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Conserved domains on  [gi|313482873|ref|NP_001186259|]
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uncharacterized protein LOC233168 isoform 2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-41 2.94e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 2.94e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 313482873    1 MTYDDVHVNFTEEEWALLSPSQKRLYKDVMLETYKNLTAIG 41
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
48-402 9.01e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 9.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873  48 NSEHFQHSRRHGRHERSHTGEKPSVYTQCGKVFAY--RSHPQNHDRMHTGEKSHEG-IQHGKAFAHQSHLQRHERIHTSK 124
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 125 KPYECNQCGKAFAHRSYLRK--HKRIHIEEKPDEWNQCGQGNLQIHKRTHSaqkPYECNQCGKAFRRHNSLQVHNRTHTG 202
Cdd:COG5048  119 DNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPGNNSSSVNTPQSNSLHP---PLPANSLSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 203 EKPYKCDQCDKAFTQQGHLRIHNRTHTGEKPYECNQCGKAFAVHSTLQIHKRT------HTAETPYECNQCGKAFRRHNT 276
Cdd:COG5048  196 IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 277 LQIHKRTHTG-EKPYKCDQCDKAFSQQGHLRIHKRT--HTGE--KPYKC--SQCGKAFARHSHLLIHERIHTGEKPYRC- 348
Cdd:COG5048  276 NESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEk 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 349 ------------------------------------NQCNKAFSQYGGLQIHKSTHTAEKPYECN--ECGKTFSQHSYLR 390
Cdd:COG5048  356 llnssskfspllnneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                        410
                 ....*....|..
gi 313482873 391 THKRTHTREKPY 402
Cdd:COG5048  436 PHKKIHTNHAPL 447
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-41 2.94e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 2.94e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 313482873    1 MTYDDVHVNFTEEEWALLSPSQKRLYKDVMLETYKNLTAIG 41
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
1-42 1.22e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 73.40  E-value: 1.22e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 313482873     1 MTYDDVHVNFTEEEWALLSPSQKRLYKDVMLETYKNLTAIGY 42
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 1-38 7.03e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 7.03e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 313482873   1 MTYDDVHVNFTEEEWALLSPSQKRLYKDVMLETYKNLT 38
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
48-402 9.01e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 9.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873  48 NSEHFQHSRRHGRHERSHTGEKPSVYTQCGKVFAY--RSHPQNHDRMHTGEKSHEG-IQHGKAFAHQSHLQRHERIHTSK 124
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 125 KPYECNQCGKAFAHRSYLRK--HKRIHIEEKPDEWNQCGQGNLQIHKRTHSaqkPYECNQCGKAFRRHNSLQVHNRTHTG 202
Cdd:COG5048  119 DNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPGNNSSSVNTPQSNSLHP---PLPANSLSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 203 EKPYKCDQCDKAFTQQGHLRIHNRTHTGEKPYECNQCGKAFAVHSTLQIHKRT------HTAETPYECNQCGKAFRRHNT 276
Cdd:COG5048  196 IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 277 LQIHKRTHTG-EKPYKCDQCDKAFSQQGHLRIHKRT--HTGE--KPYKC--SQCGKAFARHSHLLIHERIHTGEKPYRC- 348
Cdd:COG5048  276 NESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEk 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 349 ------------------------------------NQCNKAFSQYGGLQIHKSTHTAEKPYECN--ECGKTFSQHSYLR 390
Cdd:COG5048  356 llnssskfspllnneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                        410
                 ....*....|..
gi 313482873 391 THKRTHTREKPY 402
Cdd:COG5048  436 PHKKIHTNHAPL 447
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-329 5.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.67e-04
                          10        20
                  ....*....|....*....|....*.
gi 313482873  304 HLRIHKRTHTGEKPYKCSQCGKAFAR 329
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-41 2.94e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 2.94e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 313482873    1 MTYDDVHVNFTEEEWALLSPSQKRLYKDVMLETYKNLTAIG 41
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
1-42 1.22e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 73.40  E-value: 1.22e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 313482873     1 MTYDDVHVNFTEEEWALLSPSQKRLYKDVMLETYKNLTAIGY 42
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 1-38 7.03e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 7.03e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 313482873   1 MTYDDVHVNFTEEEWALLSPSQKRLYKDVMLETYKNLT 38
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
48-402 9.01e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 9.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873  48 NSEHFQHSRRHGRHERSHTGEKPSVYTQCGKVFAY--RSHPQNHDRMHTGEKSHEG-IQHGKAFAHQSHLQRHERIHTSK 124
Cdd:COG5048   39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 125 KPYECNQCGKAFAHRSYLRK--HKRIHIEEKPDEWNQCGQGNLQIHKRTHSaqkPYECNQCGKAFRRHNSLQVHNRTHTG 202
Cdd:COG5048  119 DNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPGNNSSSVNTPQSNSLHP---PLPANSLSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 203 EKPYKCDQCDKAFTQQGHLRIHNRTHTGEKPYECNQCGKAFAVHSTLQIHKRT------HTAETPYECNQCGKAFRRHNT 276
Cdd:COG5048  196 IPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQSSSP 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 277 LQIHKRTHTG-EKPYKCDQCDKAFSQQGHLRIHKRT--HTGE--KPYKC--SQCGKAFARHSHLLIHERIHTGEKPYRC- 348
Cdd:COG5048  276 NESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEk 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 349 ------------------------------------NQCNKAFSQYGGLQIHKSTHTAEKPYECN--ECGKTFSQHSYLR 390
Cdd:COG5048  356 llnssskfspllnneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                        410
                 ....*....|..
gi 313482873 391 THKRTHTREKPY 402
Cdd:COG5048  436 PHKKIHTNHAPL 447
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
89-357 1.20e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873  89 HDRMHTGEKSHEGIQHGKAFAHQSHLQRHERIHTSKKPYECNQCGKAFAHRSYLRKHKRIHIEEKPdewnqcgqgnlqih 168
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS-------------- 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 169 krtHSAQKPYECNQCGKAFRRHNSLQVHNRTHTG-EKPYKCDQCDKAFTQQGHLRIHNRT--HTGE--KPYEC--NQCGK 241
Cdd:COG5048  255 ---SSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGK 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 242 AFAVHSTLQIHKRTHTAETPYEC--NQCGKAF------RRHNTLQIHKRTHTGEKPYKCDQ-CDKAFSQQGHLRIHKRTH 312
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSNsCIRNFKRDSNLSLHIITH 411

