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Conserved domains on  [gi|334185288|ref|NP_001189871|]
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sulfate transporter 4;2 [Arabidopsis thaliana]

Protein Classification

solute carrier family 26 protein( domain architecture ID 11489705)

solute carrier family 26 protein similar to eukaryotic sulfate transporters such as Arabidopsis thaliana sulfate transporter 1.1, which is a high-affinity H(+)/sulfate cotransporter that mediates the uptake of the environmental sulfate by plant roots under low-sulfur conditions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
52-609 0e+00

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


:

Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 644.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288   52 PCFLWIRTYRWhQYFKLDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAVGPVALVSLLVS 131
Cdd:TIGR00815   1 PVLRWLRKYRL-KKFKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  132 NALSGIVDPSEE-LYTELAILLALMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLKYFLGYSVSRSSKI 210
Cdd:TIGR00815  80 SLVQREGLQGLFdDYIRLAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGLSQLKGLLGLSIFVKTDI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  211 MPVIDSIIAGADQFKWPPFLLGCTILVILLVMKHVGKAKKELRFIRAAGPLTGLALGTIIAKVF--HPPSITLVGDIPQG 288
Cdd:TIGR00815 160 LGVVISTWASLHQNNWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAPAPLLVVVLATLIVTIGlhDSQGVSIVGHIPQG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  289 LPkFSFPKSFD--HAKLLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSA 366
Cdd:TIGR00815 240 LS-FFPPITFTwqHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGIANIVGSFFSCYPATGSLSRTA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  367 VNSESEAKTGLSGLVTGIIIGCSLLFLTPMFKFIPQCALAAIVISAVSGLVDYEGAIFLWRVDKRDFTLWTITSTTTLFF 446
Cdd:TIGR00815 319 VNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVGLIDIRELYLLWKADKMDFVVWLGTFLGVVFT 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  447 GIEIGVLIGVGFSLAFVIHESANPHIAVLGRLPGTTVYRNMKQYPEAYTYNGIVIVRIDAPIYFANISYIKDRLREYEVa 526
Cdd:TIGR00815 399 SIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKAQTPPGILIFRVDGPLYFANAEDLKERLLKWLE- 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  527 idkhTSKGPDmeriYFVILEMSPVTYIDSSAVEALKDLYEEYKTRGIQLAISNPNKEVLLTLARAGIVELIGKEWFFVRV 606
Cdd:TIGR00815 478 ----TLELDP----QIIILDMSAVPFLDTSGIHALEELFKELKARGIQLLLANPNPAVISTLARAGFVELIGEEHFFPSV 549

                  ...
gi 334185288  607 HDA 609
Cdd:TIGR00815 550 HDA 552
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
52-609 0e+00

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 644.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288   52 PCFLWIRTYRWhQYFKLDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAVGPVALVSLLVS 131
Cdd:TIGR00815   1 PVLRWLRKYRL-KKFKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  132 NALSGIVDPSEE-LYTELAILLALMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLKYFLGYSVSRSSKI 210
Cdd:TIGR00815  80 SLVQREGLQGLFdDYIRLAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGLSQLKGLLGLSIFVKTDI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  211 MPVIDSIIAGADQFKWPPFLLGCTILVILLVMKHVGKAKKELRFIRAAGPLTGLALGTIIAKVF--HPPSITLVGDIPQG 288
Cdd:TIGR00815 160 LGVVISTWASLHQNNWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAPAPLLVVVLATLIVTIGlhDSQGVSIVGHIPQG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  289 LPkFSFPKSFD--HAKLLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSA 366
Cdd:TIGR00815 240 LS-FFPPITFTwqHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGIANIVGSFFSCYPATGSLSRTA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  367 VNSESEAKTGLSGLVTGIIIGCSLLFLTPMFKFIPQCALAAIVISAVSGLVDYEGAIFLWRVDKRDFTLWTITSTTTLFF 446
Cdd:TIGR00815 319 VNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVGLIDIRELYLLWKADKMDFVVWLGTFLGVVFT 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  447 GIEIGVLIGVGFSLAFVIHESANPHIAVLGRLPGTTVYRNMKQYPEAYTYNGIVIVRIDAPIYFANISYIKDRLREYEVa 526
Cdd:TIGR00815 399 SIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKAQTPPGILIFRVDGPLYFANAEDLKERLLKWLE- 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  527 idkhTSKGPDmeriYFVILEMSPVTYIDSSAVEALKDLYEEYKTRGIQLAISNPNKEVLLTLARAGIVELIGKEWFFVRV 606
Cdd:TIGR00815 478 ----TLELDP----QIIILDMSAVPFLDTSGIHALEELFKELKARGIQLLLANPNPAVISTLARAGFVELIGEEHFFPSV 549

