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Conserved domains on  [gi|318037593|ref|NP_001186982|]
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melanocyte protein PMEL isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PKAT_KLD pfam20433
PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, ...
 429-480 7.05e-19

PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, Transmembrane glycoprotein NMB (GPNMB) and TMEM130, which is downstream the PKD domain. It contains six highly conserved cysteine residues that form the disulphide bonds of mature PMEL dimers. (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). This domain is perfectly conserved in PMEL and GPNMB which suggests that GPNMB also forms dimers. PMEL and GPNMB, together with TMEM130 (its most ancient paralogue), have a conserved domain architecture and have been recently described as the PKAT (PKD- and KLD-Associated Transmembrane) protein family (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.


:

Pssm-ID: 466582  Cd Length: 51  Bit Score: 80.40  E-value: 7.05e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 318037593  429 SCQGGLPKEACMEISSPGCQPPAQRLCQPVLPSPACQLVLHQILKgGSGTYC 480
Cdd:pfam20433   1 TCQGSLPTEVCTVVSDPTCQTPQNTVCNPVSPSPECQLVLRRAFN-GSGTYC 51
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 149-215 7.49e-08

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


:

Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 49.69  E-value: 7.49e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 318037593  149 NQPLTFALQLHDPSgylaeaDLSYTWDFGDSSGTlISRALVVTHTYLEPGPVTAQVVLQAAIPLTSC 215
Cdd:pfam00801  11 GQPVTFTATLADGS------NVTYTWDFGDSPGT-SGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PHA03255 super family cl31530
BDLF3; Provisional
 190-357 1.54e-03

BDLF3; Provisional


The actual alignment was detected with superfamily member PHA03255:

Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 40.66  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593 190 VTHTYLEPGPVTAQVVL-QAAIPLTSCGSSP-----VPGTT--DGHRPTAEAPNT--TAGQVPTTEVVGTTPG---QAPT 256
Cdd:PHA03255   1 MAHARDKAGAVLAMILIcETSLIWTSSGSSTasagnVTGTTavTTPSPSASGPSTnqSTTLTTTSAPITTTAIlstNTTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593 257 AEPSGTTSVQVPTTEVIST------APVQMPTAESTGMTPEKVPVSEVmgTTLAEMSTPEATGMTPAEVSIVVLSGTTAA 330
Cdd:PHA03255  81 VTSTGTTVTPVPTTSNASTinvttkVTAQNITATEAGTGTSTGVTSNV--TTRSSSTTSATTRITNATTLAPTLSSKGTS 158

                        170       180
                 ....*....|....*....|....*..
gi 318037593 331 QVTTTEWvettarELPIPEPEGPDASS 357
Cdd:PHA03255 159 NATKTTA------ELPTVPDERQPSLS 179
 
Name Accession Description Interval E-value
PKAT_KLD pfam20433
PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, ...
 429-480 7.05e-19

PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, Transmembrane glycoprotein NMB (GPNMB) and TMEM130, which is downstream the PKD domain. It contains six highly conserved cysteine residues that form the disulphide bonds of mature PMEL dimers. (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). This domain is perfectly conserved in PMEL and GPNMB which suggests that GPNMB also forms dimers. PMEL and GPNMB, together with TMEM130 (its most ancient paralogue), have a conserved domain architecture and have been recently described as the PKAT (PKD- and KLD-Associated Transmembrane) protein family (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.


Pssm-ID: 466582  Cd Length: 51  Bit Score: 80.40  E-value: 7.05e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 318037593  429 SCQGGLPKEACMEISSPGCQPPAQRLCQPVLPSPACQLVLHQILKgGSGTYC 480
Cdd:pfam20433   1 TCQGSLPTEVCTVVSDPTCQTPQNTVCNPVSPSPECQLVLRRAFN-GSGTYC 51
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 149-215 7.49e-08

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 49.69  E-value: 7.49e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 318037593  149 NQPLTFALQLHDPSgylaeaDLSYTWDFGDSSGTlISRALVVTHTYLEPGPVTAQVVLQAAIPLTSC 215
Cdd:pfam00801  11 GQPVTFTATLADGS------NVTYTWDFGDSPGT-SGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 147-209 8.16e-07

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 47.11  E-value: 8.16e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 318037593 147 LRNQPLTFALQLHDPSGYlaeADLSYTWDFGDSSGTLiSRALVVTHTYLEPGPVTAQVVLQAA 209
Cdd:cd00146   10 VAELGASVTFSASDSSGG---SIVSYKWDFGDGEVSS-SGEPTVTHTYTKPGTYTVTLTVTNA 68
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 151-210 6.96e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.36  E-value: 6.96e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593   151 PLTFALQLHDPSGYLAEaDLSYTWDFGDSSgtlISRALVVTHTYLEPGPVTAQVVLQAAI 210
Cdd:smart00089  12 VAGESVTFTATSSDDGS-IVSYTWDFGDGT---SSTGPTVTHTYTKPGTYTVTLTVTNAV 67
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 111-199 7.79e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 7.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593   111 YVPLAHSSSAF-TITDQVPFSVSVSQLR-ALDGGNKHFLRNQPLTF-ALQLHDPSGYLaeadlsYTWDFGDSSGTLISRA 187
Cdd:TIGR00864 1062 YLATVLASNAFeNISQQINMSVRAILPRvAIGTEDGLLLAGKPADFeAHPLPSPGGIH------YEWDFGDGSALLQGRQ 1135

