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Conserved domains on  [gi|311078508|ref|NP_001185648|]
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histone-binding protein RBBP7 isoform 1 [Homo sapiens]

Protein Classification

WD repeat RBAP46/RBAP48/MSI1 family protein( domain architecture ID 13780222)

WD repeat RBAP46/RBAP48/MSI1 family protein binds histones; contains an N-terminal alpha helical domain and WD40 repeats that fold into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0042393
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4005630|4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 166-446 3.64e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 3.64e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 166 HEGEVNRARYMPQNPHIIatkTPSSD--VLVFDYTkhpakpdpsgECNPDLRLRGHQKEGYGLSWNSNlSGHLLSASDDH 243
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLA---TGSGDgtIKVWDLE----------TGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 244 TVCLWDINAGPKegkivdaKAIFTGHSAVVEDVAWHLLHESLFGSvADDQKLMIWDTRsntTSKPSHLVDAHTAEVNCLS 323
Cdd:cd00200   74 TIRLWDLETGEC-------VRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVA 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 324 FNPYSEFIlATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPHNETILASSGtDRRLNVWDLSK-------IGEE 396
Cdd:cd00200  143 FSPDGTFV-ASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTgkclgtlRGHE 219

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 311078508 397 QSAEDAEDGPPELLFIHG---------------------GHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQ 446
Cdd:cd00200  220 NGVNSVAFSPDGYLLASGsedgtirvwdlrtgecvqtlsGHTNSVTSLAWSPDGKRLA-SGSADGTIRIWD 289
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 62-131 2.35e-31

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


:

Pssm-ID: 463513  Cd Length: 69  Bit Score: 114.98  E-value: 2.35e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 311078508   62 EEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEvtKPEGKDYALHWLVLGTHTSD-EQNHLVVARVHIPN 131
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 166-446 3.64e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 3.64e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 166 HEGEVNRARYMPQNPHIIatkTPSSD--VLVFDYTkhpakpdpsgECNPDLRLRGHQKEGYGLSWNSNlSGHLLSASDDH 243
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLA---TGSGDgtIKVWDLE----------TGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 244 TVCLWDINAGPKegkivdaKAIFTGHSAVVEDVAWHLLHESLFGSvADDQKLMIWDTRsntTSKPSHLVDAHTAEVNCLS 323
Cdd:cd00200   74 TIRLWDLETGEC-------VRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVA 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 324 FNPYSEFIlATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPHNETILASSGtDRRLNVWDLSK-------IGEE 396
Cdd:cd00200  143 FSPDGTFV-ASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTgkclgtlRGHE 219

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 311078508 397 QSAEDAEDGPPELLFIHG---------------------GHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQ 446
Cdd:cd00200  220 NGVNSVAFSPDGYLLASGsedgtirvwdlrtgecvqtlsGHTNSVTSLAWSPDGKRLA-SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
215-448 2.19e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.03  E-value: 2.19e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 215 RLRGHQKEGYGLSWNSNlsGHLL-SASDDHTVCLWDINAGPKEgkivdakAIFTGHSAVVEDVAWHLlHESLFGSVADDQ 293
Cdd:COG2319  157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDLATGKLL-------RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 294 KLMIWDTRsntTSKPSHLVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNE 373
Cdd:COG2319  227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 311078508 374 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQMA 448
Cdd:COG2319  301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 62-131 2.35e-31

