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Conserved domains on  [gi|310923324|ref|NP_001185636|]
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polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 [Macaca mulatta]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130259)

phosphatase PAP2 family protein may be a histidine phosphatase that catalyzes the dephosphorylation of phospholipids such as phospholipid phosphatase 6 (PLPP6), or may be an inactive member such as PLPP7

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0016791|GO:0016311|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 119-277 2.02e-71

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


:

Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 217.57  E-value: 2.02e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 119 GVCAGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQM 198
Cdd:cd03391    1 GVCARETSSWGPVRPLVKLLELSGHGIPWLAGTISCLWISSSPAGQEVLVNLLLGLLLDIITVAILKALVRRRRPAYNSP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 310923324 199 DMFVTLSVDKYSFPSGHATRAALMSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLGYMQYSIVD 277
Cdd:cd03391   81 DMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLAVPLRVLLVLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALLVE 159
 
Name Accession Description Interval E-value
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 119-277 2.02e-71

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 217.57  E-value: 2.02e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 119 GVCAGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQM 198
Cdd:cd03391    1 GVCARETSSWGPVRPLVKLLELSGHGIPWLAGTISCLWISSSPAGQEVLVNLLLGLLLDIITVAILKALVRRRRPAYNSP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 310923324 199 DMFVTLSVDKYSFPSGHATRAALMSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLGYMQYSIVD 277
Cdd:cd03391   81 DMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLAVPLRVLLVLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALLVE 159
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 144-270 3.67e-14

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 69.30  E-value: 3.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 144 GIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQMDMFVTLSVDKYSFPSGHATRAALMS 223
Cdd:COG0671   52 LLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGYSFPSGHAAAAFALA 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 310923324 224 rFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLGY 270
Cdd:COG0671  132 -LVLALLLPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGL 177
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 184-271 2.52e-10

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 57.05  E-value: 2.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324  184 IKGLVRRRRPAH-----NQMDMFVTLSVDKYSFPSGHATRAA-----LMSRFILNHLVLAIPLRVLVVLWAFVLGLSRVM 253
Cdd:pfam01569  16 LKDYFGRPRPFFlllegGLVPAPSTLPGLGYSFPSGHSATAFalallLALLLRRLRKIVRVLLALLLLVLALLVGLSRLY 95

                          90
                  ....*....|....*...
gi 310923324  254 LGRHNVTDVVFGFFLGYM 271
Cdd:pfam01569  96 LGVHFPSDVLAGALIGIL 113
acidPPc smart00014
Acid phosphatase homologues;
209-270 7.95e-10

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 55.43  E-value: 7.95e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 310923324   209 YSFPSGHATRAAlmsrFILNHLVLAIPLR-------VLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLGY 270
Cdd:smart00014  45 YSFPSGHTAFAF----AFALFLLLYLPARagrklliFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGI 109
 
Name Accession Description Interval E-value
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 119-277 2.02e-71

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 217.57  E-value: 2.02e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 119 GVCAGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQM 198
Cdd:cd03391    1 GVCARETSSWGPVRPLVKLLELSGHGIPWLAGTISCLWISSSPAGQEVLVNLLLGLLLDIITVAILKALVRRRRPAYNSP 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 310923324 199 DMFVTLSVDKYSFPSGHATRAALMSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLGYMQYSIVD 277
Cdd:cd03391   81 DMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLAVPLRVLLVLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALLVE 159
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 184-270 3.03e-14

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 67.87  E-value: 3.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 184 IKGLVRRRRP----AHNQMDMFVTLSVDKYSFPSGHATRAALMSRFI---LNHLVLAIPLRVLVVLWAFVLGLSRVMLGR 256
Cdd:cd01610   22 LKYLFGRPRPyfllRCGPDGDPLLLTEGGYSFPSGHAAFAFALALFLallLPRRLLRLLLGLLLLLLALLVGLSRVYLGV 101

                         90
                 ....*....|....
gi 310923324 257 HNVTDVVFGFFLGY 270
Cdd:cd01610  102 HYPSDVLAGALLGI 115
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 144-270 3.67e-14

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 69.30  E-value: 3.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 144 GIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQMDMFVTLSVDKYSFPSGHATRAALMS 223
Cdd:COG0671   52 LLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGYSFPSGHAAAAFALA 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 310923324 224 rFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLGY 270
Cdd:COG0671  132 -LVLALLLPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGL 177
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 184-271 2.52e-10

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 57.05  E-value: 2.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324  184 IKGLVRRRRPAH-----NQMDMFVTLSVDKYSFPSGHATRAA-----LMSRFILNHLVLAIPLRVLVVLWAFVLGLSRVM 253
Cdd:pfam01569  16 LKDYFGRPRPFFlllegGLVPAPSTLPGLGYSFPSGHSATAFalallLALLLRRLRKIVRVLLALLLLVLALLVGLSRLY 95

                          90
                  ....*....|....*...
gi 310923324  254 LGRHNVTDVVFGFFLGYM 271
Cdd:pfam01569  96 LGVHFPSDVLAGALIGIL 113
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 184-270 5.27e-10

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 57.62  E-value: 5.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 184 IKGLVRRRRPAHNQMdmfvtLSVDKYSFPSGHATRAALMSRFI-------LNHLVLAIPLRVLVVLWAFVLGLSRVMLGR 256
Cdd:cd03392   81 LKLLVQRPRPPLHLL-----VPEGGYSFPSGHAMGATVLYGFLayllarrLPRRRVRILLLILAAILILLVGLSRLYLGV 155