                           90
                   ....*....|..
gi 318037593   188 LVVTHTYLEPGP 199
Cdd:TIGR00864 1136 PAAAHTFAKRGP 1147
PHA03255 PHA03255
BDLF3; Provisional
 190-357 1.54e-03

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 40.66  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593 190 VTHTYLEPGPVTAQVVL-QAAIPLTSCGSSP-----VPGTT--DGHRPTAEAPNT--TAGQVPTTEVVGTTPG---QAPT 256
Cdd:PHA03255   1 MAHARDKAGAVLAMILIcETSLIWTSSGSSTasagnVTGTTavTTPSPSASGPSTnqSTTLTTTSAPITTTAIlstNTTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593 257 AEPSGTTSVQVPTTEVIST------APVQMPTAESTGMTPEKVPVSEVmgTTLAEMSTPEATGMTPAEVSIVVLSGTTAA 330
Cdd:PHA03255  81 VTSTGTTVTPVPTTSNASTinvttkVTAQNITATEAGTGTSTGVTSNV--TTRSSSTTSATTRITNATTLAPTLSSKGTS 158

                        170       180
                 ....*....|....*....|....*..
gi 318037593 331 QVTTTEWvettarELPIPEPEGPDASS 357
Cdd:PHA03255 159 NATKTTA------ELPTVPDERQPSLS 179
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 173-317 5.19e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593  173 TWDFGDSSGTLISRALVVTHTYLEPGPVTAQVVLQAAIPLTSCGSS------PVPGTTDG-----HRPT-AEAPNTTAGQ 240
Cdd:pfam05109 388 TFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTlnttgfAAPNTTTGlpsstHVPTnLTAPASTGPT 467

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593  241 VPTTEVV-----GTTPGQAP-TAEPSG---------------TTSVQVPTTEVISTAP-VQMPTAESTGMTPEKVPVSEV 298
Cdd:pfam05109 468 VSTADVTsptpaGTTSGASPvTPSPSPrdngteskapdmtspTSAVTTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSA 547

                         170
                  ....*....|....*....
gi 318037593  299 MGTtlaemSTPEATGMTPA 317
Cdd:pfam05109 548 VTT-----PTPNATSPTPA 561
 
Name Accession Description Interval E-value
PKAT_KLD pfam20433
PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, ...
 429-480 7.05e-19

PKAT, KLD domain; This is the Kringle-like domain (KLD) found in Melanocyte protein PMEL, Transmembrane glycoprotein NMB (GPNMB) and TMEM130, which is downstream the PKD domain. It contains six highly conserved cysteine residues that form the disulphide bonds of mature PMEL dimers. (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). This domain is perfectly conserved in PMEL and GPNMB which suggests that GPNMB also forms dimers. PMEL and GPNMB, together with TMEM130 (its most ancient paralogue), have a conserved domain architecture and have been recently described as the PKAT (PKD- and KLD-Associated Transmembrane) protein family (Chrystal et. al., Molecules 2021, 26(12), 3529; https://doi.org/10.3390/molecules26123529). PMEL and GPNMB share overlapping phenotypes and disease associations, such as melanin-based pigmentation, cancer, neurodegenerative disease and glaucoma.


Pssm-ID: 466582  Cd Length: 51  Bit Score: 80.40  E-value: 7.05e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 318037593  429 SCQGGLPKEACMEISSPGCQPPAQRLCQPVLPSPACQLVLHQILKgGSGTYC 480
Cdd:pfam20433   1 TCQGSLPTEVCTVVSDPTCQTPQNTVCNPVSPSPECQLVLRRAFN-GSGTYC 51
PKD pfam00801
PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. ...
 149-215 7.49e-08

PKD domain; This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.


Pssm-ID: 395646 [Multi-domain]  Cd Length: 70  Bit Score: 49.69  E-value: 7.49e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 318037593  149 NQPLTFALQLHDPSgylaeaDLSYTWDFGDSSGTlISRALVVTHTYLEPGPVTAQVVLQAAIPLTSC 215
Cdd:pfam00801  11 GQPVTFTATLADGS------NVTYTWDFGDSPGT-SGSGPTVTHTYLSPGTYTVTLTASNAVGSANA 70
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 147-209 8.16e-07

