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Conserved domains on  [gi|320542224|ref|NP_001188649|]
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paralytic, isoform BB [Drosophila melanogaster]

Protein Classification

sodium channel protein subunit alpha( domain architecture ID 11999295)

sodium channel protein subunit alpha is the ion conducting pore forming subunit of the channel that mediates the voltage-dependent sodium ion permeability of excitable membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1556-1806 2.55e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.55e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1556 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1632
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1633 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1710
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1711 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1790
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 320542224  1791 IAVILENYSQATEDVQ 1806
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1276-1506 1.12e-49

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 177.07  E-value: 1.12e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1276 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVM-- 1352
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLps 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1353 -------------------------------------VVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCE 1395
Cdd:pfam00520   80 lislvlssvgslsglrvlrllrllrllrlirrleglrTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1396 DMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYLYF 1475
Cdd:pfam00520  160 NPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYIYF 207
                          250       260       270
                   ....*....|....*....|....*....|.
gi 320542224  1476 VFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1506
Cdd:pfam00520  208 VSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
806-1017 3.98e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 172.45  E-value: 3.98e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   806 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 881
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   882 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKd 960
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 320542224   961 rfpDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 1017
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425 4.88e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 169.37  E-value: 4.88e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   141 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 212
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   213 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 288
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   289 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 368
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320542224   369 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 425
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1496-1548 9.11e-29

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.96  E-value: 9.11e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 320542224 1496 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1548
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1043-1272 7.25e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 107.04  E-value: 7.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1043 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPS---GKGVCRCISAEHGD 1101
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSlkkAPGGKYELDEDHMD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1102 nelelghdeiladglikkGIKE-QTQLEVAIGdgmeftiHGDMKnnkpkkskyLNNATDDDTASINSYGSHKNRPFKDES 1180
Cdd:pfam06512   81 ------------------FITNpNLTVCVPIA-------EGESD---------LENEEDDDESSQSSDEEKSKQQEQLED 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1181 HKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCCPDSYYKKFPIL 1251
Cdd:pfam06512  127 DDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCFTEGCVRRFPCC 174
                          250       260
                   ....*....|....*....|.
gi 320542224  1252 AGDDDSPFWQGWGNLRLKTFQ 1272
Cdd:pfam06512  175 AVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
544-729 3.63e-25

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 463401  Cd Length: 163  Bit Score: 103.66  E-value: 3.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   544 TSLSLPGSPFNIRRGSRSShKYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyyg 622
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGS-IFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR--- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   623 NLGSRHSSYTSHQSRISyTSHG------------------DLLGG------------------MAVMGVSTmTKESKLRN 666
Cdd:pfam11933   59 RHLERRSSYQSQASRSS-RSHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRK 136
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320542224   667 RntRNQSvgatnggttcldtnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 729
Cdd:pfam11933  137 R--RLSS-----------------------------------YQLSMDYLEePFQRQRAVSAAS 163
GPHH super family cl25190
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1817-1864 3.94e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


The actual alignment was detected with superfamily member pfam16905:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 43.02  E-value: 3.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 320542224  1817 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1864
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1556-1806 2.55e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.55e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1556 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1632
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1633 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1710
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1711 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1790
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 320542224  1791 IAVILENYSQATEDVQ 1806
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1276-1506 1.12e-49

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 177.07  E-value: 1.12e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1276 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVM-- 1352
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLps 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1353 -------------------------------------VVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCE 1395
Cdd:pfam00520   80 lislvlssvgslsglrvlrllrllrllrlirrleglrTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1396 DMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYLYF 1475
Cdd:pfam00520  160 NPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYIYF 207
                          250       260       270
                   ....*....|....*....|....*....|.
gi 320542224  1476 VFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1506
Cdd:pfam00520  208 VSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
806-1017 3.98e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 172.45  E-value: 3.98e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   806 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 881
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   882 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKd 960
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 320542224   961 rfpDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 1017
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425 4.88e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 169.37  E-value: 4.88e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   141 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 212
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   213 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 288
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   289 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 368
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320542224   369 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 425
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1496-1548 9.11e-29

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.96  E-value: 9.11e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 320542224 1496 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1548
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1043-1272 7.25e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 107.04  E-value: 7.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1043 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPS---GKGVCRCISAEHGD 1101
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSlkkAPGGKYELDEDHMD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1102 nelelghdeiladglikkGIKE-QTQLEVAIGdgmeftiHGDMKnnkpkkskyLNNATDDDTASINSYGSHKNRPFKDES 1180
Cdd:pfam06512   81 ------------------FITNpNLTVCVPIA-------EGESD---------LENEEDDDESSQSSDEEKSKQQEQLED 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1181 HKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCCPDSYYKKFPIL 1251
Cdd:pfam06512  127 DDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCFTEGCVRRFPCC 174
                          250       260
                   ....*....|....*....|.
gi 320542224  1252 AGDDDSPFWQGWGNLRLKTFQ 1272
Cdd:pfam06512  175 AVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
544-729 3.63e-25

