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Conserved domains on  [gi|302564560|ref|NP_001181827|]
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vertnin [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
 74-241 3.21e-53

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


:

Pssm-ID: 438612  Cd Length: 137  Bit Score: 179.72  E-value: 3.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564560  74 MLPLVCKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYlqgmidskvmlqavryslcseespemtslppatl 153
Cdd:cd22791    1 LEPLRVTGDGNCLFRAASLLLFGDESLHLELRLRTVLELVLNSEFY---------------------------------- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564560 154 EAIFDADVKASCFPSSFSNVWHLYALASVLRRNIYSIYPMRNL-KIRPYFNRVIRPRRCDHMPSTLHIMWAGQ--PLTSH 230
Cdd:cd22791   47 EAIYEAEIKATCKPGSYSGIWHIYALSSVLQRPIFSVYPEVGNqKIRPLLNRTIRPRKTSKSIETIHIMWTSTslKNNSS 126

                        170
                 ....*....|.
gi 302564560 231 FFRHQYFAPVV 241
Cdd:cd22791  127 NWKPNHFVPLL 137
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
276-312 2.52e-04

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


:

Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 40.68  E-value: 2.52e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 302564560 276 REPGLSYSHLCERYSVTKSTFYRWRRQSQEHRQRVAA 312
Cdd:COG2963   21 LEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFP 57
 
Name Accession Description Interval E-value
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
 74-241 3.21e-53

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


Pssm-ID: 438612  Cd Length: 137  Bit Score: 179.72  E-value: 3.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564560  74 MLPLVCKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYlqgmidskvmlqavryslcseespemtslppatl 153
Cdd:cd22791    1 LEPLRVTGDGNCLFRAASLLLFGDESLHLELRLRTVLELVLNSEFY---------------------------------- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564560 154 EAIFDADVKASCFPSSFSNVWHLYALASVLRRNIYSIYPMRNL-KIRPYFNRVIRPRRCDHMPSTLHIMWAGQ--PLTSH 230
Cdd:cd22791   47 EAIYEAEIKATCKPGSYSGIWHIYALSSVLQRPIFSVYPEVGNqKIRPLLNRTIRPRKTSKSIETIHIMWTSTslKNNSS 126

                        170
                 ....*....|.
gi 302564560 231 FFRHQYFAPVV 241
Cdd:cd22791  127 NWKPNHFVPLL 137
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
276-312 2.52e-04

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 40.68  E-value: 2.52e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 302564560 276 REPGLSYSHLCERYSVTKSTFYRWRRQSQEHRQRVAA 312
Cdd:COG2963   21 LEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFP 57
transpos_IS481 NF033577
IS481 family transposase; null
 271-305 8.97e-03

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 38.73  E-value: 8.97e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 302564560 271 LELLNR--EPGLSYSHLCERYSVTKSTFYRWRRQSQE 305
Cdd:NF033577   3 LELVRLvlEDGWSVREAARRFGISRKTVYKWLKRYRA 39
 
Name Accession Description Interval E-value
OTU_VRTN cd22791
OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU ...
 74-241 3.21e-53

OTU (ovarian tumor) domain of vertnin and similar proteins; Vertnin (VRTN) is an OTU domain-containing protein that is required for the development of thoracic vertebrae in mammals. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation. Vertnin and some subfamily members do not possess the conserved catalytic residues and may not have DUB activity. VRTN gene is associated with variations in vertebral number.


Pssm-ID: 438612  Cd Length: 137  Bit Score: 179.72  E-value: 3.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564560  74 MLPLVCKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYlqgmidskvmlqavryslcseespemtslppatl 153
Cdd:cd22791    1 LEPLRVTGDGNCLFRAASLLLFGDESLHLELRLRTVLELVLNSEFY---------------------------------- 46

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564560 154 EAIFDADVKASCFPSSFSNVWHLYALASVLRRNIYSIYPMRNL-KIRPYFNRVIRPRRCDHMPSTLHIMWAGQ--PLTSH 230
Cdd:cd22791   47 EAIYEAEIKATCKPGSYSGIWHIYALSSVLQRPIFSVYPEVGNqKIRPLLNRTIRPRKTSKSIETIHIMWTSTslKNNSS 126

                        170
                 ....*....|.
gi 302564560 231 FFRHQYFAPVV 241
Cdd:cd22791  127 NWKPNHFVPLL 137
OTU cd22744
OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved ...
 79-231 2.86e-09

OTU (ovarian tumor) domain family; The OTU family of cysteine proteases use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin, a small regulatory protein that can be conjugated to a large range of target proteins. Protein ubiquitination is a post-translational modification of mostly Lys residues that regulates many cellular processes, including protein degradation, intracellular trafficking, cell signaling, autophagy, transcription, translation, and the DNA damage response. These DUBs may play important regulatory roles at the level of protein turnover by preventing degradation.