                  ...
gi 334185288  607 HDA 609
Cdd:TIGR00815 550 HDA 552
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
64-613 1.21e-157

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 464.58  E-value: 1.21e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  64 QYFKLDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAVGPVALVSLLVSNALS--GIVdps 141
Cdd:COG0659    5 SNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVAAAVAplGSL--- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 142 eelytELAILLALMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLKYFLGYSVSRSSKImPVIDSIIAGA 221
Cdd:COG0659   82 -----ALLLAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIILGQLPHLLGLPAPGGSFL-EKLAALLAAL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 222 DQFKWPPFLLGCTILVILLVMKHVGKakkelrfiRAAGPLTGLALGTIIAKVFHPPsITLVGDIPQGLPKFSFPK-SFDH 300
Cdd:COG0659  156 GEINPPTLALGLLTLAILLLLPRLLK--------RIPGPLVAVVLGTLLVWLLGLD-VATVGEIPSGLPSFSLPDfSLET 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 301 AKLLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSAVNSESEAKTGLSGL 380
Cdd:COG0659  227 LRALLPPALTIALVGSIESLLTARAVDAMTGTRSDPNRELIAQGLANIASGLFGGLPVTGSISRSAVNVKAGARTRLSGI 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 381 VTGIIIGCSLLFLTPMFKFIPQCALAAIVISAVSGLVDYEGAIFLWRVDKRDFTLWTITSTTTLFFGIEIGVLIGVGFSL 460
Cdd:COG0659  307 VHALFLLLVLLFLAPLLAYIPLAALAAILIVVGIGLIDWRSFRRLWRAPRSDFLVMLVTFLVTVFTDLLIGVLVGVLLSL 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 461 AFVIHESANPHIAVLgRLPGtTVYRNMKQYPEAYTYNGIVIVRIDAPIYFANISYIKDRLREYEVAIDkhtskgpdmeri 540
Cdd:COG0659  387 LLFLRRVSRPHVVVL-RVPG-THFRNVERHPEAETGPGVLVYRLDGPLFFGNAERLKERLDALAPDPR------------ 452
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334185288 541 yFVILEMSPVTYIDSSAVEALKDLYEEYKTRGIQLAISNPNKEVLLTLARAGIVELIGKEWFFVRVHDAVQVC 613
Cdd:COG0659  453 -VVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLERAGLLDELGEERVFPDLDEALEAA 524
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
66-433 8.20e-139

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 410.49  E-value: 8.20e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288   66 FKLDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAVGPVALVSLLVSNALSGIVDPSEELY 145
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGAAIAKLAAKDPELG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  146 TELAILLALMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLKYFLGYS-VSRSSKIMPVIDSIIAGADQF 224
Cdd:pfam00916  81 IALAFTLTFLAGIIQLALGLLRLGFLVTFLSHAVISGFMGGAAIVILLSQLKVLLGLTnFSGPGYVVSVLQSLFTNLDKV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  225 KWPPFLLGCTILVILLVMKHVGKAKKELRFIRAAGPLTGLALGTIIAKVFHPPS---ITLVGDIPQGLPKFSFPK-SFDH 300
Cdd:pfam00916 161 NLATLVLGLLVLVILLFTKELGKKYKKLFWIPAPAPLVAVVLATLVSAIFDLLRrygVKIVGEIPSGLPPFSLPKfSWSL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  301 AKLLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSAVNSESEAKTGLSGL 380
Cdd:pfam00916 241 LSALLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANILSGLFGGYPATGAFSRSAVNIKAGAKTPLSGI 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 334185288  381 VTGIIIGCSLLFLTPMFKFIPQCALAAIVISAVSGLVDYEGAIFLWRVDKRDF 433
Cdd:pfam00916 321 IMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGKGLIDYRELKHLWRLSKLDF 373
PRK11660 PRK11660
putative transporter; Provisional
41-611 5.16e-52