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 103.66  E-value: 3.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   544 TSLSLPGSPFNIRRGSRSShKYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyyg 622
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGS-IFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR--- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   623 NLGSRHSSYTSHQSRISyTSHG------------------DLLGG------------------MAVMGVSTmTKESKLRN 666
Cdd:pfam11933   59 RHLERRSSYQSQASRSS-RSHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRK 136
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320542224   667 RntRNQSvgatnggttcldtnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 729
Cdd:pfam11933  137 R--RLSS-----------------------------------YQLSMDYLEePFQRQRAVSAAS 163
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1817-1864 3.94e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 43.02  E-value: 3.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 320542224  1817 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1864
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1556-1806 2.55e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.55e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1556 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1632
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1633 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1710
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1711 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1790
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 320542224  1791 IAVILENYSQATEDVQ 1806
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1276-1506 1.12e-49

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 177.07  E-value: 1.12e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1276 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVM-- 1352
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLps 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1353 -------------------------------------VVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKCE 1395
Cdd:pfam00520   80 lislvlssvgslsglrvlrllrllrllrlirrleglrTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1396 DMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYLYF 1475
Cdd:pfam00520  160 NPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYIYF 207
                          250       260       270
                   ....*....|....*....|....*....|.
gi 320542224  1476 VFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1506
Cdd:pfam00520  208 VSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
806-1017 3.98e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 172.45  E-value: 3.98e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   806 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 881
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   882 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKd 960
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 320542224   961 rfpDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 1017
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425 4.88e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 169.37  E-value: 4.88e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   141 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 212
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   213 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 288
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   289 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 368
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320542224   369 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 425
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1496-1548 9.11e-29

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.96  E-value: 9.11e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 320542224 1496 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1548
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1043-1272 7.25e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 107.04  E-value: 7.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1043 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPS---GKGVCRCISAEHGD 1101
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSlkkAPGGKYELDEDHMD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1102 nelelghdeiladglikkGIKE-QTQLEVAIGdgmeftiHGDMKnnkpkkskyLNNATDDDTASINSYGSHKNRPFKDES 1180
Cdd:pfam06512   81 ------------------FITNpNLTVCVPIA-------EGESD---------LENEEDDDESSQSSDEEKSKQQEQLED 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1181 HKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCCPDSYYKKFPIL 1251
Cdd:pfam06512  127 DDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCFTEGCVRRFPCC 174
                          250       260
                   ....*....|....*....|.
gi 320542224  1252 AGDDDSPFWQGWGNLRLKTFQ 1272
Cdd:pfam06512  175 AVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
544-729 3.63e-25

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 103.66  E-value: 3.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   544 TSLSLPGSPFNIRRGSRSShKYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyyg 622
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGS-IFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR--- 58
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   623 NLGSRHSSYTSHQSRISyTSHG------------------DLLGG------------------MAVMGVSTmTKESKLRN 666
Cdd:pfam11933   59 RHLERRSSYQSQASRSS-RSHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRK 136
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320542224   667 RntRNQSvgatnggttcldtnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 729
Cdd:pfam11933  137 R--RLSS-----------------------------------YQLSMDYLEePFQRQRAVSAAS 163
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1592-1799 4.10e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 56.13  E-value: 4.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1592 IFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSdiIEKYFVSPTLLRVV-----------RVAKVGRVL 1660
Cdd:pfam08016   19 VFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLN--IYRDFLADRLIKSVeaspvtfidfdRVAQLDNLY 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224  1661 RLVKG----------------AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMhvkeksgiNDVYNFKTFG 1724
Cdd:pfam08016   97 RIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--------TQAPNFSNFV 168
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320542224  1725 QSMILLFQMstsagwdgVLDAIINEEACDppdndkgypgncGSATVGITFLLSYLVISFLIVINMYIAVILENYS 1799
Cdd:pfam08016  169 KSILTLFRT--------ILGDFGYNEIFS------------GNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 223
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1817-1864 3.94e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 43.02  E-value: 3.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 320542224  1817 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1864
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
894-988 1.26e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 42.65  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542224   894 LSVLRSFRLLRVFKlakswpTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGkNYHdhkdrfpdgdlprWNFT 973
Cdd:pfam08016  106 LTWLKLFKVLRFNK------TMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG-TQA-------------PNFS 165
                           90
                   ....*....|....*
gi 320542224   974 DFMHSFMIVFRVLCG 988
Cdd:pfam08016  166 NFVKSILTLFRTILG 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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