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 313482873 313 TGEKPY--KCSQCGKAFARHSHLLIHERIHTGEKPYRCNQCNKAFSQ 357
Cdd:COG5048  412 LSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-302 2.10e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 125 KPYECNQCGKAFAHRSYLRKHKRIHIEEKPDewnqcgqgnlqihkrthsaQKPYEC--NQCGKAFRRHNSLQVHNRTHTG 202
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSVNHSGES-------------------LKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 203 EKPYKC--DQCDKAFTQ------QGHLRIHNRTHTgEKPYEC--NQCGKAFAVHSTLQIHKRTHTAETPYECN--QCGKA 270
Cdd:COG5048  349 ISPAKEklLNSSSKFSPllnnepPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKS 427

                        170       180       190
                 ....*....|....*....|....*....|..
gi 313482873 271 FRRHNTLQIHKRTHTGEKPYKCDQCDKAFSQQ 302
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-329 5.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.67e-04
                          10        20
                  ....*....|....*....|....*.
gi 313482873  304 HLRIHKRTHTGEKPYKCSQCGKAFAR 329
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-301 7.25e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.25e-04
                          10        20
                  ....*....|....*....|....*
gi 313482873  277 LQIHKRTHTGEKPYKCDQCDKAFSQ 301
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
113-138 8.24e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.24e-04
                          10        20
                  ....*....|....*....|....*.
gi 313482873  113 HLQRHERIHTSKKPYECNQCGKAFAH 138
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 286-369 8.58e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 8.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 286 GEKPYKCD--QCDKAFSQQGHLRIHKrthtgekpyKCSQCGKAFARHSHLLIHERIHTGEKPYRCNQCNKAFSQYGGLQI 363
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 313482873 364 HKSTHT 369
Cdd:COG5189  417 HRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
123-397 9.21e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 9.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 123 SKKPYECNQCGKAFAHRSYLRKHKRIHIEEKPDEWNQCGQGN-------LQIHKRTHSAQKPYECNQCG---KAFRRHNS 192
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKsfsrpleLSRHLRTHHNNPSDLNSKSLplsNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 193 LqvHNRTHTGEKPYKCDQCDKAFTQQGHLRIHNRTHTGEKPYECNQCGKAFAV----------------------HSTLQ 250
Cdd:COG5048  110 L--SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 251 IHKRTHTAETPYECNQCGKAFRRHNTLQIHKRTHTGEKPYKCDQCdkAFSQQGHLRIHKRTHTGEK--------PYKCSQ 322
Cdd:COG5048  188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdssssaseSPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 323 CGKAFARHSHLLIHERIHTG-EKPYRCNQCNKAFSQYGGLQIHKST--HTAE--KPYECNE--CGKTFSQHSYLRTHKRT 395
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                 ..
gi 313482873 396 HT 397
Cdd:COG5048  346 HT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-217 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 313482873  192 SLQVHNRTHTGEKPYKCDQCDKAFTQ 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
173-395 2.41e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 173 SAQKPYECNQCGKAFRRHNSLQVHNRTHTGEKPYKC--DQCDKAFTQQGHLRIHNRTHTGEKPYECNQ------------ 238
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskasss 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 239 ----CGKAFAVHSTLQIH---------------------KRTHTAETPYECNQCGKAFRRHNT--------------LQI 279
Cdd:COG5048  109 slssSSSNSNDNNLLSSHslppssrdpqlpdllsisnlrNNPLPGNNSSSVNTPQSNSLHPPLpanslskdpssnlsLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 280 HKRTHTGEKPYKCDQCDKAFSQQGHLRIHKRTHTGEKPYKCSQCGKAFARH------SHLLIHERIHTGEKPYRCNQCNK 353
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTA 268

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 313482873 354 AFSQYGGLQIHKSTHTA-EKPYECNECGKTFSQHSYLRTHKRT 395
Cdd:COG5048  269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRS 311
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 202-285 4.34e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 4.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 313482873 202 GEKPYKCD--QCDKAFTQQGHLRIHnRTHTgekpyECNQCGKAFAVHSTLQIHKrthTAETPYECNQCGKAFRRHNTLQI 279
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG-----HQNQKLHENPSPEKMNIFS---AKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 313482873 280 HkRTHT 285
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
220-244 4.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....*
gi 313482873  220 HLRIHNRTHTGEKPYECNQCGKAFA 244
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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