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 114.98  E-value: 2.35e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 311078508   62 EEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEvtKPEGKDYALHWLVLGTHTSD-EQNHLVVARVHIPN 131
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 212-391 3.51e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.49  E-value: 3.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 212 PDLRLRGHQKEGyGLSWNSNLSGHLLSASDDHTVCLWDInagPKEGKIVDAKAiftgHSAVVEDVAWHLLHESLFGSVAD 291
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDV---ARSQLVTEMKE----HEKRVWSIDYSSADPTLLASGSD 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 292 DQKLMIWDTRSNT---TSKPShlvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHW 368
Cdd:PLN00181 597 DGSVKLWSINQGVsigTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|...
gi 311078508 369 SphNETILASSGTDRRLNVWDLS 391
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 305-345 2.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 311078508   305 TSKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 345
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
306-345 1.17e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.17e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 311078508  306 SKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 345
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 166-446 3.64e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 129.76  E-value: 3.64e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 166 HEGEVNRARYMPQNPHIIatkTPSSD--VLVFDYTkhpakpdpsgECNPDLRLRGHQKEGYGLSWNSNlSGHLLSASDDH 243
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLA---TGSGDgtIKVWDLE----------TGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 244 TVCLWDINAGPKegkivdaKAIFTGHSAVVEDVAWHLLHESLFGSvADDQKLMIWDTRsntTSKPSHLVDAHTAEVNCLS 323
Cdd:cd00200   74 TIRLWDLETGEC-------VRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVA 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 324 FNPYSEFIlATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPHNETILASSGtDRRLNVWDLSK-------IGEE 396
Cdd:cd00200  143 FSPDGTFV-ASSSQDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTgkclgtlRGHE 219

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 311078508 397 QSAEDAEDGPPELLFIHG---------------------GHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQ 446
Cdd:cd00200  220 NGVNSVAFSPDGYLLASGsedgtirvwdlrtgecvqtlsGHTNSVTSLAWSPDGKRLA-SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
215-448 2.19e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.03  E-value: 2.19e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 215 RLRGHQKEGYGLSWNSNlsGHLL-SASDDHTVCLWDINAGPKEgkivdakAIFTGHSAVVEDVAWHLlHESLFGSVADDQ 293
Cdd:COG2319  157 TLTGHSGAVTSVAFSPD--GKLLaSGSDDGTVRLWDLATGKLL-------RTLTGHTGAVRSVAFSP-DGKLLASGSADG 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 294 KLMIWDTRsntTSKPSHLVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNE 373
Cdd:COG2319  227 TVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL-LRTLTGHSGGVNSVAFSP-DG 300

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 311078508 374 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQMA 448
Cdd:COG2319  301 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
215-448 7.21e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 7.21e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 215 RLRGHQKEGYGLSWNSNlSGHLLSASDDHTVCLWDINAGPkegkivdAKAIFTGHSAVVEDVAWHLLHESLFgSVADDQK 294
Cdd:COG2319  115 TLTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDLATGK-------LLRTLTGHSGAVTSVAFSPDGKLLA-SGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 295 LMIWDTRsntTSKPSHLVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNET 374
Cdd:COG2319  186 VRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKL-LRTLTGHSGSVRSVAFSP-DGR 259

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 311078508 375 ILASSGTDRRLNVWDLSkigeeqsaedaedgPPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQMA 448
Cdd:COG2319  260 LLASGSADGTVRLWDLA--------------TGELLRTLTGHSGGVNSVAFSPDGKLLA-SGSDDGTVRLWDLA 318
CAF1C_H4-bd pfam12265
Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved ...
 62-131 2.35e-31

Histone-binding protein RBBP4 or subunit C of CAF1 complex; The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.


Pssm-ID: 463513  Cd Length: 69  Bit Score: 114.98  E-value: 2.35e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 311078508   62 EEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEvtKPEGKDYALHWLVLGTHTSD-EQNHLVVARVHIPN 131
Cdd:pfam12265   1 EEYLIWKKNAPFLYDMLHTHALEWPSLSFDWFPD--TSEGKNYTVQRLLLGTQTSGaEQNYLYVAKVSLPS 69
WD40 COG2319
WD40 repeat [General function prediction only];
215-391 8.28e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 8.28e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 215 RLRGHQKEGYGLSWNSNlSGHLLSASDDHTVCLWDINAGpkegkivDAKAIFTGHSAVVEDVAWHLLHESLFgSVADDQK 294
Cdd:COG2319  241 TLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLA-SGSDDGT 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 295 LMIWDTRsntTSKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNET 374
Cdd:COG2319  312 VRLWDLA---TGKLLRTLTGHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGEL-LRTLTGHTGAVTSVAFSP-DGR 385

