NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|320541710|ref|NP_001188542|]
View 

arylalkylamine N-acetyltransferase-like 7, isoform B [Drosophila melanogaster]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 1904476)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  9175471|10940244
SCOP:  3000403

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ArgA super family cl43364
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 128-190 5.07e-07

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


The actual alignment was detected with superfamily member COG1246:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 47.29  E-value: 5.07e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320541710 128 VRILSVDSCYRGQGIANELVKRSVAVAKKNGFRLLKADaTGIFSQKIFRSHGFEVFSEQ--PYSK 190
Cdd:COG1246   55 LRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLL-TTSAAIHFYEKLGFEEIDKEdlPYAK 118
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 128-190 5.07e-07

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 47.29  E-value: 5.07e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320541710 128 VRILSVDSCYRGQGIANELVKRSVAVAKKNGFRLLKADaTGIFSQKIFRSHGFEVFSEQ--PYSK 190
Cdd:COG1246   55 LRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLL-TTSAAIHFYEKLGFEEIDKEdlPYAK 118
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 131-182 5.82e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 40.52  E-value: 5.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 320541710  131 LSVDSCYRGQGIANELVKRSVAVAKKNGFRLLKADaTGIFSQKIFRSHGFEV 182
Cdd:pfam13508  34 LAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELE-TTNRAAAFYEKLGFEE 84
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 128-190 5.07e-07

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 47.29  E-value: 5.07e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 320541710 128 VRILSVDSCYRGQGIANELVKRSVAVAKKNGFRLLKADaTGIFSQKIFRSHGFEVFSEQ--PYSK 190
Cdd:COG1246   55 LRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLL-TTSAAIHFYEKLGFEEIDKEdlPYAK 118
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
133-208 1.46e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 43.25  E-value: 1.46e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 320541710 133 VDSCYRGQGIANELVKRSVAVAKKNGFRLLKADATgIFSQKIFRSHGFEVFSEqPYskytDENGkvilpveAPHIK 208
Cdd:COG2153   66 VLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQ-AHAVGFYEKLGFVPVGE-EF----LEAG-------IPHID 128
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 131-182 5.82e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 40.52  E-value: 5.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 320541710  131 LSVDSCYRGQGIANELVKRSVAVAKKNGFRLLKADaTGIFSQKIFRSHGFEV 182
Cdd:pfam13508  34 LAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELE-TTNRAAAFYEKLGFEE 84
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
131-194 1.08e-04

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 40.84  E-value: 1.08e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 320541710 131 LSVDSCYRGQGIANELVKRSVAVAKKNGFRLLKADaTGIFSQKIFRSHGFEVFSEQPYSKYTDE 194
Cdd:COG3153   73 LAVDPEYRGQGIGRALMRAALEAARERGARAVVLL-GDPSLLPFYERFGFRPAGELGLTLGPDE 135
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
137-182 2.30e-04

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 40.36  E-value: 2.30e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 320541710 137 YRGQGIANELVKRSVAVAKKNGFRLLKAD--ATGIFSQKIFRSHGFEV 182
Cdd:COG1247   92 ARGRGIGRALLEALIERARARGYRRLVAVvlADNEASIALYEKLGFEE 139
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 128-187 2.62e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 39.65  E-value: 2.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 320541710 128 VRILSVDSCYRGQGIANELVKRSVAVAKKNGFRLLKADaTGI---FSQKIFRSHGFEVFSEQP 187
Cdd:COG0454   61 LKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELD-TLDgnpAAIRFYERLGFKEIERYV 122
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 131-187 3.94e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 38.48  E-value: 3.94e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 320541710 131 LSVDSCYRGQGIANELVKRSVAVAKKNGFR--LLKADATGIFSQKIFRSHGFEVFSEQP 187
Cdd:COG0456   19 LAVDPEYRGRGIGRALLEAALERARERGARrlRLEVREDNEAAIALYEKLGFEEVGERP 77
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 131-180 4.37e-03

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 35.96  E-value: 4.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 320541710  131 LSVDSCYRGQGIANELVKRSVAVAKKNGFRL--LKADATGIFSQKIFRSHGF 180
Cdd:pfam00583  65 LAVAPEYRGKGIGTALLQALLEWARERGCERifLEVAADNLAAIALYEKLGF 116
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
133-161 6.63e-03

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 34.75  E-value: 6.63e-03
                         10        20
                 ....*....|....*....|....*....
gi 320541710 133 VDSCYRGQGIANELVKRSVAVAKKNGFRL 161
Cdd:COG2388   40 VPPALRGQGIASALVEAALDDARERGLKV 68
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 133-160 8.36e-03

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 34.42  E-value: 8.36e-03
                          10        20
                  ....*....|....*....|....*...
gi 320541710  133 VDSCYRGQGIANELVKRSVAVAKKNGFR 160
Cdd:pfam14542  31 VPPALRGQGIASKLVKAALDDAREEGLK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH