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Conserved domains on  [gi|334183397|ref|NP_001185257|]
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DNA-binding bromodomain-containing protein [Arabidopsis thaliana]

Protein Classification

bromodomain-containing protein( domain architecture ID 10144616)

bromodomain-containing protein may act as transcription regulator involved in chromatin-based DNA damage response (DDR) pathways, which maintain genome integrity from cell-intrinsic and extrinsic DNA-damaging sources

CATH:  1.20.920.10
Gene Ontology:  GO:0005515|GO:0006338|GO:0006357|GO:0070577
PubMed:  11911891|11487477|26472704|1350857|34548613|28847823|31582847
SCOP:  4000871

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 212-314 2.46e-30

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


:

Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 114.85  E-value: 2.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 212 NKQELEDSLIVIKKIMKMEAADPFNVPVNPEALGIPDYFDIIKTPMDFGTICNNFEKG------NKYMNSEDVYKDVNYI 285
Cdd:cd05494    1 DYEALERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKVNNIVETgardleDLQIVQEDPADKQIDD 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 334183397 286 WNNCSKYNKKGDY-----IVDLMKRVKKNFMKYW 314
Cdd:cd05494   81 EGRRSPSNIYAVEaleqlIVFQCKQVKGLKQKRH 114
 
Name Accession Description Interval E-value
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 212-314 2.46e-30

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 114.85  E-value: 2.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 212 NKQELEDSLIVIKKIMKMEAADPFNVPVNPEALGIPDYFDIIKTPMDFGTICNNFEKG------NKYMNSEDVYKDVNYI 285
Cdd:cd05494    1 DYEALERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKVNNIVETgardleDLQIVQEDPADKQIDD 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 334183397 286 WNNCSKYNKKGDY-----IVDLMKRVKKNFMKYW 314
Cdd:cd05494   81 EGRRSPSNIYAVEaleqlIVFQCKQVKGLKQKRH 114
BROMO smart00297
bromo domain;
222-315 1.15e-17

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 78.47  E-value: 1.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397   222 VIKKIMKMEAADPFNVPVNPEAlgIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSKYNKKGDYIVD 301
Cdd:smart00297  15 VLDKLDSHPLSWPFLKPVSRKE--APDYYDIIKKPMDLKTIKKKLENG-KYSSVEEFVADFNLMFSNARTYNGPDSEVYK 91

                           90
                   ....*....|....
gi 334183397   302 LMKRVKKNFMKYWT 315
Cdd:smart00297  92 DAKKLEKFFEKKLR 105
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 222-296 1.38e-15

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 71.96  E-value: 1.38e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334183397  222 VIKKIMKMEAADPFNVPVNPEALgiPDYFDIIKTPMDFGTICNNFEkGNKYMNSEDVYKDVNYIWNNCSKYNKKG 296
Cdd:pfam00439   4 ILDKLMEHPIAAPFLEPVDPDEY--PDYYSVIKKPMDLSTIKKKLE-NGEYKSLAEFLADVKLIFSNARTYNGPG 75
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 165-296 1.34e-07

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 54.04  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 165 VKVQDVVVGQKDTKTSEENSQASKKEAEIATiSLQKEEKKTDQNLRYNKQELEDSLIVIKKIMKMEAADPFNVPVNPEAL 244
Cdd:COG5076   98 SLRFDEIVFLAIESVTPESGLGSLLMAHLKT-SVKKRKTPKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKR 176

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 334183397 245 GIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSKYNKKG 296
Cdd:COG5076  177 EYPDYYEIIKSPMDLLTIQKKLKNG-RYKSFEEFVSDLNLMFDNCKLYNGPD 227
 
Name Accession Description Interval E-value
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 212-314 2.46e-30

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 114.85  E-value: 2.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 212 NKQELEDSLIVIKKIMKMEAADPFNVPVNPEALGIPDYFDIIKTPMDFGTICNNFEKG------NKYMNSEDVYKDVNYI 285
Cdd:cd05494    1 DYEALERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKVNNIVETgardleDLQIVQEDPADKQIDD 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 334183397 286 WNNCSKYNKKGDY-----IVDLMKRVKKNFMKYW 314
Cdd:cd05494   81 EGRRSPSNIYAVEaleqlIVFQCKQVKGLKQKRH 114
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 223-314 6.01e-23

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 93.55  E-value: 6.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 223 IKKIMKMEAADPFNVPVNPEALGIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSKYNKKGDYIVDL 302
Cdd:cd05506    9 LRKLMKHKWGWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKG-EYSSPEEFAADVRLTFANAMRYNPPGNDVHTM 87

                         90
                 ....*....|..
gi 334183397 303 MKRVKKNFMKYW 314
Cdd:cd05506   88 AKELLKIFETRW 99
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 223-313 1.20e-21