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 188.62  E-value: 5.16e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  41 MTFFDWIDAifpcfLWIRTYRWHQYFKlDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAV 120
Cdd:PRK11660  10 RPFSALIDA-----CWKEKYTAARFTR-DLIAGITVGIIAIPLAMALAIASGVPPQYGLYTAAVAGIVIALTGGSRFSVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 121 GPVAlvsllvsnALSGIVDPSEELYTELAILLA-LMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLKYF 199
Cdd:PRK11660  84 GPTA--------AFVVILYPVSQQFGLAGLLVAtLMSGIILILMGLARLGRLIEYIPLSVTLGFTSGIGIVIATLQIKDF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 200 LGYSVSRsskiMPV-----IDSIIAGADQFKWPPFLLGCTILVILLVMKHVGkakkelrfIRAAGPLTGLALGTIIAKVF 274
Cdd:PRK11660 156 FGLQMAH----VPEhylekVGALFQALPTINWGDALIGIVTLGVLILWPRLK--------IRLPGHLPALLAGTAVMGVL 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 275 HP--PSITLVGD--------------IPQGLPKFSFP------------KSFDHAKLLLPTSALITGVAILESVGIAKAL 326
Cdd:PRK11660 224 NLlgGHVATIGSrfhyvladgsqgngIPPLLPQFVLPwnlpgadgqpftLSWDLIRALLPAAFSMAMLGAIESLLCAVVL 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 327 AAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSAVNSESEAKTGLSGLVTGIIIGCSLLFLTPMFKFIPQCALA 406
Cdd:PRK11660 304 DGMTGTKHSANSELVGQGLGNIVAPFFGGITATAAIARSAANVRAGATSPISAVIHALLVLLALLVLAPLLSYLPLSAMA 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 407 AIVISAVSGLVDYEGAIFLWRV-DKRDFTLWTITSTTTLFFGIEIGVLIGVGFSLAFVIHEsanphIAVLGRLPGTTVYr 485
Cdd:PRK11660 384 ALLLMVAWNMSEAHKVVDLLRHaPKDDIIVMLLCMSLTVLFDMVIAISVGIVLASLLFMRR-----IAEMTRLAPISVQ- 457
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 486 nmkQYPEaytynGIVIVRIDAPIYFA---NI-SYIKDRLREYEVaidkhtskgpdmeriyfVILEMSPVTYIDSSAVEAL 561
Cdd:PRK11660 458 ---DVPD-----DVLVLRINGPLFFAaaeRLfTELESRTEGKRI-----------------VVLQWDAVPVLDAGGLDAF 512
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 334185288 562 KDLYEEYKtRGIQLAISNPNKEVLLTLARAGIVELIGKEWFFVRVHDAVQ 611
Cdd:PRK11660 513 QRFVKRLP-EGCELRICNLQFQPLRTLARAGIQPIPGRLAFYPTLREALA 561
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
490-606 2.35e-28

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 109.25  E-value: 2.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 490 YPEAYTYNGIVIVRIDAPIYFANISYIKDRLREYEVaidkhtskgpDMERIYFVILEMSPVTYIDSSAVEALKDLYEEYK 569
Cdd:cd07042    1 YPLAEEPPGVLIYRIDGPLFFGNAEYFKDRLLRLVD----------EDPPLKVVILDLSAVNFIDSTAAEALEELVKDLR 70
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 334185288 570 TRGIQLAISNPNKEVLLTLARAGIVELIGKEWFFVRV 606
Cdd:cd07042   71 KRGVELYLAGLNPQVRELLERAGLLDEIGEENFFPTL 107
 
Name Accession Description Interval E-value
sulP TIGR00815
high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with ...
52-609 0e+00

