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Conserved domains on  [gi|334185371|ref|NP_001189901|]
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Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-420 1.74e-30

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.89  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371   4 ILKAARTSGSLNLSNRSLNFDPITWDVPTEVYQCLETTGEGENWWEAVDLQKLILAHNDIEVLREDLKNLACLVVLNVSH 83
Cdd:COG4886   26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  84 NKlsqlpaAIGELTAMKSLDVSFNSISELPEQIGSAISLVKLDCSSNRLKELPDSIGRCLDLSDLKATNNQISSLPEDMV 163
Cdd:COG4886  106 NE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 164 NCSKLSKLDVEGNKLTALsenhiaswtmlaelnacknmlgvlPQNIGSLSRLIRLDLHQNKISSVPPSIGGCSSLVEFYL 243
Cdd:COG4886  180 NLTNLKELDLSNNQITDL------------------------PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 244 GINSLSTLPaEIGDLSRLGTLDLRSNQLKEYPVGACKLKLSYLDLSNNSLTGLHPELGNMTTLRKLVLVGNPLRTLRSSL 323
Cdd:COG4886  236 SNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 324 VNGPTAALLKYLRSRLSNSEETSASTPTKENVIASAARMSISSKELSLEGLNLSDVPSEVWESGEITKVNLSKNSIEELP 403
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394

                        410
                 ....*....|....*..
gi 334185371 404 AQLSTSVSLQTLILSRN 420
Cdd:COG4886  395 TTTAGVLLLTLALLDAV 411
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
348-589 8.26e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 8.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 348 STPTKE--NVIASAARMSISSK----ELSLEGLNLSDVPSEVWEsgEITKVNLSKNSIEELPAQLSTSVslQTLILSRNK 421
Cdd:PRK15370 156 EAPAKEaaNREEAVQRMRDCLKnnktELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQGNI--KTLYANSNQ 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 422 IKDWPgailKSLPN-LMCLKLDNNPLNQIPLdgfQVVSGLQILDLSVNAVS-------------------FREHPKfcHL 481
Cdd:PRK15370 232 LTSIP----ATLPDtIQEMELSINRITELPE---RLPSALQSLDLFHNKISclpenlpeelrylsvydnsIRTLPA--HL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 482 PQ-LRELYLSRIQLSEVPEDILnlSNLIILDLNQNSLQSIPKGIKnmTSLKHLDISNNNISSLPPElglLEPTLEVLRLD 560
Cdd:PRK15370 303 PSgITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPET---LPPTITTLDVS 375

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 334185371 561 GNPLRSirrpiLERGTKAVLNYLKD------RLPD 589
Cdd:PRK15370 376 RNALTN-----LPENLPAALQIMQAsrnnlvRLPE 405
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-420 1.74e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.89  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371   4 ILKAARTSGSLNLSNRSLNFDPITWDVPTEVYQCLETTGEGENWWEAVDLQKLILAHNDIEVLREDLKNLACLVVLNVSH 83
Cdd:COG4886   26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  84 NKlsqlpaAIGELTAMKSLDVSFNSISELPEQIGSAISLVKLDCSSNRLKELPDSIGRCLDLSDLKATNNQISSLPEDMV 163
Cdd:COG4886  106 NE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 164 NCSKLSKLDVEGNKLTALsenhiaswtmlaelnacknmlgvlPQNIGSLSRLIRLDLHQNKISSVPPSIGGCSSLVEFYL 243
Cdd:COG4886  180 NLTNLKELDLSNNQITDL------------------------PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 244 GINSLSTLPaEIGDLSRLGTLDLRSNQLKEYPVGACKLKLSYLDLSNNSLTGLHPELGNMTTLRKLVLVGNPLRTLRSSL 323
Cdd:COG4886  236 SNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 324 VNGPTAALLKYLRSRLSNSEETSASTPTKENVIASAARMSISSKELSLEGLNLSDVPSEVWESGEITKVNLSKNSIEELP 403
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394

                        410
                 ....*....|....*..
gi 334185371 404 AQLSTSVSLQTLILSRN 420
Cdd:COG4886  395 TTTAGVLLLTLALLDAV 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-556 8.88e-28

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 118.80  E-value: 8.88e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  72 NLACLVVLNVSHNKLS-QLPAAIGELTAMKSLDVSFNSIS-ELPEQI-GSAISLVKLDCSSNRLK-ELPDSIGRCLDLSD 147
Cdd:PLN00113  67 NSSRVVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIfTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 148 LkaTNNQIS-SLPEDMVNCSKLSKLDVEGNKLTALSENHIASWTMLAELNACKNML-GVLPQNIGSLSRLIRLDLHQNKI 225
Cdd:PLN00113 147 L--SNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 226 S-SVPPSIGGCSSLVEFYLGINSLS-TLPAEIGDLSRLGTLDLRSNQLK-EYPVGACKL-KLSYLDLSNNSLTGLHPEL- 300
Cdd:PLN00113 225 SgEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLqKLISLDLSDNSLSGEIPELv 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 301 GNMTTLRKLVLVGNPLR-TLRSSLVNGPTAALLKYLRSRLSNseETSASTPTKENVIAsaarMSISSKELSLEglnlsdV 379
Cdd:PLN00113 305 IQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSG--EIPKNLGKHNNLTV----LDLSTNNLTGE------I 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 380 PSEVWESGEITKVNLSKNSIE-ELPAQLSTSVSLQTLILSRNKIK-DWPGAILKsLPNLMCLKLDNNPLN--------QI 449
Cdd:PLN00113 373 PEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTK-LPLVYFLDISNNNLQgrinsrkwDM 451

