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
498-716 1.46e-28

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 118.27  E-value: 1.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 498 PGWRelkePGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVSSlltnlgisaESASLLISALTTLLMLPCILVSM 577
Cdd:cd17437  178 PRWT----PAVRRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIKS---------KDKLLLATVAVGVTKTLFILVAT 244
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 578 RLMDVTGRRSLMLSTIPILILSLVTLVIGSLV----NLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRG 653
Cdd:cd17437  245 FLLDKVGRRPLLLTSTGGMTLSLTALATSLTFidrnGGGLTWALVLAITAVCSFVAFFSIGAGPITWVYSSEIFPLRLRA 324
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334185889 654 LCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVI 716
Cdd:cd17437  325 QGASLGVVVNRLMSGTVSMTFLSMSKAITTGGTFFLFAGVAAAAWVFFYFFLPETKGKSLEEI 387
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
512-720 1.18e-27

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 116.20  E-value: 1.18e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 512 LMVGVGLQILQQFAGINGVMYYTPQILEETGVSslltnlgisaESASLLISALTTLLMLPCILVSMRLMDVTGRR-SLML 590
Cdd:cd17356  198 TILGIMLQLFQQLTGINYFFYYGTTIFQSTGLT----------GSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRtCLLI 267
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 591 STIPILILSLVTLVIGS--LVNLGGSINALISTASVTVYLSC-----FVMGFGAIPNILCSEIFPTSVRGLCITICALTF 663
Cdd:cd17356  268 GAAGMSICLFIYAAVGVryLIPNPQSGTSNKSAGNGMIVFIClfifsFATTWGPIAWVYVAEVFPLRVRSKGMALATAFN 347
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 334185889 664 WICDIIVTYTLPVMLKSIGiAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVISEFF 720
Cdd:cd17356  348 WLWNFLISFFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFFFVPETKGLTLEEIDELF 403
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
500-710 1.44e-27

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 116.59  E-value: 1.44e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 500 WRELKEPGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVSSLLtnlgisAESASLLISALTTLLmlpcILVSMRL 579
Cdd:cd17357  247 MQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQL------AEWANLGIGIVNVLS----TIVGPFL 316
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 580 MDVTGRRSLMLSTIPILILSLVTLVIGSLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITIC 659
Cdd:cd17357  317 IEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLG 396
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 334185889 660 ALTFWICDIIVTYTLPVmLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKG 710
Cdd:cd17357  397 SSVNWTSNFIVGMAFPP-LQSIGGGFVFIIFAIPCALFLLYLYRYLPETKG 446
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
502-714 7.24e-27

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 113.82  E-value: 7.24e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 502 ELKEPGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVSSlltnlgisAESASLLISALTTLLMLpcilVSMRLMD 581
Cdd:cd17433  228 LLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKD--------SSVASVIVAAIQVLFTA----VAALIMD 295
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 582 VTGRRSLmlstipiLILSLVTLVIGSlvnlggSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICAL 661
Cdd:cd17433  296 RAGRKVL-------LVLSGVVMVFST------AAFGWLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVL 362
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 334185889 662 TFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLE 714
Cdd:cd17433  363 TNWLMAFLVTKEFSSLMEVLSSYGTFWLFSAFCAFSVLFTLFCVPETKGKTLE 415
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
1-193 7.62e-26

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 108.36  E-value: 7.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   1 MRSVVLVALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSS 80
Cdd:COG0477    9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGAS--SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  81 VLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYclVFGMSLQES 160
Cdd:COG0477   87 LLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP--LLGGLLVAA 164
                        170       180       190
                 ....*....|....*....|....*....|...
gi 334185889 161 PSWRLMLGVLSIPSIAYFVLaAFFLPESPRWLV 193
Cdd:COG0477  165 LGWRWIFLINAPLGLLALVL-RLRLPESRGLLL 196
xylE PRK10077
D-xylose transporter XylE; Provisional
512-714 5.50e-25

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 109.01  E-value: 5.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 512 LMVGVGLQILQQFAGINGVMYYTPQILEETGVSSlltnlgisaeSASLLISALTTLLMLPCILVSMRLMDVTGRRSLMLs 591
Cdd:PRK10077 272 IVIGVMLSVFQQFVGINVVLYYAPEIFKTLGAST----------DIALLQTIIVGVINLTFTVLAIMTVDKFGRKPLQI- 340
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 592 tIPILILSLVTLVIGSLvnLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDIIVT 671
Cdd:PRK10077 341 -IGALGMAIGMFSLGTA--FYTQAPGIVALLSMLFYVAAFAMSWGPVCWVLLSEIFPNAIRGKALAIAVAAQWIANYFVS 417
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 334185889 672 YTLPVMLKSIGIAGVF------GIYAIVCAVAWVFVYLKVPETKGMPLE 714
Cdd:PRK10077 418 WTFPMMDKNSWLVAHFhngfsyWIYGCMGVLAALFMWKFVPETKGKTLE 466
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
53-209 7.60e-24

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 105.87  E-value: 7.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   53 LIGATlittFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGL 132
Cdd:TIGR00898 141 LLGSF----VFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAI 216
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334185889  133 LNTFPQFCGSGG-MFLSYCLVFgmslqeSPSWRLMLGVLSIPSIAYFVLaAFFLPESPRWLVSKGRMDEARQVLQRLR 209
Cdd:TIGR00898 217 VGTLIQVFFSLGlVLLPLVAYF------IPDWRWLQLAVSLPTFLFFLL-SWFVPESPRWLISQGRIEEALKILQRIA 287
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-190 1.27e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 103.13  E-value: 1.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   2 RSVVLVALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSV 81
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGAS--PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  82 LYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSycLVFGMSLQESP 161
Cdd:COG2814   84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG--PLLGGLLADLF 161
                        170       180
                 ....*....|....*....|....*....
gi 334185889 162 SWRLMLGVLSIPSIAYFVLAAFFLPESPR 190
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLLRLLPESRP 190
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
7-218 1.48e-23

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 104.62  E-value: 1.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   7 VALAAAIGNMLQ-GWDNATIAGAVIYIKK---EFHLEK-----EPK----IEGLIVAMSLIGATLITTFSGPVSDKVGRR 73
Cdd:cd17432    1 ATLAAAFGSSFQyGYNLSVVNSPTPYIQNfynETWTERygtplEEStltlLWSLTVSIFPLGGLFGSLLVGPLVIRLGRK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  74 SMLILSSVLYFLSSIVMFWSPNVY---VLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYc 150
Cdd:cd17432   81 GTLLLNNIFAIVAAILMGLSKIAKsfeMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQ- 159
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185889 151 lVFGMS--LQESPSWRLMLGVLSIPSIAYFVLAAFFlPESPRW-LVSKGRMDEARQVLQRLRGREDVSGEL 218
Cdd:cd17432  160 -VLGLRelLGNEEGWPLLLALTGVPALLQLLTLPFF-PESPRYlLIEKGDEEAARKALQRLRGKEDVDDEM 228
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
47-223 3.01e-23

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 103.57  E-value: 3.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  47 LIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWS---PNVYVLLFARLLDGFGIGLAVTLVPIYISE 123
Cdd:cd17431   54 LSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSklaKSYEMLILGRFIIGLYCGLTTGLVPMYIGE 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 124 TAPSEIRGLLNTFPQFCGSGGMFLSYclVFGM-SLQESPS-WRLMLGVLSIPSIAYFVLaAFFLPESPRWLVSK-GRMDE 200
Cdd:cd17431  134 ISPTALRGALGTLHQLGIVVGILISQ--IFGLeFILGTEElWPLLLGFTIVPAILQLAL-LPFCPESPRYLLINrNEEEE 210
                        170       180
                 ....*....|....*....|...
gi 334185889 201 ARQVLQRLRGREDVSGELALLVE 223
Cdd:cd17431  211 AKSVLKKLRGTTDVSEDIQEMKE 233
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
8-180 2.31e-22

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 99.21  E-value: 2.31e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   8 ALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSS 87
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  88 IVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMS--LQESPSWRL 165
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIplLSGDWGWRI 160
                        170
                 ....*....|....*
gi 334185889 166 MLGVLSIPSIAYFVL 180
Cdd:cd17316  161 LFLIGALPALLALLL 175
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
10-189 1.18e-21

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 97.71  E-value: 1.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  10 AAAIGNMLQGWDNAtIAGAVI----YIKKEFHLEKEPKIEG--------------LIVAMSLIGATLITTFSGPVSDKVG 71
Cdd:cd17361    1 VAALGGLIFGYDIG-ISGGVTsmdpFLEKFFPSVYEKKKGAsennyckyddqllqLFTSSLYLAGLVASLLASYVTRKWG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  72 RRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCL 151
Cdd:cd17361   80 RKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGALNIGFQLAITIGILIANLI 159
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 334185889 152 VFGMSLQESPSWRLMLGVLSIPSIAYFvLAAFFLPESP 189
Cdd:cd17361  160 NYGTSKIKPNGWRLSLGLAAVPALILL-LGSLFLPETP 196
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
503-710 4.59e-21

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 96.64  E-value: 4.59e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 503 LKEPGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVSSlltnlgisAESASLLISALTTLLMLpcilVSMRLMDV 582
Cdd:cd17431  250 FRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQ--------PVYATIGAGVVNTIFTV----VSLFLVER 317
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 583 TGRRSLMLSTIPILILSLVTLVIGSLVNLGGSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALT 662
Cdd:cd17431  318 AGRRTLHLIGLGGMAICAILMTIALLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFS 397
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 334185889 663 FWICDIIVTYTLPVMLKSIGiAGVFGIYAIVCAVAWVFVYLKVPETKG 710
Cdd:cd17431  398 NWTSNFIVGMCFQYIANLCG-PYVFIIFTVFLLTFFIFTYFKVPETKG 444
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
11-190 7.64e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 95.19  E-value: 7.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  11 AAIGNMLQGWDNATIAGAVIYIKKEFHLEKEpkIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVM 90
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSAS--QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  91 FWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMSLQESPSWRLMLGVL 170
Cdd:cd06174   79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
                        170       180
                 ....*....|....*....|
gi 334185889 171 SIPSIAYFVLAAFFLPESPR 190
Cdd:cd06174  159 AALALLAAILLLLVVPDPPE 178
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
508-716 1.03e-19

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 91.79  E-value: 1.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 508 VKRALMVGVGLQILQQFAGINGVMYYTpqileetgvSSLLTNLGISAESASLLISALTTLLMLPCILVSMRLMDVTGRRS 587
Cdd:cd17436  189 MRRRTLVGLGLVLFQQFTGQPNVLCYA---------STIFRSVGFQSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRS 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 588 LMLSTIPILILSLVtlvigslvnlggSINALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICD 667
Cdd:cd17436  260 LLIAGCSVMAVSVS------------GIGLWITLLCLMAFVSAFSIGFGPMTWLVLSEIYPADIRGRAFSFCNSFNWAAN 327
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 334185889 668 IIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVI 716
Cdd:cd17436  328 LLITLSFLDLIDVIGLSWTFLLYGVVGVAGVVFIYLFVPETKGQSLEEI 376
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
6-198 4.14e-18