                         90
                 ....*....|....
gi 310923324 257 HNVTDVVFGFFLGY 270
Cdd:cd03392  156 HYPSDVLAGWLLGL 169
acidPPc smart00014
Acid phosphatase homologues;
209-270 7.95e-10

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 55.43  E-value: 7.95e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 310923324   209 YSFPSGHATRAAlmsrFILNHLVLAIPLR-------VLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLGY 270
Cdd:smart00014  45 YSFPSGHTAFAF----AFALFLLLYLPARagrklliFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGI 109
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 134-269 1.34e-09

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 56.12  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 134 LMKLLEISGHGIPWLLGT-LYCLCRSDSWAGREVLMNLLFALLLDLLLVALIKGLVRRRRPAHNQ---MDMFVTLSVDKY 209
Cdd:cd03395   25 LMPFLTGKKLSVPIFLLLaLFILFRKGPIGLLILLLVLLAVGFADQLASGFLKPLVARLRPCNALdgvRLVVLGDQGGSY 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 210 SFPSGHATRAALMSRFILnHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLG 269
Cdd:cd03395  105 SFASSHAANSFALALFIW-LFFRRGLFSPVLLLWALLVGYSRVYVGVHYPGDVIAGALIG 163
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 184-271 2.98e-07

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 49.63  E-value: 2.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 184 IKGLVRRRRPAH---NQMDMFVTLSVDK--YSFPSGHATRA-ALMSRFILnhlvLAIPLRVLVVLWAFVLGLSRVMLGRH 257
Cdd:cd03389   88 LKFIIGRARPKLlfdDGLYGFDPFHADYafTSFPSGHSATAgAAAAALAL----LFPRYRWAFILLALLIAFSRVIVGAH 163

                         90
                 ....*....|....
gi 310923324 258 NVTDVVFGFFLGYM 271
Cdd:cd03389  164 YPSDVIAGSLLGAV 177
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 210-269 7.14e-06

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 44.93  E-value: 7.14e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 210 SFPSGHATRAA---------LMSRFILNHLVLAIP-LRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLG 269
Cdd:cd03384   73 SFPSGHASLSMyaavflalyLQARLKLRGSRLLRPlLQFLLLALALYVGLSRISDYKHHWSDVLAGALLG 142
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 209-269 1.42e-05

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 44.14  E-value: 1.42e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 310923324 209 YSFPSGHATRAALMSRFILNHLVLAIP-----LRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLG 269
Cdd:cd03388   78 YGFPSTHAMNATAISFYLLIYLYDRYQypfvlGLILALFYSTLVCLSRIYMGMHSVLDVIAGSLIG 143
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 210-269 3.75e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 43.75  E-value: 3.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 310923324 210 SFPSGHATRAA----LMSRFILNHLVLAIP----LRVLVVLW----AFVLGLSRVMLGRHNVTDVVFGFFLG 269
Cdd:cd03390  111 SFPSGHSSFAFaglgFLSLYLAGKLHIFDPrgssWRLLLALLplllAILVAVSRTRDYRHHFSDVIAGSLIG 182
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 184-271 1.94e-04

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 40.01  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 184 IKGLVRRRRPahnqmdmfVTLSVDKYSFPSGHATRA---ALMSRFILNHLVLAIPLRVLvvlwAFVLGLSRVMLGRHNVT 260
Cdd:cd03394   22 LKFAVGRARP--------DGSNNGYRSFPSGHTASAfaaATFLQYRYGWRWYGIPAYAL----ASLVGASRVVANRHWLS 89

                         90
                 ....*....|.
gi 310923324 261 DVVFGFFLGYM 271
Cdd:cd03394   90 DVLAGAAIGIL 100
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 210-276 2.05e-03

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 37.62  E-value: 2.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 310923324 210 SFPSGHATRA-ALMSRFILNHlvlAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLGYMQYSIV 276
Cdd:cd03385   78 SFPSDHTTLFfSIAFSLLLRR---RKWAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLV 142
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 209-268 6.03e-03

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 37.28  E-value: 6.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 310923324 209 YSFPSGHA-TRAALMS-RFILNHLVLAIPLRVLVVLWAF--VLGLSRVMLGRHNVTDVVFGFFL 268
Cdd:cd03396  122 CSFPSGHAsAGFALLAlYFLFRRRRPRLARLVLAAGLALgaLMGLARMARGAHFLSDVLWSLLL 185
PAP2_Aur1_like cd03386
PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of ...
 211-270 8.59e-03

PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.


Pssm-ID: 239481  Cd Length: 186  Bit Score: 36.52  E-value: 8.59e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 211 FPSGHATRAALMSRFILNHLvlAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVVFGFFLGY 270
Cdd:cd03386  119 FPSLHVAWAVLAALFLWRHR--RRLLRWLAVLWPLLIWLSTLYLGNHYFIDLVGGIALAL 176
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 184-269 8.97e-03

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 36.10  E-value: 8.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 310923324 184 IKGLVRRRRPAHnqmdmFVTLSVDKYSFPSGHATR----AALMSRFI------LNHLVLAIPLRVLVVLWAFVLGLSRVM 253
Cdd:cd03382   61 LKRIIKEPRPCS-----GAYFVRSGYGMPSSHSQFmgffAVYLLLFIylrlgrLNSLVSRFLLSLGLLLLALLVSYSRVY 135

                         90
                 ....*....|....*.
gi 310923324 254 LGRHNVTDVVFGFFLG 269
Cdd:cd03382  136 LGYHTVSQVVVGAIVG 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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