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 89.68  E-value: 1.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 223 IKKIMKMEAADPFNVPVNPEALGIPDYFDIIKTPMDFGTICNNFeKGNKYMNSEDVYKDVNYIWNNCSKYNKKgDYIVDL 302
Cdd:cd05500   13 IRSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKL-KSNVYTSVEEFTADFNLMVDNCLTFNGP-EHPVSQ 90

                         90
                 ....*....|..
gi 334183397 303 M-KRVKKNFMKY 313
Cdd:cd05500   91 MgKRLQAAFEKH 102
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 232-314 1.56e-20

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 86.56  E-value: 1.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 232 ADPFNVPVNPEALGIPDYFDIIKTPMDFGTICNNFEKgNKYMNSEDVYKDVNYIWNNCSKYNKKGDYIVDLMKRVKKNFM 311
Cdd:cd05498   21 AWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDN-REYADAQEFAADVRLMFSNCYKYNPPDHPVHAMARKLQDVFE 99


                 ...
gi 334183397 312 KYW 314
Cdd:cd05498  100 DRW 102
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 222-312 7.30e-20

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 84.78  E-value: 7.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 222 VIKKIMKMEAADPFNVPVNPEALGIPDYFDIIKTPMDFGTICNNFEKgNKYMNSEDVYKDVNYIWNNCSKYNKKGDYIVD 301
Cdd:cd05497   13 VLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLEN-NYYWSASECIQDFNTMFTNCYIYNKPGDDVVL 91

                         90
                 ....*....|.
gi 334183397 302 LMKRVKKNFMK 312
Cdd:cd05497   92 MAQTLEKLFLQ 102
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 215-314 1.05e-18

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 81.26  E-value: 1.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 215 ELEDSLIVIKKIMK--MEAADPFNVPVNPEalGIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSKY 292
Cdd:cd04369    1 LKKKLRSLLDALKKlkRDLSEPFLEPVDPK--EAPDYYEVIKNPMDLSTIKKKLKNG-EYKSLEEFEADVRLIFSNAKTY 77

                         90       100
                 ....*....|....*....|..
gi 334183397 293 NKKGDYIVDLMKRVKKNFMKYW 314
Cdd:cd04369   78 NGPGSPIYKDAKKLEKLFEKLL 99
BROMO smart00297
bromo domain;
222-315 1.15e-17

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 78.47  E-value: 1.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397   222 VIKKIMKMEAADPFNVPVNPEAlgIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSKYNKKGDYIVD 301
Cdd:smart00297  15 VLDKLDSHPLSWPFLKPVSRKE--APDYYDIIKKPMDLKTIKKKLENG-KYSSVEEFVADFNLMFSNARTYNGPDSEVYK 91

                           90
                   ....*....|....
gi 334183397   302 LMKRVKKNFMKYWT 315
Cdd:smart00297  92 DAKKLEKFFEKKLR 105
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 215-314 1.33e-17

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 78.48  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 215 ELEDSLIVIKKIMKMEAAD---PFNVPVNPEALGIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSK 291
Cdd:cd05499    1 ELKFCEEVLKELMKPKHSAynwPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNG-QYQSAKEFERDVRLIFKNCYT 79

                         90       100
                 ....*....|....*....|...
gi 334183397 292 YNKKGDYIVDLMKRVKKNFMKYW 314
Cdd:cd05499   80 FNPEGTDVYMMGHQLEEVFNDKW 102
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 222-295 1.57e-16

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 75.56  E-value: 1.57e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334183397 222 VIKKIMKMEA-ADPFNVPVNPEALGIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSKYNKK 295
Cdd:cd05495   11 TLEKLYKQDPeSLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTG-QYQDPWQYVDDVWLMFDNAWLYNRK 84
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 222-296 1.38e-15

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 71.96  E-value: 1.38e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334183397  222 VIKKIMKMEAADPFNVPVNPEALgiPDYFDIIKTPMDFGTICNNFEkGNKYMNSEDVYKDVNYIWNNCSKYNKKG 296
Cdd:pfam00439   4 ILDKLMEHPIAAPFLEPVDPDEY--PDYYSVIKKPMDLSTIKKKLE-NGEYKSLAEFLADVKLIFSNARTYNGPG 75
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 201-319 1.22e-14

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 70.50  E-value: 1.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 201 EEKKTDQNLRYNKQELEDsliVIKKIMKMEAADPFNVPVNpeALGIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYK 280
Cdd:cd05504    2 RRSEGRHHGPLNLSALEQ---LLVEIVKHKDSWPFLRPVS--KIEVPDYYDIIKKPMDLGTIKEKLNMG-EYKLAEEFLS 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 334183397 281 DVNYIWNNCSKYNKKGDYIVDLMKRVKKNFMKYWTSAGL 319
Cdd:cd05504   76 DIQLVFSNCFLYNPEHTSVYKAGTRLQRFFIKRCRKLGL 114
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 226-314 5.33e-13

