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Conserved domains on  [gi|320542146|ref|NP_001188610|]
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paralytic, isoform O [Drosophila melanogaster]

Protein Classification

sodium channel protein subunit alpha( domain architecture ID 11998267)

sodium channel protein subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1261-1532 7.02e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 223.30  E-value: 7.02e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1261 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVMVS 1339
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1340 LINFVASLVGAGGIqaFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1419
Cdd:pfam00520   80 LISLVLSSVGSLSG--LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1420 CEDMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYL 1499
Cdd:pfam00520  158 WENPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 320542146  1500 YFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1532
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1582-1832 3.66e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.87  E-value: 3.66e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1582 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1658
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1659 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1736
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1737 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1816
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 320542146  1817 IAVILENYSQATEDVQ 1832
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
788-999 5.59e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 172.07  E-value: 5.59e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   788 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 863
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   864 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKd 942
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 320542146   943 rfpDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 999
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
152-436 7.20e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 168.98  E-value: 7.20e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   152 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 223
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   224 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 299
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   300 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 379
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320542146   380 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 436
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1522-1574 1.48e-28

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.58  E-value: 1.48e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 320542146 1522 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1574
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1025-1257 1.84e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 108.58  E-value: 1.84e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1025 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPSGERTNQISWIWSEEHGD 1086
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSLKKAPGGKYELDEDHMD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1087 nelelghdeiladglikkGIKE-QTQLEVAIGdgmeftiHGDMKnnkpkkskyLNNATDDDTASINSYGSHKNRPFKDES 1165
Cdd:pfam06512   81 ------------------FITNpNLTVCVPIA-------EGESD---------LENEEDDDESSQSSDEEKSKQQEQLED 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1166 HKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCCPDSYYKKFPIL 1236
Cdd:pfam06512  127 DDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCFTEGCVRRFPCC 174
                          250       260
                   ....*....|....*....|.
gi 320542146  1237 AGDDDSPFWQGWGNLRLKTFQ 1257
Cdd:pfam06512  175 AVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl super family cl13384
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
553-719 1.08e-14

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


The actual alignment was detected with superfamily member pfam11933:

Pssm-ID: 463401  Cd Length: 163  Bit Score: 73.61  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   553 STYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyygNLGSRHSSYTSHQSRISyT 631
Cdd:pfam11933   19 SIFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR---RHLERRSSYQSQASRSS-R 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   632 SHG------------------DLLGG------------------MAVMGVSTmTKESKLRNRntRNQSvgatnggttcld 675
Cdd:pfam11933   77 SHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRKR--RLSS------------ 141
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 320542146   676 tnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 719
Cdd:pfam11933  142 -----------------------YQLSMDYLEePFQRQRAVSAAS 163
GPHH super family cl25190
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1843-1890 4.23e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


The actual alignment was detected with superfamily member pfam16905:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 43.02  E-value: 4.23e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 320542146  1843 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1890
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1261-1532 7.02e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 223.30  E-value: 7.02e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1261 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVMVS 1339
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1340 LINFVASLVGAGGIqaFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1419
Cdd:pfam00520   80 LISLVLSSVGSLSG--LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1420 CEDMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYL 1499
Cdd:pfam00520  158 WENPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 320542146  1500 YFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1532
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1582-1832 3.66e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.87  E-value: 3.66e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1582 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1658
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1659 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1736
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1737 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1816
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 320542146  1817 IAVILENYSQATEDVQ 1832
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
788-999 5.59e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 172.07  E-value: 5.59e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   788 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 863
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   864 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKd 942
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 320542146   943 rfpDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 999
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
152-436 7.20e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 168.98  E-value: 7.20e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   152 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 223
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   224 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 299
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   300 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 379
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320542146   380 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 436
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1522-1574 1.48e-28