high affinity sulphate transporter 1; The SulP family is a large and ubiquitous family with over 30 sequenced members derived from bacteria, fungi, plants and animals. Many organisms including Bacillus subtilis, Synechocystis sp, Saccharomyces cerevisiae, Arabidopsis thaliana and Caenorhabditis elegans possess multiple SulP family paralogues. Many of these proteins are functionally characterized, and all are sulfate uptake transporters. Some transport their substrate with high affinities, while others transport it with relatively low affinities. Most function by SO42- :H+symport, but SO42- :HCO3- antiport has been reported for the rat protein (spP45380). The bacterial proteins vary in size from 434 residues to 566 residues with one exception, a Mycobacterium tuberculosis protein with 784 residues. The eukaryotic proteins vary in size from 611 residues to 893 residues with one exception, a protein designated "early nodulin 70 protein" from Glycine max which is reported to be of 485 residues. Thus, the eukaryotic proteins are almost without exception larger than the prokaryotic proteins. These proteins exhibit 10-13 putative transmembrane a-helical spanners (TMSs) depending on the protein. The phylogenetic tree for the SulP family reveals five principal branches. Three of these are bacterial specific as follows: one bears a single protein from M. tuberculosis; a second bears two proteins, one from M. tuberculosis, the other from Synechocystis sp, and the third bears all remaining prokaryotic proteins. The remaining two clusters bear only eukaryotic proteins with the animal proteins all localized to one branch and the plant and fungal proteins localized to the other. The generalized transport reactions catalyzed by SulP family proteins are: (1) SO42- (out) + nH+ (out) --> SO42- (in) + nH+ (in). (2) SO42- (out) + nHCO3- (in) SO42- (in) + nHCO3- (out). [Transport and binding proteins, Anions]


Pssm-ID: 273284 [Multi-domain]  Cd Length: 552  Bit Score: 644.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288   52 PCFLWIRTYRWhQYFKLDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAVGPVALVSLLVS 131
Cdd:TIGR00815   1 PVLRWLRKYRL-KKFKGDLMAGLTVGILLIPQAIAYAKLAGLPPIYGLYTSFVPPIIYALFGSSRHIAIGPTASVSLLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  132 NALSGIVDPSEE-LYTELAILLALMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLKYFLGYSVSRSSKI 210
Cdd:TIGR00815  80 SLVQREGLQGLFdDYIRLAFTATLLAGIFQVIMGLLRLGFLIEYLSHAVLVGFTAGAAITIGLSQLKGLLGLSIFVKTDI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  211 MPVIDSIIAGADQFKWPPFLLGCTILVILLVMKHVGKAKKELRFIRAAGPLTGLALGTIIAKVF--HPPSITLVGDIPQG 288
Cdd:TIGR00815 160 LGVVISTWASLHQNNWCTLVIGLLFLLFLLATKELGKRNKKLLWAPAPAPLLVVVLATLIVTIGlhDSQGVSIVGHIPQG 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  289 LPkFSFPKSFD--HAKLLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSA 366
Cdd:TIGR00815 240 LS-FFPPITFTwqHLPTLAPDAIAIAIVGLTESILTARVFAAMTGYEIDANKELVALGIANIVGSFFSCYPATGSLSRTA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  367 VNSESEAKTGLSGLVTGIIIGCSLLFLTPMFKFIPQCALAAIVISAVSGLVDYEGAIFLWRVDKRDFTLWTITSTTTLFF 446
Cdd:TIGR00815 319 VNYKAGCKTQLSAIVMAIVVLLVLLVLAPLFYYIPLAALAAIIISAAVGLIDIRELYLLWKADKMDFVVWLGTFLGVVFT 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  447 GIEIGVLIGVGFSLAFVIHESANPHIAVLGRLPGTTVYRNMKQYPEAYTYNGIVIVRIDAPIYFANISYIKDRLREYEVa 526
Cdd:TIGR00815 399 SIEIGLLVGVSLSAFFFILRVARPRAAVLGRIPGTEDYENIEQYPKAQTPPGILIFRVDGPLYFANAEDLKERLLKWLE- 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  527 idkhTSKGPDmeriYFVILEMSPVTYIDSSAVEALKDLYEEYKTRGIQLAISNPNKEVLLTLARAGIVELIGKEWFFVRV 606
Cdd:TIGR00815 478 ----TLELDP----QIIILDMSAVPFLDTSGIHALEELFKELKARGIQLLLANPNPAVISTLARAGFVELIGEEHFFPSV 549

                  ...
gi 334185288  607 HDA 609
Cdd:TIGR00815 550 HDA 552
SUL1 COG0659
Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and ...
64-613 1.21e-157