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 450 P---------------LDGFQVVSGLQILDLSVNAVSFREHPKFCHLPQLRELYLSRIQLS-EVPEDILNLSNLIILDLN 513
Cdd:PLN00113 452 PslqmlslarnkffggLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLS 531

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 334185371 514 QNSLQ-SIPKGIKNMTSLKHLDISNNNIS-SLPPELGLLEPTLEV 556
Cdd:PLN00113 532 HNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQV 576
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
348-589 8.26e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 8.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 348 STPTKE--NVIASAARMSISSK----ELSLEGLNLSDVPSEVWEsgEITKVNLSKNSIEELPAQLSTSVslQTLILSRNK 421
Cdd:PRK15370 156 EAPAKEaaNREEAVQRMRDCLKnnktELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQGNI--KTLYANSNQ 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 422 IKDWPgailKSLPN-LMCLKLDNNPLNQIPLdgfQVVSGLQILDLSVNAVS-------------------FREHPKfcHL 481
Cdd:PRK15370 232 LTSIP----ATLPDtIQEMELSINRITELPE---RLPSALQSLDLFHNKISclpenlpeelrylsvydnsIRTLPA--HL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 482 PQ-LRELYLSRIQLSEVPEDILnlSNLIILDLNQNSLQSIPKGIKnmTSLKHLDISNNNISSLPPElglLEPTLEVLRLD 560
Cdd:PRK15370 303 PSgITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPET---LPPTITTLDVS 375

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 334185371 561 GNPLRSirrpiLERGTKAVLNYLKD------RLPD 589
Cdd:PRK15370 376 RNALTN-----LPENLPAALQIMQAsrnnlvRLPE 405
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 389-569 1.64e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.90  E-value: 1.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 389 ITKVNLSKNSIEELPAqLSTSVSLQTLILSRNKIKDWPGaiLKSLPNLMCLKLDNNPLNQIplDGFQVVSGLQILDLSVN 468
Cdd:cd21340    4 ITHLYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 469 AVSFREHpkFCHLPQLRELYLS--RIQLSEV----PEDILNLSN-LIILDLNQNSLQSIpKGIKNMTSLKHLDISNNNIS 541
Cdd:cd21340   79 RISVVEG--LENLTNLEELHIEnqRLPPGEKltfdPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155

                        170       180       190
                 ....*....|....*....|....*....|
gi 334185371 542 SLPPELGLLE--PTLEVLRLDGNPLRSIRR 569
Cdd:cd21340  156 DLEELLDLLSswPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
505-564 1.24e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.24e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185371  505 SNLIILDLNQNSLQSIPKGI-KNMTSLKHLDISNNNISSLPPELGLLEPTLEVLRLDGNPL 564
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 125-316 1.87e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 125 LDCSSNRLKELPDsIGRCLDLSDLKATNNQISSLpEDMVNCSKLSKLDVEGNKLTALsenhiaswtmlaelnacknmlgv 204
Cdd:cd21340    7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI----------------------- 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 205 lpQNIGSLSRLIRLDLHQNKISSVpPSIGGCSSLVEFYLGINSLST------LPAEIGDLSR-LGTLDLRSNQLKEYPVG 277
Cdd:cd21340   62 --ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLPPgekltfDPRSLAALSNsLRVLNISGNNIDSLEPL 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 334185371 278 ACKLKLSYLDLSNNSLTGLH---PELGNMTTLRKLVLVGNPL 316
Cdd:cd21340  139 APLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPV 180
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 389-573 5.15e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 5.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 389 ITKVNLSKNSI-----EELPAQLSTSVSLQTLILSRNKIKDwPGAI-----LKSLPNLMCLKLDNNPL------------ 446
Cdd:COG5238  182 VETVYLGCNQIgdegiEELAEALTQNTTVTTLWLKRNPIGD-EGAEilaeaLKGNKSLTTLDLSNNQIgdegvialaeal 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 447 -------------NQIPLDG-------FQVVSGLQILDLSVN------AVSFREHPKfcHLPQLRELYLSRIQLSEV--- 497
Cdd:COG5238  261 knnttvetlylsgNQIGAEGaialakaLQGNTTLTSLDLSVNrigdegAIALAEGLQ--GNKTLHTLNLAYNGIGAQgai 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 498 --PEDILNLSNLIILDLNQNSL-----QSIPKGIKNMTSLKHLDISNNNISSLPPEL---GLLEPTLEVLRLDGNPLRSI 567
Cdd:COG5238  339 alAKALQENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIGKQGAEAlidALQTNRLHTLILDGNLIGAE 418


