NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|307691260|ref|NP_001182696|]
View 

leucine-rich repeat-containing protein 74A [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 117-342 7.37e-40

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 149.17  E-value: 7.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 117 NTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnSSLWKLKLSGNSFKEECAALLC 196
Cdd:COG5238  179 NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN-KSLTTLDLSNNQIGDEGVIALA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 197 QALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGA 276
Cdd:COG5238  258 EALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGA 337

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 307691260 277 LALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRN 342
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN 403
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 117-342 7.37e-40

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 149.17  E-value: 7.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 117 NTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnSSLWKLKLSGNSFKEECAALLC 196
Cdd:COG5238  179 NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN-KSLTTLDLSNNQIGDEGVIALA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 197 QALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGA 276
Cdd:COG5238  258 EALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGA 337

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 307691260 277 LALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRN 342
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN 403
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 73-333 1.94e-33

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 128.63  E-value: 1.94e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260  73 EACKLVGVVPASYfiRNMEESCVNLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGiMSLMEMLHENYYLQELN 152
Cdd:cd00116   38 EAAKALASALRPQ--PSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDG-CGVLESLLRSSSLQELK 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 153 VSDNNLGLEGARIISNFLQENNSSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVG 232
Cdd:cd00116  115 LNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCN 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 233 LQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGALALGDALR-LNSCLVYVDVSRNGITNEGASKISKGL 311
Cdd:cd00116  195 LEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVL 274

                        250       260
                 ....*....|....*....|..
gi 307691260 312 ENNECLQVLKLFLNPLSLEGAY 333
Cdd:cd00116  275 AEKESLLELDLRGNKFGEEGAQ 296
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 117-342 7.37e-40

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 149.17  E-value: 7.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 117 NTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnSSLWKLKLSGNSFKEECAALLC 196
Cdd:COG5238  179 NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGN-KSLTTLDLSNNQIGDEGVIALA 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 197 QALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGA 276
Cdd:COG5238  258 EALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGA 337

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 307691260 277 LALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRN 342
Cdd:COG5238  338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTN 403
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 72-341 2.85e-39

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 147.63  E-value: 2.85e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260  72 LEACKLVGVVPAS--YFIRNMEESCVNLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQ 149
Cdd:COG5238  160 GLAARLGLLAAISmaKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLT 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 150 ELNVSDNNLGLEGARIISNFLQeNNSSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLAL 229
Cdd:COG5238  240 TLDLSNNQIGDEGVIALAEALK-NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 230 NVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISK 309
Cdd:COG5238  319 NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALID 398

                        250       260       270
                 ....*....|....*....|....*....|..
gi 307691260 310 GLENNEcLQVLKLFLNPLSLEGAYSLIMAIKR 341
Cdd:COG5238  399 ALQTNR-LHTLILDGNLIGAEAQQRLEQLLER 429
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 105-343 6.28e-37

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 141.08  E-value: 6.28e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 105 MGTKAIAITLVSNTTVLKLELGDNCIQEEGIMSLMEMLHE--NYYLQELNVSDNNLGLEGARIISNFLQENNSsLWKLKL 182
Cdd:COG5238  137 LPRRINLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKAlqNNSVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 183 SGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQSLNLSWNHFNIRGAVALCNGLRSNVTLK 262
Cdd:COG5238  216 KRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLT 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 263 KLDVSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRN 342
Cdd:COG5238  296 SLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGN 375


                 .
gi 307691260 343 P 343
Cdd:COG5238  376 T 376
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 73-333 1.94e-33

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 128.63  E-value: 1.94e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260  73 EACKLVGVVPASYfiRNMEESCVNLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGiMSLMEMLHENYYLQELN 152
Cdd:cd00116   38 EAAKALASALRPQ--PSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDG-CGVLESLLRSSSLQELK 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 153 VSDNNLGLEGARIISNFLQENNSSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVG 232
Cdd:cd00116  115 LNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCN 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 233 LQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGALALGDALR-LNSCLVYVDVSRNGITNEGASKISKGL 311
Cdd:cd00116  195 LEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVL 274

                        250       260
                 ....*....|....*....|..
gi 307691260 312 ENNECLQVLKLFLNPLSLEGAY 333
Cdd:cd00116  275 AEKESLLELDLRGNKFGEEGAQ 296
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 156-344 5.78e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 118.35  E-value: 5.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 156 NNLGLEGARIISNFLQenNSSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALNVGLQS 235
Cdd:COG5238  163 ARLGLLAAISMAKALQ--NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 236 LNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSMNGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNE 315
Cdd:COG5238  241 LDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNK 320

                        170       180
                 ....*....|....*....|....*....
gi 307691260 316 CLQVLKLFLNPLSLEGAYSLIMAIKRNPK 344
Cdd:COG5238  321 TLHTLNLAYNGIGAQGAIALAKALQENTT 349
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 114-375 4.97e-27