Sulfate permease or related transporter, MFS superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 440424 [Multi-domain]  Cd Length: 529  Bit Score: 464.58  E-value: 1.21e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  64 QYFKLDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAVGPVALVSLLVSNALS--GIVdps 141
Cdd:COG0659    5 SNLRGDLLAGLTVALVALPLALAFAIAAGLPPEAGLYAAIVGGIVYALFGGSRLLISGPTAALAVVVAAAVAplGSL--- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 142 eelytELAILLALMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLKYFLGYSVSRSSKImPVIDSIIAGA 221
Cdd:COG0659   82 -----ALLLAATLLAGVLQLLLGLLRLGRLARFIPRPVIVGFLAGIAILIILGQLPHLLGLPAPGGSFL-EKLAALLAAL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 222 DQFKWPPFLLGCTILVILLVMKHVGKakkelrfiRAAGPLTGLALGTIIAKVFHPPsITLVGDIPQGLPKFSFPK-SFDH 300
Cdd:COG0659  156 GEINPPTLALGLLTLAILLLLPRLLK--------RIPGPLVAVVLGTLLVWLLGLD-VATVGEIPSGLPSFSLPDfSLET 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 301 AKLLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSAVNSESEAKTGLSGL 380
Cdd:COG0659  227 LRALLPPALTIALVGSIESLLTARAVDAMTGTRSDPNRELIAQGLANIASGLFGGLPVTGSISRSAVNVKAGARTRLSGI 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 381 VTGIIIGCSLLFLTPMFKFIPQCALAAIVISAVSGLVDYEGAIFLWRVDKRDFTLWTITSTTTLFFGIEIGVLIGVGFSL 460
Cdd:COG0659  307 VHALFLLLVLLFLAPLLAYIPLAALAAILIVVGIGLIDWRSFRRLWRAPRSDFLVMLVTFLVTVFTDLLIGVLVGVLLSL 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 461 AFVIHESANPHIAVLgRLPGtTVYRNMKQYPEAYTYNGIVIVRIDAPIYFANISYIKDRLREYEVAIDkhtskgpdmeri 540
Cdd:COG0659  387 LLFLRRVSRPHVVVL-RVPG-THFRNVERHPEAETGPGVLVYRLDGPLFFGNAERLKERLDALAPDPR------------ 452
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334185288 541 yFVILEMSPVTYIDSSAVEALKDLYEEYKTRGIQLAISNPNKEVLLTLARAGIVELIGKEWFFVRVHDAVQVC 613
Cdd:COG0659  453 -VVILDLSAVPFIDATALEALEELAERLRARGITLELAGLKPPVRDLLERAGLLDELGEERVFPDLDEALEAA 524
Sulfate_transp pfam00916
Sulfate permease family; This family of integral membrane proteins are known as the Sulfate ...
66-433 8.20e-139

Sulfate permease family; This family of integral membrane proteins are known as the Sulfate Permease (SulP) family. SulP is a large family found in all domains of life. Although sulfate is a commonly transported ion there are many other activities in this family. See the TCDB description for a comprehensive summary.


Pssm-ID: 459995 [Multi-domain]  Cd Length: 379  Bit Score: 410.49  E-value: 8.20e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288   66 FKLDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAVGPVALVSLLVSNALSGIVDPSEELY 145
Cdd:pfam00916   1 LKGDLIAGITVAILAIPQALAYAILAGLPPIYGLYSSFVPGFVYALFGTSRHLAIGPVAVLSLMVGAAIAKLAAKDPELG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  146 TELAILLALMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLKYFLGYS-VSRSSKIMPVIDSIIAGADQF 224
Cdd:pfam00916  81 IALAFTLTFLAGIIQLALGLLRLGFLVTFLSHAVISGFMGGAAIVILLSQLKVLLGLTnFSGPGYVVSVLQSLFTNLDKV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  225 KWPPFLLGCTILVILLVMKHVGKAKKELRFIRAAGPLTGLALGTIIAKVFHPPS---ITLVGDIPQGLPKFSFPK-SFDH 300
Cdd:pfam00916 161 NLATLVLGLLVLVILLFTKELGKKYKKLFWIPAPAPLVAVVLATLVSAIFDLLRrygVKIVGEIPSGLPPFSLPKfSWSL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  301 AKLLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSAVNSESEAKTGLSGL 380
Cdd:pfam00916 241 LSALLPDALAIAIVGLLEAIAISKSFAKKKGYEVDSNQELVALGFANILSGLFGGYPATGAFSRSAVNIKAGAKTPLSGI 320
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 334185288  381 VTGIIIGCSLLFLTPMFKFIPQCALAAIVISAVSGLVDYEGAIFLWRVDKRDF 433
Cdd:pfam00916 321 IMAVIVLLVLLFLTPLFAYIPKAVLAAIIIVAGKGLIDYRELKHLWRLSKLDF 373
PRK11660 PRK11660
putative transporter; Provisional
41-611 5.16e-52