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 86.78  E-value: 4.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   6 LVALAAAIGNMLQGWDNATIAGAVIYIKKEfhLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFL 85
Cdd:cd17435    1 LSSVTAAVSGLLVGYELGIISGALLQLRTL--LALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  86 SSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMSlQESPSWRL 165
Cdd:cd17435   79 GSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFA-NVSNGWKY 157
                        170       180       190
                 ....*....|....*....|....*....|...
gi 334185889 166 MLGvLSIPSIAYFVLAAFFLPESPRWLVSKGRM 198
Cdd:cd17435  158 MFG-LVIPLAALQAIAMYFLPPSPRFLVMKDNM 189
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
500-714 6.91e-18

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 86.81  E-value: 6.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 500 WRELKEPGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVsslLTNLGISAesasllisALTTLLMLPCILVSMRL 579
Cdd:cd17434  226 WAELKTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAV---ILEPKYDA--------ALVGAVRLLSVAIAASL 294
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 580 MDVTGRRSLMLSTIPILILSLVTLvigslvnlggsinALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITIC 659
Cdd:cd17434  295 MDKAGRKILLFTSAFLMFAANLSM-------------GLIPLIAAMLFIMGYAMGWGPITWLLMSEILPLKARGVASGLC 361
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 334185889 660 ALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLE 714
Cdd:cd17434  362 VVVSWITAFVLTQLFLPVVVTFGLQVPFLFFAAVCAVSIIFTACCVPETKGRTLE 416
MFS_1 pfam07690
Major Facilitator Superfamily;
12-205 1.01e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 85.16  E-value: 1.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   12 AIGNMLQGWDNATIAGAV-IYIKKEFHLEKEPKieGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVM 90
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALpLLLAEDLGISPTEI--GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   91 FWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSycLVFGMSLQESPSWRLMLGVL 170
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALG--PLLGGLLASLFGWRAAFLIL 157
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 334185889  171 SIPSIAYFVLAAFFLPESPRWLVSKGRMDEARQVL 205
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV 192
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
512-707 4.92e-17

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 83.84  E-value: 4.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 512 LMVGVGLQILQQFAGINGVMYYTPQILEETGvsslltnlgiSAESASLLISALTTLLMLPCILVSMRLMDVTGRRSLMLS 591
Cdd:cd17361  201 LVIAILIPFFQQLTGINVIMFYAPVLFQTLG----------FGSDASLISAVITGAVNVVSTLVSIYLVDRFGRRFLLLE 270
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 592 TIPILILSLVTLVIGSLVNLGGSINALISTASVTVYLSC-FVMGF----GAIPNILCSEIFPTSVRGLCITICALTFWIC 666
Cdd:cd17361  271 GGVQMLASQVAIGILLAVKFGDGGELPKAYAIAVVVLIClYVAAFawswGPLGWLVPSEIFPLETRSAGQSLTVAVNFLF 350
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 334185889 667 DIIVTYTLPVMLKSIGiAGVFGIYAIVCAVAWVFVYLKVPE 707
Cdd:cd17361  351 TFVIAQAFLSMLCAMK-FGIFLFFAGWVVVMSLFVYFLLPE 390
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
46-190 5.20e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 83.39  E-value: 5.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:cd17325   34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIA 113
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334185889 126 PSEIRGLLNTFPQFCGSGGMFLSycLVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFLPESPR 190
Cdd:cd17325  114 PPEERGRAMGIFSSAIGLGFLIG--PLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRP 176
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
46-208 2.96e-16

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 83.10  E-value: 2.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   46 GLIVAMSL-IGATlittFSGPVSDKVGRRSMLILS----SVLYFLSSIVMFWSpnvyVLLFARLLDGFGIGLAVTLVPIY 120
Cdd:TIGR01299 208 GLIVYLGMmVGAF----FWGGLADKLGRKQCLLIClsvnGFFAFFSSFVQGYG----FFLFCRLLSGFGIGGAIPIVFSY 279
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  121 ISETAPSEIRG-LLNTFPQFCGSGGMFLS---------YCLVFGM-SLQESPSWRLMLGVLSIPSIaYFVLAAFFLPESP 189
Cdd:TIGR01299 280 FAEFLAQEKRGeHLSWLCMFWMIGGIYAAamawaiiphYGWSFQMgSAYQFHSWRVFVIVCAFPCV-FAIGALTFMPESP 358
                         170
                  ....*....|....*....
gi 334185889  190 RWLVSKGRMDEARQVLQRL 208
Cdd:TIGR01299 359 RFFLENGKHDEAWMILKLI 377
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
512-716 2.99e-16

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 81.38  E-value: 2.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 512 LMVGVGLQILQQFAGINGVMYYTPQILEETGVSSlltnlGISAESASLLISALTTLLMLPCILvsmrLMDVTGRRSLMLS 591
Cdd:cd17435  193 LLIGLTLVFFVQITGQPNILFYASTVLKSVGFQS-----NEAASLASTGVGVVKVVSTIPAIF----LVDKVGSKTFLCI 263
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 592 TIPILILSLVTLvigslvnlggsiNALISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDIIVT 671
Cdd:cd17435  264 GSSVMAVSLVTM------------GLWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLIS 331
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 334185889 672 YTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETKGMPLEVI 716
Cdd:cd17435  332 LTFLTVTELIGLPWVCFIYTAMSLASLVFVIMFVPETKGCSLEQI 376
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
6-194 3.00e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 81.07  E-value: 3.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   6 LVALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEpkIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFL 85
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAA--QLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  86 SSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYclVFGMSLQESPSWRL 165
Cdd:COG2271   88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAP--PLLGWLLAAFGWRA 165
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 334185889 166 MLGVLSIPSIAYFVL------AAFFLPESPRWLVS 194
Cdd:COG2271  166 AFLILGLPGLLLALLrfwllaLAYFLVYFALYGFL 200
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
54-212 3.27e-16

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 81.46  E-value: 3.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  54 IGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLL 133
Cdd:cd17433   52 LGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTL 131
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334185889 134 NTFPQFCGSGGMFLSYclVFGMSLQespsWRLMLGVLSIPSiAYFVLAAFFLPESPRWLVSKGRMDEARQVLQRLRGRE 212
Cdd:cd17433  132 GSCVQLMVVIGIMGAY--LAGLVLD----WRWLAVLGSIPP-TLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPD 203
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
6-209 9.43e-16

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 79.92  E-value: 9.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   6 LVALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEPKieGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFL 85
Cdd:COG2223    5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL--GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  86 SSIVMFWSPNVYVLLFARLLDGFGIGlAVTLVPI-YISETAPSEIRGLLNTFPQFCGSGGMFLSycLVFGMSLQESPSWR 164
Cdd:COG2223   83 GLLLLALAVSYWLLLLLGLLLGIGGG-GSFAVGIaLVSKWFPPDRRGLALGLAAGGGNLGAAVA--AFLAPLLIAAFGWR 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 334185889 165 LMLGVLSIPSIAYFVLAAFFLPESP--RWLVSKGRMDEARQVLQRLR 209
Cdd:COG2223  160 NAFLILGILLLVVAVLAWLFLRDPPagAAAAAKASLRDQLEALRDPR 206
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
2-204 1.50e-15

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 79.32  E-value: 1.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889    2 RSVVLVALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSV 81
Cdd:TIGR00895  13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLD--PVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   82 LYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFpQFCG-----SGGMFLSYCLV--FG 154
Cdd:TIGR00895  91 LFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGL-MFCGypigaAVGGFLAGWLIpvFG 169
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 334185889  155 mslqespsWRLMLGVLSIPSIAYFVLAAFFLPESPRWLVSKGRMDEARQV 204
Cdd:TIGR00895 170 --------WRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIV 211
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
500-710 1.55e-15

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 79.58  E-value: 1.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 500 WRELKEPGVKRALMVGVGLQILQQFAGINGVMYYTPQILEETGVSS---LLTNLGISAesasllISALTTLLmlpCILVS 576
Cdd:cd17432  247 LELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEdkiQYVTVGTGA------CEVLATIT---CVLVI 317
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 577 MRLmdvtGRRSLMLSTIPILILSLVTLVIGslVNLGGSINAL--ISTASVTVYLSCFVMGFGAIPNILCSEIFPTSVRGL 654
Cdd:cd17432  318 ERL----GRRPLLIGGFGLMAVWCAVLTVA--LSLQNTVSWMpyLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPA 391
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 334185889 655 CITICALTFWICDIIVTYTLPVMLKSIGiAGVFGIYAIVCAVAWVFVYLKVPETKG 710
Cdd:cd17432  392 AFMVAGSLNWLSNFLVGLLFPFIQEGLG-AYCFLVFAVICLLTAIYIFFVLPETKG 446
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
46-208 2.17e-15

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 79.46  E-value: 2.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSL-IGATLIttfsGPVSDKVGRRSMLILS----SVLYFLSSIVMFWSpnvyVLLFARLLDGFGIGLAVTLVPIY 120
Cdd:cd17363   40 GLIVYLGMmVGAFVW----GGLADKLGRKQCLLIAlsvnGVFAFLSSFVQGYG----FFLFCRLLSGIGIGGSIPIVFSY 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 121 ISETAPSEIRG-LLNTFPQFCGSGGMFLS---------YCLVFGM-SLQESPSWRLMLGVLSIPSIAYfVLAAFFLPESP 189
Cdd:cd17363  112 FAEFLAREKRGeHLSWLCMFWMIGGLYASamawaiiphYGWGFSMgTAYQFHSWRVFVIVCALPSVAS-VVALTFMPESP 190
                        170
                 ....*....|....*....
gi 334185889 190 RWLVSKGRMDEARQVLQRL 208
Cdd:cd17363  191 RFLLEVGKHDEAWMILKQV 209
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
46-208 3.27e-15

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 78.81  E-value: 3.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITtfsGPVSDKVGRRSMLILS----SVLYFLSSIVMFWSpnvyVLLFARLLDGFGIGLAVTLVPIYI 121
Cdd:cd17438   40 GLIVYLGMMAGAFIW---GGLADKLGRKRCLIISlainASFAFLSSFVQGYG----AFLFCRLISGFGIGGSLPIVFAYF 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 122 SETAPSEIRG-LLNTFPQFCGSGGMFLS---------YCLVFGMSLQ-ESPSWRLMLGVLSIPSIAYfVLAAFFLPESPR 190
Cdd:cd17438  113 SEFLAREKRGeHLSWLCMFWMIGGLYASamawsiiphYGWGFSMGTNyHFHSWRVFVIICALPCIAS-IIALKFMPESPR 191
                        170
                 ....*....|....*...
gi 334185889 191 WLVSKGRMDEARQVLQRL 208
Cdd:cd17438  192 FLLEMGKHDEAWMILKNI 209
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
46-208 4.89e-15