Pssm-ID: 438581 [Multi-domain]  Cd Length: 128  Bit Score: 55.52  E-value: 2.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564560  79 CKGEGSLLFEAASMLLWGDAGLSLELRARTVVEMLLHRHYYLQGMidskvmlqavryslcseespemtsLPPATLEAIFD 158
Cdd:cd22744    5 VPGDGNCLFRALAHALYGDQESHRELRQEVVDYLRENPDLYEPAE------------------------LADEDDGEDFD 60

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 302564560 159 ADVKASCFPSSFSNVWHLYALASVLRRNIYSIYPMRNlkirpYFNRVIRPRRCDHMPSTLHIMWAGQpltSHF 231
Cdd:cd22744   61 EYLQRMRKPGTWGGELELQALANALNVPIVVYSEDGG-----FLPVSVFGPGPGPSGRPIHLLYTGG---NHY 125
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
276-312 2.52e-04

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 40.68  E-value: 2.52e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 302564560 276 REPGLSYSHLCERYSVTKSTFYRWRRQSQEHRQRVAA 312
Cdd:COG2963   21 LEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFP 57
OTU_C64 cd22750
OTU (ovarian tumor) domain of family C64 cysteine proteases; This group includes proteins ...
 71-208 1.58e-03

OTU (ovarian tumor) domain of family C64 cysteine proteases; This group includes proteins classified as family C64 cysteine protease by MEROPS, such as tumor necrosis factor (TNF) alpha-induced protein 3 (TNFAIP3), ZRANB1, OTU domain-containing protein 7A (OTUD7A), and OTUD7B. It also includes VCIP135. These proteins are deubiquitinases (DUBs)/ubiquitin thioesterases (EC 3.4.19.12) that mediates the deubiquitination of protein substrates. TNFAIP3 also contains ubiquitin ligase activity. It antagonizes IKK [IkappaB (inhibitor of kappaB) kinase] activation by modulating Lys63-linked polyubiquitination of cytokine-receptor-associated factors including TRAF2/6 (tumour-necrosis-factor-receptor-associated factor 2/6) and RIP1 (receptor-interacting protein 1). ZRANB1 binds, deubiquitinates, and stabilizes EZH2, which is the catalytic component of the Polycomb repressive complex 2 (PRC2) that silences gene transcription by methylating histone H3 at lysine 27 and is mutated or highly expressed in many types of cancer, including lymphoma, melanoma, prostate cancer, ovarian cancer, and breast cancer. OTUD7A has been identified as a critical gene for brain function, while OTUD7B functions as a negative regulator of the non-canonical NF-kappaB pathway by mediating the deubiquitination of TRAF3, an inhibitor of the NF-kappaB pathway, resulting in preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappaB. VCIP135 controls Golgi membrane dynamics in the cell cycle and is required for Golgi and ER assembly. This group belongs to the OTU family of cysteine proteases that use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad.


Pssm-ID: 438587  Cd Length: 185  Bit Score: 40.02  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302564560  71 PRNMLPLVCKGEGSLLFEAASMLLWGDAGLSLELRaRTVVEMLLHR--HYYLQGMIDSKV-MLQAVRYSLCSE------- 140
Cdd:cd22750   19 VSRLVPLHTRGDGNCLLHAVSLALWGVEDRDLLLR-SALHETLQNDqeRRFRARWRRQQLkSGQELGLSLDEEalqaewe 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 302564560 141 ------ESPEMTSLPPATLEAIfdadvkascfpssfsnvwHLYALASVLRRNIYsIYPMRnlKIRPYFNRVIRP 208
Cdd:cd22750   98 eilkaaETPTVPAGPGSYLEEI------------------HIFVLANVLRRPII-VLADD--SARSLEGSALQD 150
transpos_IS481 NF033577
IS481 family transposase; null
 271-305 8.97e-03

IS481 family transposase; null


Pssm-ID: 468094 [Multi-domain]  Cd Length: 283  Bit Score: 38.73  E-value: 8.97e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 302564560 271 LELLNR--EPGLSYSHLCERYSVTKSTFYRWRRQSQE 305
Cdd:NF033577   3 LELVRLvlEDGWSVREAARRFGISRKTVYKWLKRYRA 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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