                        170
                 ....*....|....*..
gi 311078508 375 ILASSGTDRRLNVWDLS 391
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
214-448 1.10e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 214 LRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPkegkivdAKAIFTGHSAVVEDVAWHLLHESLfGSVADDQ 293
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA-------LLATLLGHTAAVLSVAFSPDGRLL-ASASADG 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 294 KLMIWDTrsnTTSKPSHLVDAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWSPhNE 373
Cdd:COG2319  101 TVRLWDL---ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKL-LRTLTGHSGAVTSVAFSP-DG 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 311078508 374 TILASSGTDRRLNVWDLSKigeeqsaedaedgpPELLFIHGGHTAKISDFSWNPNEPWVIcSVSEDNIMQIWQMA 448
Cdd:COG2319  175 KLLASGSDDGTVRLWDLAT--------------GKLLRTLTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 263-450 5.53e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 5.53e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 263 KAIFTGHSAVVEDVAWHLlHESLFGSVADDQKLMIWDTrsnTTSKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVA 342
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDL---ETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 343 LWDLRNLKLkLHTFESHKDEIFQVHWSPHNeTILASSGTDRRLNVWDLSKIGEEQSAEdaedgppellfihgGHTAKISD 422
Cdd:cd00200   77 LWDLETGEC-VRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVETGKCLTTLR--------------GHTDWVNS 140

                        170       180
                 ....*....|....*....|....*...
gi 311078508 423 FSWNPNePWVICSVSEDNIMQIWQMAEN 450
Cdd:cd00200  141 VAFSPD-GTFVASSSQDGTIKLWDLRTG 167
WD40 COG2319
WD40 repeat [General function prediction only];
215-348 3.31e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 3.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 215 RLRGHQKEGYGLSWNSNlSGHLLSASDDHTVCLWDInagpKEGKIVdakAIFTGHSAVVEDVAWHLLHESLFgSVADDQK 294
Cdd:COG2319  283 TLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDL----ATGKLL---RTLTGHTGAVRSVAFSPDGKTLA-SGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 311078508 295 LMIWDTRsntTSKPSHLVDAHTAEVNCLSFNPYSEfILATGSADKTVALWDLRN 348
Cdd:COG2319  354 VRLWDLA---TGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 212-391 3.51e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.49  E-value: 3.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 212 PDLRLRGHQKEGyGLSWNSNLSGHLLSASDDHTVCLWDInagPKEGKIVDAKAiftgHSAVVEDVAWHLLHESLFGSVAD 291
Cdd:PLN00181 525 PVVELASRSKLS-GICWNSYIKSQVASSNFEGVVQVWDV---ARSQLVTEMKE----HEKRVWSIDYSSADPTLLASGSD 596

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 292 DQKLMIWDTRSNT---TSKPShlvdahtAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHW 368
Cdd:PLN00181 597 DGSVKLWSINQGVsigTIKTK-------ANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRF 669

                        170       180
                 ....*....|....*....|...
gi 311078508 369 SphNETILASSGTDRRLNVWDLS 391
Cdd:PLN00181 670 V--DSSTLVSSSTDNTLKLWDLS 690
PTZ00420 PTZ00420
coronin; Provisional
 204-350 1.35e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 53.80  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 204 PDPSGECNPDLRLRGHQKEGYGLSwnsnlsghllsASDDHTVCLWDINAGPKEGKIVDAKAI-------FTGHSAVVEDV 276
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIA-----------CSSGFVAVPWEVEGGGLIGAIRLENQMrkppvikLKGHTSSILDL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 311078508 277 AWHLLHESLFGSVADDQKLMIWDTRSNTTS-----KPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLK 350
Cdd:PTZ00420  81 QFNPCFSEILASGSEDLTIRVWEIPHNDESvkeikDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
PTZ00420 PTZ00420
coronin; Provisional
 349-450 1.91e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 53.42  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 349 LKLKLHTfeshkDEIFQVHWSPHNETILASSGTDRRLNVWDLSKigEEQSAEDAEDgpPelLFIHGGHTAKISDFSWNPN 428
Cdd:PTZ00420  68 IKLKGHT-----SSILDLQFNPCFSEILASGSEDLTIRVWEIPH--NDESVKEIKD--P--QCILKGHKKKISIIDWNPM 136

                         90       100
                 ....*....|....*....|..
gi 311078508 429 EPWVICSVSEDNIMQIWQMaEN 450
Cdd:PTZ00420 137 NYYIMCSSGFDSFVNIWDI-EN 157
PTZ00421 PTZ00421
coronin; Provisional
 243-389 2.12e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.36  E-value: 2.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 243 HTVClwdinagpkeGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDT-----RSNTTSKPSHLvDAHTA 317
Cdd:PTZ00421  58 HTDY----------GKLASNPPILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeeglTQNISDPIVHL-QGHTK 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 311078508 318 EVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKlHTFESHKDEIFQVHWSPHNeTILASSGTDRRLNVWD 389
Cdd:PTZ00421 127 KVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV-EVIKCHSDQITSLEWNLDG-SLLCTTSKDKKLNIID 196
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 305-345 2.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 311078508   305 TSKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 345
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 162-357 5.61e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 5.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 162 IKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYtkhPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASD 241
Cdd:PTZ00421  70 ILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGI---PEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGA 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 242 DHTVCLWDINAGPkegkivdAKAIFTGHSAVVEDVAWHlLHESLFGSVADDQKLMIWDTRSNT--TSKPSHlvdAHTAEV 319
Cdd:PTZ00421 147 DMVVNVWDVERGK-------AVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGTivSSVEAH---ASAKSQ 215

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 311078508 320 NCLsFNPYSEFILATG---SADKTVALWDLRNLKLKLHTFE 357
Cdd:PTZ00421 216 RCL-WAKRKDLIITLGcskSQQRQIMLWDTRKMASPYSTVD 255
WD40 pfam00400
WD domain, G-beta repeat;
306-345 1.17e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.17e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 311078508  306 SKPSHLVDAHTAEVNCLSFNPYSEFiLATGSADKTVALWD 345
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 353-389 5.79e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 5.79e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 311078508   353 LHTFESHKDEIFQVHWSPHNeTILASSGTDRRLNVWD 389
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 322-444 2.77e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 2.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311078508 322 LSFNPYSEFILATGSADKTVALWDL------RNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSK--I 393
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERgkA 160

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 311078508 394 GEEQSAedaedgppellfihggHTAKISDFSWNPNEPwVICSVSEDNIMQI 444
Cdd:PTZ00421 161 VEVIKC----------------HSDQITSLEWNLDGS-LLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
353-389 3.73e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 311078508  353 LHTFESHKDEIFQVHWSPhNETILASSGTDRRLNVWD 389
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 216-249 4.99e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 4.99e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 311078508   216 LRGHQKEGYGLSWNSNlSGHLLSASDDHTVCLWD 249
Cdd:smart00320   8 LKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 313-369 2.37e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 2.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 311078508  313 DAHTAEVNCLSFNPySEFILATGSADKTVALWDLRNLKLkLHTFESHKDEIFQVHWS 369
Cdd:pfam12894  35 DKEDLEVTSLAWRP-DGKLLAVGYSDGTVRLLDAENGKI-VHHFSAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
216-249 6.61e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 6.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 311078508  216 LRGHQKEGYGLSWNSNlSGHLLSASDDHTVCLWD 249
Cdd:pfam00400   7 LEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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