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 78.42  E-value: 4.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRR-SMLILSSV---LYFLSSIVMFWSpnvyVLLFARLLDGFGIGLAVTLVPIYI 121
Cdd:cd17440   37 GWLGSIVYLGMMVGAFFWGGLADKVGRRqSLLICMSVngfFAFLSSFVQGYG----LFLFCRLLSGFGIGGAVPTVFSYF 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 122 SETAPSEIRG-LLNTFPQFCGSGGMFLS---------YCLVFGM-SLQESPSWRLMLGVLSIPSIAYfVLAAFFLPESPR 190
Cdd:cd17440  113 AEVLAREKRGeHLSWLCMFWMIGGIYASamawaiiphYGWSFSMgSAYQFHSWRVFVIVCALPCVSS-VVALTFMPESPR 191
                        170
                 ....*....|....*...
gi 334185889 191 WLVSKGRMDEARQVLQRL 208
Cdd:cd17440  192 FLLEVGKHDEAWMILKQI 209
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
66-217 8.22e-15

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 77.18  E-value: 8.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  66 VSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGM 145
Cdd:cd17434   64 LNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGS 143
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334185889 146 FLSYclVFGMSLqespSWRLMLGVLSIPSIAYFVLAAfFLPESPRWLVSKGRMDEARQVLQRLRGRE-DVSGE 217
Cdd:cd17434  144 LALY--ALGLLL----PWRWLAVAGEVPVVIMILLLC-FMPNSPRFLISKGKDEKALKALAWLRGPNtDYMTE 209
2_A_01_02 TIGR00880
Multidrug resistance protein;
46-188 2.09e-14

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 70.76  E-value: 2.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334185889  126 PSEIRGLLNTFPQFCGSGGMFLSycLVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFLPES 188
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLG--PPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
46-208 2.17e-13

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 73.14  E-value: 2.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSL-IGATLIttfsGPVSDKVGRRSMLILS----SVLYFLSSIVMFWSpnvyVLLFARLLDGFGIGLAVTLVPIY 120
Cdd:cd17439   40 GLIVYLGMmVGAFLW----GGLADRIGRRQCLLISlsvnSVFAFFSSFVQGYG----TFLFCRLLSGVGIGGSIPIVFSY 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 121 ISETAPSEIRG-LLNTFPQFCGSGGMF---LSYCLV--FGMSLQ-----ESPSWRLMLGVLSIPSIAYfVLAAFFLPESP 189
Cdd:cd17439  112 FSEFLAQEKRGeHLSWLCMFWMIGGIYasaMAWAIIphYGWSFQmgsayQFHSWRVFVLVCAFPSVFA-IGALTTMPESP 190
                        170
                 ....*....|....*....
gi 334185889 190 RWLVSKGRMDEARQVLQRL 208
Cdd:cd17439  191 RFFLENGKHDEAWMVLKQV 209
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-187 2.53e-13

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 72.19  E-value: 2.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   1 MRSVVLVALAAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEpkIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSS 80
Cdd:COG0738    3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDA--QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  81 VLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFpQFCGSGGMFLSYCLVFGM-SLQE 159
Cdd:COG0738   81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLL-HAFFSLGALLGPLLGGLLiLLGL 159
                        170       180
                 ....*....|....*....|....*....
gi 334185889 160 SPSWRLMLGVLSIPSIAYFVLAAFF-LPE 187
Cdd:COG0738  160 SLSWHLPYLILAVLLLLLALLFLRSkLPE 188
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
15-181 3.52e-13

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 71.46  E-value: 3.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  15 NMLQGWDnATIAGAVI-YIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWS 93
Cdd:cd17365    8 IVLDGFD-LAVMGFVApALAQDWGLS--PAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  94 PNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFpQFCG--SGGMFLSYclvFGMSLQESPSWRLMLGVLS 171
Cdd:cd17365   85 QSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTL-MFCGypLGAALGGF---LAAALIPAFGWRSVFLLGG 160
                        170
                 ....*....|
gi 334185889 172 IPSIAYFVLA 181
Cdd:cd17365  161 VPPLILLPLL 170
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
4-190 1.39e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 69.90  E-value: 1.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   4 VVLVALAAAIGNMLQGWDNATIAG-AVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRS--MLILSS 80
Cdd:COG2271  178 ALLRFWLLALAYFLVYFALYGFLTwLPTYLVEVRGLS--LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGL 255
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  81 VLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYcLVFGMsLQES 160
Cdd:COG2271  256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP-LLVGY-LLDA 333
                        170       180       190
                 ....*....|....*....|....*....|
gi 334185889 161 PSWRLMLGVLSIPSIAYFVLAAFFLPESPR 190
Cdd:COG2271  334 TGYQAAFLLLAALALLAALLALLLLRETRK 363
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-148 3.35e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.46  E-value: 3.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   2 RSVVLVALAAAIGNMLQGwdnATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSV 81
Cdd:COG2814  207 PRLLLLLLLAFLLGFGFF---ALFTYLPLYLQEVLGLS--ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLL 281
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334185889  82 LYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLS 148
Cdd:COG2814  282 LLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
6-198 9.19e-12

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 67.52  E-value: 9.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   6 LVALAAAIGNMLQGWDNATIAGAVIYIKKEFHL---EKEpkiegLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVL 82
Cdd:cd17436    1 LTATVSLLGGLTFGYELGIISGALLQLQTDFSLscfEQE-----ALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLV 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  83 YFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGMSlQESPS 162
Cdd:cd17436   76 LLAGSLILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFS-NVLTG 154
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 334185889 163 WRLMLGVLSIPSIAYFvLAAFFLPESPRWLVSKGRM 198
Cdd:cd17436  155 WRYMFGLAIIPAAIQF-ASILLLPKKPEVLNIKDNM 189
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
46-190 3.47e-11

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 65.65  E-value: 3.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334185889 126 PSEIRGLLNTFPQFCGSGGMFLSycLVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFLPESPR 190
Cdd:cd17324  117 PPEKRGRAIGLVFSGLTLGLVLG--RPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP 179
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
52-184 4.49e-11

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 65.07  E-value: 4.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  52 SLIGATLITTFSgpvSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRG 131
Cdd:cd17378   46 CLIGSGVLGHLA---DSSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRG 122
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 334185889 132 LLNTFPQFCGSGG-MFLSyclvfGMSLQESPSWRLMLGVLSIPSIAYFVLAAFF 184
Cdd:cd17378  123 QVGMSTFFFFVLGfMSLP-----GIAYLNGSSWRVLYFWTSIPALIYCILVYLF 171
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
46-190 8.38e-11

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 64.51  E-value: 8.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:COG2807   56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF 135
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334185889 126 PSEIrGLLNTFPQFCGSGGMFLSycLVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFLPESPR 190
Cdd:COG2807  136 PDRV-GLMTGLYTAAMGLGAALA--AGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPA 197
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
47-194 1.53e-10

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 63.68  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  47 LIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYiSETAP 126
Cdd:cd17441   38 LLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTLY-AEFLP 116
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334185889 127 SEIRG----LLNTFPQFcgsGGMFLSYCLVFGMslqESPSWRLMLGVLSIPsIAYFVLAAFFLPESPRWLVS 194
Cdd:cd17441  117 MKSRAkcilLIEVFWAL---GTVFEVLLAVFVM---PTLGWRWLLILSALP-LLIFAVLCFWLPESARYWTT 181
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
510-703 1.73e-10

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 63.39  E-value: 1.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 510 RALMVGVGLQILQQFAGINGVMYYTPQILEetgvssllTNLGISAESASLlISALTTLLMLPCILVSMRLMDVTGRRSLM 589
Cdd:cd17316  176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQ--------TVLGLSPATSSL-YLLLISLGALVGALIAGLLSDRIGRKKTL 246
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 590 LSTIPILILSLVTLvigsLVNLGGSINALIstaSVTVYLSCFVMGFGAIPNILCSEIFPTSVR----GLCITICALTFwi 665
Cdd:cd17316  247 VIGLILSGILALPL----FYLLSGSPTLLL---LLLFILSFFVGGVWGALYAYLAELFPTEVRatgvGLSYNLGRLGG-- 317
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 334185889 666 cdIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYL 703
Cdd:cd17316  318 --GGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
46-197 3.89e-10

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 62.32  E-value: 3.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:cd17371   37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYV 116
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334185889 126 PSEIRGLLNTFPQFCGSGGMFL---SYCLVFGMSLQESpSWRLMLGVLSIPSIAYFVLaAFFLPESPRWLVSKGR 197
Cdd:cd17371  117 PARHRGKALGYVQSGWAVGWLLatlLAALLFPLLPPEI-AWRVLFLLGALPALLVLFI-RRFVKEPPQWQAARAA 189
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
2-184 7.60e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 61.48  E-value: 7.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   2 RSVVLVALAAAIGNMLQGwdnATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSV 81
Cdd:cd06173  208 PLLRLLLLALALFALLGG---ALTVLLPLLAKEVLGGG--AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGAL 282
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  82 LYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSycLVFGMSLQESP 161
Cdd:cd06173  283 LLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLG--ALLAGLLADAL 360
                        170       180
                 ....*....|....*....|...
gi 334185889 162 SWRLMLGVLSIPSIAYFVLAAFF 184
Cdd:cd06173  361 GLSAVFLLAGALLLLAALLLLLL 383
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
62-209 2.36e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 59.90  E-value: 2.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  62 FSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYI----SETAPSEIRGLLNtfp 137
Cdd:cd17320   53 LYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVrdlySGAELAKIFSLLM--- 129
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334185889 138 qfcgsGGMFLSYCL--VFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFLPESprwLVSKGRMDEARQVLQRLR 209
Cdd:cd17320  130 -----MILAIAPALapLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPET---LPEEKRKPLLSSLLRAYK 195
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
4-187 2.62e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 59.90  E-value: 2.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   4 VVLVALAAAIGnmlqGWDNATIAGAVIYIKKEFHLEKEPKIegLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLY 83
Cdd:cd17323    1 VFIISFLTFVV----TFGSSIYSPALPQIAEDFHVSEEVAN--LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIF 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  84 FLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSycLVFGMSLQESPSW 163
Cdd:cd17323   75 VIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALG--PIIGGFITQSLGW 152
                        170       180
                 ....*....|....*....|....
gi 334185889 164 RLMLGVLSIPSIAYFVLAAFFLPE 187
Cdd:cd17323  153 RWIFWFLAIISGFCLILIFLFLPI 176
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-211 2.85e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 59.92  E-value: 2.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   1 MRSVVLVALAAAIGNMLQGwdnatiAGAVIYIKkeFHLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSS 80
Cdd:COG2211  230 FLLLLLAYLLFFLALALVA------ALLLYYFK--YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  81 VLYFLSSIVMFWSP--NVYVLLFARLLDGFGIGLAVTLVPIYISETAPSE--------------IRGLLNTFPQFCGS-- 142
Cdd:COG2211  302 LLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrreglyfgIFTFAIKLGQALAGal 381
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 143 GGMFLSYC-LVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFLpespRWLVSKGRMDEARQVLQRLRGR 211
Cdd:COG2211  382 AGLLLALFgYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLL----FYPLTRERHAEIRAELAARRAA 447
PRK03893 PRK03893
putative sialic acid transporter; Provisional
10-137 3.90e-09

