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Conserved domains on  [gi|320542182|ref|NP_001188628|]
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paralytic, isoform AG [Drosophila melanogaster]

Protein Classification

sodium channel protein subunit alpha( domain architecture ID 11998267)

sodium channel protein subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1258-1529 9.73e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 222.91  E-value: 9.73e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1258 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVMVS 1336
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1337 LINFVASLVGAGGIqaFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1416
Cdd:pfam00520   80 LISLVLSSVGSLSG--LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1417 CEDMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYL 1496
Cdd:pfam00520  158 WENPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 320542182  1497 YFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1529
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1579-1829 4.97e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.48  E-value: 4.97e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1579 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1655
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1656 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1733
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1734 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1813
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 320542182  1814 IAVILENYSQATEDVQ 1829
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
785-996 7.32e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 171.68  E-value: 7.32e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   785 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 860
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   861 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKd 939
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 320542182   940 rfpDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 996
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425 8.97e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 168.60  E-value: 8.97e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   141 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 212
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   213 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 288
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   289 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 368
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320542182   369 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 425
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1519-1571 9.95e-29

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.96  E-value: 9.95e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 320542182 1519 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1571
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1022-1254 1.83e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 108.58  E-value: 1.83e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1022 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPSGERTNQISWIWSEEHGD 1083
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSLKKAPGGKYELDEDHMD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1084 nelelghdeiladglikkGIKE-QTQLEVAIGdgmeftiHGDMKnnkpkkskyLNNATDDDTASINSYGSHKNRPFKDES 1162
Cdd:pfam06512   81 ------------------FITNpNLTVCVPIA-------EGESD---------LENEEDDDESSQSSDEEKSKQQEQLED 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1163 HKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCCPDSYYKKFPIL 1233
Cdd:pfam06512  127 DDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCFTEGCVRRFPCC 174
                          250       260
                   ....*....|....*....|.
gi 320542182  1234 AGDDDSPFWQGWGNLRLKTFQ 1254
Cdd:pfam06512  175 AVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl super family cl13384
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
542-708 1.08e-14

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


The actual alignment was detected with superfamily member pfam11933:

Pssm-ID: 463401  Cd Length: 163  Bit Score: 73.61  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   542 STYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyygNLGSRHSSYTSHQSRISyT 620
Cdd:pfam11933   19 SIFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR---RHLERRSSYQSQASRSS-R 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   621 SHG------------------DLLGG------------------MAVMGVSTmTKESKLRNRntRNQSvgatnggttcld 664
Cdd:pfam11933   77 SHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRKR--RLSS------------ 141
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 320542182   665 tnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 708
Cdd:pfam11933  142 -----------------------YQLSMDYLEePFQRQRAVSAAS 163
GPHH super family cl25190
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1840-1887 4.10e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


The actual alignment was detected with superfamily member pfam16905:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 43.02  E-value: 4.10e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 320542182  1840 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1887
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1258-1529 9.73e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 222.91  E-value: 9.73e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1258 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVMVS 1336
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1337 LINFVASLVGAGGIqaFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1416
Cdd:pfam00520   80 LISLVLSSVGSLSG--LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1417 CEDMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYL 1496
Cdd:pfam00520  158 WENPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 320542182  1497 YFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1529
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1579-1829 4.97e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.48  E-value: 4.97e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1579 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1655
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1656 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1733
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1734 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1813
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 320542182  1814 IAVILENYSQATEDVQ 1829
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
785-996 7.32e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 171.68  E-value: 7.32e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   785 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 860
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   861 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKd 939
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 320542182   940 rfpDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 996
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425 8.97e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 168.60  E-value: 8.97e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   141 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 212
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   213 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 288
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   289 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 368
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320542182   369 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 425
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1519-1571 9.95e-29

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.96  E-value: 9.95e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 320542182 1519 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1571
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1022-1254 1.83e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 108.58  E-value: 1.83e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1022 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPSGERTNQISWIWSEEHGD 1083
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSLKKAPGGKYELDEDHMD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1084 nelelghdeiladglikkGIKE-QTQLEVAIGdgmeftiHGDMKnnkpkkskyLNNATDDDTASINSYGSHKNRPFKDES 1162
Cdd:pfam06512   81 ------------------FITNpNLTVCVPIA-------EGESD---------LENEEDDDESSQSSDEEKSKQQEQLED 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1163 HKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCCPDSYYKKFPIL 1233
Cdd:pfam06512  127 DDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCFTEGCVRRFPCC 174
                          250       260
                   ....*....|....*....|.
gi 320542182  1234 AGDDDSPFWQGWGNLRLKTFQ 1254
Cdd:pfam06512  175 AVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
542-708 1.08e-14

