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Conserved domains on  [gi|334182693|ref|NP_001185037|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
432-559 1.23e-08

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 432 GDTKSIpLTVEWStlgnPD--FLLAGCHDGTVALWKFSTTkssedtRPLLFFSADTAPIRAVAWAPgesdqeSANIVATA 509
Cdd:COG2319  244 GHSGSV-RSVAFS----PDgrLLASGSADGTVRLWDLATG------ELLRTLTGHSGGVNSVAFSP------DGKLLASG 306

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 334182693 510 GHAG-LKFWDLRDPfRPLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRI 559
Cdd:COG2319  307 SDDGtVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-623 1.41e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 1.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 354 HNGKVvWDMKWRPSYagdslnkhsmGYLAVLLGNGSLEVWDVPM------------PKATSALYLSSKKAAT--DPRFVK 419
Cdd:cd00200    8 HTGGV-TCVAFSPDG----------KLLATGSGDGTIKVWDLETgellrtlkghtgPVRDVAASADGTYLASgsSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 420 lapVFKCSNLKC-----GDTKSIpLTVEWSTlgNPDFLLAGCHDGTVALWKFSTTKssedtrPLLFFSADTAPIRAVAWA 494
Cdd:cd00200   77 ---LWDLETGECvrtltGHTSYV-SSVAFSP--DGRILSSSSRDKTIKVWDVETGK------CLTTLRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 495 PgesdqeSANIVATAGHAG-LKFWDLRDpFRPLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRIlslvkvaYDvpatg 573
Cdd:cd00200  145 P------DGTFVASSSQDGtIKLWDLRT-GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL-------WD----- 205

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 334182693 574 rpyPNTKQQgLSVYNCSTFPIWSIQVSRLTGIAAYCTADGSIFHFELTTK 623
Cdd:cd00200  206 ---LSTGKC-LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
432-559 1.23e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 432 GDTKSIpLTVEWStlgnPD--FLLAGCHDGTVALWKFSTTkssedtRPLLFFSADTAPIRAVAWAPgesdqeSANIVATA 509
Cdd:COG2319  244 GHSGSV-RSVAFS----PDgrLLASGSADGTVRLWDLATG------ELLRTLTGHSGGVNSVAFSP------DGKLLASG 306

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 334182693 510 GHAG-LKFWDLRDPfRPLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRI 559
Cdd:COG2319  307 SDDGtVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 441-622 1.07e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 441 VEWSTLGNpdFLLAGCHDGTVALWKFsttkssEDTRPLLFFSADTAPIRAVAWAPgesDQESaniVATAGHAG-LKFWDL 519
Cdd:cd00200   15 VAFSPDGK--LLATGSGDGTIKVWDL------ETGELLRTLKGHTGPVRDVAASA---DGTY---LASGSSDKtIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 520 RDPfRPLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRIlslvkvaYDVPaTGRPypntkqqgLSVYNCSTFPIWSIQV 599
Cdd:cd00200   81 ETG-ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV-------WDVE-TGKC--------LTTLRGHTDWVNSVAF 143

                        170       180
                 ....*....|....*....|...
gi 334182693 600 SRLTGIAAYCTADGSIFHFELTT 622
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRT 166
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-623 1.41e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 1.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 354 HNGKVvWDMKWRPSYagdslnkhsmGYLAVLLGNGSLEVWDVPM------------PKATSALYLSSKKAAT--DPRFVK 419
Cdd:cd00200    8 HTGGV-TCVAFSPDG----------KLLATGSGDGTIKVWDLETgellrtlkghtgPVRDVAASADGTYLASgsSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 420 lapVFKCSNLKC-----GDTKSIpLTVEWSTlgNPDFLLAGCHDGTVALWKFSTTKssedtrPLLFFSADTAPIRAVAWA 494
Cdd:cd00200   77 ---LWDLETGECvrtltGHTSYV-SSVAFSP--DGRILSSSSRDKTIKVWDVETGK------CLTTLRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 495 PgesdqeSANIVATAGHAG-LKFWDLRDpFRPLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRIlslvkvaYDvpatg 573
Cdd:cd00200  145 P------DGTFVASSSQDGtIKLWDLRT-GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL-------WD----- 205

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 334182693 574 rpyPNTKQQgLSVYNCSTFPIWSIQVSRLTGIAAYCTADGSIFHFELTTK 623
Cdd:cd00200  206 ---LSTGKC-LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
432-559 1.23e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 432 GDTKSIpLTVEWStlgnPD--FLLAGCHDGTVALWKFSTTkssedtRPLLFFSADTAPIRAVAWAPgesdqeSANIVATA 509
Cdd:COG2319  244 GHSGSV-RSVAFS----PDgrLLASGSADGTVRLWDLATG------ELLRTLTGHSGGVNSVAFSP------DGKLLASG 306

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 334182693 510 GHAG-LKFWDLRDPfRPLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRI 559
Cdd:COG2319  307 SDDGtVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
449-625 4.34e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 4.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 449 PD--FLLAGCHDGTVALWkfsttkSSEDTRPLLFFSADTAPIRAVAWAP-GEsdqesanIVATAGHAG-LKFWDLRDPfR 524
Cdd:COG2319  130 PDgkTLASGSADGTVRLW------DLATGKLLRTLTGHSGAVTSVAFSPdGK-------LLASGSDDGtVRLWDLATG-K 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 525 PLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRIlslvkvaYDVpATGRPypntkqqgLSVYNCSTFPIWSIQVSRLTG 604
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL-------WDL-ATGKL--------LRTLTGHSGSVRSVAFSPDGR 259