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 65.09  E-value: 5.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 226 IMKMEAAD---PFNVPVNPEAlgIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSKYNKKGDYIVDL 302
Cdd:cd05503    9 LDEMEAHEdawPFLEPVNTKL--VPGYRKIIKKPMDFSTIREKLESG-QYKTLEEFAEDVRLVFDNCETFNEDDSEVGRA 85

                         90
                 ....*....|..
gi 334183397 303 MKRVKKNFMKYW 314
Cdd:cd05503   86 GHNMRKFFEKRW 97
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 222-293 1.49e-12

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 64.30  E-value: 1.49e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334183397 222 VIKKIMKMEAADPFNVPVNPEAlgIPDYFDIIKTPMDFGTICNNFEKGNkYMNSEDVYKDVNYIWNNCSKYN 293
Cdd:cd05528   11 VLKRLASDKRFNAFTKPVDEEE--VPDYYEIIKQPMDLQTILQKLDTHQ-YLTAKDFLKDIDLIVTNALEYN 79
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 234-296 9.84e-12

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 61.42  E-value: 9.84e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334183397 234 PFNVPVNPEAlgIPDYFDIIKTPMDFGTICNNFEKgNKYMNSEDVYKDVNYIWNNCSKYNKKG 296
Cdd:cd05509   21 PFLEPVDKEE--APDYYDVIKKPMDLSTMEEKLEN-GYYVTLEEFVADLKLIFDNCRLYNGPD 80
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 230-312 5.12e-11

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 59.76  E-value: 5.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 230 EAADPFNVPVNP-EAlgiPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSKYNKKGDYIVdlmkRVKK 308
Cdd:cd05510   24 EHSTPFLTKVSKrEA---PDYYDIIKKPMDLGTMLKKLKNL-QYKSKAEFVDDLNLIWKNCLLYNSDPSHPL----RRHA 95


                 ....
gi 334183397 309 NFMK 312
Cdd:cd05510   96 NFMK 99
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 222-293 5.85e-11

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 59.59  E-value: 5.85e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 334183397 222 VIKKIMKMEAADPFNVPVNPEAlgIPDYFDIIKTPMDFGTICNNFEKgNKYMNSEDVYKDVNYIWNNCSKYN 293
Cdd:cd05511    8 IVNELKNLPDSWPFHTPVNKKK--VPDYYKIIKRPMDLQTIRKKISK-HKYQSREEFLEDIELIVDNSVLYN 76
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 215-310 8.65e-11

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 58.70  E-value: 8.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 215 ELEDSLIVIKKIMKMEAADPFNVPVNPEAlgIPDYFDIIKTPMDFGTICNNFEkGNKYMNSEDVYKDVNYIWNNCSKYNK 294
Cdd:cd05505    1 ELQKCEEILSKILKYRFSWPFREPVTADE--AEDYKKVITNPMDLQTMQTKCS-CGSYSSVQEFLDDMKLVFSNAEKYYE 77

                         90
                 ....*....|....*.
gi 334183397 295 KGDYIVDLMKRVKKNF 310
Cdd:cd05505   78 NGSYVLSCMRKTEQCC 93
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 220-295 8.94e-11

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 58.56  E-value: 8.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 220 LIVIKKIM-KMEAADP---FNVPVNPEAlgIPDYFDIIKTPMDFGTICNNFEKgNKYMNSEDVYKDVNYIWNNCSKYNKK 295
Cdd:cd05512    3 EVLLRKTLdQLQEKDTaeiFSEPVDLSE--VPDYLDHIKQPMDFSTMRKKLES-QRYRTLEDFEADFNLIINNCLAYNAK 79
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 217-295 1.53e-10

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 58.62  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 217 EDSLIVIKKIMKMEAADPFNVPVNpeALGIPDYFDIIKTPMDFGTICNNFEKGNkYMNSEDVYKDVNYIWNNCSKY--NK 294
Cdd:cd05496    8 KQCKELVNLMWDCEDSEPFRQPVD--LLKYPDYRDIIDTPMDLGTVKETLFGGN-YDDPMEFAKDVRLIFSNSKSYtpNK 84


                 .
gi 334183397 295 K 295
Cdd:cd05496   85 R 85
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 247-299 1.80e-08

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 52.45  E-value: 1.80e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 334183397 247 PDYFDIIKTPMDFGTICNNFeKGNKYMNSEDVYKDVNYIWNNCSKYNKKGDYI 299
Cdd:cd05518   37 PDYYKIILEPIDLKTIEHNI-RNDKYATEEELMDDFKLMFRNARHYNEEGSQV 88
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 234-294 2.10e-08