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 73.61  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   542 STYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyygNLGSRHSSYTSHQSRISyT 620
Cdd:pfam11933   19 SIFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR---RHLERRSSYQSQASRSS-R 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   621 SHG------------------DLLGG------------------MAVMGVSTmTKESKLRNRntRNQSvgatnggttcld 664
Cdd:pfam11933   77 SHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRKR--RLSS------------ 141
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 320542182   665 tnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 708
Cdd:pfam11933  142 -----------------------YQLSMDYLEePFQRQRAVSAAS 163
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1840-1887 4.10e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 43.02  E-value: 4.10e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 320542182  1840 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1887
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1258-1529 9.73e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 222.91  E-value: 9.73e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1258 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVMVS 1336
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1337 LINFVASLVGAGGIqaFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1416
Cdd:pfam00520   80 LISLVLSSVGSLSG--LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1417 CEDMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYL 1496
Cdd:pfam00520  158 WENPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 320542182  1497 YFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1529
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1579-1829 4.97e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.48  E-value: 4.97e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1579 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1655
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1656 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1733
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1734 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1813
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 320542182  1814 IAVILENYSQATEDVQ 1829
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
785-996 7.32e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 171.68  E-value: 7.32e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   785 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 860
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   861 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKd 939
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 320542182   940 rfpDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 996
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
141-425 8.97e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 168.60  E-value: 8.97e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   141 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 212
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   213 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 288
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   289 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 368
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320542182   369 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 425
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1519-1571 9.95e-29

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.96  E-value: 9.95e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 320542182 1519 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1571
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1022-1254 1.83e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 108.58  E-value: 1.83e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1022 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPSGERTNQISWIWSEEHGD 1083
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSLKKAPGGKYELDEDHMD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1084 nelelghdeiladglikkGIKE-QTQLEVAIGdgmeftiHGDMKnnkpkkskyLNNATDDDTASINSYGSHKNRPFKDES 1162
Cdd:pfam06512   81 ------------------FITNpNLTVCVPIA-------EGESD---------LENEEDDDESSQSSDEEKSKQQEQLED 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1163 HKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCCPDSYYKKFPIL 1233
Cdd:pfam06512  127 DDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCFTEGCVRRFPCC 174
                          250       260
                   ....*....|....*....|.
gi 320542182  1234 AGDDDSPFWQGWGNLRLKTFQ 1254
Cdd:pfam06512  175 AVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
542-708 1.08e-14

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 73.61  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   542 STYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyygNLGSRHSSYTSHQSRISyT 620
Cdd:pfam11933   19 SIFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR---RHLERRSSYQSQASRSS-R 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   621 SHG------------------DLLGG------------------MAVMGVSTmTKESKLRNRntRNQSvgatnggttcld 664
Cdd:pfam11933   77 SHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRKR--RLSS------------ 141
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 320542182   665 tnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 708
Cdd:pfam11933  142 -----------------------YQLSMDYLEePFQRQRAVSAAS 163
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1615-1822 5.59e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 55.75  E-value: 5.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1615 IFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSdiIEKYFVSPTLLRVV-----------RVAKVGRVL 1683
Cdd:pfam08016   19 VFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLN--IYRDFLADRLIKSVeaspvtfidfdRVAQLDNLY 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182  1684 RLVKG----------------AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMhvkeksgiNDVYNFKTFG 1747
Cdd:pfam08016   97 RIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--------TQAPNFSNFV 168
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320542182  1748 QSMILLFQMstsagwdgVLDAIINEEACDppdndkgypgncGSATVGITFLLSYLVISFLIVINMYIAVILENYS 1822
Cdd:pfam08016  169 KSILTLFRT--------ILGDFGYNEIFS------------GNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 223
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1840-1887 4.10e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 43.02  E-value: 4.10e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 320542182  1840 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1887
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
873-967 1.45e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 42.26  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542182   873 LSVLRSFRLLRVFKlakswpTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGkNYHdhkdrfpdgdlprWNFT 952
Cdd:pfam08016  106 LTWLKLFKVLRFNK------TMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG-TQA-------------PNFS 165
                           90
                   ....*....|....*
gi 320542182   953 DFMHSFMIVFRVLCG 967
Cdd:pfam08016  166 NFVKSILTLFRTILG 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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