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.58  E-value: 1.48e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 320542146 1522 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1574
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1025-1257 1.84e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 108.58  E-value: 1.84e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1025 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPSGERTNQISWIWSEEHGD 1086
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSLKKAPGGKYELDEDHMD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1087 nelelghdeiladglikkGIKE-QTQLEVAIGdgmeftiHGDMKnnkpkkskyLNNATDDDTASINSYGSHKNRPFKDES 1165
Cdd:pfam06512   81 ------------------FITNpNLTVCVPIA-------EGESD---------LENEEDDDESSQSSDEEKSKQQEQLED 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1166 HKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCCPDSYYKKFPIL 1236
Cdd:pfam06512  127 DDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCFTEGCVRRFPCC 174
                          250       260
                   ....*....|....*....|.
gi 320542146  1237 AGDDDSPFWQGWGNLRLKTFQ 1257
Cdd:pfam06512  175 AVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
553-719 1.08e-14

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 73.61  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   553 STYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyygNLGSRHSSYTSHQSRISyT 631
Cdd:pfam11933   19 SIFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR---RHLERRSSYQSQASRSS-R 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   632 SHG------------------DLLGG------------------MAVMGVSTmTKESKLRNRntRNQSvgatnggttcld 675
Cdd:pfam11933   77 SHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRKR--RLSS------------ 141
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 320542146   676 tnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 719
Cdd:pfam11933  142 -----------------------YQLSMDYLEePFQRQRAVSAAS 163
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1843-1890 4.23e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 43.02  E-value: 4.23e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 320542146  1843 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1890
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1261-1532 7.02e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 223.30  E-value: 7.02e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1261 NKYFETAVITMILMSSLALALEDVHLPQRPiLQDILYYMDRIFTVIFFLEMLIKWLALGFKV-YFTNAWCWLDFVIVMVS 1339
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP-LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1340 LINFVASLVGAGGIqaFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1419
Cdd:pfam00520   80 LISLVLSSVGSLSG--LRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1420 CEDMNgtklsheiipnrnacesenytwvNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREvdkqpiretNIYMYL 1499
Cdd:pfam00520  158 WENPD-----------------------NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAYI 205
                          250       260       270
                   ....*....|....*....|....*....|...
gi 320542146  1500 YFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAG 1532
Cdd:pfam00520  206 YFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1582-1832 3.66e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 192.87  E-value: 3.66e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1582 FDIIIMLFIGLNMFTMTLDRYDASD-TYNAVLDYLNAIFVVIFSSECLLKIFA--LRYHYFIEPWNLFDVVVVILSILGL 1658
Cdd:pfam00520    4 FELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1659 VLSDIiekyfVSPTLLRVVRVAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV--KE 1736
Cdd:pfam00520   84 VLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1737 KSGINDVYNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEacdppdndkgypgncgSATVGITFLLSYLVISFLIVINMY 1816
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK----------------GEFWAYIYFVSFIILGGFLLLNLF 222
                          250
                   ....*....|....*.
gi 320542146  1817 IAVILENYSQATEDVQ 1832
Cdd:pfam00520  223 IAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
788-999 5.59e-48

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 172.07  E-value: 5.59e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   788 DPFVELFITLCIVVNTMFMAMDHHDMNKE-MERVLKSGNYFFTATFAIEATMKLMAMSPKY-YFQEGWNIFDFIIVAL-- 863
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPsl 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   864 -SLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKd 942
Cdd:pfam00520   81 iSLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE- 159
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 320542146   943 rfpDGDLPRWNFTDFMHSFMIVFRVLCGE-WIESMWDCM-YVGDVSCIPFFLATVVIGN 999
Cdd:pfam00520  160 ---NPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIdGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
152-436 7.20e-47

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 168.98  E-value: 7.20e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   152 HPLFSLFIITTILVNCILMIM--------PTTPTVESTEVIFTGIYTFESAVKVMARGFIlcpFTYLRDAWNWLDFVVIA 223
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeePLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   224 LAYVTMGID----LGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLtq 299
Cdd:pfam00520   78 PSLISLVLSsvgsLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   300 kcikkfpldGSWGnltdenwdyhnrnssnwysedegisfplcgnisgagqcdddyvclqgfgpNPNYGYTSFDSFGWAFL 379
Cdd:pfam00520  156 ---------KTWE--------------------------------------------------NPDNGRTNFDNFPNAFL 176
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320542146   380 SAFRLMTQDFWEDLYQLVLRAAGP-WHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQ 436
Cdd:pfam00520  177 WLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1522-1574 1.48e-28