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 110.91  E-value: 4.97e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 114 LVSNTTVLKLElgDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLG--LEGARIISNFLQeNNSSLWKLKLSGNSFKEEC 191
Cdd:cd00116   21 KLLCLQVLRLE--GNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLT-KGCGLQELDLSDNALGPDG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 192 AALLcQALSSNYRIRSLNLSHNEFSDIGGEHLG---QMLALNvgLQSLNLSWNHFNIRGAVALCNGLRSNVTLKKLDVSM 268
Cdd:cd00116   98 CGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAkglKDLPPA--LEKLVLGRNRLEGASCEALAKALRANRDLKELNLAN 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 269 NGFGNEGALALGDALRLNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIkRNPKSRME 348
Cdd:cd00116  175 NGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASAL-LSPNISLL 253

                        250       260
                 ....*....|....*....|....*..
gi 307691260 349 DIDISNVLVSEQFVKVLDGVCAIHPQL 375
Cdd:cd00116  254 TLSLSCNDITDDGAKDLAEVLAEKESL 280
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 97-288 1.88e-25

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 106.29  E-value: 1.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260  97 LNHHGLGPMGTKAIAITLVSNTTVL-KLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENnS 175
Cdd:cd00116  115 LNNNGLGDRGLRLLAKGLKDLPPALeKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKAN-C 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 176 SLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHL-GQMLALNVGLQSLNLSWNHFNIRGAVALCNG 254
Cdd:cd00116  194 NLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALaSALLSPNISLLTLSLSCNDITDDGAKDLAEV 273

                        170       180       190
                 ....*....|....*....|....*....|....
gi 307691260 255 LRSNVTLKKLDVSMNGFGNEGALALGDALRLNSC 288
Cdd:cd00116  274 LAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 86-239 1.01e-14

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 75.08  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260  86 FIRNMEEscVNLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARI 165
Cdd:cd00116  163 ANRDLKE--LNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAA 240

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 307691260 166 ISNFLQENNSSLWKLKLSGNSFKEECAALLCQALSSNYRIRSLNLSHNEFSDIGGEHLGQMLALN-VGLQSLNLS 239
Cdd:cd00116  241 LASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPgNELESLWVK 315
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 95-208 3.63e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 64.81  E-value: 3.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260  95 VNLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQENN 174
Cdd:COG5238  325 LNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR 404

                         90       100       110
                 ....*....|....*....|....*....|....
gi 307691260 175 ssLWKLKLSGNSFKEECAALLCQALSsnyRIRSL 208
Cdd:COG5238  405 --LHTLILDGNLIGAEAQQRLEQLLE---RIKSV 433
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-328 5.14e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 5.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260  96 NLNHHGLGPMGTKAIAITLVSNTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLglegariISNFlqennS 175
Cdd:COG4886   46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNL-----T 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 176 SLWKLKLSGNSFKEecaalLCQALSSNYRIRSLNLSHNEFSDIGGEhlgqmLALNVGLQSLNLSWNhfNIRGavaLCNGL 255
Cdd:COG4886  114 NLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPEP-----LGNLTNLKSLDLSNN--QLTD---LPEEL 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 307691260 256 RSNVTLKKLDVSMNGFGNegalaLGDALRLNSCLVYVDVSRNGITNegaskISKGLENNECLQVLKLFLNPLS 328
Cdd:COG4886  179 GNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLT 241
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 285-399 1.68e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 285 LNSCLVYVDVSRNGITNEGASKISKGLENNECLQVLKLFLNPLSLEGAYSLIMAIKRNPKSRMedIDISNVLVSEQFVKV 364
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTT--LDLSNNQIGDEGVIA 255

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 307691260 365 LDGVCAIHPQLDVVY---------------KGLQGLSTKKSISLGTNPMR 399
Cdd:COG5238  256 LAEALKNNTTVETLYlsgnqigaegaialaKALQGNTTLTSLDLSVNRIG 305
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 95-187 1.79e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260  95 VNLNHHGLGPMGTKAIAITLVS-NTTVLKLELGDNCIQEEGIMSLMEMLHENYYLQELNVSDNNLGLEGARIISNFLQEN 173
Cdd:cd00116  226 LNLGDNNLTDAGAAALASALLSpNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEP 305

                         90
                 ....*....|....
gi 307691260 174 NSSLWKLKLSGNSF 187
Cdd:cd00116  306 GNELESLWVKDDSF 319
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 122-269 7.88e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 7.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307691260 122 KLELGDNCIqeegimSLMEMLHENYYLQELNVSDNNLGlegariisnflqennsslwklklSGNSFKEECAALlcQALSS 201
Cdd:cd21340   72 KLYLGGNRI------SVVEGLENLTNLEELHIENQRLP-----------------------PGEKLTFDPRSL--AALSN 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 307691260 202 NYRIrsLNLSHNEFSDIggehlgQMLALNVGLQSLNLSWNhfNIRGAVALCNGLRSNVTLKKLDVSMN 269
Cdd:cd21340  121 SLRV--LNISGNNIDSL------EPLAPLRNLEQLDASNN--QISDLEELLDLLSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH