NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|334184965|ref|NP_001189769|]
View 

agenet domain protein (DOMAIN OF UNKNOWN FUNCTION 724 6) [Arabidopsis thaliana]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
DUF724 pfam05266
Protein of unknown function (DUF724); This family contains several uncharacterized proteins ...
521-708 3.52e-94

Protein of unknown function (DUF724); This family contains several uncharacterized proteins found in Arabidopsis thaliana and other plants. This region is often found associated with Agenet domains and may contain coiled-coil.


:

Pssm-ID: 428400 [Multi-domain]  Cd Length: 188  Bit Score: 289.94  E-value: 3.52e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965  521 ILPFAKKSPFWKMYETQEVCKIAPQSPHFSPLFEAKEELREWTAVGMMVSFYGLLEEVKNLQLDVSPSTLGSLSCSFAEL 600
Cdd:pfam05266   1 VLPFVKKSPLWKTIESMEVFKKVPQRPHFSPLLESKEELREGSALGMMVSFAGLLEKVKKLQVDDSRSVFESLMESFAEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965  601 EKHGFDVAAPQSRINKMLSLQDERAKKAEERKGLEKKIEAGEIEGHTYEEEMAELELKILELKRQQVVAKEMKEATDKVT 680
Cdd:pfam05266  81 EKHGFDVKAPQSRINKLLSLKDRQTKLLEELKKLEKKIAEEESEKRKLEEEIDELEKKILELERQLALAKEKKEAADKEI 160
                         170       180
                  ....*....|....*....|....*...
gi 334184965  681 SGMKSYAEMINQEIEDLRLEFQSTASAP 708
Cdd:pfam05266 161 ARLKSEAEKLEQEIQDVELEFEATASAP 188
Tudor_Agenet_AtDUF_rpt1_3 cd20405
first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 ...
5-71 3.11e-21

first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the first and third Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410476  Cd Length: 65  Bit Score: 87.70  E-value: 3.11e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334184965   5 IRKGSEVEVSSTEEGFADAWFRGILQENPTksGRKKLRVRYLTLLNDDALSPLIENIEPRFIRPVPP 71
Cdd:cd20405    1 FSKGTEVEVSSEEEGFRGSWYRAIVVKEPE--GEKKFLVKYDELLLDDGSEPLEETVDLRRVRPVPP 65
Tudor_Agenet_AtDUF_rpt2_4 cd20406
second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 ...
82-128 3.72e-17

second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the second and fourth Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410477  Cd Length: 47  Bit Score: 75.32  E-value: 3.72e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 334184965  82 EGTVVDADHKDGWWTGVIIKKLENGKFWVYYDSPPDIIEFERNQLRP 128
Cdd:cd20406    1 LGDKVDAFYNGGWWPGVVTKVLEDNRYLVYLDATKEELEFEHSDLRP 47
Tudor_Agenet_AtDUF_rpt1_3 cd20405
first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 ...
150-218 1.09e-16

first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the first and third Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410476  Cd Length: 65  Bit Score: 74.60  E-value: 1.09e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334184965 150 FSSGTMAEVSTIVDKAEVAWFPAMIIKEIEvdGEKKFIVKDCNkhLSFSGDEARTNSTIDSSRVRPTPP 218
Cdd:cd20405    1 FSKGTEVEVSSEEEGFRGSWYRAIVVKEPE--GEKKFLVKYDE--LLLDDGSEPLEETVDLRRVRPVPP 65
Tudor_Agenet_AtDUF_rpt2_4 cd20406
second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 ...
227-273 3.09e-15

second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the second and fourth Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410477  Cd Length: 47  Bit Score: 69.93  E-value: 3.09e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 334184965 227 LMDRVEVFRGSVWRQGLVRGVLDHNCYMVCLVVTKEEPVVKHSDLRP 273
Cdd:cd20406    1 LGDKVDAFYNGGWWPGVVTKVLEDNRYLVYLDATKEELEFEHSDLRP 47
 
Name Accession Description Interval E-value
DUF724 pfam05266
Protein of unknown function (DUF724); This family contains several uncharacterized proteins ...
521-708 3.52e-94

Protein of unknown function (DUF724); This family contains several uncharacterized proteins found in Arabidopsis thaliana and other plants. This region is often found associated with Agenet domains and may contain coiled-coil.