                 ....*.
gi 334185371 568 RRPILE 573
Cdd:COG5238  419 AQQRLE 424
LRR_8 pfam13855
Leucine rich repeat;
53-109 1.44e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 334185371   53 LQKLILAHNDIEVLRED-LKNLACLVVLNVSHNKLSQL-PAAIGELTAMKSLDVSFNSI 109
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-420 1.74e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.89  E-value: 1.74e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371   4 ILKAARTSGSLNLSNRSLNFDPITWDVPTEVYQCLETTGEGENWWEAVDLQKLILAHNDIEVLREDLKNLACLVVLNVSH 83
Cdd:COG4886   26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  84 NKlsqlpaAIGELTAMKSLDVSFNSISELPEQIGSAISLVKLDCSSNRLKELPDSIGRCLDLSDLKATNNQISSLPEDMV 163
Cdd:COG4886  106 NE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 164 NCSKLSKLDVEGNKLTALsenhiaswtmlaelnacknmlgvlPQNIGSLSRLIRLDLHQNKISSVPPSIGGCSSLVEFYL 243
Cdd:COG4886  180 NLTNLKELDLSNNQITDL------------------------PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 244 GINSLSTLPaEIGDLSRLGTLDLRSNQLKEYPVGACKLKLSYLDLSNNSLTGLHPELGNMTTLRKLVLVGNPLRTLRSSL 323
Cdd:COG4886  236 SNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 324 VNGPTAALLKYLRSRLSNSEETSASTPTKENVIASAARMSISSKELSLEGLNLSDVPSEVWESGEITKVNLSKNSIEELP 403
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394

                        410
                 ....*....|....*..
gi 334185371 404 AQLSTSVSLQTLILSRN 420
Cdd:COG4886  395 TTTAGVLLLTLALLDAV 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-556 8.88e-28

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 118.80  E-value: 8.88e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  72 NLACLVVLNVSHNKLS-QLPAAIGELTAMKSLDVSFNSIS-ELPEQI-GSAISLVKLDCSSNRLK-ELPDSIGRCLDLSD 147
Cdd:PLN00113  67 NSSRVVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIfTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 148 LkaTNNQIS-SLPEDMVNCSKLSKLDVEGNKLTALSENHIASWTMLAELNACKNML-GVLPQNIGSLSRLIRLDLHQNKI 225
Cdd:PLN00113 147 L--SNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 226 S-SVPPSIGGCSSLVEFYLGINSLS-TLPAEIGDLSRLGTLDLRSNQLK-EYPVGACKL-KLSYLDLSNNSLTGLHPEL- 300
Cdd:PLN00113 225 SgEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLqKLISLDLSDNSLSGEIPELv 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 301 GNMTTLRKLVLVGNPLR-TLRSSLVNGPTAALLKYLRSRLSNseETSASTPTKENVIAsaarMSISSKELSLEglnlsdV 379
Cdd:PLN00113 305 IQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSG--EIPKNLGKHNNLTV----LDLSTNNLTGE------I 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 380 PSEVWESGEITKVNLSKNSIE-ELPAQLSTSVSLQTLILSRNKIK-DWPGAILKsLPNLMCLKLDNNPLN--------QI 449
Cdd:PLN00113 373 PEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTK-LPLVYFLDISNNNLQgrinsrkwDM 451

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 450 P---------------LDGFQVVSGLQILDLSVNAVSFREHPKFCHLPQLRELYLSRIQLS-EVPEDILNLSNLIILDLN 513
Cdd:PLN00113 452 PslqmlslarnkffggLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLS 531

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*
gi 334185371 514 QNSLQ-SIPKGIKNMTSLKHLDISNNNIS-SLPPELGLLEPTLEV 556
Cdd:PLN00113 532 HNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQV 576
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 76-521 4.69e-27

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 116.87  E-value: 4.69e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  76 LVVLNVSHNKLSQlPAAIGELTAMKSLDVSFNSIS-ELPEQIGSAISLVKLDCSSNRLK-ELPDSIGRCLDLSDLKATNN 153
Cdd:PLN00113 120 LRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASN 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 154 Q-ISSLPEDMVNCSKLSKLDVEGNKLTALSENHIASWTMLAELNACKNML-GVLPQNIGSLSRLIRLDLHQNKIS-SVPP 230
Cdd:PLN00113 199 QlVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLtGPIPSSLGNLKNLQYLFLYQNKLSgPIPP 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 231 SIGGCSSLVEFYLGINSLS-------------------------TLPAEIGDLSRLGTLDLRSNQLK-EYPVGACKLK-L 283
Cdd:PLN00113 279 SIFSLQKLISLDLSDNSLSgeipelviqlqnleilhlfsnnftgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNnL 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 284 SYLDLSNNSLTGLHPE-LGNMTTLRKLVLVGNPLrtlrSSLVNGPTAALLKYLRSRLSNSEeTSASTPTKENVIASAARM 362
Cdd:PLN00113 359 TVLDLSTNNLTGEIPEgLCSSGNLFKLILFSNSL----EGEIPKSLGACRSLRRVRLQDNS-FSGELPSEFTKLPLVYFL 433

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 363 SISSKELSleglnlSDVPSEVWESGEITKVNLSKNSIE-ELPaQLSTSVSLQTLILSRNKIKDWPGAILKSLPNLMCLKL 441
Cdd:PLN00113 434 DISNNNLQ------GRINSRKWDMPSLQMLSLARNKFFgGLP-DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 442 DNNPLNQIPLDGFQVVSGLQILDLSVNAVSFREHPKFCHLPQLRELYLSRIQLS-EVPEDILNLSNLIILDLNQNSLQ-S 519
Cdd:PLN00113 507 SENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHgS 586