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 59.71  E-value: 3.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  10 AAAIGNMLQGWDNATIAGAVIYIKKEFHLekepkieGLIVAMSLIGATLITTFSG-----PVSDKVGRRSMLILSSVLYF 84
Cdd:PRK03893  24 AAWLGYLLDGFDFVLITLVLTEVQGEFGL-------TTVQAASLISAAFISRWFGglllgAMGDRYGRRLAMVISIVLFS 96
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334185889  85 LSSIVMFWSPNVYVLLFARLLDGFGI----GLAVTlvpiYISETAPSEIRG-----LLNTFP 137
Cdd:PRK03893  97 VGTLACGFAPGYWTLFIARLVIGMGMageyGSSAT----YVIESWPKHLRNkasgfLISGFS 154
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
46-131 4.11e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 59.14  E-value: 4.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:cd17489   34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113

                 ....*.
gi 334185889 126 PSEIRG 131
Cdd:cd17489  114 PPSRRG 119
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
45-186 6.54e-09

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 58.31  E-value: 6.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  45 EGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYiSET 124
Cdd:cd17372   36 VALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASWY-LEF 114
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334185889 125 APSEIRG-LLNTFPQFCGSGGMFLSYCLVFGMSlqeSPSWRLMLGVLSIPSIaYFVLAAFFLP 186
Cdd:cd17372  115 LPAKSRGtWMVLFSVFWTVGTIFEASLAWLVMP---RLGWRWLLAFSSVPSS-LLLVFYRWTP 173
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
524-709 7.33e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 58.34  E-value: 7.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 524 FAGINGVMYYTPQILEETgvsslltnLGISAESASLLISALTtLLMLPCILVSMRLMDVTGRRSlmlsTIPILILSLVTL 603
Cdd:COG2271  193 YFALYGFLTWLPTYLVEV--------RGLSLAQAGLLLSLPF-LAGIVGSLLGGWLSDRLGRRR----KLVLAIGLLLAA 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 604 VIGSLVNLGGSINALISTASVtvyLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIGI 683
Cdd:COG2271  260 LALLLLALLPSPALAIALLFL---AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
                        170       180
                 ....*....|....*....|....*.
gi 334185889 684 AGVFGIYAIVCAVAWVFVYLKVPETK 709
Cdd:COG2271  337 QAAFLLLAALALLAALLALLLLRETR 362
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
2-222 8.20e-09

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 58.44  E-value: 8.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   2 RSVVLVALAAAIGnMLQGWDNATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSV 81
Cdd:PRK11551  12 RLALTIGLCFLVA-LLEGLDLQSAGVAAPRMAQEFGLD--VAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  82 LYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVtlvPIYI---SETAPSEIRGLLNTFpQFCGS--GGMFLSyclVFGMS 156
Cdd:PRK11551  89 LFGLFSLATAQAWDFPSLLVARLLTGVGLGGAL---PNLIaltSEAVGPRLRGTAVSL-MYCGVpfGGALAS---VIGVL 161
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334185889 157 LQESPSWRLMLGVLSIPSIAYFVLAAFFLPESPRWLVSKGRMDEARQVLQRLRGREDVSGELALLV 222
Cdd:PRK11551 162 AAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRALFGEGRATATLLLWI 227
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
2-185 1.03e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 57.97  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   2 RSVVLVALAAAIGNMLQGWDNATIAgavIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSV 81
Cdd:cd17325  199 RRLLALFLAIFVLAFAFGALEPFLP---LYAAELGGLS--PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  82 LYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRG----LLNTFpqfcGSGGMFLSyCLVFGMsL 157
Cdd:cd17325  274 LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGtamgLFNTA----FSLGMVLG-PLLGGF-L 347
                        170       180
                 ....*....|....*....|....*...
gi 334185889 158 QESPSWRLMLGVLSIPSIAYFVLAAFFL 185
Cdd:cd17325  348 YDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
53-186 1.19e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 57.21  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  53 LIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGL 132
Cdd:cd17317   35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSF 114
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 334185889 133 LNTFPQFCGSGGmflsYCLVFGMSLQeSPSWRLMLGVLSIPSIAYFVLaAFFLP 186
Cdd:cd17317  115 VGILFGLFWALG----YMLLALLAYL-IRDWRWLQLAISLPGLLFLLL-LWWLP 162
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
9-222 1.70e-08

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 57.30  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   9 LAAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEPKIEGLIVA--------MSLIGATLIttfsGPVSDKVGRRSMLILSS 80
Cdd:cd17367    2 LGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAavfavgflMRPIGGWLF----GRLADRIGRRAALTLSV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  81 VLYFLSSIVM----------FWSPnvYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYC 150
Cdd:cd17367   78 SLMAAGSLVIavtptyatigIWAP--IILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALG 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 151 LVFGMSLQESP------SWRL--MLGvlsipsiAYFVLAAFFLpesprwlvsKGRMDEARQVLQRLRGREDVSGELALLV 222
Cdd:cd17367  156 VLLVLQHTLGEdqmaawGWRIpfLLG-------GVLAVVVLWL---------RRGLEETESFEAIAESNEASAGTLRELR 219
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
46-238 2.28e-08

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 56.95  E-value: 2.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:cd17333   34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 126 PSEIRGLLNTFPQFCGSGGMFLSycLVFGMSLQESPSW---RLMLGVLSIPsIAYFVLAAFFLPESPRWLVSKGRMDEAR 202
Cdd:cd17333  114 EESSATRLNVLHGFFGLGALIGP--LIATSLLTSELSWswaYLIIGLIYLL-LAILILLTLFPELPSARNPQQSVGAFSA 190
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 334185889 203 QVLQRLRGREDVSGELALLvegLGVGKDTSIEEYVI 238
Cdd:cd17333  191 SASRLLRNPSIILGALALF---LYVGAETAFSSWVP 223
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
2-131 4.51e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 56.04  E-value: 4.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   2 RSVVLVALAAAIGNMLQGwdnATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDK-VGRRSMLILSS 80
Cdd:cd17474  198 RGLLTFLVSAFLYFFLYF---AFLTYLPFLLELLYGIS--PIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGL 272
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 334185889  81 VLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRG 131
Cdd:cd17474  273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERG 323
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
500-709 4.63e-08

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 56.15  E-value: 4.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 500 WRELKepGVKRALMVGVGLQILQQFAgingvmYYTpqilEETGVSSLLTN-LGISAESASLLISALTTLLMLPCILVSMr 578
Cdd:cd17367  215 LRELR--RHPRELLLVVGLTAGGTLA------FYT----WTTYLQKFLVNtAGFSKGDATWITTAALLVFMLLQPLGGR- 281
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 579 LMDVTGRRSLMlstIPILILSLVTLViGSLVNLGGSINALISTASVTVYLsCFVMGFGAIPNILCSEIFPTSVRGLCIti 658
Cdd:cd17367  282 LSDRIGRRPLL---LFFGIGGTLATV-PLLSALDHTDSPYTAFALVLVGL-VFLSGYTSINAVVKAELFPTHVRALGV-- 354
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 334185889 659 cALTFWICDIIVTYTLP---VMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPETK 709
Cdd:cd17367  355 -GLPYALAVAIFGGTAPyvaLWLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
9-227 4.81e-08

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 56.10  E-value: 4.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   9 LAAAIGNMLQGWDNATIAGAVIYIKKEFHlekEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSI 88
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLG---PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSI 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  89 VMFWSPNVYVLLFARLLDGFGIGLAVtLVPIYISETAPSEIRGLLN---TFPQFCGSG-GMFLSYCLVfgmsLQESPSWR 164
Cdd:cd06179   78 VAGTAKSVNMLIGGQALIGIGAGTQG-LGAAVASELVPNKYRGLVQgvvNLVASPGSAlGPLIAGALV----EANAAGWR 152
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334185889 165 lmlGVLSIPSIAYFV----LAAFFLPESPRWLVSKGRmdeaRQVLQRLrgreDVSGeLALLVEGLGV 227
Cdd:cd06179  153 ---WIFYINAIFNALalilLFFFYHPPPRPQLHGSST----RQKLKRL----DWVG-LFLLIAGLVL 207
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
42-185 5.38e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 55.66  E-value: 5.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  42 PKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYI 121
Cdd:cd17473  232 AALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWA 311
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334185889 122 SETAPSEIRGLLNTFPQFCGSGGMFLSyCLVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFL 185
Cdd:cd17473  312 MSLVPPELRGRAMGIVTSAFFLGQFLS-PLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
509-700 5.83e-08

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 55.61  E-value: 5.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 509 KRALMVGVGLQILQqfaginGVMYYTPQILeetGVSSLLTNLGISAeSASLLISALTTLLMLPCILVSMRLMDVTGRRSL 588
Cdd:cd17369  227 WRALLLAIGLRLAE------NVLFYLFTTF---ALSYATQTLGVDR-STVLLAVLIASVVAAITIPLFGWLSDRVGRRPV 296
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 589 MLSTIPILILSLVTLVigSLVNLGGsiNALISTASVTVYLSCFVMGFGAIPnILCSEIFPTSVR--GLciticALTFWIC 666
Cdd:cd17369  297 YLAGALLAALFAFPFF--WLLDTGS--TWLIVLAAVVVLGVLHGMMYGPQA-AFLAELFPTRVRytGA-----SLGYQLG 366
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 334185889 667 DIIVTYTLPVMLKSI--------GIAGVFGIYAIVCAVAWVF 700
Cdd:cd17369  367 AILGGGFAPLIATALvaatgswwPVALYLAALAVISLVAALF 408
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
7-190 6.02e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 55.70  E-value: 6.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   7 VALAAAIgNMLQGWDNATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLS 86
Cdd:cd17328    1 VAVLFLI-NLLNYMDRFTIAGVLPDIQSDFLID--DSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  87 SIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYcLVFGMSLQESPSWRLM 166
Cdd:cd17328   78 TLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGY-VVGGLVAQATGGWRWA 156
                        170       180
                 ....*....|....*....|....
gi 334185889 167 LGVLSIPSIAYFVLAAFFLPESPR 190
Cdd:cd17328  157 FRVTGVLGVLLAILLLLFVREPPR 180
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
532-708 6.35e-08