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 109.58  E-value: 1.48e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 320542146 1522 DNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRPQAIVF 1574
Cdd:cd13433     1 DNFNQLKKKYGGGLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIF 53
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
1025-1257 1.84e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 108.58  E-value: 1.84e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1025 DNDTNKIAEAFNRIGRFKSWVKRNIADCF------------------KLIRNKLTNQISDQPSGERTNQISWIWSEEHGD 1086
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCcrlckepqlpkkkpltelKDARSKLTNQIANHTSLKKAPGGKYELDEDHMD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1087 nelelghdeiladglikkGIKE-QTQLEVAIGdgmeftiHGDMKnnkpkkskyLNNATDDDTASINSYGSHKNRPFKDES 1165
Cdd:pfam06512   81 ------------------FITNpNLTVCVPIA-------EGESD---------LENEEDDDESSQSSDEEKSKQQEQLED 126
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1166 HKGS---------AETMEGEEKrdaskedlgldeeldeegeceegpldgdiiIHAHDEDILDeyPADCCPDSYYKKFPIL 1236
Cdd:pfam06512  127 DDSSssegstvdlQDPEEELEK------------------------------IPEEAEELKE--PEDCFTEGCVRRFPCC 174
                          250       260
                   ....*....|....*....|.
gi 320542146  1237 AGDDDSPFWQGWGNLRLKTFQ 1257
Cdd:pfam06512  175 AVDTTKGPWKIWWNLRKTCYR 195
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
553-719 1.08e-14

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 73.61  E-value: 1.08e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   553 STYTIRnGRGRfgipgsdrkplvlstyqDAQQHLPYADDSNAVTPMSE-ENGAIIVPVyygNLGSRHSSYTSHQSRISyT 631
Cdd:pfam11933   19 SIFSFR-GRGR-----------------DVGSENDFADDENSTFEDSEsRRGSLFVPR---RHLERRSSYQSQASRSS-R 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   632 SHG------------------DLLGG------------------MAVMGVSTmTKESKLRNRntRNQSvgatnggttcld 675
Cdd:pfam11933   77 SHPglpqngkrhstvdcngvvSLVGGgpeptspggqllpevildKPATGDST-TTEEELRKR--RLSS------------ 141
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 320542146   676 tnhkldhrdyeiglectdeagkiKHHDNPFIE-PVQTQTVVDMKD 719
Cdd:pfam11933  142 -----------------------YQLSMDYLEePFQRQRAVSAAS 163
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1618-1825 5.20e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 55.75  E-value: 5.20e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1618 IFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSdiIEKYFVSPTLLRVV-----------RVAKVGRVL 1686
Cdd:pfam08016   19 VFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLN--IYRDFLADRLIKSVeaspvtfidfdRVAQLDNLY 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146  1687 RLVKG----------------AKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMhvkeksgiNDVYNFKTFG 1750
Cdd:pfam08016   97 RIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--------TQAPNFSNFV 168
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320542146  1751 QSMILLFQMstsagwdgVLDAIINEEACDppdndkgypgncGSATVGITFLLSYLVISFLIVINMYIAVILENYS 1825
Cdd:pfam08016  169 KSILTLFRT--------ILGDFGYNEIFS------------GNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 223
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1843-1890 4.23e-05

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 43.02  E-value: 4.23e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 320542146  1843 YYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNK--YK-IISMDIP 1890
Cdd:pfam16905    2 FVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARvaYKrLVRMNMP 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
876-970 1.43e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 42.26  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320542146   876 LSVLRSFRLLRVFKlakswpTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGkNYHdhkdrfpdgdlprWNFT 955
Cdd:pfam08016  106 LTWLKLFKVLRFNK------TMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG-TQA-------------PNFS 165
                           90
                   ....*....|....*
gi 320542146   956 DFMHSFMIVFRVLCG 970
Cdd:pfam08016  166 NFVKSILTLFRTILG 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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