                 ..
gi 334185371 520 IP 521
Cdd:PLN00113 587 LP 588
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-323 2.22e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 2.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  56 LILAHNDIEVLREDLKNLACLVVLNVSHNKLSQLPAAIGELTAMKSLDVSFNSISELPEQIGSAISLVKLDCSSNRLKEL 135
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 136 PDSIGRCLDLSDLKATNNQISSLPEDMVNCSKLSKLDVEGNKLTALSENhIASWTMLAELNACKNMLGVLPQNIGSLSRL 215
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 216 IRLDLHQNKISSVPPSIGGCSSLVEFYLGINSLSTLPAEIGDLSRLGTLDLRSNQLKEYPVGACKLK-LSYLDLSNNSLT 294
Cdd:COG4886  162 KSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTnLETLDLSNNQLT 241

                        250       260
                 ....*....|....*....|....*....
gi 334185371 295 GLhPELGNMTTLRKLVLVGNPLRTLRSSL 323
Cdd:COG4886  242 DL-PELGNLTNLEELDLSNNQLTDLPPLA 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
143-585 2.06e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 2.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 143 LDLSDLKATNNQISSLPEDMVNCSKLSKLDVEGNKLTALSENHIASWTMLAELNACKNMLGVLPQNIGSLSRLIRLDLHQ 222
Cdd:COG4886   26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 223 NKissvppSIGGCSSLVEFYLGINSLSTLPAEIGDLSRLGTLDLRSNQLKEYPVGACKLK-LSYLDLSNNSLTGLHPELG 301
Cdd:COG4886  106 NE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTnLKSLDLSNNQLTDLPEELG 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 302 NMTTLRKLVLVGNPLRTLRSSLvngptaallkylrSRLSNseetsastptkenviasaarmsisskelsleglnlsdvps 381
Cdd:COG4886  180 NLTNLKELDLSNNQITDLPEPL-------------GNLTN---------------------------------------- 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 382 evwesgeITKVNLSKNSIEELPAQLSTSVSLQTLILSRNKIKDWPGaiLKSLPNLMCLKLDNNPLNQIPLDGFqvVSGLQ 461
Cdd:COG4886  207 -------LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN--LTNLK 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 462 ILDLSVNAVSFREHPKFCHLPQLRELYLSRIQLSEVPEDILNLSNLIILDLNQNSLQSIPKGIKNMTSLKHLDISNNNIS 541
Cdd:COG4886  276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLL 355

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 334185371 542 SLPPELGLLEPTLEVLRLDGNPLRSIRRPILERGTKAVLNYLKD 585
Cdd:COG4886  356 LNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
164-589 4.58e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 4.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 164 NCSKLSKLDVEGNKLTALSENHIASWTMLAELNACKNMLGVLPQNIGSLSRLIRLDLHQNKISSVPPSIGGCSSLVEFYL 243
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 244 GINSLSTLPAEIGDLSRLGTLDLRSNQLKEYPVgacklKLSYLDLSNNSLTGLHPELGNMTTLRKLVLVGNPLRTLRSSL 323
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLT-----NLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 324 VNgptaalLKYLrsrlsnseetsastptkenviasaarmsissKELSLEGLNLSDVPSEVWESGEITKVNLSKNSIEELP 403
Cdd:COG4886  156 GN------LTNL-------------------------------KSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLP 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 404 AQLSTSVSLQTLILSRNKIKDWPGAiLKSLPNLMCLKLDNNPLNQIPldGFQVVSGLQILDLSVNAVSfrEHPKFCHLPQ 483
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLT--DLPPLANLTN 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 484 LRELYLSRIQLSEVPEDILNLSNLIILDLNQNSLQSIPKGIKNMTSLKHLDISNNNISSLPPELGLLEPTLEVLRLDGNP 563
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353

                        410       420
                 ....*....|....*....|....*.
gi 334185371 564 LRSIRRPILERGTKAVLNYLKDRLPD 589
Cdd:COG4886  354 LLLNLLSLLLTLLLTLGLLGLLEATL 379
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
56-275 8.44e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 87.44  E-value: 8.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  56 LILAHNDIEVLREDLKnlACLVVLNVSHNKLSQLPAAIGEltAMKSLDVSFNSISELPEQIGSAisLVKLDCSSNRLKEL 135
Cdd:PRK15370 204 LILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLPSA--LQSLDLFHNKISCL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 136 PDSIGRclDLSDLKATNNQISSLPEDMVncSKLSKLDVEGNKLTALSENHIASwtmLAELNACKNMLGVLPQNIGslSRL 215
Cdd:PRK15370 278 PENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLPPG---LKTLEAGENALTSLPASLP--PEL 348