putative transporter; Provisional


Pssm-ID: 183265 [Multi-domain]  Cd Length: 568  Bit Score: 188.62  E-value: 5.16e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  41 MTFFDWIDAifpcfLWIRTYRWHQYFKlDLMAGITVGIMLVPQAMSYARLAGLQPIYGLYSSFVPVFVYAVFGSSRQLAV 120
Cdd:PRK11660  10 RPFSALIDA-----CWKEKYTAARFTR-DLIAGITVGIIAIPLAMALAIASGVPPQYGLYTAAVAGIVIALTGGSRFSVS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 121 GPVAlvsllvsnALSGIVDPSEELYTELAILLA-LMVGIFESIMGFLRLGWLIRFISHSVISGFTTASAVVIGLSQLKYF 199
Cdd:PRK11660  84 GPTA--------AFVVILYPVSQQFGLAGLLVAtLMSGIILILMGLARLGRLIEYIPLSVTLGFTSGIGIVIATLQIKDF 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 200 LGYSVSRsskiMPV-----IDSIIAGADQFKWPPFLLGCTILVILLVMKHVGkakkelrfIRAAGPLTGLALGTIIAKVF 274
Cdd:PRK11660 156 FGLQMAH----VPEhylekVGALFQALPTINWGDALIGIVTLGVLILWPRLK--------IRLPGHLPALLAGTAVMGVL 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 275 HP--PSITLVGD--------------IPQGLPKFSFP------------KSFDHAKLLLPTSALITGVAILESVGIAKAL 326
Cdd:PRK11660 224 NLlgGHVATIGSrfhyvladgsqgngIPPLLPQFVLPwnlpgadgqpftLSWDLIRALLPAAFSMAMLGAIESLLCAVVL 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 327 AAKNRYELDSNSELFGLGVANIFGSLFSAYPTTGSFSRSAVNSESEAKTGLSGLVTGIIIGCSLLFLTPMFKFIPQCALA 406
Cdd:PRK11660 304 DGMTGTKHSANSELVGQGLGNIVAPFFGGITATAAIARSAANVRAGATSPISAVIHALLVLLALLVLAPLLSYLPLSAMA 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 407 AIVISAVSGLVDYEGAIFLWRV-DKRDFTLWTITSTTTLFFGIEIGVLIGVGFSLAFVIHEsanphIAVLGRLPGTTVYr 485
Cdd:PRK11660 384 ALLLMVAWNMSEAHKVVDLLRHaPKDDIIVMLLCMSLTVLFDMVIAISVGIVLASLLFMRR-----IAEMTRLAPISVQ- 457
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 486 nmkQYPEaytynGIVIVRIDAPIYFA---NI-SYIKDRLREYEVaidkhtskgpdmeriyfVILEMSPVTYIDSSAVEAL 561
Cdd:PRK11660 458 ---DVPD-----DVLVLRINGPLFFAaaeRLfTELESRTEGKRI-----------------VVLQWDAVPVLDAGGLDAF 512
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|
gi 334185288 562 KDLYEEYKtRGIQLAISNPNKEVLLTLARAGIVELIGKEWFFVRVHDAVQ 611
Cdd:PRK11660 513 QRFVKRLP-EGCELRICNLQFQPLRTLARAGIQPIPGRLAFYPTLREALA 561
STAS_SulP_like_sulfate_transporter cd07042
Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, ...
490-606 2.35e-28

Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; The SulP family is a large and diverse family of anion transporters, with members from eubacteria, plants, fungi, and mammals. They contain 10 to 14 transmembrane helices which form the catalytic core of the protein and a C-terminal extension, the STAS (Sulphate Transporter and AntiSigma factor antagonist) domain which plays a role in the function and regulation of the transport activity. The STAS domain is found in the C-terminal region of sulphate transporters and bacterial anti-sigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 132913 [Multi-domain]  Cd Length: 107  Bit Score: 109.25  E-value: 2.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 490 YPEAYTYNGIVIVRIDAPIYFANISYIKDRLREYEVaidkhtskgpDMERIYFVILEMSPVTYIDSSAVEALKDLYEEYK 569
Cdd:cd07042    1 YPLAEEPPGVLIYRIDGPLFFGNAEYFKDRLLRLVD----------EDPPLKVVILDLSAVNFIDSTAAEALEELVKDLR 70
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 334185288 570 TRGIQLAISNPNKEVLLTLARAGIVELIGKEWFFVRV 606
Cdd:cd07042   71 KRGVELYLAGLNPQVRELLERAGLLDEIGEENFFPTL 107
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
490-609 2.87e-26