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 55.36  E-value: 6.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 532 YYTPQILEETGVSSLLTNLGISAESASLLISALTTLLM----LPCILVSMRLMDVTGRRSLMLSTIPILILSLVTLViGS 607
Cdd:cd17364  212 FYGQNLFQSTIISAIGFSKTMNAYQELFNIAVGQLIIAlagtVPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILA-GP 290
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 608 LVNLGGSINALISTASVTVYLSCFvmGFGAIPNILCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVF 687
Cdd:cd17364  291 YDHWKISTIGFFVLYGLTFFFSNF--GPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVL 368
                        170       180
                 ....*....|....*....|.
gi 334185889 688 GIYAIVCAVAWVFVYLKVPET 708
Cdd:cd17364  369 IILAGVALLGIILTLLFPEEK 389
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
25-190 9.19e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.89  E-value: 9.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  25 IAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSP-NVYVLLFAR 103
Cdd:COG2223  225 SSWLPPYLVDQFGLS--AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLF 302
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 104 LLDGFGIGLAVTLVPIYISETAPSEIR----GLLNTfpqFCGSGGMFLSycLVFGMSLQESPSWRLMLGVLSIPSIAYFV 179
Cdd:COG2223  303 LLLGLALGGGNGAVFALVPDIFPTKNAgavyGLVGA---AGGLGGFLGP--LLFGALLDATGSYTAAFLVFAVLALVALV 377
                        170
                 ....*....|.
gi 334185889 180 LAAFFLPESPR 190
Cdd:COG2223  378 LTLLLYRRPRR 388
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
46-183 1.06e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 54.53  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFW--SPNVYVLLFARLLDGFGIGLAVTLVPIYISE 123
Cdd:cd17316  216 SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYllSGSPTLLLLLLFILSFFVGGVWGALYAYLAE 295
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185889 124 TAPSEIRGLLNTFPQFCGS-GGMFLSYclVFGMSLQESPSWrLMLGVLSIPSIAYFVLAAF 183
Cdd:cd17316  296 LFPTEVRATGVGLSYNLGRlGGGGAPP--LIALLLASTGGT-GVPALILALLAIVALIVAL 353
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
23-190 1.14e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 54.50  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  23 ATIAGAVIYIKKEFHLEKEPKIeGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFA 102
Cdd:cd17473   16 AAIAPALPAIAQHFVPNSELLV-PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLAS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 103 RLLDGFGIGL----AVTLVPIYISETAPSEIRGLLNTFPQFcgsGGMFLsycLVFGMSLQESpSWRLMLGVLSIpSIAYF 178
Cdd:cd17473   95 RALLGIGVAGimtlATALIGDYFEGEERAKMLGLQSAAMSL---GGVVF---LLLGGALAEI-GWRAPFLVYLL-ALPVL 166
                        170
                 ....*....|..
gi 334185889 179 VLAAFFLPESPR 190
Cdd:cd17473  167 ILVLLFLPEPAR 178
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
543-709 2.02e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 53.82  E-value: 2.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 543 VSSLLTNLGISAESASLLISAlTTLLMLPCILVSMRLMDVTGRRslmlstiPILILSLVTLVIGSLVnlggsinALISTA 622
Cdd:COG2814   33 LPLIAADLGASPAQAGLVVTA-YLLGAALGAPLAGRLADRFGRR-------RVLLLGLLLFALGSLL-------CALAPS 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 623 SVTVYLSCFVMGFGA-----IPNILCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVA 697
Cdd:COG2814   98 LWLLLAARFLQGLGAgalfpAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLA 177
                        170
                 ....*....|..
gi 334185889 698 WVFVYLKVPETK 709
Cdd:COG2814  178 LLLLLRLLPESR 189
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
7-189 3.10e-07

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 53.30  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   7 VALAAAIGNMLQGWDNATIA-GAVIYIKKEFHLEKEPKIeGLIVAMSLIGATLI-----TTFSGPVSDKVGRRSMLILSS 80
Cdd:cd17369    3 VALASLVGTAIEWYDFFIYGtAAALVFNKLFFPAVDPAA-GTLAAFATFGVGFLarplgGVVFGHFGDRIGRKKTLVLTL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  81 VLYFLSSIVM----------FWSPNVYVLLfaRLLDGFGIGL----AVTLVpiyiSETAPSEIRGLLNTFPQFCGSGGMF 146
Cdd:cd17369   82 LLMGIATFLIgllptyaqigILAPILLVLL--RLLQGLALGGewggAVLMA----VEHAPPKRRGFYGSFPQLGAPVGLL 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 334185889 147 LSYCLVFGMSLQESPS------WRlmlgvlsIPSIAYFVLAAFFL------PESP 189
Cdd:cd17369  156 LATGVFLLLSALLSDEaflswgWR-------IPFLLSAVLVAVGLyirlrlEETP 203
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
50-180 3.12e-07

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 53.06  E-value: 3.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  50 AMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGI-GLAVTLVPIyISETAPSE 128
Cdd:cd17374   42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVsGISINTLIL-GTEWTTPR 120
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 334185889 129 IRGLLNTFPQFCGSGGMFLSYCLVFGMslqesPSWRLMLGVLSIPSIAYFVL 180
Cdd:cd17374  121 HRALAITLTSCFFSIGQMLLAGLAYAI-----RDWRLLQLVVSVPFFLFFLY 167
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
31-130 3.13e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 52.97  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  31 YIKKEFHLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGI 110
Cdd:cd17330   22 YVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTG 101
                         90       100
                 ....*....|....*....|
gi 334185889 111 GlAVTLVPIYISETAPSEIR 130
Cdd:cd17330  102 G-NVSVAQAYIADITDEEER 120
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
46-175 3.28e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 52.95  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:cd17477   34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALA 113
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 334185889 126 PSEIRGLLNTFPQFCGSGGMFLSYcLVFGMSLQESPSWRLMLGVLSIPSI 175
Cdd:cd17477  114 TNENRGRVLGLYSTVLGLGFALGP-LLLALVGTAGALPFLIAAVLLLLAL 162
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
9-177 9.67e-07

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 51.61  E-value: 9.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   9 LAAAIGNMLQGWDNATIAGAVIYIKKEFhLEKEPKIEGLIVAMSLIGATLITTFSGPV-----SDKVGRRSMLILSSVLY 83
Cdd:cd17368    2 LAATSGNALEFFDFGVYGFFAVYIGRLF-FPSGSEFASLLLTFATFGVGFFMRPIGAIvlgayADRIGRKPAMTLTLAIM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  84 FLSSIVM----------FWSPnvYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQF------CGSGGMFL 147
Cdd:cd17368   81 ALGTLLIalaptyatigIAAP--LLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSAsqqvaiVAGALVGY 158
                        170       180       190
                 ....*....|....*....|....*....|..
gi 334185889 148 SYCLVFGMSLQESPSWR--LMLGVLSIPSIAY 177
Cdd:cd17368  159 LLSLTLTAEALAEWGWRipFFIGLLIIPLGLW 190
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
4-190 1.10e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 51.42  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   4 VVLVALAAAIGNMLQGwdnaTIAGAVIYIKKEFHLEkEPKIEGLIVAMSLIGAtLITTFSGPVSDKVGRRSMLILSSVLY 83
Cdd:cd17474    1 LYAVFFATLLAVLGVS----IVDPILPAIAEALGAS-PAQVGLLITAFTLPAA-VLMPVAGVLADRFGRKKVLLPGLLLF 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  84 FLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGllntfpQFCGSGGMFLSyclvFGMSLqeSP-- 161
Cdd:cd17474   75 GIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERA------KAMGLYEAALG----LGIAV--GPll 142
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 334185889 162 -------SWRLMLGVLSIPSIAYFVLAAFFLPESPR 190
Cdd:cd17474  143 ggllaaiSWRYPFFLLAALIPVAFLAILFLLPEPKE 178
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
46-181 1.34e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 51.27  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKV-GRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISET 124
Cdd:cd06174  242 GLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 334185889 125 APSEIRGLLNTFPQFCGSGGMFLSYcLVFGMSLQESPSWRLMLGVLSIPSIAYFVLA 181
Cdd:cd06174  322 FPPEIRGTAFGLLNTFGFLGGAIGP-LLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
53-188 1.59e-06

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 50.85  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   53 LIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSE---- 128
Cdd:TIGR00710  50 LLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEelsr 129
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334185889  129 ---IRGLLNTFPQFCGSggMFLSYCLVFGmslqespSWRLMLGVLSIPSIAYFVLAAFFLPES 188
Cdd:TIGR00710 130 iysILMPVLALAPAVAP--LLGGYILVWL-------SWHAIFAFLSLAGILLSALIFFILPET 183
MFS_1 pfam07690
Major Facilitator Superfamily;
46-148 1.90e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 50.49  E-value: 1.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSP---NVYVLLFARLLDGFGIGLAVTLVPIYIS 122
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSltlSSLWLLLALLLLGFGFGLVFPALNALVS 317
                          90       100
                  ....*....|....*....|....*.
gi 334185889  123 ETAPSEIRGLLNTFPQFCGSGGMFLS 148
Cdd:pfam07690 318 DLAPKEERGTASGLYNTAGSLGGALG 343
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
10-165 1.99e-06

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 50.82  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  10 AAAIGNMLQGWDNATIAGAVIYIKKEFHLEKEPKIEGLIVAMSLIGATLIT----TFSGPVSDKVGRRSMLILSSVLYFL 85
Cdd:cd17366    3 AAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRplggLVFGPLGDKYGRQKVLAITIILMAA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  86 SSIVM----------FWSPnvYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGM 155
Cdd:cd17366   83 STFCIgllptyatigVWAP--ILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLL 160
                        170
                 ....*....|....*.
gi 334185889 156 SLQESPS------WRL 165
Cdd:cd17366  161 TLLLTEAqmldwgWRI 176
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
46-184 2.32e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 50.64  E-value: 2.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVG-RRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLdGFGIGLAVTLVPIYISET 124
Cdd:COG2807  253 GLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL-GLGQGGLFPLALTLIGLR 331
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185889 125 APS-EIRGLLNTFPQFCGSGGMFLSyCLVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFF 184
Cdd:COG2807  332 ARTpAEAAALSGMAQSVGYLLAALG-PLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
MFS_MFSD5_like cd17487
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ...
55-109 3.29e-06

Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341040  Cd Length: 385  Bit Score: 49.91  E-value: 3.29e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 334185889  55 GATLI-TTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFwSPNVYVLLFARLLDGFG 109
Cdd:cd17487   49 GSSVVfGTFVGSLADKFGRKRACLLFCVLYSLSCLTKH-SPNFGVLLLGRVLGGIS 103
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
2-130 6.13e-06

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 49.06  E-value: 6.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   2 RSVVLVALAAAIGNMLQgwdNATIAGAVIYIKKEFHLEKEPKIEGLIVAmsLIGATLITTFSGPVSDKVGRRSMLILSSV 81
Cdd:cd17369  228 RALLLAIGLRLAENVLF---YLFTTFALSYATQTLGVDRSTVLLAVLIA--SVVAAITIPLFGWLSDRVGRRPVYLAGAL 302
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 334185889  82 LYFLSSIVMFW----SPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIR 130
Cdd:cd17369  303 LAALFAFPFFWlldtGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVR 355
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
53-185 7.01e-06

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 48.95  E-value: 7.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  53 LIGATLIttfsGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGL 132
Cdd:cd17446   47 LVGAIVF----GGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAV 122
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 334185889 133 LNTFPQFCGSGGMFLSYCLVFGMslqesPSWRLMLGVLSIPSIAYFVLAAFFL 185
Cdd:cd17446  123 VGTLLGYCYTLGQLILAGVAYAI-----RDWRWLQLAVSLPFFIFFLYSWWFP 170
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
21-186 9.74e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 48.34  E-value: 9.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  21 DNATIAGAVIYIKKEFHLEKEPKieGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLL 100
Cdd:cd17319   18 DRVNISVAAPTIMKDLGLSPTQY--GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLY 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 101 FARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTFpQFCGS--GGMFLSYCLVFgmsLQESPSWRLMLGVLSIPSIAYF 178
Cdd:cd17319   96 VLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGL-FNSGAplGAAIGPPLSGW---LLLLFGWRWAFIIEGLLGLLLA 171

                 ....*...
gi 334185889 179 VLAAFFLP 186
Cdd:cd17319  172 VLWWFYLR 179
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
47-131 9.86e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 48.31  E-value: 9.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  47 LIVAMSLIGAtLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAP 126
Cdd:cd17370  239 LYALFNLVYA-LAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVP 317

                 ....*
gi 334185889 127 SEIRG 131
Cdd:cd17370  318 AELRG 322
MFS_1 pfam07690
Major Facilitator Superfamily;
546-709 1.01e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.18  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  546 LLTNLGISAESASLLISAlTTLLMLPCILVSMRLMDVTGRRslmlstiPILILSLVTLVIGSLVnlggsinALISTASVT 625
Cdd:pfam07690  23 LAEDLGISPTEIGLLLTL-FSLGYALAQPLAGRLSDRFGRR-------RVLLIGLLLFALGLLL-------LLFASSLWL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  626 VYLSCFVMGFG-----AIPNILCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVF 700
Cdd:pfam07690  88 LLVLRVLQGLGagalfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL 167

                  ....*....
gi 334185889  701 VYLKVPETK 709
Cdd:pfam07690 168 LLLPRPPPE 176
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
46-112 2.43e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.19  E-value: 2.43e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGL 112
Cdd:cd17504   34 SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAV 100
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
444-652 2.84e-05

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 46.97  E-value: 2.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 444 PFSRRGSLLSFHPEGdghdQVNGYVQAAALVSQASMMpggKGETAMLPKevkdgpGWR-------ELKEPGV--KRALMV 514
Cdd:cd17366  131 PDRKRGFLGSWLEFG----TLAGFILGAGLVTLLTLL---LTEAQMLDW------GWRipfliaaPLGLVGLylRRPLLI 197
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 515 GVGLQILQQFAGINgVMYYTPQILEETgvsslltnLGISAESASLLISaLTTLLMLPCILVSMRLMDVTGRRSLML-STI 593
Cdd:cd17366  198 CIGLVLVFNVTNYM-LLSYMPSYLEET--------LGYSETHGLLVII-IIMVTMLVLQPFLGRLSDRVGRKPVYAaGLA 267
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 334185889 594 PILILSLVTLvigSLVNLGGSINALISTASVTVYLSCFVmgfGAIPNILcSEIFPTSVR 652
Cdd:cd17366  268 GLLVLAVPAF---LLMNSGSIAAIFIGLLVLGLLLSCYT---ATMASTL-PALFPTHVR 319
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
48-185 3.88e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.40  E-value: 3.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  48 IVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPS 127
Cdd:cd17321   36 VVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPG 115
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 334185889 128 EIRGL-LNTFPQFCGSGGMFlsyCLVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFL 185
Cdd:cd17321  116 ERRGRaLGLWGAVVGIGAAL---GPLLGGLLLELFGWRWIFLINVPIGLVALLLARTFS 171
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
9-173 4.30e-05

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 46.50  E-value: 4.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   9 LAAAIGNMLQGWDNATIaGAVIYIKKEFHLEKE----PKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSM-------LI 77
Cdd:cd17364    2 IIAGMGFFTDAYDLFSI-SLVTKILGRLYYGGKgslpSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVygveliiMI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  78 LSSVLYFLSsiVMFWSPNVYVLLFA-RLLDGFGIGLAVTLVPIYISETAPSEIRG-LLNTFPQFCGSGGMF-----LSYC 150
Cdd:cd17364   81 IGTILSALS--PGSTPLGVMGWLIFfRFLLGIGIGGDYPLSATIMSEYANKKRRGaLIAAVFAMQGFGILAgaivtLILS 158
                        170       180
                 ....*....|....*....|....*....
gi 334185889 151 LVFGMSLQESPS------WRLMLGVLSIP 173
Cdd:cd17364  159 AIFEHPLPAGTYhhadlvWRIVLGLGAIP 187
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
53-186 5.72e-05

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 45.80  E-value: 5.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  53 LIGATLIttfsGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGL 132
Cdd:cd17379   47 LIGSIVI----GYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRT 122
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 334185889 133 LNTFPQFCGSGGMFLSYCLVFGMslqesPSWRLMLGVLSIPSIaYFVLAAFFLP 186
Cdd:cd17379  123 VGIVYQMFFTLGLLILPGIAYFI-----PHWRWLQLAVTLPNF-LFLLYYWFIP 170
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
31-187 6.47e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 45.76  E-value: 6.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  31 YIKKEFHLEKEPKieGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVY-VLLFARLLDGFG 109
Cdd:cd17371  235 YLTGERGLSFEGS--AGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPtLILILGFPLGFF 312
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334185889 110 IGLAVTLVPIYISETAPSEIRGllnTFPQFCGSGGMFLSYCLVFGM-SLQESPSWRLMLGVLSIPSIAYFVLAAFFLPE 187
Cdd:cd17371  313 ASGPFSGMGAYLTELFPTAVRA---TAQGFCYNVGRIIGALFPFLVgFLATSGSLGTAIAVFAAVYYIAGLVLALLLPE 388
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
46-190 9.15e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.66  E-value: 9.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVG-----RRSMLILSSVLYFLSSIVMFWSPN-------VYVLLFARLldgFGIGLA 113
Cdd:COG2211   49 GLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDlsptgklIYALVTYLL---LGLAYT 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 114 VTLVPIY--ISE-TAPSEIRGLLNTFPQFCGSGGMFLSYCLVFGM----SLQESPSWRLMLGVLSIPSIAYFVLAAFFLP 186
Cdd:COG2211  126 LVNIPYSalGAElTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLvaafGGDAALGYRLTALIFAVLGLLAFLLTFFGTK 205

                 ....
gi 334185889 187 ESPR 190
Cdd:COG2211  206 ERPV 209
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
64-190 9.36e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 45.28  E-value: 9.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  64 GPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGiglAVTLVPI-YISETAPSEIRGLLNTfpqFCG- 141
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG---AISSVVMaLLADLTREENRTKAMA---LIGa 126
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 334185889 142 SGGMFLSYCLVFGMSLQES---PSWRLMLGVLSIPSIAYfvlAAFFLPESPR 190
Cdd:cd17472  127 SIGIAFAISMVLGPLLAAHlgvSGLFLITAILSLVSLLI---LLFFVPDPPK 175
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
564-697 9.54e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 45.26  E-value: 9.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 564 LTTLLM----LPCILVSMRLMDVTGRRslmlstiPILILSLVTLVIGSLVNlggsinALISTASVTVYLSCFVMGFGAIP 639
Cdd:cd17317  195 LNFFLSglveIPAYFLALLLLDRLGRR-------WTLSGSLLLAGLACLVT------ALLPDDENTLALTLALVGKFAIS 261
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334185889 640 ------NILCSEIFPTSVRGLCITICALTFWICDIIVTYTlpVMLKSIGIAG---VFGIYAIVCAVA 697
Cdd:cd17317  262 aafsviYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFI--VLLGKIGPLLpliIFGVLALLGGLL 326
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
64-110 1.16e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 45.27  E-value: 1.16e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 334185889  64 GPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGI 110
Cdd:PRK11043  62 GPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGV 108
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
46-190 1.31e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 44.84  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILS-SVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISET 124
Cdd:cd17370   37 GLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILgYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADA 116
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 125 APSEIR----GLLNTFPQFcgsgGMFLSYCLVFGMSLQESPSWRLMLGVLSIPSIAYFVLAAFFLPESPR 190
Cdd:cd17370  117 TPPSGRgkafGLHRALDTL----GAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVVKEYPR 182
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
46-210 3.04e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 43.70  E-value: 3.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:cd17478   34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAA 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 126 PSEiRGLLNTFPQFCGSGGMFLSYCL-VFGMSLQESPSWrlmLGVLSIPSIAYFVLAAFFLPESPRWLVSKGRMDEARQV 204
Cdd:cd17478  114 GGR-RGLAMSIFSVGGNLGFALGPLIaAALVALFGGLGL---LILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARST 189

                 ....*.
gi 334185889 205 LQRLRG 210
Cdd:cd17478  190 LKGVWR 195
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
7-132 3.18e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.72  E-value: 3.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   7 VALAAAIGNMlqgwdNATIAG-AVIYIKKEFHLEKEpKIEGLIVAMSLIGATLITtFSGPVSDKVGRRSMLILSSVLYFL 85
Cdd:cd17503    1 LLLGAFMAIL-----DTTIVNvALPTIMGDLGASLD-TVQWVITSYLLALAIMIP-LSGWLADRFGTRRLFLTALALFTL 73
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 334185889  86 SSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGL 132
Cdd:cd17503   74 GSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGA 120
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
491-665 3.19e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.42  E-value: 3.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 491 PKEVKDGPGWRELKEPGVKRALMVGVGLQILQqFAGINGVMYYTPQILEEtgvsslltNLGISAESASLLIsALTTLLML 570
Cdd:COG2814  188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLL-GFGFFALFTYLPLYLQE--------VLGLSASAAGLLL-ALFGLGGV 257
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 571 PCILVSMRLMDVTGRRslmlstiPILILSLVTLVIGSLVnlggsinALISTASVTVYLSCFVMGFG---AIPNI--LCSE 645
Cdd:COG2814  258 LGALLAGRLADRFGRR-------RLLLIGLLLLALGLLL-------LALAGSLWLLLLALFLLGFGfglLFPLLqaLVAE 323
                        170       180
                 ....*....|....*....|
gi 334185889 646 IFPTSVRGLCITICALTFWI 665
Cdd:COG2814  324 LAPPEARGRASGLYNSAFFL 343
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
47-170 3.44e-04