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 47.11  E-value: 8.16e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 318037593 147 LRNQPLTFALQLHDPSGYlaeADLSYTWDFGDSSGTLiSRALVVTHTYLEPGPVTAQVVLQAA 209
Cdd:cd00146   10 VAELGASVTFSASDSSGG---SIVSYKWDFGDGEVSS-SGEPTVTHTYTKPGTYTVTLTVTNA 68
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 151-210 6.96e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.36  E-value: 6.96e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593   151 PLTFALQLHDPSGYLAEaDLSYTWDFGDSSgtlISRALVVTHTYLEPGPVTAQVVLQAAI 210
Cdd:smart00089  12 VAGESVTFTATSSDDGS-IVSYTWDFGDGT---SSTGPTVTHTYTKPGTYTVTLTVTNAV 67
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 150-201 7.13e-04

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 38.79  E-value: 7.13e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 318037593  150 QPLTF-ALQLHDPSGYLaeadLSYTWDFGDssGTlISRALVVTHTYLEPG--PVT 201
Cdd:pfam18911  18 ETVTFdASASDDPDGDI----LSYRWDFGD--GT-TATGANVSHTYAAPGtyTVT 65
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 111-199 7.79e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 42.76  E-value: 7.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593   111 YVPLAHSSSAF-TITDQVPFSVSVSQLR-ALDGGNKHFLRNQPLTF-ALQLHDPSGYLaeadlsYTWDFGDSSGTLISRA 187
Cdd:TIGR00864 1062 YLATVLASNAFeNISQQINMSVRAILPRvAIGTEDGLLLAGKPADFeAHPLPSPGGIH------YEWDFGDGSALLQGRQ 1135

                           90
                   ....*....|..
gi 318037593   188 LVVTHTYLEPGP 199
Cdd:TIGR00864 1136 PAAAHTFAKRGP 1147
PHA03255 PHA03255
BDLF3; Provisional
 190-357 1.54e-03

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 40.66  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593 190 VTHTYLEPGPVTAQVVL-QAAIPLTSCGSSP-----VPGTT--DGHRPTAEAPNT--TAGQVPTTEVVGTTPG---QAPT 256
Cdd:PHA03255   1 MAHARDKAGAVLAMILIcETSLIWTSSGSSTasagnVTGTTavTTPSPSASGPSTnqSTTLTTTSAPITTTAIlstNTTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593 257 AEPSGTTSVQVPTTEVIST------APVQMPTAESTGMTPEKVPVSEVmgTTLAEMSTPEATGMTPAEVSIVVLSGTTAA 330
Cdd:PHA03255  81 VTSTGTTVTPVPTTSNASTinvttkVTAQNITATEAGTGTSTGVTSNV--TTRSSSTTSATTRITNATTLAPTLSSKGTS 158

                        170       180
                 ....*....|....*....|....*..
gi 318037593 331 QVTTTEWvettarELPIPEPEGPDASS 357
Cdd:PHA03255 159 NATKTTA------ELPTVPDERQPSLS 179
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 211-375 1.69e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593 211 PLTSCGSSPVPGTTDGHRPTAEAPntTAGQVPTTevvgtTPGQAPTAEPSGTTSVQVPTTEVISTAPVQMPTAESTGMTP 290
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAP--AAAPVAQA-----AAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAP 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593 291 EKVPVSevmgttLAEMSTPEAtgmtpaevsivvlsgttAAQVTTTEWVETTARELPIPEPEGPDASSIMSTESITGSLGP 370
Cdd:PRK14951 439 AAAPAA------VALAPAPPA-----------------QAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGD 495


                 ....*
gi 318037593 371 LLDGT 375
Cdd:PRK14951 496 VWHAT 500
PHA03247 PHA03247
large tegument protein UL36; Provisional
 211-370 3.21e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593  211 PLTSCGSSPVPGTTDGHRPTAEAPNTTAGQVPTTEVVGTTPGQAPTAEPSGTTSVQVPTTE-------VISTAPVQMPTA 283
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGParparppTTAGPPAPAPPA 2773

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593  284 ESTGMTPEKVPVSEVMGTTLAEMSTPEATgmTPAEVSIVVLSGTTAAQVTTTEWVETTARELPIPEPEGPDASSIMSTES 363
Cdd:PHA03247 2774 APAAGPPRRLTRPAVASLSESRESLPSPW--DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851


                  ....*..
gi 318037593  364 ITGSLGP 370
Cdd:PHA03247 2852 LGGSVAP 2858
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 173-317 5.19e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593  173 TWDFGDSSGTLISRALVVTHTYLEPGPVTAQVVLQAAIPLTSCGSS------PVPGTTDG-----HRPT-AEAPNTTAGQ 240
Cdd:pfam05109 388 TFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTlnttgfAAPNTTTGlpsstHVPTnLTAPASTGPT 467

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 318037593  241 VPTTEVV-----GTTPGQAP-TAEPSG---------------TTSVQVPTTEVISTAP-VQMPTAESTGMTPEKVPVSEV 298
Cdd:pfam05109 468 VSTADVTsptpaGTTSGASPvTPSPSPrdngteskapdmtspTSAVTTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSA 547

                         170
                  ....*....|....*....
gi 318037593  299 MGTtlaemSTPEATGMTPA 317
Cdd:pfam05109 548 VTT-----PTPNATSPTPA 561
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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