                        170       180
                 ....*....|....*....|.
gi 334182693 605 IAAYCTADGSIFHFELTTKAV 625
Cdd:COG2319  260 LLASGSADGTVRLWDLATGEL 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 441-622 1.07e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 441 VEWSTLGNpdFLLAGCHDGTVALWKFsttkssEDTRPLLFFSADTAPIRAVAWAPgesDQESaniVATAGHAG-LKFWDL 519
Cdd:cd00200   15 VAFSPDGK--LLATGSGDGTIKVWDL------ETGELLRTLKGHTGPVRDVAASA---DGTY---LASGSSDKtIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 520 RDPfRPLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRIlslvkvaYDVPaTGRPypntkqqgLSVYNCSTFPIWSIQV 599
Cdd:cd00200   81 ETG-ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV-------WDVE-TGKC--------LTTLRGHTDWVNSVAF 143

                        170       180
                 ....*....|....*....|...
gi 334182693 600 SRLTGIAAYCTADGSIFHFELTT 622
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRT 166
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-623 1.41e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 1.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 354 HNGKVvWDMKWRPSYagdslnkhsmGYLAVLLGNGSLEVWDVPM------------PKATSALYLSSKKAAT--DPRFVK 419
Cdd:cd00200    8 HTGGV-TCVAFSPDG----------KLLATGSGDGTIKVWDLETgellrtlkghtgPVRDVAASADGTYLASgsSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 420 lapVFKCSNLKC-----GDTKSIpLTVEWSTlgNPDFLLAGCHDGTVALWKFSTTKssedtrPLLFFSADTAPIRAVAWA 494
Cdd:cd00200   77 ---LWDLETGECvrtltGHTSYV-SSVAFSP--DGRILSSSSRDKTIKVWDVETGK------CLTTLRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 495 PgesdqeSANIVATAGHAG-LKFWDLRDpFRPLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRIlslvkvaYDvpatg 573
Cdd:cd00200  145 P------DGTFVASSSQDGtIKLWDLRT-GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL-------WD----- 205

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 334182693 574 rpyPNTKQQgLSVYNCSTFPIWSIQVSRLTGIAAYCTADGSIFHFELTTK 623
Cdd:cd00200  206 ---LSTGKC-LGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 447-615 1.98e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 1.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 447 GNPDFLLAGCHDGTVALWKFSTTKssedtrPLLFFSADTAPIRAVAWAPgesdqESANIVATAGHAGLKFWDLRDpFRPL 526
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGK------CVATLTGHTGEVNSVAFSP-----DGEKLLSSSSDGTIKLWDLST-GKCL 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 527 WDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRIlslvkvaYDVpATGRPypntkqqgLSVYNCSTFPIWSIQVSRLTGIA 606
Cdd:cd00200  213 GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-------WDL-RTGEC--------VQTLSGHTNSVTSLAWSPDGKRL 276


                 ....*....
gi 334182693 607 AYCTADGSI 615
Cdd:cd00200  277 ASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
448-615 2.65e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 2.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 448 NPDFLLAGCHDGTVALWKFSTtkssedTRPLLFFSADTAPIRAVAWAPgesdqeSANIVATAGHAG-LKFWDLRDPfRPL 526
Cdd:COG2319   89 DGRLLASASADGTVRLWDLAT------GLLLRTLTGHTGAVRSVAFSP------DGKTLASGSADGtVRLWDLATG-KLL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 527 WDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRILSLvkvaydvpATGRPypntkqqgLSVYNCSTFPIWSIQVSRLTGIA 606
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--------ATGKL--------LRTLTGHTGAVRSVAFSPDGKLL 219


                 ....*....
gi 334182693 607 AYCTADGSI 615
Cdd:COG2319  220 ASGSADGTV 228
WD40 COG2319
WD40 repeat [General function prediction only];
439-559 4.52e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 4.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 439 LTVEWStlgnPD--FLLAGCHDGTVALWKFSTTKssedtrPLLFFSADTAPIRAVAWAPGEsdqesaNIVATAGHAG-LK 515
Cdd:COG2319  292 NSVAFS----PDgkLLASGSDDGTVRLWDLATGK------LLRTLTGHTGAVRSVAFSPDG------KTLASGSDDGtVR 355

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 334182693 516 FWDLRDPfRPLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRI 559
Cdd:COG2319  356 LWDLATG-ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 440-559 2.54e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 2.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 440 TVEWSTLGNPdfLLAGCHDGTVALWKFSTTKSSEDtrpllfFSADTAPIRAVAWAPgesdqeSANIVATAGHAG-LKFWD 518
Cdd:cd00200  182 SVAFSPDGEK--LLSSSSDGTIKLWDLSTGKCLGT------LRGHENGVNSVAFSP------DGYLLASGSEDGtIRVWD 247

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 334182693 519 LRDpFRPLWDLHPVPRFIYSLDWLQDPSCVLLSFDDGTLRI 559
Cdd:cd00200  248 LRT-GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
439-521 1.64e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334182693 439 LTVEWSTLGNpdFLLAGCHDGTVALWKFSTTKssedtrPLLFFSADTAPIRAVAWAPgesdqeSANIVATAGHAG-LKFW 517
Cdd:COG2319  334 RSVAFSPDGK--TLASGSDDGTVRLWDLATGE------LLRTLTGHTGAVTSVAFSP------DGRTLASGSADGtVRLW 399


                 ....
gi 334182693 518 DLRD 521
Cdd:COG2319  400 DLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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