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 43.52  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  47 LIVAMSLIGATLIttfSGPVSDKVGRRSMLILSSVLYFLSSIVMFW----SPNVYVLLFARLLDGFGIGLAVTLVPIYIS 122
Cdd:cd17368  265 LLAGVANFIWAPL---GGALSDRIGRRPVLLVITLAALVTLYPVFAwltaAPSFGRLLLVLLVLSFFFGMYGGAMVVALV 341
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 334185889 123 ETAPSEIR----GLLNTFPQ--FCGSGGMFLSYCLVFGMSLQeSPSWRLMLGVL 170
Cdd:cd17368  342 ELFPVRVRstgfSLVYALAVaiFGGFAQFIVTWLIELTGSPL-APAWYLMGAAL 394
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
550-708 4.42e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 4.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 550 LGISAESASLLISALTTLLMLPCILVSMrLMDVTGRR-----SLMLSTIPILILSLVT-----LVIGSLVNLGGSINALI 619
Cdd:COG2223   35 FGLSAAQLGLLFAIPVLVGALLRIPLGF-LVDRFGPRrvlliGLLLLGIGLLLLALAVsywllLLLGLLLGIGGGGSFAV 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 620 STASVtvylscfvmgfgaipnilcSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWV 699
Cdd:COG2223  114 GIALV-------------------SKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAV 174

                 ....*....
gi 334185889 700 FVYLKVPET 708
Cdd:COG2223  175 LAWLFLRDP 183
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
38-136 4.86e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.98  E-value: 4.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  38 LEKEPKIEGLIvaMSLIGAtlITTFSGPV----SDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDG-FG--I 110
Cdd:cd17390   26 LGASPTVIGLI--GSVYGA--LQLFSSPLvgswSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGiFKhtQ 101
                         90       100
                 ....*....|....*....|....*.
gi 334185889 111 GLAVTLVPIYISETAPSEIRGLLNTF 136
Cdd:cd17390  102 SLCKAYLSDLVSEQERSRVLGRFNAA 127
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
62-186 6.53e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 42.57  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  62 FSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSP---NVYVLLFArLLDGFGIGLAVTLVPIYISETAPSEIR----GLLN 134
Cdd:cd17317  210 LALLLLDRLGRRWTLSGSLLLAGLACLVTALLPddeNTLALTLA-LVGKFAISAAFSVIYLYTAELYPTVVRntgvGLCS 288
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 334185889 135 TFPQFCGSGGMFLSYCLVFGMSLQEspswrLMLGVLSIPSIayfvLAAFFLP 186
Cdd:cd17317  289 TVARVGAILAPFIVLLGKIGPLLPL-----IIFGVLALLGG----LLTLLLP 331
emrD PRK11652
multidrug transporter EmrD;
5-113 7.60e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 42.59  E-value: 7.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   5 VLVALAAAIGNMLQgwdnaTIAGAVI-YIKKEFHLEkepkiEGLIVAmsLIGATLIT-----TFSGPVSDKVGRRSMLIL 78
Cdd:PRK11652  11 FMLVLLVAVGQMAQ-----TIYVPAIaDMARDLNVR-----EGAVQA--VMAAYLLTyglsqLFYGPLSDRVGRRPVILV 78
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 334185889  79 SSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLA 113
Cdd:PRK11652  79 GMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVG 113
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
71-190 8.21e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.59  E-value: 8.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  71 GRRSMLILSSVLYFLSSIVMFWSPN-------VYVLLFARLldgFGIGLAVTLVPI--YISE-TAPSEIRGLLNTFPQFC 140
Cdd:cd17332   68 RFRPWLLWGAIPLALLFVLLFTTPDgsgtgklIYALITYIL---LDLLYTLVNIPYtaLIPElTDDPEERTSLTSWRMFF 144
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 334185889 141 GSGGMFLSYCLV------FGMSLQeSPSWRLMLGVLSIPSIAYFVLAAFFLPESPR 190
Cdd:cd17332  145 ATIGGLLVTVLPpplvayFGGGNA-SRGYFLTALIIGIIGIILLLICFFGTRERVV 199
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
50-147 8.39e-04

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 42.26  E-value: 8.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  50 AMSLIGA--TLITT-FSGPVSDKVGRRSMLILSSVLYFLSSIV------MFWSPNVYVLLFARLLDGFGIGLAVTLVPI- 119
Cdd:cd17386   34 YMNLMGSipPLFSSlFLGSWSDRYGRKPPLLMSLVGLLLSSLIlvlivyFTTVPSVWWFYLSAIPLALFGGFTAFLSASf 113
                         90       100
                 ....*....|....*....|....*....
gi 334185889 120 -YISETAPSEIRGLLNTFPQFCGSGGMFL 147
Cdd:cd17386  114 aYISDISSEKKRTYRMAILEVALGLGGFL 142
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
32-187 9.13e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 42.18  E-value: 9.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  32 IKKEFHLEKEPKIEGLIVAMSLIGATLITTFsgpVSDKVGRRSMLILSSVLYFLSSIVM---F-------------WSPN 95
Cdd:cd17358  266 IFDEAGSGLDPNTATIIIGVVQVVGTLVATL---LVDRLGRRPLLLVSAIGMGIGLLALglyFylqehgallssvsWLPL 342
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  96 VYVLLFarlLDGFGIGLaVTLVPIYISETAPSEIRGLLntfpqfcGSGGMFLSYCLVFGMS-----LQESPSWRLMLGVL 170
Cdd:cd17358  343 VGLVIY---IISFSIGL-GPLPWVIMSEIFPAKIKGLA-------GSLVTLVNWLFAFIVTktfpfLTLAWGASGTFWIF 411
                        170
                 ....*....|....*..
gi 334185889 171 SIPSIAYFVLAAFFLPE 187
Cdd:cd17358  412 AGICGLALVFVLLFVPE 428
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
12-125 9.43e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.21  E-value: 9.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  12 AIGNMLQGWDNATIAGAVIYIKKeFHLEKEPKIEGLIVAMsLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMF 91
Cdd:cd17332  227 LLAYLLYFLAFNIVNTVLVYYFK-YVLGGRAELVLLLLLI-LSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLF 304
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 334185889  92 WSP--NVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:cd17332  305 FLPpgNLVLILVLAVLAGIGYGGANLLPWAMLADVI 340
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
4-126 1.06e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 42.18  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   4 VVLVALAAAIGNM-----LQGWDNATIAGAVIYIKKEFHLEKEPKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLIL 78
Cdd:cd17504   75 SLLAAFAPNLPVLiagraLQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWT 154
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 334185889  79 SSVLYFLSSIV-------MFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAP 126
Cdd:cd17504  155 AAPVAVLLAALvplidlrLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTP 209
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
53-111 1.06e-03

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 42.23  E-value: 1.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 334185889  53 LIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIG 111
Cdd:PRK15402  58 LAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLC 116
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
42-197 1.37e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 42.02  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   42 PKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSM-------LILSSVLyflsSIVMFWSPNVYV---LLFARLLDGFGIG 111
Cdd:TIGR00887  55 SSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVygmeliiMIIATVA----SGLSPGSSPKSVmatLCFWRFWLGVGIG 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  112 LAVTLVPIYISETAPSEIRGLL-------NTFPQFcgSGGM---FLSYClvFGMSLQESPS---------------WRLM 166
Cdd:TIGR00887 131 GDYPLSAIITSEFATKKWRGAMmaavfamQGFGIL--AGAIvalIVLAG--FKHSLEAAADeasctgscvpavdymWRIL 206
                         170       180       190
                  ....*....|....*....|....*....|....
gi 334185889  167 LGVLSIPSIayfvLAAFF---LPESPRWLVSKGR 197
Cdd:TIGR00887 207 IGFGAVPAL----LALYFrltIPETPRYTADVAK 236
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
28-189 1.38e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.83  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  28 AVIYIKKEFHLEKEpkIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDG 107
Cdd:cd17329   22 MAIYLHQQLGLSAS--IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 108 FGIGLAVTLVPIYISETAPSEIRGLLNTFPQFCGSGGMFLSyCLVFGMSLQESPSWRLMLGVLSipSIAYFVLAAFFLPE 187
Cdd:cd17329  100 FGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFLAAAVL--FLLAALVLLFLLPE 176

                 ..
gi 334185889 188 SP 189
Cdd:cd17329  177 TR 178
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
13-184 1.41e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 41.40  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  13 IGNMLQGWDNATIAGAVIYIKKEFH-LEKEpkieGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMF 91
Cdd:cd17502    3 LALFLAALDQTIVATALPTIVAEFGgLSLV----SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCG 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  92 WSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLntfpqfcgSGGMFLSYCL------VFGMSLQESPSWR- 164
Cdd:cd17502   79 LAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKY--------QGYIGAVFGIasvagpLIGGAFTDHLSWRw 150
                        170       180
                 ....*....|....*....|....*
gi 334185889 165 -----LMLGVLSIPSIAYFVLAAFF 184
Cdd:cd17502  151 cfyinLPIGGLALALLRTILLSSIF 175
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
527-714 1.47e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 41.93  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  527 INGVMYYtpqileetGVSSLLTNLGISAesasLLISALTTLLMLPCILVSMRLMDVTGRR-SLMLSTIPILILSLVT-LV 604
Cdd:TIGR00898 338 TTAFSYY--------GLVLDLGNLGGNI----YLDLFISGLVELPAKLITLLLIDRLGRRyTMAASLLLAGVALLLLlFV 405
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  605 IGSLVNLggsinaliSTASVTVYLSCFVMGFGAIpNILCSEIFPTSVRGLCITICALtfwICDI--IVTytlPVMLKSIG 682
Cdd:TIGR00898 406 PVDLYFL--------RTALAVLGKFGITSAFQMV-YLYTAELYPTVVRNLGVGVCST---MARVgsIIS---PFLVYLGE 470
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 334185889  683 I-----AGVFGIYAIVCAVAWVFVylkvPETKGMPLE 714
Cdd:TIGR00898 471 KwlflpLVLFGGLALLAGILTLFL----PETKGVPLP 503
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
44-147 1.59e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 41.48  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  44 IEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISE 123
Cdd:cd17391  241 ISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK 320
                         90       100
                 ....*....|....*....|....
gi 334185889 124 TAPSEIRGLLNTFPQFCGSGGMFL 147
Cdd:cd17391  321 ITPKEVAGRIFGYNQSFQYLGNVA 344
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
46-108 2.59e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 40.71  E-value: 2.59e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGF 108
Cdd:cd17391   39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV 101
Sugar_tr pfam00083
Sugar (and other) transporter;
13-188 2.66e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 40.72  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   13 IGNMLQGWDNATIAGAVIY----IKKEFHLeKEPKIEGLIVAMSLIGATLIttfSGPVSDKVGRRSMLILSSVLYFLSSI 88
Cdd:pfam00083 257 IGVMLQIFQQLTGINAIFYysttIFENLGL-SDSFLVTIIVGVVNFVFTFI---AIFLVDRFGRRPLLLLGAAGMAICFV 332
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   89 VMF---------WSPNVYVLLFARLLDGFGIGLAVTLVP-IYISETAPSEIRGLLNTFPQFCGSGGMFLsyCLVFGMSLQ 158
Cdd:pfam00083 333 ILGivallgvskSDWAGIVAIVFIALFIAFFAMGWGPVPwVIVSELFPLSVRSKAMALATAANWLANFL--IGFLFPIIT 410
                         170       180       190
                  ....*....|....*....|....*....|
gi 334185889  159 ESPSWRLMLGVLSIPSIAYFVLAAFFLPES 188
Cdd:pfam00083 411 DAIGLGYTFFIFAGLLVLFIIFVFFFVPET 440
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
46-112 3.28e-03