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 216 IRLDLHQNKISSVPPSIGgcSSLVEFYLGINSLSTLPAEIGdlSRLGTLDLRSNQLKEYP 275
Cdd:PRK15370 349 QVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLP--AALQIMQASRNNLVRLP 404
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
348-589 8.26e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.81  E-value: 8.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 348 STPTKE--NVIASAARMSISSK----ELSLEGLNLSDVPSEVWEsgEITKVNLSKNSIEELPAQLSTSVslQTLILSRNK 421
Cdd:PRK15370 156 EAPAKEaaNREEAVQRMRDCLKnnktELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQGNI--KTLYANSNQ 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 422 IKDWPgailKSLPN-LMCLKLDNNPLNQIPLdgfQVVSGLQILDLSVNAVS-------------------FREHPKfcHL 481
Cdd:PRK15370 232 LTSIP----ATLPDtIQEMELSINRITELPE---RLPSALQSLDLFHNKISclpenlpeelrylsvydnsIRTLPA--HL 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 482 PQ-LRELYLSRIQLSEVPEDILnlSNLIILDLNQNSLQSIPKGIKnmTSLKHLDISNNNISSLPPElglLEPTLEVLRLD 560
Cdd:PRK15370 303 PSgITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPET---LPPTITTLDVS 375

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 334185371 561 GNPLRSirrpiLERGTKAVLNYLKD------RLPD 589
Cdd:PRK15370 376 RNALTN-----LPENLPAALQIMQAsrnnlvRLPE 405
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 389-569 1.64e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.90  E-value: 1.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 389 ITKVNLSKNSIEELPAqLSTSVSLQTLILSRNKIKDWPGaiLKSLPNLMCLKLDNNPLNQIplDGFQVVSGLQILDLSVN 468
Cdd:cd21340    4 ITHLYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 469 AVSFREHpkFCHLPQLRELYLS--RIQLSEV----PEDILNLSN-LIILDLNQNSLQSIpKGIKNMTSLKHLDISNNNIS 541
Cdd:cd21340   79 RISVVEG--LENLTNLEELHIEnqRLPPGEKltfdPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155

                        170       180       190
                 ....*....|....*....|....*....|
gi 334185371 542 SLPPELGLLE--PTLEVLRLDGNPLRSIRR 569
Cdd:cd21340  156 DLEELLDLLSswPSLRELDLTGNPVCKKPK 185
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
53-212 7.30e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 71.65  E-value: 7.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  53 LQKLILAHNDIEVLREDLKNlaCLVVLNVSHNKLSQLPAAIGelTAMKSLDVSFNSISELPEQIgsAISLVKLDCSSNRL 132
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETL--PPGLKTLEAGENAL 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 133 KELPDSIGRclDLSDLKATNNQISSLPEDMVncSKLSKLDVEGNKLTALSENHIASwtmLAELNACKNMLGVLPQNIGSL 212
Cdd:PRK15370 338 TSLPASLPP--ELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLPAA---LQIMQASRNNLVRLPESLPHF 410
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-247 3.33e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.41  E-value: 3.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  66 LREDLKNLACLVVLNVSHNKLS-QLPAAIGELTAMKSLDVSFNSIS-ELPEQIGSAiSLVKLDCSSNRLKE-LPDSIGRC 142
Cdd:PLN00113 420 LPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFgGLPDSFGSK-RLENLDLSRNQFSGaVPRKLGSL 498

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 143 LDLSDLKATNNQISS-LPEDMVNCSKLSKLDVEGNKLTALSENHIASWTMLAELNACKNML-GVLPQNIGSLSRLIRLDL 220
Cdd:PLN00113 499 SELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLsGEIPKNLGNVESLVQVNI 578

                        170       180
                 ....*....|....*....|....*..
gi 334185371 221 HQNKISSVPPSIGGcsslvefYLGINS 247
Cdd:PLN00113 579 SHNHLHGSLPSTGA-------FLAINA 598
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 364-564 7.80e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 7.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 364 ISSKELSleGLNLS-DVPSEVWESGEITKVNLSKNSIE-ELPAQLS-TSVSLQTLILSRNkikDWPGAILK-SLPNLMCL 439
Cdd:PLN00113  71 VVSIDLS--GKNISgKISSAIFRLPYIQTINLSNNQLSgPIPDDIFtTSSSLRYLNLSNN---NFTGSIPRgSIPNLETL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 440 KLDNNPLN-QIPLDgFQVVSGLQILDLSVNAVSFREHPKFCHLPQLRELYLSRIQLS----------------------- 495
Cdd:PLN00113 146 DLSNNMLSgEIPND-IGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnl 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 496 --------------------------EVPEDILNLSNLIILDLNQNSLQ-SIPKGIKNMTSLKHLDISNNNISSLPPELG 548
Cdd:PLN00113 225 sgeipyeiggltslnhldlvynnltgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGEIPELV 304

                        250
                 ....*....|....*.
gi 334185371 549 LLEPTLEVLRLDGNPL 564
Cdd:PLN00113 305 IQLQNLEILHLFSNNF 320
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
76-376 2.51e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 53.63  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  76 LVVLNVSHNKLSQLPAAIGELTAMKSLDVSFNSISELPEqigsaiSLVKLDCSSNRLKELPdsiGRCLDLSDLKATNNQI 155
Cdd:PRK15387 264 LLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPP------GLQELSVSDNQLASLP---ALPSELCKLWAYNNQL 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 156 SSLPEDMVNCSKLSkldvegnkltaLSENHIASwtmlaelnacknmLGVLPqnigslSRLIRLDLHQNKISSVPPSIGGC 235
Cdd:PRK15387 335 TSLPTLPSGLQELS-----------VSDNQLAS-------------LPTLP------SELYKLWAYNNRLTSLPALPSGL 384