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 103.46  E-value: 2.87e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  490 YPEAYTYNGIVIVRIDAPIYFANISYIKDRLREYEVAidkhtskgpdmERIYFVILEMSPVTYIDSSAVEALKDLYEEYK 569
Cdd:pfam01740   1 YPEAEEIPGILILRLDGPLDFANAESLRERLLRALEE-----------GEIKHVVLDLSAVPFIDSSGLGALEELYKELR 69
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 334185288  570 TRGIQLAISNPNKEVLLTLARAGIVELIgkeWFFVRVHDA 609
Cdd:pfam01740  70 RRGVELVLVGPSPEVARTLEKTGLDDII---KIFPTVAEA 106
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
497-593 1.42e-07

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 49.47  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 497 NGIVIVRIDAPIYFANISYIKDRLREyevAIDKHTSKgpdmeriyfVILEMSPVTYIDSSAVEALKDLYEEYKTRGIQLA 576
Cdd:COG1366    8 DGVLVLPLIGELDAARAPELREALLE---ALETGARR---------VVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLV 75
                         90
                 ....*....|....*..
gi 334185288 577 ISNPNKEVLLTLARAGI 593
Cdd:COG1366   76 LVGVSPAVARVLELTGL 92
STAS_anti-anti-sigma_factors cd07043
Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key ...
492-597 4.66e-07

Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Anti-anti-sigma factors play an important role in the regulation of several sigma factors and their corresponding anti-sigma factors. Upon dephosphorylation they bind the anti-sigma factor and induce the release of the sigma factor from the anti-sigma factor. In a feedback mechanism the anti-anti-sigma factor can be inactivated via phosphorylation by the anti-sigma factor. Well studied examples from Bacillus subtilis are SpoIIAA (regulating sigmaF and sigmaC which play an important role in sporulation) and RsbV (regulating sigmaB involved in the general stress response). The STAS domain is also found in the C- terminal region of sulphate transporters and stressosomes.


Pssm-ID: 132914 [Multi-domain]  Cd Length: 99  Bit Score: 48.29  E-value: 4.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 492 EAYTYNGIVIVRIDAPIYFANISYIKDRLREyevAIDKHTSKgpdmeriyfVILEMSPVTYIDSSAVEALKDLYEEYKTR 571
Cdd:cd07043    2 TVEERGGVLVVRLSGELDAATAPELREALEE---LLAEGPRR---------LVLDLSGVTFIDSSGLGVLLGAYKRARAA 69
                         90       100
                 ....*....|....*....|....*.
gi 334185288 572 GIQLAISNPNKEVLLTLARAGIVELI 597
Cdd:cd07043   70 GGRLVLVNVSPAVRRVLELTGLDRLF 95
Xan_ur_permease pfam00860
Permease family; This family includes permeases for diverse substrates such as xanthine, ...
140-417 1.61e-06

Permease family; This family includes permeases for diverse substrates such as xanthine, uracil and vitamin C. However many members of this family are functionally uncharacterized and may transport other substrates. Members of this family have ten predicted transmembrane helices.


Pssm-ID: 395690 [Multi-domain]  Cd Length: 389  Bit Score: 50.76  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  140 PSEELYTELAILLALMVGIFESIMGFLRLGWLIRFISHSVISGFTTasavVIGLSQLKYFLgysvsrssKIMPVIDSIIA 219
Cdd:pfam00860  84 DWGIALAGLFGAVLVAGVLFTLISFTGLRGRLARLFPPVVTGPVVL----LIGLSLAPIAV--------KGAGGGWAIAD 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  220 GADQFKWPPFLLGCTILVILLVMKHVGKAkkelrFIRAAGPLTGLALGTIIA----------KVFHPPSITLVGDIPQGL 289
Cdd:pfam00860 152 GLTVGLLDLLGLAVVVLAVILLLSVFLKG-----FFRQGPILIGIIAGWLLAlfmgivnfspEVMDAPWFQLPHPFPFGT 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288  290 PKFSFPksfdhaklLLPTSALITGVAILESVGIAKALAAKNRYELDSNSEL----FGLGVANIFGSLFSAYPTTGSFSRS 365
Cdd:pfam00860 227 PLFNPG--------LILTMLAVALVAIVESTGDIRAVAKVSGRDLKPKPDLrrglLADGLATLLSGLFGAFPTTTYAENI 298
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 334185288  366 AVNSESEAKTGLSGLVTGII---IGCSlLFLTPMFKFIPqcalaAIVISAVSGLV 417
Cdd:pfam00860 299 GVVALTKVYSRRVGVTAGVIlilLGLI-PKFAALFSSIP-----SPVLGGVMLVM 347
NCS2 COG2252
Xanthine/guanine/uracil/vitamin C permease GhxP/GhxQ, nucleobase:cation symporter 2 ( NCS2) ...
224-410 1.50e-04