Pssm-ID: 428400 [Multi-domain]  Cd Length: 188  Bit Score: 289.94  E-value: 3.52e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965  521 ILPFAKKSPFWKMYETQEVCKIAPQSPHFSPLFEAKEELREWTAVGMMVSFYGLLEEVKNLQLDVSPSTLGSLSCSFAEL 600
Cdd:pfam05266   1 VLPFVKKSPLWKTIESMEVFKKVPQRPHFSPLLESKEELREGSALGMMVSFAGLLEKVKKLQVDDSRSVFESLMESFAEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965  601 EKHGFDVAAPQSRINKMLSLQDERAKKAEERKGLEKKIEAGEIEGHTYEEEMAELELKILELKRQQVVAKEMKEATDKVT 680
Cdd:pfam05266  81 EKHGFDVKAPQSRINKLLSLKDRQTKLLEELKKLEKKIAEEESEKRKLEEEIDELEKKILELERQLALAKEKKEAADKEI 160
                         170       180
                  ....*....|....*....|....*...
gi 334184965  681 SGMKSYAEMINQEIEDLRLEFQSTASAP 708
Cdd:pfam05266 161 ARLKSEAEKLEQEIQDVELEFEATASAP 188
Tudor_Agenet_AtDUF_rpt1_3 cd20405
first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 ...
5-71 3.11e-21

first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the first and third Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410476  Cd Length: 65  Bit Score: 87.70  E-value: 3.11e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334184965   5 IRKGSEVEVSSTEEGFADAWFRGILQENPTksGRKKLRVRYLTLLNDDALSPLIENIEPRFIRPVPP 71
Cdd:cd20405    1 FSKGTEVEVSSEEEGFRGSWYRAIVVKEPE--GEKKFLVKYDELLLDDGSEPLEETVDLRRVRPVPP 65
Tudor_Agenet_AtDUF_rpt2_4 cd20406
second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 ...
82-128 3.72e-17

second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the second and fourth Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410477  Cd Length: 47  Bit Score: 75.32  E-value: 3.72e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 334184965  82 EGTVVDADHKDGWWTGVIIKKLENGKFWVYYDSPPDIIEFERNQLRP 128
Cdd:cd20406    1 LGDKVDAFYNGGWWPGVVTKVLEDNRYLVYLDATKEELEFEHSDLRP 47
Tudor_Agenet_AtDUF_rpt1_3 cd20405
first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 ...
150-218 1.09e-16

first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the first and third Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410476  Cd Length: 65  Bit Score: 74.60  E-value: 1.09e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334184965 150 FSSGTMAEVSTIVDKAEVAWFPAMIIKEIEvdGEKKFIVKDCNkhLSFSGDEARTNSTIDSSRVRPTPP 218
Cdd:cd20405    1 FSKGTEVEVSSEEEGFRGSWYRAIVVKEPE--GEKKFLVKYDE--LLLDDGSEPLEETVDLRRVRPVPP 65
Tudor_Agenet_AtDUF_rpt2_4 cd20406
second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 ...
227-273 3.09e-15

second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the second and fourth Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410477  Cd Length: 47  Bit Score: 69.93  E-value: 3.09e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 334184965 227 LMDRVEVFRGSVWRQGLVRGVLDHNCYMVCLVVTKEEPVVKHSDLRP 273
Cdd:cd20406    1 LGDKVDAFYNGGWWPGVVTKVLEDNRYLVYLDATKEELEFEHSDLRP 47
Agenet pfam05641
Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the ...
8-71 2.65e-14

Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the agenet domain is unknown. This family now matches both the two Agenet domains in the FMR proteins.


Pssm-ID: 461700  Cd Length: 61  Bit Score: 67.72  E-value: 2.65e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334184965    8 GSEVEVSSTEEGFADAWFRGILQENPtksGRKKLRVRYLTLLNDDALSPLIENIEPRFIRPVPP 71
Cdd:pfam05641   1 GDKVEVLSDEEGFRGAWFRAKVIKVL---KGDKYLVEYDDLLDEDGGGPLEEWVPASDIRPCPP 61
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
79-134 2.04e-13

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


Pssm-ID: 214798  Cd Length: 59  Bit Score: 65.04  E-value: 2.04e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 334184965    79 VLEEGTVVDADHKDGWWTGVIIKKLENGKFWVYYD--SPPDIIEFERNQLRPHLRWSG 134
Cdd:smart00743   2 DFKEGDRVEVFSEDSWWEAVVTKVLGDGKYLVEYKgeSEPLELTVDWSDLRPHPPWVD 59
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
223-279 4.32e-13

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


Pssm-ID: 214798  Cd Length: 59  Bit Score: 64.27  E-value: 4.32e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 334184965   223 EKYELMDRVEVFRGSVWRQGLVRGVLDHNCYMVCLV--VTKEEPVVKHSDLRPCKVWED 279
Cdd:smart00743   1 SDFKEGDRVEVFSEDSWWEAVVTKVLGDGKYLVEYKgeSEPLELTVDWSDLRPHPPWVD 59
Agenet pfam05641
Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the ...
153-218 3.42e-10

Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the agenet domain is unknown. This family now matches both the two Agenet domains in the FMR proteins.


Pssm-ID: 461700  Cd Length: 61  Bit Score: 56.17  E-value: 3.42e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334184965  153 GTMAEVSTIVDKAEVAWFPAMIIKEIevdGEKKFIVKDcnKHLSFSGDEARTNSTIDSSRVRPTPP 218
Cdd:pfam05641   1 GDKVEVLSDEEGFRGAWFRAKVIKVL---KGDKYLVEY--DDLLDEDGGGPLEEWVPASDIRPCPP 61
Agenet pfam05641
Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the ...
83-129 9.52e-05

Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the agenet domain is unknown. This family now matches both the two Agenet domains in the FMR proteins.


Pssm-ID: 461700  Cd Length: 61  Bit Score: 40.76  E-value: 9.52e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 334184965   83 GTVVDADHKDG-----WWTGVIIKKLENGKFWVYYDSPPDIIE-------FERNQLRPH 129
Cdd:pfam05641   1 GDKVEVLSDEEgfrgaWFRAKVIKVLKGDKYLVEYDDLLDEDGggpleewVPASDIRPC 59
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
619-698 5.22e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 42.56  E-value: 5.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965 619 SLQDERAKKAEERKGLEKKIEAGEiegHTYEEEMAELELKILELKRQ------QVVAKEMKEATDKVTSGMKSYAEMINQ 692
Cdd:cd16269  209 AAEQERKLLEEQQRELEQKLEDQE---RSYEEHLRQLKEKMEEERENllkeqeRALESKLKEQEALLEEGFKEQAELLQE 285

                 ....*.
gi 334184965 693 EIEDLR 698
Cdd:cd16269  286 EIRSLK 291
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
148-219 5.19e-03

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


Pssm-ID: 214798  Cd Length: 59  Bit Score: 35.76  E-value: 5.19e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334184965   148 SMFSSGTMAEVSTivdkaEVAWFPAMIIKeieVDGEKKFIVKdcnkhlsFSGDEARTNSTIDSSRVRPTPPP 219
Cdd:smart00743   1 SDFKEGDRVEVFS-----EDSWWEAVVTK---VLGDGKYLVE-------YKGESEPLELTVDWSDLRPHPPW 57
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
619-703 6.03e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965   619 SLQDERAKKAEERKGLEKKIEAGEIEGHTYEEEMAELELKILELKRQQVVAKemKEATDKVTSGMKSYAEMINQEIEDLR 698
Cdd:TIGR02169  748 SLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAE--LSKLEEEVSRIEARLREIEQKLNRLT 825

                   ....*
gi 334184965   699 LEFQS 703
Cdd:TIGR02169  826 LEKEY 830
 
Name Accession Description Interval E-value
DUF724 pfam05266
Protein of unknown function (DUF724); This family contains several uncharacterized proteins ...
521-708 3.52e-94

Protein of unknown function (DUF724); This family contains several uncharacterized proteins found in Arabidopsis thaliana and other plants. This region is often found associated with Agenet domains and may contain coiled-coil.


Pssm-ID: 428400 [Multi-domain]  Cd Length: 188  Bit Score: 289.94  E-value: 3.52e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965  521 ILPFAKKSPFWKMYETQEVCKIAPQSPHFSPLFEAKEELREWTAVGMMVSFYGLLEEVKNLQLDVSPSTLGSLSCSFAEL 600
Cdd:pfam05266   1 VLPFVKKSPLWKTIESMEVFKKVPQRPHFSPLLESKEELREGSALGMMVSFAGLLEKVKKLQVDDSRSVFESLMESFAEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965  601 EKHGFDVAAPQSRINKMLSLQDERAKKAEERKGLEKKIEAGEIEGHTYEEEMAELELKILELKRQQVVAKEMKEATDKVT 680
Cdd:pfam05266  81 EKHGFDVKAPQSRINKLLSLKDRQTKLLEELKKLEKKIAEEESEKRKLEEEIDELEKKILELERQLALAKEKKEAADKEI 160
                         170       180
                  ....*....|....*....|....*...
gi 334184965  681 SGMKSYAEMINQEIEDLRLEFQSTASAP 708
Cdd:pfam05266 161 ARLKSEAEKLEQEIQDVELEFEATASAP 188
Tudor_Agenet_AtDUF_rpt1_3 cd20405
first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 ...
5-71 3.11e-21

first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the first and third Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410476  Cd Length: 65  Bit Score: 87.70  E-value: 3.11e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 334184965   5 IRKGSEVEVSSTEEGFADAWFRGILQENPTksGRKKLRVRYLTLLNDDALSPLIENIEPRFIRPVPP 71
Cdd:cd20405    1 FSKGTEVEVSSEEEGFRGSWYRAIVVKEPE--GEKKFLVKYDELLLDDGSEPLEETVDLRRVRPVPP 65
Tudor_Agenet_AtDUF_rpt2_4 cd20406
second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 ...
82-128 3.72e-17

second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the second and fourth Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410477  Cd Length: 47  Bit Score: 75.32  E-value: 3.72e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 334184965  82 EGTVVDADHKDGWWTGVIIKKLENGKFWVYYDSPPDIIEFERNQLRP 128
Cdd:cd20406    1 LGDKVDAFYNGGWWPGVVTKVLEDNRYLVYLDATKEELEFEHSDLRP 47
Tudor_Agenet_AtDUF_rpt1_3 cd20405
first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 ...
150-218 1.09e-16

first and third Tudor-like Agenet domains found in a family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the first and third Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410476  Cd Length: 65  Bit Score: 74.60  E-value: 1.09e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334184965 150 FSSGTMAEVSTIVDKAEVAWFPAMIIKEIEvdGEKKFIVKDCNkhLSFSGDEARTNSTIDSSRVRPTPP 218
Cdd:cd20405    1 FSKGTEVEVSSEEEGFRGSWYRAIVVKEPE--GEKKFLVKYDE--LLLDDGSEPLEETVDLRRVRPVPP 65
Tudor_Agenet_AtDUF_rpt2_4 cd20406
second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 ...
227-273 3.09e-15

second and fourth Tudor-like Agenet domains found in the family of Arabidopsis thaliana DUF724 domain-containing proteins (AtDUFs); The family includes a group of AtDUFs (AtDUF1-3 and AtDUF6-8) that may be involved in the polar growth of plant cells via transportation of RNAs. Members of this family have four Tudor-like Agenet domains, except for AtDUF8, which contains only two copies of the Tudor-like Agenet domain. AtDUF4 and AtDUF5 are not included here due to the lack of a Tudor-like Agenet domain. The model corresponds to the second and fourth Tudor-like Agenet domains in AtDUF1-3 and AtDUF6-7, as well as the first Tudor-like Agenet domain in AtDUF8. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410477  Cd Length: 47  Bit Score: 69.93  E-value: 3.09e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 334184965 227 LMDRVEVFRGSVWRQGLVRGVLDHNCYMVCLVVTKEEPVVKHSDLRP 273
Cdd:cd20406    1 LGDKVDAFYNGGWWPGVVTKVLEDNRYLVYLDATKEELEFEHSDLRP 47
Agenet pfam05641
Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the ...
8-71 2.65e-14

Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the agenet domain is unknown. This family now matches both the two Agenet domains in the FMR proteins.


Pssm-ID: 461700  Cd Length: 61  Bit Score: 67.72  E-value: 2.65e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334184965    8 GSEVEVSSTEEGFADAWFRGILQENPtksGRKKLRVRYLTLLNDDALSPLIENIEPRFIRPVPP 71
Cdd:pfam05641   1 GDKVEVLSDEEGFRGAWFRAKVIKVL---KGDKYLVEYDDLLDEDGGGPLEEWVPASDIRPCPP 61
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
79-134 2.04e-13