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 236 SSLVEFYLGINSLSTLPAEIGDLSRLGTldlRSNQLKEYPVGacklkLSYLDLSNNSLTGLHPELGNMTTLRKLVLVGNP 315
Cdd:PRK15387 385 KELIVSGNRLTSLPVLPSELKELMVSGN---RLTSLPMLPSG-----LLSLSVYRNQLTRLPESLIHLSSETTVNLEGNP 456

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334185371 316 L--RTLRS----SLVNGPTAALLKYLRSRLSNSEETSA--------STPTKENVIASAARMSISSKELSLEGLNL 376
Cdd:PRK15387 457 LseRTLQAlreiTSAPGYSGPIIRFDMAGASAPRETRAlhlaaadwLVPAREGEPAPADRWHMFGQEDNADAFSL 531
LRR_8 pfam13855
Leucine rich repeat;
505-564 1.24e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.24e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185371  505 SNLIILDLNQNSLQSIPKGI-KNMTSLKHLDISNNNISSLPPELGLLEPTLEVLRLDGNPL 564
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
482-540 5.86e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.86e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185371  482 PQLRELYLSRIQLSEVPEDIL-NLSNLIILDLNQNSLQSI-PKGIKNMTSLKHLDISNNNI 540
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 497-564 1.43e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.43e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 497 VPEDILNLSNLIILDLNQNSLQ-SIPKGIKNMTSLKHLDISNNNIS-SLPPELGLLEpTLEVLRLDGNPL 564
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLT-SLRILNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 125-316 1.87e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 125 LDCSSNRLKELPDsIGRCLDLSDLKATNNQISSLpEDMVNCSKLSKLDVEGNKLTALsenhiaswtmlaelnacknmlgv 204
Cdd:cd21340    7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI----------------------- 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 205 lpQNIGSLSRLIRLDLHQNKISSVpPSIGGCSSLVEFYLGINSLST------LPAEIGDLSR-LGTLDLRSNQLKEYPVG 277
Cdd:cd21340   62 --ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLPPgekltfDPRSLAALSNsLRVLNISGNNIDSLEPL 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 334185371 278 ACKLKLSYLDLSNNSLTGLH---PELGNMTTLRKLVLVGNPL 316
Cdd:cd21340  139 APLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPV 180
PLN03150 PLN03150
hypothetical protein; Provisional
 65-153 1.89e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 1.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  65 VLREDLKNLACLVVLNVSHNKL-SQLPAAIGELTAMKSLDVSFNSIS-ELPEQIGSAISLVKLDCSSNRLK-ELPDSIG- 140
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALGg 512

                         90
                 ....*....|...
gi 334185371 141 RCLDLSDLKATNN 153
Cdd:PLN03150 513 RLLHRASFNFTDN 525
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 458-564 2.15e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 2.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 458 SGLQILDLSVNAVSFREHPKFCHLPQLRELYLSRIQLS-EVPEDILNLS-NLIILDLNQNSLQ-SIPKGikNMTSLKHLD 534
Cdd:PLN00113  69 SRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTgSIPRG--SIPNLETLD 146

                         90       100       110
                 ....*....|....*....|....*....|.
gi 334185371 535 ISNNNIS-SLPPELGLLEpTLEVLRLDGNPL 564
Cdd:PLN00113 147 LSNNMLSgEIPNDIGSFS-SLKVLDLGGNVL 176
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-132 2.19e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  52 DLQKLILAHNDIE-VLREDLKNLACLVVLNVSHNKLS-QLPAAIGELTAMKSLDVSFNSIS-ELPEQIGSAISLVKLDCS 128
Cdd:PLN00113 500 ELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNIS 579


                 ....
gi 334185371 129 SNRL 132
Cdd:PLN00113 580 HNHL 583
PLN03150 PLN03150
hypothetical protein; Provisional
 203-298 2.21e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 203 GVLPQNIGSLSRLIRLDLHQNKI-SSVPPSIGGCSSLVEFYLGINSLS-TLPAEIGDLSRLGTLDLRSNQLK-EYP--VG 277
Cdd:PLN03150 432 GFIPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPaaLG 511

                         90       100
                 ....*....|....*....|....*
gi 334185371 278 ACKLKLSYLDLSNNS----LTGLHP 298
Cdd:PLN03150 512 GRLLHRASFNFTDNAglcgIPGLRA 536
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
14-121 6.37e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 6.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  14 LNLSNRSLNFDPITwdVPTEvyqcLETTGEGENWWEAV------DLQKLILAHNDIEVLREDLKnlACLVVLNVSHNKLS 87
Cdd:PRK15370 309 LNVQSNSLTALPET--LPPG----LKTLEAGENALTSLpaslppELQVLDVSKNQITVLPETLP--PTITTLDVSRNALT 380

                         90       100       110
                 ....*....|....*....|....*....|....
gi 334185371  88 QLPAAIGelTAMKSLDVSFNSISELPEQIGSAIS 121
Cdd:PRK15370 381 NLPENLP--AALQIMQASRNNLVRLPESLPHFRG 412
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-196 6.91e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 6.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  53 LQKLILAHNDIEVLrEDLKNLACLVVLNVSHNKLSQLpAAIGELTAMKSLDVSfNSISELPEQI--------GSAISLVK 124
Cdd:cd21340   48 LTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIE-NQRLPPGEKLtfdprslaALSNSLRV 124

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334185371 125 LDCSSNRLKELPDSigRCLD-LSDLKATNNQISSLPE--DMV-NCSKLSKLDVEGNKLTALS---ENHIASWTMLAELN 196
Cdd:cd21340  125 LNISGNNIDSLEPL--APLRnLEQLDASNNQISDLEEllDLLsSWPSLRELDLTGNPVCKKPkyrDKIILASKSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 251-316 1.95e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 1.95e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334185371 251 LPAEIGDLSRLGTLDLRSNQLK-EYPVGACKLK-LSYLDLSNNSLTGLHPE-LGNMTTLRKLVLVGNPL 316
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITsLEVLDLSYNSFNGSIPEsLGQLTSLRILNLNGNSL 502
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
345-544 2.74e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 2.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 345 TSASTPTKENVIASAARMSISSKELSLEG---------LNLSDVPSEVWESG----------EITKVNLSKNSIEELPAq 405
Cdd:PRK15387 161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAavvqkmracLNNGNAVLNVGESGlttlpdclpaHITTLVIPDNNLTSLPA- 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 406 lsTSVSLQTLILSRNKIKDWPgaILKslPNLMCLKLDNNPLNQIPldgfQVVSGLQILDLSVNAV-SFREHPkfchlPQL 484
Cdd:PRK15387 240 --LPPELRTLEVSGNQLTSLP--VLP--PGLLELSIFSNPLTHLP----ALPSGLCKLWIFGNQLtSLPVLP-----PGL 304

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 485 RELYLSRIQLSEVPEDILNLSNLIILDLNQNSLQSIPKGiknmtsLKHLDISNNNISSLP 544
Cdd:PRK15387 305 QELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSG------LQELSVSDNQLASLP 358
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 358-562 2.76e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 358 SAARMSISSKELSLEGLNLSDVPSEVWESGEITKVNLSKNSIEELPAQ----LSTSVSLQTLILSRNKIKDWPGAIL-KS 432
Cdd:cd00116   52 SLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGvlesLLRSSSLQELKLNNNGLGDRGLRLLaKG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 433 LPNLMC----LKLDNNPLNQIPLDG----FQVVSGLQILDLSVNAVSFREHPKFCHlpqlrelylsriqlsevpeDILNL 504
Cdd:cd00116  132 LKDLPPalekLVLGRNRLEGASCEAlakaLRANRDLKELNLANNGIGDAGIRALAE-------------------GLKAN 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334185371 505 SNLIILDLNQNSL-----QSIPKGIKNMTSLKHLDISNNNISS-----LPPELGLLEPTLEVLRLDGN 562
Cdd:cd00116  193 CNLEVLDLNNNGLtdegaSALAETLASLKSLEVLNLGDNNLTDagaaaLASALLSPNISLLTLSLSCN 260
PLN03150 PLN03150
hypothetical protein; Provisional
 171-256 4.50e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 4.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 171 LDVEGnkLTALSENHIASWTMLAELNACKNML-GVLPQNIGSLSRLIRLDLHQNKIS-SVPPSIGGCSSLVEFYLGINSL 248
Cdd:PLN03150 425 LDNQG--LRGFIPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 ....*....
gi 334185371 249 S-TLPAEIG 256
Cdd:PLN03150 503 SgRVPAALG 511
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 389-573 5.15e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 5.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 389 ITKVNLSKNSI-----EELPAQLSTSVSLQTLILSRNKIKDwPGAI-----LKSLPNLMCLKLDNNPL------------ 446
Cdd:COG5238  182 VETVYLGCNQIgdegiEELAEALTQNTTVTTLWLKRNPIGD-EGAEilaeaLKGNKSLTTLDLSNNQIgdegvialaeal 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 447 -------------NQIPLDG-------FQVVSGLQILDLSVN------AVSFREHPKfcHLPQLRELYLSRIQLSEV--- 497
Cdd:COG5238  261 knnttvetlylsgNQIGAEGaialakaLQGNTTLTSLDLSVNrigdegAIALAEGLQ--GNKTLHTLNLAYNGIGAQgai 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 498 --PEDILNLSNLIILDLNQNSL-----QSIPKGIKNMTSLKHLDISNNNISSLPPEL---GLLEPTLEVLRLDGNPLRSI 567
Cdd:COG5238  339 alAKALQENTTLHSLDLSDNQIgdegaIALAKYLEGNTTLRELNLGKNNIGKQGAEAlidALQTNRLHTLILDGNLIGAE 418


                 ....*.
gi 334185371 568 RRPILE 573
Cdd:COG5238  419 AQQRLE 424
PLN03150 PLN03150
hypothetical protein; Provisional
 371-486 5.30e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 5.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 371 LEGLNLSD------VPSEVWESGEITKVNLSKNSIE-ELPAQLSTSVSLQTLILSRNKIKdwpGAILKSLPNLMCLKLDN 443
Cdd:PLN03150 420 IDGLGLDNqglrgfIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFN---GSIPESLGQLTSLRILN 496