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 40.32  E-value: 3.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGL 112
Cdd:cd17393   37 GLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGA 103
PRK12307 PRK12307
MFS transporter;
9-195 3.34e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 40.68  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   9 LAAAIGNMLQGWDNATIAGAVIYIKKEFHLEKepkIEG-LIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSS 87
Cdd:PRK12307  21 FSAWLGYVFDGFDFMLIFYIMYLIKADLGLTD---MEGaFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGT 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  88 IVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETAPSEIRGLLNTF-PQFCGSGGMFLSYclvFGMSLQESPSWR-- 164
Cdd:PRK12307  98 GLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFlVSGFGIGNIIAAY---FMPSFAEAYGWRaa 174
                        170       180       190
                 ....*....|....*....|....*....|.
gi 334185889 165 LMLGVLSIPSIAYFVLAAfflPESPRWLVSK 195
Cdd:PRK12307 175 FFVGLLPVLLVIYIRARA---PESKEWEEAK 202
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
49-148 3.42e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.25  E-value: 3.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  49 VAMSLIGATLITT---FSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:cd17330  214 LLLALVGIAGILAqllLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSV 293
                         90       100
                 ....*....|....*....|...
gi 334185889 126 PSEIRGLLNTFPQFCGSGGMFLS 148
Cdd:cd17330  294 PSKEQGKAQGIIQSLQSLARIIG 316
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
54-188 3.59e-03

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 40.56  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  54 IGATLITTFS----GPVSDKVGRRSMLILSSVLYFLSS----IVMFWSPNVYVLLFARLLDG----FGIGLAVTLVpiYI 121
Cdd:cd17449   72 LGGFLVGLFSvtllGPWSDSVGRRPVLILPSLGLALQAavylLVMYLQLHVAYFLIGRILSGllgdFNGILAGCFA--YV 149
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334185889 122 SETAPSEIRGLLNTFPQFC-GSGGMFLSycLVFGMSLQE----SPSWrLMLGVlsipSIAYFVLAAFFLPES 188
Cdd:cd17449  150 ADVSDRRSRTFRVAVLEAClGLAGMLAS--IIGGQWRKAqgyiNPFW-LVLAL----NLAAALYAAFCVGES 214
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
46-119 4.59e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.87  E-value: 4.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVM-FWSPNVYVLLFARLLDGFGIGLAVTLVPI 119
Cdd:cd17503  217 GLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLaFLTPDTSLWLIILPLFIRGLGMGLVFMPL 291
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
29-191 5.01e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 39.93  E-value: 5.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  29 VIYIKKEFHLEKEPKieGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVY-VLLFARLLDG 107
Cdd:cd17341   22 GPVIRDDLGLSTSQI--GLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYwGLLVLGFLLG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 108 F-GIGLAVTLVpiYISETAPSEIRGLLNTFPQFCGSGGMFLSYCL---VFGMSLQESPS--WRLMLGVLSIPSIAYFVLA 181
Cdd:cd17341  100 FaGANFASGQP--WASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLaplIAGAIVFDGGFvgWRNAFFVPGILLAIAAVLV 177
                        170
                 ....*....|...
gi 334185889 182 AFF---LPESPRW 191
Cdd:cd17341  178 LLFgddLPTGKAS 190
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
46-140 5.24e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.84  E-value: 5.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  46 GLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDGFGIGLAVTLVPIYISETA 125
Cdd:cd17324  237 IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA 316
                         90
                 ....*....|....*
gi 334185889 126 PsEIRGLLNTFPQFC 140
Cdd:cd17324  317 P-EARGLASSLYLAA 330
MFS_1 pfam07690
Major Facilitator Superfamily;
481-653 5.29e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 5.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  481 PGGKGETAMLPKEVKDGPGWRELKEPGVKRALMVgvglqILQQFAGINGVMYYTPQILEETGVSSLLtnlgisaesaSLL 560
Cdd:pfam07690 175 PESKRPKPAEEARLSLIVAWKALLRDPVLWLLLA-----LLLFGFAFFGLLTYLPLYQEVLGLSALL----------AGL 239
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  561 ISALTTLLMLPCILVSMRLMDVTGRRSLMLSTIPILILSLVTLVIgslvnlggsinALISTASVTVYLSCFVMGFG---- 636
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL-----------LSLTLSSLWLLLALLLLGFGfglv 308
                         170
                  ....*....|....*...
gi 334185889  637 -AIPNILCSEIFPTSVRG 653
Cdd:pfam07690 309 fPALNALVSDLAPKEERG 326
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
565-697 5.48e-03

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 39.80  E-value: 5.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 565 TTLLMLPCILVSMRLMDVTGRRSLMlsTIPILILSLVTLVIGSLVnlggsinaliSTASVTVYL---SCFVMGFGAIPNI 641
Cdd:cd17441  242 TTLSEFPGLLVTLWIIDRFGRKKTM--ALCFFVFSFCTLLLFSCV----------GRFSLTVLLfiaRAFISGGFQAAYV 309
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 334185889 642 LCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSiGIAGVFGIYAIVCAVA 697
Cdd:cd17441  310 YTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLES-SVYLTLSVYSGCCLLA 364
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
48-107 6.46e-03

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 39.64  E-value: 6.46e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  48 IVAMSLIGATLITTFSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFARLLDG 107
Cdd:cd17396   40 VISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAG 99
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
548-703 6.75e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.48  E-value: 6.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 548 TNLGISAESASLLISALTTLLMLPCILVSMrLMDVTGRRslmlstiPILILSLVTLVIGSLVNLGGSINALISTASVTVY 627
Cdd:COG2223  234 DQFGLSAATAGLLAALFALLGALGRPLGGW-LSDRIGGR-------RVLLIVFALMALGLLLLALALGSLWLFLVLFLLL 305
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334185889 628 LSCFVMGFGAIPNiLCSEIFPTSVRGLCITICALTFWICDIIVTYTLPVMLKSIG-IAGVFGIYAIVCAVAWVFVYL 703
Cdd:COG2223  306 GLALGGGNGAVFA-LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLL 381
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
543-714 6.96e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 39.33  E-value: 6.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 543 VSSLLTNLGISAESASLLISALTTLLMLPCILVSmRLMDVTGRRslmlstiPILILSLVTLVIGSLvnLGGSINALISTA 622
Cdd:cd06174   19 LPALLQSFGLSASQLGLLFALFSLGYALLQPLAG-LLADRFGRR-------PVLLLGLLLFALGAL--LFAFAPSFWLLL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 623 SVTVYLSCFVMGFGAIPNILCSEIFPTSVRGLCITICALTFWICDII--VTYTLPVMLKSIGIAGVFGIYAIVCAVAWVF 700
Cdd:cd06174   89 LGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILgpLLGGILASSLGFGWRAVFLIAAALALLAAIL 168
                        170
                 ....*....|....
gi 334185889 701 VYLKVPETKGMPLE 714
Cdd:cd06174  169 LLLVVPDPPESARA 182
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
2-112 9.15e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.07  E-value: 9.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889   2 RSVVLVALAAAIGNMLQGwdnATIAGAVIYIKKEFHLEkePKIEGLIVAMSLIGATLITTFSGPVSDKVGRRSMLILSSV 81
Cdd:COG0738  210 PRLLLGGLAIFLYVGAEG---AIGDWLPLYLKDVLGLS--EATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL 284
                         90       100       110
                 ....*....|....*....|....*....|.
gi 334185889  82 LYFLSSIVMFWSPNVYVLLFARLLDGFGIGL 112
Cdd:COG0738  285 LAAVGLLLALLAPGPWLALIGLALVGLGLSL 315
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
491-708 9.50e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 39.21  E-value: 9.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 491 PKEVKDGPGWRELKEPGVKRALMVGVGLQILQQFaGINGVMYYTPQILEETgvsslltnLGISAESaSLLISALTTLLML 570
Cdd:cd17371  190 RRHFADRPSLRELFSPPLLRTTLLASLLATGALG-GYYGITTWLPSYLTGE--------RGLSFEG-SAGYLVVTILGGF 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889 571 PCILVSMRLMDVTGRRSLmlstipILILSLVTLVIGSLVNLGGSINALISTASVTVYLSCFVMgFGAIPNILcSEIFPTS 650
Cdd:cd17371  260 LGYLAGGFLADRIGRRNN------FALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGP-FSGMGAYL-TELFPTA 331
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 334185889 651 VRGLCITICALTFWICDIIVTYTLPVMLKSIGIAGVFGIYAIVCAVAWVFVYLKVPET 708
Cdd:cd17371  332 VRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
62-146 9.74e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 39.15  E-value: 9.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185889  62 FSGPVSDKVGRRSMLILSSVLYFLSSIVMFWSPNVYVLLFarLLDGFGIGLAVTLVPIY--ISETAPSEIR------GLL 133
Cdd:cd17313  300 PIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALV--LFALGGIGWATININPYplVSDYHSESGRgqgtdtGLL 377
                         90
                 ....*....|....*.
gi 334185889 134 NTF---PQFCGSGGMF 146
Cdd:cd17313  378 NLAislAQILVSLLAG 393
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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