NAD-binding protein; ion transporter; potassium channel family protein; potassium voltage-gated channel protein; potassium voltage-gated channel subfamily KQT member; ion transporter; ion transporter( domain architecture ID 11998258)
NAD-binding protein may be the NAD-binding component of a potassium uptake system similar to Mycobacterium tuberculosis Trk system potassium uptake protein TrkA; ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes; ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes; also contains a double zinc ribbon domain; ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes; contains a double zinc ribbon domain; ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes; contains a zinc-ribbon domain; potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes; potassium voltage-gated channel protein similar to Drosophila melanogaster potassium channels (Shaker, Shaw and Shab), as well as the members from Homo sapiens potassium voltage-gated channel subfamilies (A, C, G, S, and V); potassium voltage-gated channel subfamily KQT member (KCNQ) similar to human KCNQ1, also known as Kv7.1, which is a voltage-dependent K+ channel that regulates gastric acid secretion, salt and glucose homeostasis, and heart rhythm; ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes; ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-953
1.18e-49
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 175.92 E-value: 1.18e-49
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-382
2.27e-27
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
:
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 111.98 E-value: 2.27e-27
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
499-665
5.54e-15
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
The actual alignment was detected with superfamily member pfam11933:
Pssm-ID: 463401 Cd Length: 163 Bit Score: 73.61 E-value: 5.54e-15
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
979-1023
3.13e-11
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
The actual alignment was detected with superfamily member pfam06512:
Pssm-ID: 461936 Cd Length: 195 Bit Score: 63.89 E-value: 3.13e-11
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-953
1.18e-49
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 175.92 E-value: 1.18e-49
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-382
2.27e-27
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 111.98 E-value: 2.27e-27
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
499-665
5.54e-15
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Pssm-ID: 463401 Cd Length: 163 Bit Score: 73.61 E-value: 5.54e-15
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
979-1023
3.13e-11
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
Pssm-ID: 461936 Cd Length: 195 Bit Score: 63.89 E-value: 3.13e-11
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-953
1.18e-49
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 175.92 E-value: 1.18e-49
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-382
2.27e-27
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 111.98 E-value: 2.27e-27
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
499-665
5.54e-15
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Pssm-ID: 463401 Cd Length: 163 Bit Score: 73.61 E-value: 5.54e-15
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
979-1023
3.13e-11
Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.
Pssm-ID: 461936 Cd Length: 195 Bit Score: 63.89 E-value: 3.13e-11
Polycystin cation channel; This family contains the cation channel region from group II of ...
830-924
4.35e-04
Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.
Pssm-ID: 462341 [Multi-domain] Cd Length: 225 Bit Score: 43.03 E-value: 4.35e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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