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 52.29  E-value: 2.10e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334183397 234 PFNVPVNPEalgIPDYFDIIKTPMDFGTICNNFEKGN--KYMNSEDVYKDVNYIWNNCSKYNK 294
Cdd:cd05502   24 PFHEPVSPS---VPNYYKIIKTPMDLSLIRKKLQPKSpqHYSSPEEFVADVRLMFKNCYKFNE 83
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 165-296 1.34e-07

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 54.04  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 165 VKVQDVVVGQKDTKTSEENSQASKKEAEIATiSLQKEEKKTDQNLRYNKQELEDSLIVIKKIMKMEAADPFNVPVNPEAL 244
Cdd:COG5076   98 SLRFDEIVFLAIESVTPESGLGSLLMAHLKT-SVKKRKTPKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKR 176

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 334183397 245 GIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSKYNKKG 296
Cdd:COG5076  177 EYPDYYEIIKSPMDLLTIQKKLKNG-RYKSFEEFVSDLNLMFDNCKLYNGPD 227
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 232-301 3.27e-07

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 48.96  E-value: 3.27e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334183397 232 ADPF-NVPVNPEalgIPDYFDIIKTPMDFGTICNNFEKGnKYMNSEDVYKDVNYIWNNCSKYNKKGDYIVD 301
Cdd:cd05516   25 AEVFiQLPSRKE---LPEYYELIRKPVDFKKIKERIRNH-KYRSLEDLEKDVMLLCQNAQTFNLEGSLIYE 91
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 222-312 5.53e-06

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 45.09  E-value: 5.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 222 VIKKIMKMEAADPFNVPVNpEALGiPDYFDIIKTPMDFGTICNNFEKgNKYMNSEDVYKDVNYIWNNCSKYNKKGDYIVD 301
Cdd:cd05513    9 LIRQLQRKDPHGFFAFPVT-DFIA-PGYSSIIKHPMDFSTMKEKIKN-NDYQSIEEFKDDFKLMCENAMKYNKPDTIYYK 85

                         90
                 ....*....|.
gi 334183397 302 LMKRVKKNFMK 312
Cdd:cd05513   86 AAKKLLHSGMK 96
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 232-310 1.43e-05

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 44.64  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 232 ADPFNVPVNpEALGIPDYFDIIKTPMDFGTICNNFEkgNKYMNS-EDVYKDVNYIWNNCSKYNKKGDYIVDLMKRVKKNF 310
Cdd:cd05529   45 AEYFEYPVD-LRAWYPDYWNRVPVPMDLETIRSRLE--NRYYRSlEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWL 121
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 247-299 1.66e-05

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 43.83  E-value: 1.66e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 334183397 247 PDYFDIIKTPMDFGTICNNFEkGNKYMNSEDVYKDVNYIWNNCSKYNKKGDYI 299
Cdd:cd05515   37 PDYYDVIKKPIDMEKIRSKIE-GNQYQSLDDMVSDFVLMFDNACKYNEPDSQI 88
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 227-308 4.00e-04

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 39.67  E-value: 4.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 227 MKMEAADPFNVPVNPEALgiPDYFDIIKTPMDFGTICNNFEKgNKYMNSEDVYKDVNYIWNNCSKYNKKGDYIVDLMKRV 306
Cdd:cd05508   15 MKQPGAEPFLKPVDLEQF--PDYAQYVFKPMDLSTLEKNVRK-KAYGSTDAFLADAKWILHNAIIYNGGDHKLTQAAKAI 91


                 ..
gi 334183397 307 KK 308
Cdd:cd05508   92 VK 93
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 213-310 5.85e-04

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 39.34  E-value: 5.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334183397 213 KQELEDSLIVIkkimkMEAADPFNVPVN------PEALGIPDYFDIIKTPMDFGTICNNFeKGNKYMNSEDVYKDVNYIW 286
Cdd:cd05517    2 KQILEQLLEAV-----MTATDPSGRLISelfqklPSKVLYPDYYAVIKEPIDLKTIAQRI-QSGYYKSIEDMEKDLDLMV 75

                         90       100
                 ....*....|....*....|....
gi 334183397 287 NNCSKYNKKGDYIVDLMKRVKKNF 310
Cdd:cd05517   76 KNAKTFNEPGSQVYKDANAIKKIF 99
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 247-293 4.01e-03

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 36.93  E-value: 4.01e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 334183397 247 PDYFDIIKTPMDFGTIcNNFEKGNKYMNSEDVYKDVNYIWNNCSKYN 293
Cdd:cd05520   37 PDYYQEIKNPISLQQI-RTKLKNGEYETLEELEADLNLMFENAKRYN 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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