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 334185371 444 npLNQIPLDGfQVVSGLQILDLSVNAVSFREHPKFCHLPQLRE 486
Cdd:PLN03150 497 --LNGNSLSG-RVPAALGGRLLHRASFNFTDNAGLCGIPGLRA 536
LRR_8 pfam13855
Leucine rich repeat;
434-491 9.25e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 9.25e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 334185371  434 PNLMCLKLDNNPLNQIPLDGFQVVSGLQILDLSVNAVSFREHPKFCHLPQLRELYLSR 491
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSG 58
PLN03150 PLN03150
hypothetical protein; Provisional
 481-548 1.01e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.01e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334185371 481 LPQLRelYLSRIQLS------EVPEDILNLSNLIILDLNQNSLQ-SIPKGIKNMTSLKHLDISNNNISS-LPPELG 548
Cdd:PLN03150 438 ISKLR--HLQSINLSgnsirgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGrVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
411-468 1.13e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 334185371  411 SLQTLILSRNKIKDWPGAILKSLPNLMCLKLDNNPLNQIPLDGFQVVSGLQILDLSVN 468
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
53-109 1.44e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 334185371   53 LQKLILAHNDIEVLRED-LKNLACLVVLNVSHNKLSQL-PAAIGELTAMKSLDVSFNSI 109
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
259-316 1.84e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185371  259 SRLGTLDLRSNQLKEYPVGACK--LKLSYLDLSNNSLTGLHPE-LGNMTTLRKLVLVGNPL 316
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKglSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 53-180 3.79e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 3.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  53 LQKLILAHNDI-----EVLREDLKNLACLVVLNVSHNKLSQ-----LPAAIGELTAMKSLDVSFNSISElpeqiGSAISL 122
Cdd:COG5238  294 LTSLDLSVNRIgdegaIALAEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENTTLHSLDLSDNQIGD-----EGAIAL 368

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 334185371 123 VKLDCSSNRLKElpdsigrcLDLSDLKATNNQISSLpEDMVNCSKLSKLDVEGNKLTA 180
Cdd:COG5238  369 AKYLEGNTTLRE--------LNLGKNNIGKQGAEAL-IDALQTNRLHTLILDGNLIGA 417
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 192-537 5.01e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 5.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  192 LAELNACKNMLGVLPQNIGSLSRLIRLDLHQNKISSVPPSIGGCSSLVEFYLG-INSLSTLPAEIGDLSRLGTLDL-RSN 269
Cdd:PLN03210  613 LVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSdCSSLVELPSSIQYLNKLEDLDMsRCE 692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  270 QLKEYPVGACKLKLSYLDLSNNSLTGLHPELGnmTTLRKLVLVGNPLRTLRSSLvngptaallkylrsRLSNSEETS--- 346
Cdd:PLN03210  693 NLEILPTGINLKSLYRLNLSGCSRLKSFPDIS--TNISWLDLDETAIEEFPSNL--------------RLENLDELIlce 756

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  347 -ASTPTKENVIASAARMSISSKelSLEGLNLSDVPSEVwesgeitkvnlsknsieELPAQLSTSVSLQTLILSRNKIkdw 425
Cdd:PLN03210  757 mKSEKLWERVQPLTPLMTMLSP--SLTRLFLSDIPSLV-----------------ELPSSIQNLHKLEHLEIENCIN--- 814

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371  426 pgaiLKSLPNLMCLKLdnnpLNQIPLDGfqvVSGLQIL-DLSVNavsfrehpkfchlpqLRELYLSRIQLSEVPEDILNL 504
Cdd:PLN03210  815 ----LETLPTGINLES----LESLDLSG---CSRLRTFpDISTN---------------ISDLNLSRTGIEEVPWWIEKF 868

                         330       340       350
                  ....*....|....*....|....*....|....
gi 334185371  505 SNLIILDLNQ-NSLQSIPKGIKNMTSLKHLDISN 537
Cdd:PLN03210  869 SNLSFLDMNGcNNLQRVSLNISKLKHLETVDFSD 902
LRR_8 pfam13855
Leucine rich repeat;
213-271 5.13e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 5.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334185371  213 SRLIRLDLHQNKISSVPPSI-GGCSSLVEFYLGINSLSTL-PAEIGDLSRLGTLDLRSNQL 271
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 394-534 7.10e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 7.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185371 394 LSKNSIEELPaQLSTSVSLQTLILSRNKIKDWPGaiLKSLPNLMCLKLDNNPL---NQIPLDGFQVVS---GLQILDLSV 467
Cdd:cd21340   53 LQNNQIEKIE-NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLppgEKLTFDPRSLAAlsnSLRVLNISG 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334185371 468 NAVSFREhpKFCHLPQLRELYLSRIQLS---EVPEDILNLSNLIILDLNQNSLQSIPK----GIKNMTSLKHLD 534
Cdd:cd21340  130 NNIDSLE--PLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLTGNPVCKKPKyrdkIILASKSLEVLD 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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