Xanthine/guanine/uracil/vitamin C permease GhxP/GhxQ, nucleobase:cation symporter 2 ( NCS2) family [Nucleotide transport and metabolism];


Pssm-ID: 441853  Cd Length: 435  Bit Score: 44.65  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 224 FKWPPFLLGCTILVILLVMkhvgkakkELRFIRAAgPLTGLALGTIIAKVF---HPPS--ITLVGDIPQGLPKFSFPKSF 298
Cdd:COG2252  170 LTSPPVLLALIGLLLTAVL--------MARKVKGA-ILIGILATTILGIILgvtPLPSgiVSLPPSLAPTFGQLDFSGAL 240
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 299 DHAKLLLPTSALItgVAILESVGIAKALAAKNRYeLDSNSELFGLG-------VANIFGSLFSAYPTTgSFSRSAVNSES 371
Cdd:COG2252  241 SLGLLPVVFTFLF--VDFFDTMGTLIGVASRAGL-LDEDGNLPRLGralladaIATVAGALLGTSTVT-TYVESAAGVAA 316
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 334185288 372 EAKTGLSGLVTGIIIGCSlLFLTPMFKFIPQCALAAIVI 410
Cdd:COG2252  317 GGRTGLTAVVTGLLFLLA-LFFSPLASAVPAAATAPALI 354
STAS cd06844
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of ...
498-593 1.63e-03

Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain is found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors, like anti-anti-sigma factors and "stressosome" components. The sigma factor regulators are involved in protein-protein interaction which is regulated by phosphorylation.


Pssm-ID: 132911 [Multi-domain]  Cd Length: 100  Bit Score: 38.23  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334185288 498 GIVIVRIDAPIYFANISYIKDRLREYEVAIDKHTskgpdmeriyfVILEMSPVTYIDSSAVEALKDLYEEYKTRGIQLAI 577
Cdd:cd06844    8 DYWVVRLEGELDHHSVEQFKEELLHNITNVAGKT-----------IVIDISALEFMDSSGTGVLLERSRLAEAVGGQFVL 76
                         90
                 ....*....|....*.
gi 334185288 578 SNPNKEVLLTLARAGI 593
Cdd:cd06844   77 TGISPAVRITLTESGL 92
ant_ant_sig TIGR00377
anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to ...
543-597 2.14e-03

anti-anti-sigma factor; This superfamily includes small (105-125 residue) proteins related to SpoIIAA of Bacillus subtilis, an anti-anti-sigma factor. SpoIIAA can bind to and inhibit the anti-sigma F factor SpoIIAB. Also, it can be phosphorylated by SpoIIAB on a Ser residue at position 59 of the seed alignment. A similar arrangement is inferred for RsbV, an anti-anti-sigma factor for sigma B. This Ser is fairly well conserved within a motif resembling MXS[STA]G[VIL]X[VIL][VILF] among homologous known or predicted anti-anti-sigma factors. Regions similar to SpoIIAA and apparently homologous, but differing considerably near the phosphorlated Ser of SpoIIAA, appear in a single copy in several longer proteins. [Regulatory functions, Protein interactions]


Pssm-ID: 273042 [Multi-domain]  Cd Length: 108  Bit Score: 38.35  E-value: 2.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 334185288  543 VILEMSPVTYIDSSAVEALKDLYEEYKTRGIQLAISNPNKEVLLTLARAGIVELI 597
Cdd:TIGR00377  46 IVLDLEDLEFMDSSGLGVLLGRYKQVRRVGGQLVLVSVSPRVARLLDITGLLRII 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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