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Conserved domains on  [gi|334182820|ref|NP_001185081|]
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K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

Protein Classification

MADS-box domain-containing protein( domain architecture ID 10083661)

MADS-box domain-containing protein with a K-box coiled-coil region; the MADS-box domain (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor) is a conserved DNA-binding/dimerization region present in a variety of transcription factors from three eukaryotic kingdoms, plants, animals, and fungi

Gene Ontology:  GO:0003700
PubMed:  29802068

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-76 6.01e-46

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


:

Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 147.31  E-value: 6.01e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334182820   2 GRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCsSSSMLRTLERYQKCNYG 76
Cdd:cd00265    1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFS-SPSMEKIIERYQKTSGS 74
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 95-160 2.68e-24

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


:

Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 92.53  E-value: 2.68e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334182820   95 QQEYLKLKERYDALQRTQRNLLGEDLGPLSTKELESLERQLDSSLKQIRALRTQFMLDQLNDLQSK 160
Cdd:pfam01486  10 QQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLLLEQIEELKKK 75
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-76 6.01e-46

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 147.31  E-value: 6.01e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334182820   2 GRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCsSSSMLRTLERYQKCNYG 76
Cdd:cd00265    1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFS-SPSMEKIIERYQKTSGS 74
MADS smart00432
MADS domain;
2-60 7.64e-37

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 123.82  E-value: 7.64e-37
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 334182820     2 GRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSS 60
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFASP 59
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
10-57 4.75e-29

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 103.28  E-value: 4.75e-29
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 334182820   10 RIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEF 57
Cdd:pfam00319   1 RIENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 95-160 2.68e-24

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 92.53  E-value: 2.68e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334182820   95 QQEYLKLKERYDALQRTQRNLLGEDLGPLSTKELESLERQLDSSLKQIRALRTQFMLDQLNDLQSK 160
Cdd:pfam01486  10 QQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLLLEQIEELKKK 75
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 1-99 1.88e-13

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 68.89  E-value: 1.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182820   1 MGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSSS--SMLRTLEryQKCNYGAP 78
Cdd:COG5068   81 VTGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPKleSVVKSLE--GKSLIQSP 158

                         90       100
                 ....*....|....*....|.
gi 334182820  79 EPNVPSREALAVELSSQQEYL 99
Cdd:COG5068  159 CSNAPSDSSEEPSSSASFSVD 179
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
81-163 3.99e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.21  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182820  81 NVPSREALAVELSSQQEYLKLKERYDALQRTQRNLLGEDLGPLSTKELESLERQLDSSLKQIRALRtqfmlDQLNDLQSK 160
Cdd:COG4717  380 GVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELE-----EELEELREE 454


                 ...
gi 334182820 161 LAD 163
Cdd:COG4717  455 LAE 457
 
Name Accession Description Interval E-value
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-76 6.01e-46

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 147.31  E-value: 6.01e-46
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 334182820   2 GRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCsSSSMLRTLERYQKCNYG 76
Cdd:cd00265    1 GRGKIEIKRIENSTNRQVTFSKRRNGLLKKAHELSVLCDAEVALIIFSSSGKLYEFS-SPSMEKIIERYQKTSGS 74
MADS smart00432
MADS domain;
2-60 7.64e-37

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 123.82  E-value: 7.64e-37
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 334182820     2 GRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSS 60
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTFSKRRNGLFKKAHELSVLCDAEVALIVFSPTGKLYEFASP 59
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 2-60 4.28e-35

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 119.16  E-value: 4.28e-35
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 334182820   2 GRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSS 60
Cdd:cd00120    1 GRGKIEIKRIENKTSRQVTFSKRRNGLFKKASELSVLCDAEVAVIVFSPSGKLYEFWSS 59
MADS_SRF_like cd00266
SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) ...
 2-70 8.44e-30

SRF-like/Type I subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero- and homo-dimers. Differs from the MEF-like/Type II subgroup mainly in position of the alpha 2 helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238166 [Multi-domain]  Cd Length: 83  Bit Score: 106.58  E-value: 8.44e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334182820   2 GRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSSSSMLRTLERY 70
Cdd:cd00266    1 GRKKIKIKRIENKKKRAVTFSKRRQGLFKKASELSTLCGAEVAVIVYSPSGKLYVFWPSSEVEGVISRF 69
SRF-TF pfam00319
SRF-type transcription factor (DNA-binding and dimerization domain);
10-57 4.75e-29

SRF-type transcription factor (DNA-binding and dimerization domain);


Pssm-ID: 459760 [Multi-domain]  Cd Length: 48  Bit Score: 103.28  E-value: 4.75e-29
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 334182820   10 RIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEF 57
Cdd:pfam00319   1 RIENKRARQVTFSKRRKGLFKKASELSVLCGAEVAVIVFSPTGKLYTF 48
K-box pfam01486
K-box region; The K-box region is commonly found associated with SRF-type transcription ...
 95-160 2.68e-24

K-box region; The K-box region is commonly found associated with SRF-type transcription factors see pfam00319. The K-box is a possible coiled-coil structure. Possible role in multimer formation.


Pssm-ID: 460228 [Multi-domain]  Cd Length: 91  Bit Score: 92.53  E-value: 2.68e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334182820   95 QQEYLKLKERYDALQRTQRNLLGEDLGPLSTKELESLERQLDSSLKQIRALRTQFMLDQLNDLQSK 160
Cdd:pfam01486  10 QQEAAKLKKEIENLQRSQRQLLGEDLSSLSLKELQQLEQQLEKSLKRIRSRKNQLLLEQIEELKKK 75
ARG80 COG5068
Regulator of arginine metabolism and related MADS box-containing transcription factors ...
 1-99 1.88e-13

Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription];


Pssm-ID: 227400 [Multi-domain]  Cd Length: 412  Bit Score: 68.89  E-value: 1.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182820   1 MGRGRVELKRIENKINRQVTFAKRRNGLLKKAYELSVLCDAEVALIIFSNRGKLYEFCSSS--SMLRTLEryQKCNYGAP 78
Cdd:COG5068   81 VTGRKIGISYITNKTKRSVTFSKRKHGINKKAFELSVLTGTEVLLLVISENGLVHTFTTPKleSVVKSLE--GKSLIQSP 158

                         90       100
                 ....*....|....*....|.
gi 334182820  79 EPNVPSREALAVELSSQQEYL 99
Cdd:COG5068  159 CSNAPSDSSEEPSSSASFSVD 179
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
81-163 3.99e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.21  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182820  81 NVPSREALAVELSSQQEYLKLKERYDALQRTQRNLLGEDLGPLSTKELESLERQLDSSLKQIRALRtqfmlDQLNDLQSK 160
Cdd:COG4717  380 GVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELE-----EELEELREE 454


                 ...
gi 334182820 161 LAD 163
Cdd:COG4717  455 LAE 457
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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