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


Pssm-ID: 214798  Cd Length: 59  Bit Score: 65.04  E-value: 2.04e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 334184965    79 VLEEGTVVDADHKDGWWTGVIIKKLENGKFWVYYD--SPPDIIEFERNQLRPHLRWSG 134
Cdd:smart00743   2 DFKEGDRVEVFSEDSWWEAVVTKVLGDGKYLVEYKgeSEPLELTVDWSDLRPHPPWVD 59
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
223-279 4.32e-13

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


Pssm-ID: 214798  Cd Length: 59  Bit Score: 64.27  E-value: 4.32e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 334184965   223 EKYELMDRVEVFRGSVWRQGLVRGVLDHNCYMVCLV--VTKEEPVVKHSDLRPCKVWED 279
Cdd:smart00743   1 SDFKEGDRVEVFSEDSWWEAVVTKVLGDGKYLVEYKgeSEPLELTVDWSDLRPHPPWVD 59
Agenet pfam05641
Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the ...
153-218 3.42e-10

Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the agenet domain is unknown. This family now matches both the two Agenet domains in the FMR proteins.


Pssm-ID: 461700  Cd Length: 61  Bit Score: 56.17  E-value: 3.42e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334184965  153 GTMAEVSTIVDKAEVAWFPAMIIKEIevdGEKKFIVKDcnKHLSFSGDEARTNSTIDSSRVRPTPP 218
Cdd:pfam05641   1 GDKVEVLSDEEGFRGAWFRAKVIKVL---KGDKYLVEY--DDLLDEDGGGPLEEWVPASDIRPCPP 61
Agenet pfam05641
Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the ...
83-129 9.52e-05

Agenet domain; This domain is related to the TUDOR domain pfam00567. The function of the agenet domain is unknown. This family now matches both the two Agenet domains in the FMR proteins.


Pssm-ID: 461700  Cd Length: 61  Bit Score: 40.76  E-value: 9.52e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 334184965   83 GTVVDADHKDG-----WWTGVIIKKLENGKFWVYYDSPPDIIE-------FERNQLRPH 129
Cdd:pfam05641   1 GDKVEVLSDEEgfrgaWFRAKVIKVLKGDKYLVEYDDLLDEDGggpleewVPASDIRPC 59
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
619-698 5.22e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 42.56  E-value: 5.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965 619 SLQDERAKKAEERKGLEKKIEAGEiegHTYEEEMAELELKILELKRQ------QVVAKEMKEATDKVTSGMKSYAEMINQ 692
Cdd:cd16269  209 AAEQERKLLEEQQRELEQKLEDQE---RSYEEHLRQLKEKMEEERENllkeqeRALESKLKEQEALLEEGFKEQAELLQE 285

                 ....*.
gi 334184965 693 EIEDLR 698
Cdd:cd16269  286 EIRSLK 291
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
619-698 5.16e-03

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 39.58  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965  619 SLQDERAKKAEERKGLEKKIEAGEIeghTYEEEMAELELKILELKRQQ------VVAKEMKEATDKVTSGMKSYAEMINQ 692
Cdd:pfam02841 215 AAEAEQELLREKQKEEEQMMEAQER---SYQEHVKQLIEKMEAEREQLlaeqerMLEHKLQEQEELLKEGFKTEAESLQK 291

                  ....*.
gi 334184965  693 EIEDLR 698
Cdd:pfam02841 292 EIQDLK 297
Agenet smart00743
Tudor-like domain present in plant sequences; Domain in plant sequences with possible ...
148-219 5.19e-03

Tudor-like domain present in plant sequences; Domain in plant sequences with possible chromatin-associated functions.


Pssm-ID: 214798  Cd Length: 59  Bit Score: 35.76  E-value: 5.19e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334184965   148 SMFSSGTMAEVSTivdkaEVAWFPAMIIKeieVDGEKKFIVKdcnkhlsFSGDEARTNSTIDSSRVRPTPPP 219
Cdd:smart00743   1 SDFKEGDRVEVFS-----EDSWWEAVVTK---VLGDGKYLVE-------YKGESEPLELTVDWSDLRPHPPW 57
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
619-703 6.03e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334184965   619 SLQDERAKKAEERKGLEKKIEAGEIEGHTYEEEMAELELKILELKRQQVVAKemKEATDKVTSGMKSYAEMINQEIEDLR 698
Cdd:TIGR02169  748 SLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAE--LSKLEEEVSRIEARLREIEQKLNRLT 825

                   ....*
gi 334184965   699 LEFQS 703
Cdd:TIGR02169  826 LEKEY 830
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure